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UniProtKB - G3P6T7 (G3P6T7_GASAC)

Entry version 39 (12 Aug 2020)
Sequence version 1 (16 Nov 2011)
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Protein
Submitted name:

Zgc:92107

Gene
N/A
Organism
Gasterosteus aculeatus (Three-spined stickleback)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zgc:92107Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGasterosteus aculeatus (Three-spined stickleback)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri69293 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Neoteleostei › Acanthomorphata › Eupercaria › Perciformes › Cottioidei › Gasterosteales › Gasterosteidae › Gasterosteus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007635 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		69293.ENSGACP00000013311

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 36WWInterPro annotationAdd BLAST35
Domaini48 – 75WWInterPro annotationAdd BLAST28
Domaini714 – 865MyTH4InterPro annotationAdd BLAST152
Domaini913 – 1101Rho-GAPInterPro annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni88 – 171DisorderedSequence analysisAdd BLAST84
Regioni183 – 242DisorderedSequence analysisAdd BLAST60
Regioni330 – 358DisorderedSequence analysisAdd BLAST29
Regioni372 – 492DisorderedSequence analysisAdd BLAST121
Regioni534 – 587DisorderedSequence analysisAdd BLAST54
Regioni601 – 666DisorderedSequence analysisAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi110 – 134PolyampholyteSequence analysisAdd BLAST25
Compositional biasi183 – 237PolarSequence analysisAdd BLAST55
Compositional biasi330 – 352PolarSequence analysisAdd BLAST23
Compositional biasi379 – 393PolarSequence analysisAdd BLAST15
Compositional biasi429 – 466PolarSequence analysisAdd BLAST38
Compositional biasi601 – 625PolarSequence analysisAdd BLAST25

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QR6X, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000164502

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		G3P6T7

Identification of Orthologs from Complete Genome Data

More...OMAi		CGWDPPT

TreeFam database of animal gene trees

More...TreeFami		TF323577

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.555.10, 1 hit
1.25.40.530, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000857, MyTH4_dom
IPR038185, MyTH4_dom_sf
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
IPR001202, WW_dom
IPR036020, WW_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00784, MyTH4, 1 hit
PF00620, RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00139, MyTH4, 1 hit
SM00324, RhoGAP, 1 hit
SM00456, WW, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48350, SSF48350, 1 hit
SSF51045, SSF51045, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51016, MYTH4, 1 hit
PS50238, RHOGAP, 1 hit
PS50020, WW_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3P6T7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
FVSFSSDWVE ILEPRSRERM YVNLTTGECG WDPPSGVPVR QADGNQWWEL 
        60         70         80         90        100
FDAQSGRFYY YNSTGRRTVW HRPQGADIVP LSQLQAMRRR GEHGTTGSVG 
       110        120        130        140        150
SAGSQGRFTP LPERDRDGPG APEPGHEAGE PEVDPAADSR SQGDGSSAEN 
       160        170        180        190        200
STDGSKDQQR DASQRWQPAP GSKAAMLVKV NSMSRSQPIP ASQQQHLQHS 
       210        220        230        240        250
AHGKPNTFTL HPNTIKPQGG LLNSTQGYKT APSGKTATDP RQAHHLRKAS 
       260        270        280        290        300
NGSFCLVTSD GSHPSPLLHR SQTSTPCPVS PHYGCTTPIY DEPVSECPIY 
       310        320        330        340        350
DEPPTDMEVE GAHLYNGHPL SRLTPTHSLQ KPIQLQPPGS SHPGSRHRRN 
       360        370        380        390        400
PSASDYSPAG LECIKHMINV DPKQGLLSGS PVPTGTPSPT SRQDPVLLKD 
       410        420        430        440        450
REPGTPGPST LDKKQSWRVL EATVQRAMEA RHSRQSSQAS QDFPSSTPQA 
       460        470        480        490        500
TANYQDSGYS TGLSPSLRRK SRRRVGAGGG AGGRPGSVGS SGELSALNER 
       510        520        530        540        550
LMAEMREVVS RSNTMREVRA GLDPEIGERV VAARTRSPAD SLRWYAGGGS 
       560        570        580        590        600
ASRSASREEL PGASRSLSRA GNHGNPALTP LEMPGRQKRT YEKVDTLEMS 
       610        620        630        640        650
VNSQASLSSP ETPGPPSQEG TLELQAQLES RKKGMTDGRT ASLGPHRPPT 
       660        670        680        690        700
HDTSEGGDGA GGRTRGSSYQ LCYATLRQPP PPDTGMEDWA SKHLNMHTQG 
       710        720        730        740        750
LFRRRVSIAN MLSWNRGSIK KPMLVTSNRA VRKEACEMFK LVQAYMGDRP 
       760        770        780        790        800
SRLDRRHCAL LIVTKCWDMP GLRDELYVQL VRQTTGNATP ESLAAGWELM 
       810        820        830        840        850
AVSMAFFAPS PKFRCYLEGY IQRHTEPVSD NKLTQFILEQ QELKLKKNSK 
       860        870        880        890        900
SRKKRKQNTD VEEALPISTY AKFCYRKLQK VAITGGKKGL RKPTLEEIDH 
       910        920        930        940        950
SRRAIVTPSL FGSSLEEVME RQSELFPDRK LPWVQVQLSQ YVLALGGAQT 
       960        970        980        990       1000
EGIFRVPGDI DEVNALKLQV DQWRIPENLS DPNVPASLMK LWYRELEEPL 
      1010       1020       1030       1040       1050
IPMNFYKQCV SNCDDPVAAI AVVQSLPELN RLVLCYFIHF LQVFAQPSNV 
      1060       1070       1080       1090       1100
AITKMDVNNL AMVMAPNCLR CQSDDPRIIF ENTRKEMSFL RMLIVHLETG 

FIEGVV
Length:1,106
Mass (Da):121,969
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF0A6F783957A1B9F
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSGACT00000013336; ENSGACP00000013311; ENSGACG00000010079

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi69293.ENSGACP00000013311

Genome annotation databases

EnsembliENSGACT00000013336; ENSGACP00000013311; ENSGACG00000010079

Phylogenomic databases

eggNOGiENOG502QR6X, Eukaryota
GeneTreeiENSGT00940000164502
InParanoidiG3P6T7
OMAiCGWDPPT
TreeFamiTF323577

Family and domain databases

Gene3Di1.10.555.10, 1 hit
1.25.40.530, 1 hit
InterProiView protein in InterPro
IPR000857, MyTH4_dom
IPR038185, MyTH4_dom_sf
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
IPR001202, WW_dom
IPR036020, WW_dom_sf
PfamiView protein in Pfam
PF00784, MyTH4, 1 hit
PF00620, RhoGAP, 1 hit
SMARTiView protein in SMART
SM00139, MyTH4, 1 hit
SM00324, RhoGAP, 1 hit
SM00456, WW, 2 hits
SUPFAMiSSF48350, SSF48350, 1 hit
SSF51045, SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS51016, MYTH4, 1 hit
PS50238, RHOGAP, 1 hit
PS50020, WW_DOMAIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3P6T7_GASAC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3P6T7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: August 12, 2020
This is version 39 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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