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Entry version 64 (07 Oct 2020)
Sequence version 2 (28 Feb 2018)
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Protein
Submitted name:

Afadin, adherens junction formation factor

Gene

AFDN

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesionARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Afadin, adherens junction formation factorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AFDNImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9595 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001519 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGGOG00000007655, Expressed in testis and 6 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9593.ENSGGOP00000007498

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 110Ras-associatingInterPro annotationAdd BLAST96
Domaini223 – 325Ras-associatingInterPro annotationAdd BLAST103
Domaini630 – 877DiluteInterPro annotationAdd BLAST248
Domaini962 – 1048PDZInterPro annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni105 – 170DisorderedSequence analysisAdd BLAST66
Regioni326 – 361DisorderedSequence analysisAdd BLAST36
Regioni501 – 557DisorderedSequence analysisAdd BLAST57
Regioni1062 – 1178DisorderedSequence analysisAdd BLAST117
Regioni1190 – 1428DisorderedSequence analysisAdd BLAST239
Regioni1456 – 1483DisorderedSequence analysisAdd BLAST28
Regioni1524 – 1715DisorderedSequence analysisAdd BLAST192

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi120 – 170PolyampholyteSequence analysisAdd BLAST51
Compositional biasi326 – 346PolyampholyteSequence analysisAdd BLAST21
Compositional biasi506 – 530PolarSequence analysisAdd BLAST25
Compositional biasi1084 – 1100PolarSequence analysisAdd BLAST17
Compositional biasi1109 – 1124PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1126 – 1164PolarSequence analysisAdd BLAST39
Compositional biasi1229 – 1255PolyampholyteSequence analysisAdd BLAST27
Compositional biasi1257 – 1295PolarSequence analysisAdd BLAST39
Compositional biasi1315 – 1330Pro-richSequence analysisAdd BLAST16
Compositional biasi1361 – 1397PolyampholyteSequence analysisAdd BLAST37
Compositional biasi1398 – 1428PolarSequence analysisAdd BLAST31
Compositional biasi1469 – 1483PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1545 – 1631PolyampholyteSequence analysisAdd BLAST87
Compositional biasi1653 – 1667PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1668 – 1699PolarSequence analysisAdd BLAST32
Compositional biasi1700 – 1715PolyampholyteSequence analysisAdd BLAST16

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1892, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155237

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000594_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3QXF6

TreeFam database of animal gene trees

More...
TreeFami
TF350731

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00060, FHA, 1 hit
cd15471, Myo5p-like_CBD_afadin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037977, CBD_Afadin
IPR002710, Dilute_dom
IPR000253, FHA_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR008984, SMAD_FHA_dom_sf
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01843, DIL, 1 hit
PF00498, FHA, 1 hit
PF00595, PDZ, 1 hit
PF00788, RA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01132, DIL, 1 hit
SM00240, FHA, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49879, SSF49879, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51126, DILUTE, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

G3QXF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
TVHRTWSAQY LDLEFHGVMR FYFQDKAAGN FATKCIRVSS TATTQDVIET
60 70 80 90 100
LAEKFRPDMR MLSSPKYSLY EVHVSGEERR LDIDEKPLVV QLNWNKDDRE
110 120 130 140 150
GRFVLKNEND AIPPKKAQSN GPEKQEKEGV IQNFKRTLSK KEKKEKKKRE
160 170 180 190 200
KETLRQASDK DDRPFQGEDV ENSRLAAEVY KDMPETSFTR TISNPEVVMK
210 220 230 240 250
RRRQQKLEKR MQEFRSSDGR PDSGGTLRIY ADSLKPNIPY KTILLSTTDP
260 270 280 290 300
ADFAVAEALE KYGLEKENPK DYCIARVMLP PGAQHSDEKG AKEIILDDDE
310 320 330 340 350
CPLQIFREWP SDKGILVFQL KRRPPDHIPK KTKKHLEGKT PKGKERADGS
360 370 380 390 400
GYGSTLPPEK LPYLVELSPD GSDSRDKPKL YRLQLSVTEV GTEKLDDNSI
410 420 430 440 450
QLFGPGIQPH HCDLTNMDGV VTVTPRSMDA ETYVEGQRIS ETTMLQSGMK
460 470 480 490 500
VQFGASHVFK FVDPSQDHAL AKRSVDGGLM VKGPRHKPGI VQETTFDLGG
510 520 530 540 550
DIHSGTALPT SKSTTRLDSD RVSSASSTAE RGMVKPMIRV EQQPDYRRQE
560 570 580 590 600
SRTQDASGPE LILPASIEFR ESSEDSFLSA IINYTNSSTV HFKLSPTYVL
610 620 630 640 650
YMACRYVLSN QYRPDISPTE RTHKVIAVVN KMVSMMEGVI QEVDQVDQKQ
660 670 680 690 700
KNIAGALAFW MANASELLNF IKQDRDLSRI TLDAQDVLAH LVQMAFKYLV
710 720 730 740 750
HCLQSELNNY MPAFLDDPEE NSLQRPKIDD VLHTLTGAMS LLRRCRVNAA
760 770 780 790 800
LTIQLFSQLF HFINMWLFNR LVTDPDSGLC SHYWGAIIRQ QLGHIEAWAE
810 820 830 840 850
KQGLELAADC HLSRIVQATT LLTMDKYAPD DIPNINSTCF KLNSLQLQAL
860 870 880 890 900
LQNYHCAPDE PFIPTDLIEN VVAVAENTAD ELARSDGREV QLEEDPDLQL
910 920 930 940 950
PFLLPEDGYS CDVVRNIPNG LQEFLDPLCQ RGKLVYMLLP HTRVTYSVSP
960 970 980 990 1000
RTAQPLRKEP EIITVTLKKQ NGMGLSIVAA KGAGQDKLGI YVKSVVKGGA
1010 1020 1030 1040 1050
ADVDGRLAAG DQLLSVDGRS LVGLSQERAA ELMTRTSSVV TLEVAKQGAI
1060 1070 1080 1090 1100
YHGLATLLNQ PSPMMQRISD RRGSGKPRPK SEGFELYNNS TQNGSPESPQ
1110 1120 1130 1140 1150
LPWAEYSEPK KLPGDDRLMK NRADHRSSPN VANQPPSPGG KSTYASGTTA
1160 1170 1180 1190 1200
KITSVSTGNL CTEEQTPPPR PEAYPIPTQT YTREYFTFPA SKSQDRMAPP
1210 1220 1230 1240 1250
QNQWPNYEEK PHMHTDSNHS SIAIQRVTRS QEELREDKAY QLERHRIEAA
1260 1270 1280 1290 1300
MDRKSDSDMW INQSSSLDSS TSSQEHLNHS SKSVTPASTL TKSGPGRWKT
1310 1320 1330 1340 1350
PAAIPATPVA VSQPIRTDLP PPPPPPPVHY AGDFDGMSMD LPLPPPPSAN
1360 1370 1380 1390 1400
QIGLPSAQVA AAERKKREEH QRWYEKEKAR LEEERERKRR EQERKLGQMR
1410 1420 1430 1440 1450
TQSLNPAPFS PLTAQQMKPE KPSTLQRPQE TVIRELQPQQ QPRTIERRDL
1460 1470 1480 1490 1500
QYITVSKEEL SSGDSLSPDP WKRDAKEKLE KQQQMHIVDM LSKEIQELQS
1510 1520 1530 1540 1550
KPDRSAEESD RLRKLMLEWQ FQKRLQESKQ KDEDDEEEED DDVDTMLIMQ
1560 1570 1580 1590 1600
RLEAERRARL QDEERRRQQQ LEEMRKREAE DRARQEEERR RQEEERTKRD
1610 1620 1630 1640 1650
AEEKRRQEEG YYSHLEAERR RQHDEAARRL LEPEAPGPNS YPGPTGAAVG
1660 1670 1680 1690 1700
AHDACRDAKE KRSKSQDADS PGSSGAPENL TFKERQRLFS QGQDVSNKVK
1710
ASRKLTELEN ELNTK
Length:1,715
Mass (Da):194,380
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i477025204729046B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I2Z2D7A0A2I2Z2D7_GORGO
Afadin, adherens junction formation...
AFDN
1,793Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I2YER3A0A2I2YER3_GORGO
Afadin, adherens junction formation...
AFDN
1,786Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CABD030049035 Genomic DNA No translation available.
CABD030049036 Genomic DNA No translation available.
CABD030049037 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGGOT00000007700; ENSGGOP00000007498; ENSGGOG00000007655

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030049035 Genomic DNA No translation available.
CABD030049036 Genomic DNA No translation available.
CABD030049037 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000007498

Genome annotation databases

EnsembliENSGGOT00000007700; ENSGGOP00000007498; ENSGGOG00000007655

Phylogenomic databases

eggNOGiKOG1892, Eukaryota
GeneTreeiENSGT00940000155237
HOGENOMiCLU_000594_1_0_1
InParanoidiG3QXF6
TreeFamiTF350731

Gene expression databases

BgeeiENSGGOG00000007655, Expressed in testis and 6 other tissues

Family and domain databases

CDDicd00060, FHA, 1 hit
cd15471, Myo5p-like_CBD_afadin, 1 hit
Gene3Di2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR037977, CBD_Afadin
IPR002710, Dilute_dom
IPR000253, FHA_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR008984, SMAD_FHA_dom_sf
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF01843, DIL, 1 hit
PF00498, FHA, 1 hit
PF00595, PDZ, 1 hit
PF00788, RA, 2 hits
SMARTiView protein in SMART
SM01132, DIL, 1 hit
SM00240, FHA, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 2 hits
SUPFAMiSSF49879, SSF49879, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS51126, DILUTE, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3QXF6_GORGO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3QXF6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: February 28, 2018
Last modified: October 7, 2020
This is version 64 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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