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UniProtKB - G3QXF6 (G3QXF6_GORGO)

Entry version 64 (07 Oct 2020)
Sequence version 2 (28 Feb 2018)
Previous versions | rss
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Protein
Submitted name:

Afadin, adherens junction formation factor

Gene

AFDN

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesionARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Afadin, adherens junction formation factorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AFDNImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9595 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Gorilla ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001519 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSGGOG00000007655, Expressed in testis and 6 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9593.ENSGGOP00000007498

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 110Ras-associatingInterPro annotationAdd BLAST96
Domaini223 – 325Ras-associatingInterPro annotationAdd BLAST103
Domaini630 – 877DiluteInterPro annotationAdd BLAST248
Domaini962 – 1048PDZInterPro annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni105 – 170DisorderedSequence analysisAdd BLAST66
Regioni326 – 361DisorderedSequence analysisAdd BLAST36
Regioni501 – 557DisorderedSequence analysisAdd BLAST57
Regioni1062 – 1178DisorderedSequence analysisAdd BLAST117
Regioni1190 – 1428DisorderedSequence analysisAdd BLAST239
Regioni1456 – 1483DisorderedSequence analysisAdd BLAST28
Regioni1524 – 1715DisorderedSequence analysisAdd BLAST192

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi120 – 170PolyampholyteSequence analysisAdd BLAST51
Compositional biasi326 – 346PolyampholyteSequence analysisAdd BLAST21
Compositional biasi506 – 530PolarSequence analysisAdd BLAST25
Compositional biasi1084 – 1100PolarSequence analysisAdd BLAST17
Compositional biasi1109 – 1124PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1126 – 1164PolarSequence analysisAdd BLAST39
Compositional biasi1229 – 1255PolyampholyteSequence analysisAdd BLAST27
Compositional biasi1257 – 1295PolarSequence analysisAdd BLAST39
Compositional biasi1315 – 1330Pro-richSequence analysisAdd BLAST16
Compositional biasi1361 – 1397PolyampholyteSequence analysisAdd BLAST37
Compositional biasi1398 – 1428PolarSequence analysisAdd BLAST31
Compositional biasi1469 – 1483PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1545 – 1631PolyampholyteSequence analysisAdd BLAST87
Compositional biasi1653 – 1667PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1668 – 1699PolarSequence analysisAdd BLAST32
Compositional biasi1700 – 1715PolyampholyteSequence analysisAdd BLAST16

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1892, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155237

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000594_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		G3QXF6

TreeFam database of animal gene trees

More...TreeFami		TF350731

Family and domain databases

Conserved Domains Database

More...CDDi		cd00060, FHA, 1 hit
cd15471, Myo5p-like_CBD_afadin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037977, CBD_Afadin
IPR002710, Dilute_dom
IPR000253, FHA_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR008984, SMAD_FHA_dom_sf
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01843, DIL, 1 hit
PF00498, FHA, 1 hit
PF00595, PDZ, 1 hit
PF00788, RA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01132, DIL, 1 hit
SM00240, FHA, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49879, SSF49879, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51126, DILUTE, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

G3QXF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
TVHRTWSAQY LDLEFHGVMR FYFQDKAAGN FATKCIRVSS TATTQDVIET 
        60         70         80         90        100
LAEKFRPDMR MLSSPKYSLY EVHVSGEERR LDIDEKPLVV QLNWNKDDRE 
       110        120        130        140        150
GRFVLKNEND AIPPKKAQSN GPEKQEKEGV IQNFKRTLSK KEKKEKKKRE 
       160        170        180        190        200
KETLRQASDK DDRPFQGEDV ENSRLAAEVY KDMPETSFTR TISNPEVVMK 
       210        220        230        240        250
RRRQQKLEKR MQEFRSSDGR PDSGGTLRIY ADSLKPNIPY KTILLSTTDP 
       260        270        280        290        300
ADFAVAEALE KYGLEKENPK DYCIARVMLP PGAQHSDEKG AKEIILDDDE 
       310        320        330        340        350
CPLQIFREWP SDKGILVFQL KRRPPDHIPK KTKKHLEGKT PKGKERADGS 
       360        370        380        390        400
GYGSTLPPEK LPYLVELSPD GSDSRDKPKL YRLQLSVTEV GTEKLDDNSI 
       410        420        430        440        450
QLFGPGIQPH HCDLTNMDGV VTVTPRSMDA ETYVEGQRIS ETTMLQSGMK 
       460        470        480        490        500
VQFGASHVFK FVDPSQDHAL AKRSVDGGLM VKGPRHKPGI VQETTFDLGG 
       510        520        530        540        550
DIHSGTALPT SKSTTRLDSD RVSSASSTAE RGMVKPMIRV EQQPDYRRQE 
       560        570        580        590        600
SRTQDASGPE LILPASIEFR ESSEDSFLSA IINYTNSSTV HFKLSPTYVL 
       610        620        630        640        650
YMACRYVLSN QYRPDISPTE RTHKVIAVVN KMVSMMEGVI QEVDQVDQKQ 
       660        670        680        690        700
KNIAGALAFW MANASELLNF IKQDRDLSRI TLDAQDVLAH LVQMAFKYLV 
       710        720        730        740        750
HCLQSELNNY MPAFLDDPEE NSLQRPKIDD VLHTLTGAMS LLRRCRVNAA 
       760        770        780        790        800
LTIQLFSQLF HFINMWLFNR LVTDPDSGLC SHYWGAIIRQ QLGHIEAWAE 
       810        820        830        840        850
KQGLELAADC HLSRIVQATT LLTMDKYAPD DIPNINSTCF KLNSLQLQAL 
       860        870        880        890        900
LQNYHCAPDE PFIPTDLIEN VVAVAENTAD ELARSDGREV QLEEDPDLQL 
       910        920        930        940        950
PFLLPEDGYS CDVVRNIPNG LQEFLDPLCQ RGKLVYMLLP HTRVTYSVSP 
       960        970        980        990       1000
RTAQPLRKEP EIITVTLKKQ NGMGLSIVAA KGAGQDKLGI YVKSVVKGGA 
      1010       1020       1030       1040       1050
ADVDGRLAAG DQLLSVDGRS LVGLSQERAA ELMTRTSSVV TLEVAKQGAI 
      1060       1070       1080       1090       1100
YHGLATLLNQ PSPMMQRISD RRGSGKPRPK SEGFELYNNS TQNGSPESPQ 
      1110       1120       1130       1140       1150
LPWAEYSEPK KLPGDDRLMK NRADHRSSPN VANQPPSPGG KSTYASGTTA 
      1160       1170       1180       1190       1200
KITSVSTGNL CTEEQTPPPR PEAYPIPTQT YTREYFTFPA SKSQDRMAPP 
      1210       1220       1230       1240       1250
QNQWPNYEEK PHMHTDSNHS SIAIQRVTRS QEELREDKAY QLERHRIEAA 
      1260       1270       1280       1290       1300
MDRKSDSDMW INQSSSLDSS TSSQEHLNHS SKSVTPASTL TKSGPGRWKT 
      1310       1320       1330       1340       1350
PAAIPATPVA VSQPIRTDLP PPPPPPPVHY AGDFDGMSMD LPLPPPPSAN 
      1360       1370       1380       1390       1400
QIGLPSAQVA AAERKKREEH QRWYEKEKAR LEEERERKRR EQERKLGQMR 
      1410       1420       1430       1440       1450
TQSLNPAPFS PLTAQQMKPE KPSTLQRPQE TVIRELQPQQ QPRTIERRDL 
      1460       1470       1480       1490       1500
QYITVSKEEL SSGDSLSPDP WKRDAKEKLE KQQQMHIVDM LSKEIQELQS 
      1510       1520       1530       1540       1550
KPDRSAEESD RLRKLMLEWQ FQKRLQESKQ KDEDDEEEED DDVDTMLIMQ 
      1560       1570       1580       1590       1600
RLEAERRARL QDEERRRQQQ LEEMRKREAE DRARQEEERR RQEEERTKRD 
      1610       1620       1630       1640       1650
AEEKRRQEEG YYSHLEAERR RQHDEAARRL LEPEAPGPNS YPGPTGAAVG 
      1660       1670       1680       1690       1700
AHDACRDAKE KRSKSQDADS PGSSGAPENL TFKERQRLFS QGQDVSNKVK 
      1710 
ASRKLTELEN ELNTK
Length:1,715
Mass (Da):194,380
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i477025204729046B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I2Z2D7A0A2I2Z2D7_GORGO
Afadin, adherens junction formation...
AFDN
1,793Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I2YER3A0A2I2YER3_GORGO
Afadin, adherens junction formation...
AFDN
1,786Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CABD030049035 Genomic DNA No translation available.
CABD030049036 Genomic DNA No translation available.
CABD030049037 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSGGOT00000007700; ENSGGOP00000007498; ENSGGOG00000007655

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030049035 Genomic DNA No translation available.
CABD030049036 Genomic DNA No translation available.
CABD030049037 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000007498

Genome annotation databases

EnsembliENSGGOT00000007700; ENSGGOP00000007498; ENSGGOG00000007655

Phylogenomic databases

eggNOGiKOG1892, Eukaryota
GeneTreeiENSGT00940000155237
HOGENOMiCLU_000594_1_0_1
InParanoidiG3QXF6
TreeFamiTF350731

Gene expression databases

BgeeiENSGGOG00000007655, Expressed in testis and 6 other tissues

Family and domain databases

CDDicd00060, FHA, 1 hit
cd15471, Myo5p-like_CBD_afadin, 1 hit
Gene3Di2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR037977, CBD_Afadin
IPR002710, Dilute_dom
IPR000253, FHA_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR008984, SMAD_FHA_dom_sf
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF01843, DIL, 1 hit
PF00498, FHA, 1 hit
PF00595, PDZ, 1 hit
PF00788, RA, 2 hits
SMARTiView protein in SMART
SM01132, DIL, 1 hit
SM00240, FHA, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 2 hits
SUPFAMiSSF49879, SSF49879, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS51126, DILUTE, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3QXF6_GORGO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3QXF6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: February 28, 2018
Last modified: October 7, 2020
This is version 64 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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