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Protein
Submitted name:

Poly(A) polymerase alpha

Gene

PAPOLA

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions. Also active with manganese.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109ATPUniRule annotation1
Metal bindingi113Magnesium 1; catalyticUniRule annotation1
Metal bindingi113Magnesium 2; catalyticUniRule annotation1
Metal bindingi115Magnesium 1; catalyticUniRule annotation1
Metal bindingi115Magnesium 2; catalyticUniRule annotation1
Metal bindingi167Magnesium 2; catalyticUniRule annotation1
Binding sitei167ATPUniRule annotation1
Binding sitei228ATPUniRule annotation1
Binding sitei237ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 102ATPUniRule annotation3
Nucleotide bindingi113 – 115ATPUniRule annotation3
Nucleotide bindingi246 – 247ATPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Poly(A) polymerase alphaImported
Gene namesi
Name:PAPOLAImported
OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Chromosome 14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSGGOG00000006287

Interactioni

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000006157

Structurei

3D structure databases

ProteinModelPortaliG3QTX2
SMRiG3QTX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 363PAP_centralInterPro annotationAdd BLAST343
Domaini87 – 174NTP_transf_2InterPro annotationAdd BLAST88
Domaini366 – 433PAP_RNA-bindInterPro annotationAdd BLAST68

Phylogenomic databases

GeneTreeiENSGT00390000017928
InParanoidiG3QTX2
KOiK14376
OMAiMGIVVRH
OrthoDBiEOG091G0571
TreeFamiTF300842

Family and domain databases

InterProiView protein in InterPro
IPR011068 NuclTrfase_I-like_C
IPR007012 PolA_pol_cen_dom
IPR007010 PolA_pol_RNA-bd_dom
IPR014492 PolyA_polymerase
IPR002934 Polymerase_NTP_transf_dom
PANTHERiPTHR10682 PTHR10682, 1 hit
PfamiView protein in Pfam
PF01909 NTP_transf_2, 1 hit
PF04928 PAP_central, 1 hit
PF04926 PAP_RNA-bind, 1 hit
PIRSFiPIRSF018425 PolyA_polymerase, 1 hit
SUPFAMiSSF55003 SSF55003, 1 hit

Sequencei

Sequence statusi: Complete.

G3QTX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFPVTTQGS QQTQPPQKHY GITSPISLAA PKETDCVLTQ KLIETLKPFG
60 70 80 90 100
VFEEEEELQR RILILGKLNN LVKEWIREIS ESKNLPQSVI ENVGGKIFTF
110 120 130 140 150
GSYRLGVHTK GADIDALCVA PRHVDRSDFF TSFYDKLKLQ EEVKDLRAVE
160 170 180 190 200
EAFVPVIKLC FDGIEIDILF ARLALQTIPE DLDLRDDSLL KNLDIRCIRS
210 220 230 240 250
LNGCRVTDEI LHLVPNIDNF RLTLRAIKLW AKRHNIYSNI LGFLGGVSWA
260 270 280 290 300
MLVARTCQLY PNAIASTLVH KFFLVFSKWE WPNPVLLKQP EECNLNLPVW
310 320 330 340 350
DPRVNPSDRY HLMPIITPAY PQQNSTYNVS VSTRMVMVEE FKQGLAITDE
360 370 380 390 400
ILLSKAEWSK LFEAPNFFQK YKHYIVLLAS APTEKQRLEW VGLVESKIRI
410 420 430 440 450
LVGSLEKNEF ITLAHVNPQS FPAPKENPDK EEFRTMWVIG LVFKKTENSE
460 470 480 490 500
NLSVDLTYDI QSFTDTVYRQ AINSKMFEVD MKIAAMHVKR KQLHQLLPNH
510 520 530 540 550
VLQKKKKHST EGVKLTALND SSLDLSMDSD NSMSVPSPTS ATKTSPLNSS
560 570 580 590 600
GSSQGRNSPA PAVTAASVTN IQATEVSVPQ VNSSESSGGT SSESIPQTAT
610 620 630 640 650
QPAISPPPKP TVSRVVSSTR LVNPPPRSSG NAATSGNAAT KIPTPIVGVK
660 670 680 690 700
RTSSPHKEES PKKTKTEEDE TSEDANCLAL SGHDKTEAKE QLDTETSTTQ
710 720 730 740
SETIQTAASL LASQKTSSTD LSDIPALPAN PIPVIKNSIK LRLNR
Length:745
Mass (Da):82,843
Last modified:November 16, 2011 - v1
Checksum:i14A00CCCDAD9B374
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030093965 Genomic DNA No translation available.
CABD030093966 Genomic DNA No translation available.
CABD030093967 Genomic DNA No translation available.
RefSeqiXP_004055715.1, XM_004055667.2

Genome annotation databases

EnsembliENSGGOT00000006323; ENSGGOP00000006157; ENSGGOG00000006287
GeneIDi101134787
KEGGiggo:101134787

Similar proteinsi

Entry informationi

Entry nameiG3QTX2_GORGO
AccessioniPrimary (citable) accession number: G3QTX2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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