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Entry version 53 (17 Jun 2020)
Sequence version 1 (16 Nov 2011)
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Protein
Submitted name:

Regulator of G protein signaling 12a

Gene
N/A
Organism
Gasterosteus aculeatus (Three-spined stickleback)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Regulator of G protein signaling 12aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGasterosteus aculeatus (Three-spined stickleback)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri69293 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesCottioideiGasterostealesGasterosteidaeGasterosteus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007635 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
69293.ENSGACP00000025675

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 99PDZInterPro annotationAdd BLAST78
Domaini688 – 805RGSInterPro annotationAdd BLAST118
Domaini937 – 1007RBDInterPro annotationAdd BLAST71
Domaini1009 – 1079RBDInterPro annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni133 – 192DisorderedSequence analysisAdd BLAST60
Regioni384 – 493DisorderedSequence analysisAdd BLAST110
Regioni520 – 561DisorderedSequence analysisAdd BLAST42
Regioni817 – 862DisorderedSequence analysisAdd BLAST46
Regioni1083 – 1117DisorderedSequence analysisAdd BLAST35
Regioni1177 – 1226DisorderedSequence analysisAdd BLAST50
Regioni1260 – 1318DisorderedSequence analysisAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi133 – 147PolarSequence analysisAdd BLAST15
Compositional biasi160 – 176PolarSequence analysisAdd BLAST17
Compositional biasi450 – 468PolarSequence analysisAdd BLAST19
Compositional biasi837 – 862PolyampholyteSequence analysisAdd BLAST26
Compositional biasi1200 – 1218PolarSequence analysisAdd BLAST19
Compositional biasi1275 – 1303Pro-richSequence analysisAdd BLAST29

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3589 Eukaryota
ENOG410YMJD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164407

Identification of Orthologs from Complete Genome Data

More...
OMAi
YKSFTVI

TreeFam database of animal gene trees

More...
TreeFami
TF328814

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08742 RGS_RGS12, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.196.10, 1 hit
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003109 GoLoco_motif
IPR001478 PDZ
IPR036034 PDZ_sf
IPR003116 RBD_dom
IPR016137 RGS
IPR037880 RGS12_RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02188 GoLoco, 1 hit
PF00595 PDZ, 1 hit
PF02196 RBD, 2 hits
PF00615 RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01301 RGSPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00390 GoLoco, 1 hit
SM00228 PDZ, 1 hit
SM00455 RBD, 2 hits
SM00315 RGS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50877 GOLOCO, 1 hit
PS50106 PDZ, 1 hit
PS50898 RBD, 2 hits
PS50132 RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3Q715-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
IQGQPEGARR RLDLNSAAEL RGVEVIRGRA GYGFTISGQR PCLLSGIMEG
60 70 80 90 100
SPADLVGLKQ GDHIMAIGGS DVSTALHETV VQLIGSCEGP LQLVVQGASR
110 120 130 140 150
IMANPILNDA KFGTGPKSGV FQKPAVLRAI SHDSSNSSFN SSHSGIAKPR
160 170 180 190 200
PVSEPDMSQW PQWGGRQTNP FAEQRKKQSS GDTDPVFTDQ ANPDWSTLNM
210 220 230 240 250
TLVVGYLSST ELILNPTESE ESCLKAIRER IRLLGTEQST HTLVMMKVMF
260 270 280 290 300
DCVRLCDDAG AVLAALPAEN LVLGAVCAED PRFFCLVTTA HVVDGRIPED
310 320 330 340 350
GPLRASCHVF FIDPELGNHE DHIGIAGRFG FDCTPDPDAL GCLEFPLSPQ
360 370 380 390 400
DVLHFVTVLY SDMGEAVERL RVKLDAETEL QAKEMGDAGK QGSASSNGDS
410 420 430 440 450
GIGNASPPGE RADRDFPSAV REHPGAHLPS CPWDYPRAED LPPIKLSKSG
460 470 480 490 500
QKLHSGNSGG THSLSESLPG PDSLHKFYGG PPPRLEFQFK PPPPPLPLNK
510 520 530 540 550
KANVLGDPLR GSQRWFSKPK WSKALSVDPE PPPSDEWPTS IGPGTGTGTA
560 570 580 590 600
NPPPPMSNIP SNRYPSAEVM MLPPRQEWTK RFLEQREKQR KDDVAKNVRM
610 620 630 640 650
RCGRRGRKGS RFWGMGVTRA SKRRASKRMS LARSLDDLES SALSNIYYSR
660 670 680 690 700
VQLQGCCSQS SLNSNGSLPG GGSLRGAPEQ RVARWAACFE RLLQDPVGVR
710 720 730 740 750
YFSEFLKKEF SEENILFWQA CEYFSHVPAA DKKQLSQRAG EIYNSFLSSK
760 770 780 790 800
ATMPVNIDSQ AQLADDVLTS PRPDMFKTQQ LQIFNLMKFD SYSRFLKSSL
810 820 830 840 850
YQECMCAEVD GRPLPDPYQI PCSPPSKHSA GSDRSTLSTP KKKRQEASKQ
860 870 880 890 900
GSGRSLSEES RDLSGDKKRR MFFLWNKSFM EYISKRFVCK YNHWGSNGRR
910 920 930 940 950
ESQGSLSSGT SLEMATSCSA GKIESDNRHS AWERSPKHCS VVLPSGSCSS
960 970 980 990 1000
LSLRPGASIR EVLQDLCRSI SINIAAVDLF LVGGEKPLVW DQDCMTLSSR
1010 1020 1030 1040 1050
ELRVEKRTWF RLDLVPINRS VGLKAKPTKP VTEVLRPVVA KYGLHLSDLV
1060 1070 1080 1090 1100
AKVSGETEPL DLGAPISSLD GLRVVLDRID SASGKDKSKS SSLKNHPPSK
1110 1120 1130 1140 1150
SFSATERQKG GGRGGAQMDE AAIPYARGSL NPDTVLKFFE LLSRAQSSRA
1160 1170 1180 1190 1200
NDQRGLLSKE DLVLPDFLRL TPAAACSTPD SLKQGRENGV PPRGSLTAGL
1210 1220 1230 1240 1250
RSESLDSSLG SSANGHSGNR RCLMPPPRHS TFGTHLSPIC RPLDTRPILR
1260 1270 1280 1290 1300
TVEEDAHGDL TLVGEGDISS PNSTLLPPSP MPPFDGSLPE ANFTPPPPCA
1310
PPQDAGGEGK SRSGTSAV
Length:1,318
Mass (Da):143,303
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B6A52BE761759F1
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGACT00000025725; ENSGACP00000025675; ENSGACG00000019425

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi69293.ENSGACP00000025675

Genome annotation databases

EnsembliENSGACT00000025725; ENSGACP00000025675; ENSGACG00000019425

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00940000164407
OMAiYKSFTVI
TreeFamiTF328814

Family and domain databases

CDDicd08742 RGS_RGS12, 1 hit
Gene3Di1.10.196.10, 1 hit
2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR003109 GoLoco_motif
IPR001478 PDZ
IPR036034 PDZ_sf
IPR003116 RBD_dom
IPR016137 RGS
IPR037880 RGS12_RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF02188 GoLoco, 1 hit
PF00595 PDZ, 1 hit
PF02196 RBD, 2 hits
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00390 GoLoco, 1 hit
SM00228 PDZ, 1 hit
SM00455 RBD, 2 hits
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS50877 GOLOCO, 1 hit
PS50106 PDZ, 1 hit
PS50898 RBD, 2 hits
PS50132 RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3Q715_GASAC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3Q715
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: June 17, 2020
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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