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Entry version 61 (29 Sep 2021)
Sequence version 1 (16 Nov 2011)
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Protein
Submitted name:

Rho guanine nucleotide exchange factor (GEF) 11

Gene
N/A
Organism
Gasterosteus aculeatus (Three-spined stickleback)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor (GEF) 11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGasterosteus aculeatus (Three-spined stickleback)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri69293 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesCottioideiGasterostealesGasterosteidaeGasterosteus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007635 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

CytoplasmARBA annotation, MembraneARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
69293.ENSGACP00000025091

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 115PDZInterPro annotationAdd BLAST65
Domaini657 – 734DHInterPro annotationAdd BLAST78
Domaini812 – 928PHInterPro annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni132 – 187DisorderedSequence analysisAdd BLAST56
Regioni203 – 227DisorderedSequence analysisAdd BLAST25
Regioni953 – 980DisorderedSequence analysisAdd BLAST28
Regioni1013 – 1039DisorderedSequence analysisAdd BLAST27
Regioni1052 – 1177DisorderedSequence analysisAdd BLAST126
Regioni1210 – 1257DisorderedSequence analysisAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi150 – 166Pro residuesSequence analysisAdd BLAST17
Compositional biasi953 – 976Polar residuesSequence analysisAdd BLAST24
Compositional biasi1077 – 1102Polar residuesSequence analysisAdd BLAST26
Compositional biasi1210 – 1224Basic and acidic residuesSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coilARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3520, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158350

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3Q5D5

Identification of Orthologs from Complete Genome Data

More...
OMAi
EVCDGQN

TreeFam database of animal gene trees

More...
TreeFami
TF106495

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 2 hits
2.30.29.30, 1 hit
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR001478, PDZ
IPR032919, PDZ-RhoGEF
IPR036034, PDZ_sf
IPR011993, PH-like_dom_sf
IPR041020, PH_16
IPR001849, PH_domain
IPR015212, RGS-like_dom
IPR036305, RGS_sf

The PANTHER Classification System

More...
PANTHERi
PTHR45872:SF1, PTHR45872:SF1, 6 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595, PDZ, 1 hit
PF17838, PH_16, 1 hit
PF09128, RGS-like, 1 hit
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228, PDZ, 1 hit
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065, SSF48065, 1 hit
SSF48097, SSF48097, 1 hit
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010, DH_2, 1 hit
PS50106, PDZ, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3Q5D5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
FNADPRSVVS HTRLSSLTIG DSERKSSAAQ QREPMVDIHA ESAATGLVQR
60 70 80 90 100
CVVVQKDQLG FGFTVCGERV KLVQNVRPGG AAVKAGVHEG DRIIKVNGSL
110 120 130 140 150
VSSMSHQEVV KLIKSGPYAA LTLQGPPPFA ASLPLDPLPA DLPPNKRTSL
160 170 180 190 200
GGEAPPPPPP PLPSGLSSTP SQRITGPKPL QDPEVQKHAT QILRKMLEQE
210 220 230 240 250
EAELQELREE QSRNPSPSLG ERIESAQRRA RQVRVKIQQD LSRRPDVLSY
260 270 280 290 300
ISISIDPNPW YVHAAFTRAR ERERARDGGR SACSRCGSRW LQLFYLSVEA
310 320 330 340 350
YLGSSPKDAR ALAPQICSHF LDTDAPLKIR VREEYLSDIE GRLHAQEDIR
360 370 380 390 400
GPLSELQQQV LPDVQEQIQD YRNKQTMGLG SLFGEGDLLQ LDGDPVKERQ
410 420 430 440 450
VVDRQVTALW EILSKHEEDR SSPLASAVHL YLRHSGIKLR DSKVFPGLSS
460 470 480 490 500
EKEKWLAFLK TKKPSGTKKE KDGEDKKRNP ILKYIGKPRT TSQSRFYFTE
510 520 530 540 550
NNVTYQSAVK PRENTDPNMQ HPPPSKNWCE NSIQNSNFIV ILISREKLLQ
560 570 580 590 600
FTTRLNCSGT TVCFRCIIYS CIYAHVCYTI EISHFSARPS LSLKLRSLEN
610 620 630 640 650
PTPPYTPRSR RRSVDSPLAL LPDATAAALE EELSDGQNWQ DTVPPQLLAT
660 670 680 690 700
LSPGEVDRQA VIYELLTTEA SHLRTLRVLD QVFFQKMRSV LNSEELACVF
710 720 730 740 750
PNLPQVYDLH ASLCEAMKKR RETAIVQDIG DVMLARVSGS SSCNVKAVSV
760 770 780 790 800
KSHSAASSDL PALQRAQACC RGILQAVNEV VRETEHRQRL SQYQRRLDAA
810 820 830 840 850
PHFKSLDLST KRMIHEGPLT WKVSKDKQIE IQALLLSDCL LLLQRGPDDR
860 870 880 890 900
LQLRYPSRWL GGSGGGSVDS KNSFSPLVKL DALLVRPVAT DNKALYVIST
910 920 930 940 950
TERQIYELVA GTSSERNTWK NLLERTISSP GGSSPLINHG PTPIWMYNSI
960 970 980 990 1000
TEQSDSTDTH SSGDDIALSA TADTDQSEGF VGVERKAEGV AESALQDGEE
1010 1020 1030 1040 1050
LRQLILRDLE EGDAWSHNSG DTPTNETASE RSSRRPESLE TVLHFSADEW
1060 1070 1080 1090 1100
EAEPDAEAPP PDGEPPGSVQ VVRKAVVAGP SSSSSVPDDI TADQSSKPRG
1110 1120 1130 1140 1150
NTFYLVMPTE PGESATDDLS GPRVPPPPPE DGTSPRTQPE EETPAPEEEP
1160 1170 1180 1190 1200
GQSGAVRREG DEEAGPSQAG PQSHVIRNVD EIFHTIEGLM SKLRQLREIE
1210 1220 1230 1240 1250
KSHQKLLKTL REPFADEEPE DQPRCPATVS RTPSLDRGSA DGKAGGPAEP

RVQSTGF
Length:1,257
Mass (Da):138,748
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i537DCAF125B87317
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGACT00000025140; ENSGACP00000025091; ENSGACG00000018980

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi69293.ENSGACP00000025091

Genome annotation databases

EnsembliENSGACT00000025140; ENSGACP00000025091; ENSGACG00000018980

Phylogenomic databases

eggNOGiKOG3520, Eukaryota
GeneTreeiENSGT00940000158350
InParanoidiG3Q5D5
OMAiEVCDGQN
TreeFamiTF106495

Family and domain databases

Gene3Di1.20.900.10, 2 hits
2.30.29.30, 1 hit
2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR001478, PDZ
IPR032919, PDZ-RhoGEF
IPR036034, PDZ_sf
IPR011993, PH-like_dom_sf
IPR041020, PH_16
IPR001849, PH_domain
IPR015212, RGS-like_dom
IPR036305, RGS_sf
PANTHERiPTHR45872:SF1, PTHR45872:SF1, 6 hits
PfamiView protein in Pfam
PF00595, PDZ, 1 hit
PF17838, PH_16, 1 hit
PF09128, RGS-like, 1 hit
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00228, PDZ, 1 hit
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
SSF48097, SSF48097, 1 hit
SSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50010, DH_2, 1 hit
PS50106, PDZ, 1 hit
PS50003, PH_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3Q5D5_GASAC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3Q5D5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 29, 2021
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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