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UniProtKB - G3QM23 (G3QM23_GORGO)
Protein
Submitted name:
Coagulation factor VIII
Gene
F8
Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Functioni
GO - Molecular functioni
- copper ion binding Source: InterPro
- oxidoreductase activity Source: InterPro
GO - Biological processi
- blood coagulation, intrinsic pathway Source: GO_Central
Keywordsi
Ligand | CalciumARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Coagulation factor VIIIImported |
Gene namesi | Name:F8Imported |
Organismi | Gorilla gorilla gorilla (Western lowland gorilla)Imported |
Taxonomic identifieri | 9595 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Gorilla › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_5014156338 | 20 – 2351 | Sequence analysisAdd BLAST | 2332 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 172 ↔ 198 | UniRule annotation | ||
Disulfide bondi | 267 ↔ 348 | UniRule annotation | ||
Disulfide bondi | 547 ↔ 573 | UniRule annotation | ||
Disulfide bondi | 649 ↔ 730 | UniRule annotation | ||
Disulfide bondi | 1851 ↔ 1877 | UniRule annotation | ||
Disulfide bondi | 1918 ↔ 1922 | UniRule annotation | ||
Disulfide bondi | 2040 ↔ 2188 | UniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotation, SulfationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSGGOG00000003600, Expressed in heart and 7 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2040 – 2188 | F5/8 type CInterPro annotationAdd BLAST | 149 | |
Domaini | 2193 – 2345 | F5/8 type CInterPro annotationAdd BLAST | 153 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 906 – 961 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 1579 – 1610 | DisorderedSequence analysisAdd BLAST | 32 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1206 – 1226 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1593 – 1610 | Basic and acidic residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the multicopper oxidase family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, SignalSequence analysisARBA annotationPhylogenomic databases
eggNOGi | ENOG502QSFZ, Eukaryota |
GeneTreei | ENSGT00940000160294 |
HOGENOMi | CLU_000948_1_0_1 |
InParanoidi | G3QM23 |
OrthoDBi | 454773at2759 |
TreeFami | TF329807 |
Family and domain databases
CDDi | cd00057, FA58C, 2 hits |
Gene3Di | 2.60.40.420, 6 hits |
InterProi | View protein in InterPro IPR001117, Cu-oxidase IPR011706, Cu-oxidase_C IPR045087, Cu-oxidase_fam IPR011707, Cu-oxidase_N IPR033138, Cu_oxidase_CS IPR008972, Cupredoxin IPR000421, FA58C IPR024715, Factor_5/8-like IPR008979, Galactose-bd-like_sf |
PANTHERi | PTHR11709, PTHR11709, 3 hits |
Pfami | View protein in Pfam PF00394, Cu-oxidase, 1 hit PF07731, Cu-oxidase_2, 1 hit PF07732, Cu-oxidase_3, 2 hits PF00754, F5_F8_type_C, 2 hits |
PIRSFi | PIRSF000354, Factors_V_VIII, 1 hit |
SMARTi | View protein in SMART SM00231, FA58C, 2 hits |
SUPFAMi | SSF49503, SSF49503, 6 hits SSF49785, SSF49785, 2 hits |
PROSITEi | View protein in PROSITE PS01285, FA58C_1, 2 hits PS01286, FA58C_2, 2 hits PS50022, FA58C_3, 2 hits PS00079, MULTICOPPER_OXIDASE1, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
G3QM23-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQIELSTCFF LCLLRFCFSA TRRYYLGAVE LSWDYMQSDL GELPVDARFP
60 70 80 90 100
PRVPKSFPFN TSVVYKKTVF VEFTDHLFNI AKPRPPWMGL LGPTIQAEVY
110 120 130 140 150
DTVVITLKNM ASHPVSLHAV GVSYWKASEG AEYDDQTSQR EKEDDKVFPG
160 170 180 190 200
GSHTYVWQVL KENGPMASDP LCLTYSYLSH VDLVKDLNSG LIGALLVCRE
210 220 230 240 250
GSLAKEKTQT LHKFILLFAV FDEGKSWHSE TKNSLMQDRD AASARAWPKM
260 270 280 290 300
HTVNGYVNRS LPGLIGCHRK SVYWHVIGMG TTPEVHSIFL EGHTFLVRNH
310 320 330 340 350
RQASLEISPI TFLTAQTLLM DLGQFLLFCH ISSHQHDGME AYVKVDSCPE
360 370 380 390 400
EPQLRMKNNE EAEDYDDDLT DSEMDVVRFD DDNSPSFIQI RSVAKKHPKT
410 420 430 440 450
WVHYIAAEEE DWDYAPLVLA PDDRSYKSQY LNNGPQRIGR KYKKVRFMAY
460 470 480 490 500
TDETFKTREA IQHESGILGP LLYGEVGDTL LIIFKNQASR PYNIYPHGIT
510 520 530 540 550
DVRPLYSRRL PKGVKHLKDF PILPGEIFKY KWTVTVEDGP TKSDPRCLTR
560 570 580 590 600
YYSSFINMER DLASGLIGPL LICYKESVDQ RGNQIMSDKR NVILFSVFDE
610 620 630 640 650
NRSWYLTENI QRFLPNPAGV QLEDPEFQAS NIMHSINGYV FDSLQLSVCL
660 670 680 690 700
HEVAYWYILS IGAQTDFLSV FFSGYTFKHK MVYEDTLTLF PFSGETVFMS
710 720 730 740 750
MENPGLWILG CHNSDFRNRG MTALLKVSSC DKNTGDYYED SYEDISAYLL
760 770 780 790 800
SKNNAIEPRS FSQNSRYPST RQKQFNATTI PENDIEKTDP WFAHRTPMPK
810 820 830 840 850
VQNVSSSDLL MLLRQSPTPH GLSLSDLQEA KYETFSDDPS PGAIDSNNSL
860 870 880 890 900
SEMTHFRPQL HHSGDMVFTP ESGLQLILNE KLGTTAATEL KKLDFKVSST
910 920 930 940 950
SNNLISTIPS DNLAAGTDNT SSLGPPSMPV HYDSQLDTTL FGKKSSPLTE
960 970 980 990 1000
SDGPLSLSEE NNDSKLLESG LMNSQESSWG KNVSSTESGR LFKGKRAHGP
1010 1020 1030 1040 1050
ALLTKDNALF KVSISLLKTN KTSNNSATNR KTHIDGRSLL IENSPSVWQN
1060 1070 1080 1090 1100
ILESDTEFQK VTPLIHDRML MDKNATALRL NHMSNKTTSS KNMEMVQQKK
1110 1120 1130 1140 1150
EGPIPPDAEN PDMSFFKMLF LPESASWVQR THGKNSLNSG QGPSPKQLVS
1160 1170 1180 1190 1200
LGPEKSVEGQ NFLSEKNKVV VGKGEFTKDV GLKEMVFPSS RNLFLTNLDN
1210 1220 1230 1240 1250
LHENNTHNQE KKIQEEIERK ETLIQENVVL PQIHTVTGTK NFMKNLFLLS
1260 1270 1280 1290 1300
TRQNVEGSYE GAYAPVLQDF RSLNDSTNRT KKHTAHFSKK GEEENLEGLG
1310 1320 1330 1340 1350
NQTKQIVEKY ACTTRISPNT SQQNFVTQRS KRALKQFRLP LEETELEKRI
1360 1370 1380 1390 1400
IVDDTSTQWS KNMKHLTPST LTQIDYNEKE KGAITQSPLS DCLTRSHSIP
1410 1420 1430 1440 1450
QANRSPLPIA KVSSFPSIRP IYLTRVLFQD NSSHLPAASY RKKDSGVQES
1460 1470 1480 1490 1500
SHFLQGAKKN NLSLAILTLE MTGDQREVGS LGTSATNSVT YKKVENTVLP
1510 1520 1530 1540 1550
KPGLPKTSGK VELLPKVHIY QKDLFPTETS NGSPGHLDLV EGSLLQETEG
1560 1570 1580 1590 1600
GIKWNEANRP GKIPFLRVAT ESSAKTPSKL LGPLAWDNHS GTQIPKEEWK
1610 1620 1630 1640 1650
SQEKSPEKTA FKKKDTILSL NACESNHAIA AINEGQNKPE IEVTWAKQGR
1660 1670 1680 1690 1700
TERLCSQNPP VLKRHQREIT RTTLQSDQEE IDYDDTISVE MKKEDFDIYD
1710 1720 1730 1740 1750
EDENQSPRSF QKKTRHYFIA AVERLWDYGM SSSPHVLRNR AQSGSVPQFK
1760 1770 1780 1790 1800
KVVFQEFTDG SFTQPLYRGE LNEHLGLLGP YIRAEVEDNI MVTFKNQASR
1810 1820 1830 1840 1850
PYSFYSSLIS YEEDQRQGAE PRKNFVKPNE TKTYFWKVQH HMAPTKDEFD
1860 1870 1880 1890 1900
CKAWAYFSDV DLEKDVHSGL IGPLLVCHTN TLNPAHGRQV TVQEFALFFT
1910 1920 1930 1940 1950
IFDETRSWYF TENMERNCRA PCNIQMEDPT FKENYRFHAI NGYIMDTLPG
1960 1970 1980 1990 2000
LVMAQDQRIR WYLLSMGSNE NIHSIHFSGH VFTVRKKEEY KMALYNLYPG
2010 2020 2030 2040 2050
VFETVEMLPS KAGIWRVECL IGEHLHAGMS TLFLVYSNKC QTPLGMASGH
2060 2070 2080 2090 2100
IRDFQITASG QYGQWAPKLA RLHYSGSINA WSTKEPFSWI KVDLLAPMII
2110 2120 2130 2140 2150
HGIKTQGARQ KFSSLYISQF IIMYSLDGKK WQTYRGNSTG TLMVFFGNVD
2160 2170 2180 2190 2200
SSGIKHNIFN PPIIARYIRL HPTHYSIRST LRMELMGCDL NSCSMPLGME
2210 2220 2230 2240 2250
SKAISDAQIT ASSYFTNMFA TWSPSKARLH LQGRSNAWRP QVNNPKEWLQ
2260 2270 2280 2290 2300
VDFQKTMKVT GITTQGVKSL LTSMYVKEFL ISSSQDGHHW TLFFQNGKVK
2310 2320 2330 2340 2350
VFQGNQDSFT PVVNSLDPPL LTRYLRIHPQ SWMHQIALRM EVLGCEAQDL
Y
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2I2Z2W3 | A0A2I2Z2W3_GORGO | Coagulation factor VIII | F8 | 240 | Annotation score: | ||
A0A2I2ZVS6 | A0A2I2ZVS6_GORGO | Coagulation factor VIII | F8 | 219 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CABD030129328 Genomic DNA No translation available. CABD030129329 Genomic DNA No translation available. CABD030129330 Genomic DNA No translation available. CABD030129331 Genomic DNA No translation available. CABD030129332 Genomic DNA No translation available. CABD030129333 Genomic DNA No translation available. CABD030129334 Genomic DNA No translation available. CABD030129335 Genomic DNA No translation available. CABD030129336 Genomic DNA No translation available. CABD030129337 Genomic DNA No translation available. |
RefSeqi | XP_004065205.1, XM_004065157.1 |
Genome annotation databases
Ensembli | ENSGGOT00000003629; ENSGGOP00000003549; ENSGGOG00000003600 |
GeneIDi | 101152070 |
KEGGi | ggo:101152070 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CABD030129328 Genomic DNA No translation available. CABD030129329 Genomic DNA No translation available. CABD030129330 Genomic DNA No translation available. CABD030129331 Genomic DNA No translation available. CABD030129332 Genomic DNA No translation available. CABD030129333 Genomic DNA No translation available. CABD030129334 Genomic DNA No translation available. CABD030129335 Genomic DNA No translation available. CABD030129336 Genomic DNA No translation available. CABD030129337 Genomic DNA No translation available. |
RefSeqi | XP_004065205.1, XM_004065157.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9593.ENSGGOP00000003549 |
Genome annotation databases
Ensembli | ENSGGOT00000003629; ENSGGOP00000003549; ENSGGOG00000003600 |
GeneIDi | 101152070 |
KEGGi | ggo:101152070 |
Organism-specific databases
CTDi | 2157 |
Phylogenomic databases
eggNOGi | ENOG502QSFZ, Eukaryota |
GeneTreei | ENSGT00940000160294 |
HOGENOMi | CLU_000948_1_0_1 |
InParanoidi | G3QM23 |
OrthoDBi | 454773at2759 |
TreeFami | TF329807 |
Gene expression databases
Bgeei | ENSGGOG00000003600, Expressed in heart and 7 other tissues |
Family and domain databases
CDDi | cd00057, FA58C, 2 hits |
Gene3Di | 2.60.40.420, 6 hits |
InterProi | View protein in InterPro IPR001117, Cu-oxidase IPR011706, Cu-oxidase_C IPR045087, Cu-oxidase_fam IPR011707, Cu-oxidase_N IPR033138, Cu_oxidase_CS IPR008972, Cupredoxin IPR000421, FA58C IPR024715, Factor_5/8-like IPR008979, Galactose-bd-like_sf |
PANTHERi | PTHR11709, PTHR11709, 3 hits |
Pfami | View protein in Pfam PF00394, Cu-oxidase, 1 hit PF07731, Cu-oxidase_2, 1 hit PF07732, Cu-oxidase_3, 2 hits PF00754, F5_F8_type_C, 2 hits |
PIRSFi | PIRSF000354, Factors_V_VIII, 1 hit |
SMARTi | View protein in SMART SM00231, FA58C, 2 hits |
SUPFAMi | SSF49503, SSF49503, 6 hits SSF49785, SSF49785, 2 hits |
PROSITEi | View protein in PROSITE PS01285, FA58C_1, 2 hits PS01286, FA58C_2, 2 hits PS50022, FA58C_3, 2 hits PS00079, MULTICOPPER_OXIDASE1, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | G3QM23_GORGO | |
Accessioni | G3QM23Primary (citable) accession number: G3QM23 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | February 28, 2018 | |
Last modified: | May 25, 2022 | |
This is version 64 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |