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Entry version 46 (05 Jun 2019)
Sequence version 1 (16 Nov 2011)
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Protein
Submitted name:

CWF19 like cell cycle control factor 2

Gene

CWF19L2

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CWF19 like cell cycle control factor 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CWF19L2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9595 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001519 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGGOG00000000049 Expressed in 7 organ(s), highest expression level in adult mammalian kidney

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9593.ENSGGOP00000000048

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini664 – 786CwfJ_C_1InterPro annotationAdd BLAST123
Domaini795 – 889CwfJ_C_2InterPro annotationAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 147DisorderedSequence analysisAdd BLAST147
Regioni270 – 484DisorderedSequence analysisAdd BLAST215

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili170 – 197Sequence analysisAdd BLAST28
Coiled coili502 – 522Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi12 – 76PolyampholyteSequence analysisAdd BLAST65
Compositional biasi77 – 100BasicSequence analysisAdd BLAST24
Compositional biasi107 – 121PolarSequence analysisAdd BLAST15
Compositional biasi123 – 147PolyampholyteSequence analysisAdd BLAST25
Compositional biasi270 – 292PolyampholyteSequence analysisAdd BLAST23
Compositional biasi293 – 328PolarSequence analysisAdd BLAST36
Compositional biasi329 – 347PolyampholyteSequence analysisAdd BLAST19
Compositional biasi348 – 362PolarSequence analysisAdd BLAST15
Compositional biasi368 – 383PolyampholyteSequence analysisAdd BLAST16
Compositional biasi385 – 407PolarSequence analysisAdd BLAST23
Compositional biasi408 – 477PolyampholyteSequence analysisAdd BLAST70

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155627

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3QCV0

Identification of Orthologs from Complete Genome Data

More...
OMAi
YSDKAQN

Database of Orthologous Groups

More...
OrthoDBi
1407830at2759

TreeFam database of animal gene trees

More...
TreeFami
TF351271

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.428.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040194 Cwf19-like
IPR006768 Cwf19-like_C_dom-1
IPR006767 Cwf19-like_C_dom-2
IPR036265 HIT-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12072 PTHR12072, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04677 CwfJ_C_1, 1 hit
PF04676 CwfJ_C_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54197 SSF54197, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G3QCV0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATSMAADRG RFESAKSIEE RKEQTRNARA EVLRQAKANF EKEERRKELK
60 70 80 90 100
RLRGEDTWML PDVNERIEQF SQEHSVKKKK KKDKHSKKAK KEKKKKSKKQ
110 120 130 140 150
KYEKNNESSD SSSSSEDEWV EAVPSQTPDK EKAWKVKDEK SEKDDTQIIK
160 170 180 190 200
RDEWMTVDFM SVKTVSSSSL KAEKETMRKI EQEKTQALEQ SKLMERELNP
210 220 230 240 250
YWKDGGTGLP PEDCSVSSIT KVSVVEDGGL SWLRKSYLRM KEQAEKQSRN
260 270 280 290 300
FEDIVAERYG SMEIFQSKLE DAEKAASTKE DYRRERWRKP TYSDKAQNCQ
310 320 330 340 350
ESRESDLVKY GNSSRDRYTT TDTAKNSNNE KFIGDEKDKR PGSLETCRRE
360 370 380 390 400
SNPRQNQEFS FGNLRAKFLR PSDDEELSFH SKGRKFEPPS SSSALVAQGS
410 420 430 440 450
LCSGFRKPTK NSEERLTSWS RSDGRGDKKP SNQKPLETGT DEYQHVPEDP
460 470 480 490 500
REKSQDEVLR DDPPKKEHLR DTKSTFAGSP EHESIHILSV DEKNKLGAKI
510 520 530 540 550
IKAEMMGNME LAEQLKVQLE KANKFKETIT QIPKKSGVEN EDQQEVILVR
560 570 580 590 600
TDQSGRVWPV NTPGKSLESQ GGRGKRQMVS THEEKERVRY FHDDDNLSLN
610 620 630 640 650
DLVKNEKMGT AENQNKLFMR MASKFMGKTD GDYYTLDDMF VSKAAERERL
660 670 680 690 700
GEEEESQRKK AVAEHRSLAA QMEKCLYCFD SSQFPKHLIV AVGVKVYLCL
710 720 730 740 750
PNVRSLTEGH CLIVPLQHHR AATLLDEDIW EEIQMFRKSL VNMFEDKGLD
760 770 780 790 800
CIFLETNMSM KKQYHMVYEC IPLPKEVGDM APIYFKKAIM ESDEEWSMNK
810 820 830 840 850
KLIDLSSKDI RKSVPRGLPY FSVDFGLHGG FAHVIEDQHK FSHYFGKEII
860 870 880 890
GGMLDIEPRL WRKGIRESFE DQRKKALQFA QWWKPYDFTK SKNC
Length:894
Mass (Da):103,670
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B206197FB8351A1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I2YAC7A0A2I2YAC7_GORGO
CWF19 like cell cycle control facto...
CWF19L2
417Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CABD030081400 Genomic DNA No translation available.
CABD030081401 Genomic DNA No translation available.
CABD030081402 Genomic DNA No translation available.
CABD030081403 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_004052119.2, XM_004052071.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGGOT00000000049; ENSGGOP00000000048; ENSGGOG00000000049

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
101147772

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ggo:101147772

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030081400 Genomic DNA No translation available.
CABD030081401 Genomic DNA No translation available.
CABD030081402 Genomic DNA No translation available.
CABD030081403 Genomic DNA No translation available.
RefSeqiXP_004052119.2, XM_004052071.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000000048

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGGOT00000000049; ENSGGOP00000000048; ENSGGOG00000000049
GeneIDi101147772
KEGGiggo:101147772

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
143884

Phylogenomic databases

GeneTreeiENSGT00940000155627
InParanoidiG3QCV0
OMAiYSDKAQN
OrthoDBi1407830at2759
TreeFamiTF351271

Gene expression databases

BgeeiENSGGOG00000000049 Expressed in 7 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

Gene3Di3.30.428.10, 1 hit
InterProiView protein in InterPro
IPR040194 Cwf19-like
IPR006768 Cwf19-like_C_dom-1
IPR006767 Cwf19-like_C_dom-2
IPR036265 HIT-like_sf
PANTHERiPTHR12072 PTHR12072, 1 hit
PfamiView protein in Pfam
PF04677 CwfJ_C_1, 1 hit
PF04676 CwfJ_C_2, 1 hit
SUPFAMiSSF54197 SSF54197, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3QCV0_GORGO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3QCV0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: June 5, 2019
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health

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