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Entry version 53 (22 Apr 2020)
Sequence version 1 (16 Nov 2011)
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Protein
Submitted name:

Arginine-glutamic acid dipeptide (RE) repeats a

Gene
N/A
Organism
Gasterosteus aculeatus (Three-spined stickleback)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Arginine-glutamic acid dipeptide (RE) repeats aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGasterosteus aculeatus (Three-spined stickleback)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri69293 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesCottioideiGasterostealesGasterosteidaeGasterosteus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007635 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusSAAS annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
69293.ENSGACP00000009800

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini137 – 293BAHInterPro annotationAdd BLAST157
Domaini294 – 397ELM2InterPro annotationAdd BLAST104
Domaini401 – 453SANTInterPro annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 93DisorderedSequence analysisAdd BLAST93
Regioni474 – 504DisorderedSequence analysisAdd BLAST31
Regioni552 – 1084DisorderedSequence analysisAdd BLAST533
Regioni1105 – 1135DisorderedSequence analysisAdd BLAST31
Regioni1546 – 1572DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 38PolyampholyteSequence analysisAdd BLAST38
Compositional biasi474 – 496PolarSequence analysisAdd BLAST23
Compositional biasi566 – 581PolyampholyteSequence analysisAdd BLAST16
Compositional biasi587 – 633PolarSequence analysisAdd BLAST47
Compositional biasi634 – 721PolyampholyteSequence analysisAdd BLAST88
Compositional biasi722 – 765PolarSequence analysisAdd BLAST44
Compositional biasi766 – 780Pro-richSequence analysisAdd BLAST15
Compositional biasi802 – 821PolarSequence analysisAdd BLAST20
Compositional biasi822 – 866Pro-richSequence analysisAdd BLAST45
Compositional biasi884 – 909PolarSequence analysisAdd BLAST26
Compositional biasi910 – 970Pro-richSequence analysisAdd BLAST61
Compositional biasi979 – 1007Pro-richSequence analysisAdd BLAST29
Compositional biasi1015 – 1078Pro-richSequence analysisAdd BLAST64

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2133 Eukaryota
ENOG410ZIND LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153615

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3NWT1

Identification of Orthologs from Complete Genome Data

More...
OMAi
PCRRLNS

TreeFam database of animal gene trees

More...
TreeFami
TF328554

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00202 ZnF_GATA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002951 Atrophin-like
IPR001025 BAH_dom
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR000679 Znf_GATA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03154 Atrophin-1, 2 hits
PF01426 BAH, 1 hit
PF01448 ELM2, 1 hit
PF00320 GATA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00439 BAH, 1 hit
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00401 ZnF_GATA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51038 BAH, 1 hit
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3NWT1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LPIDKDEDLT GRPSRERTEE GKSRRQDGDR ESESSRPRRS CTLEGGAKNY
60 70 80 90 100
AESEHSEDED NDNGSTGGGS GTAEEGGKKG KKKTPKKKSR YERTENGEIT
110 120 130 140 150
SFITEDDVVY RPGVCIYFRG ERENTGSITC GVQIHAGAHE AVHFLLIPKP
160 170 180 190 200
AISCNCTQLI LSLRSVVPNH HNPLLLHSGR PPVGSKRDHL LMNVKWYYRQ
210 220 230 240 250
SEVPDSVYQH LVQDRNNEND SGRELVITDP VVRSRELFIS DYVDTYHAAA
260 270 280 290 300
LRGKCNISHF SDIFAAREFK ARIDSFFYIL GYNPETRRLN STQGEIRVGP
310 320 330 340 350
SHQAKLPELQ PFPSPAGQAV TENEELVWMP GVNDCDLLMY LRAARSMAAF
360 370 380 390 400
AGMCDGGSTE DECLAASRDD TTLNALNTLH ESSYDAGKAL QRLVKKPVPK
410 420 430 440 450
LIEKCWSEDE VKRFIKGLRQ FGKNFFRIRK ELLPNKETGE LITFYYYWKK
460 470 480 490 500
TPEAASCRAH RRHRRQPVFR RIKTRTASTP VNTPSRPPSS EFLDLSSASE
510 520 530 540 550
DDFDSEDSEQ ELKGYACRHC FTTTSKDWHH GGRENILLCT DCRIHFKKYG
560 570 580 590 600
ELPPIEKPVD PPPFMFKPVK EEEDGLSGKH SMRTRRNRGS MSTLRSGRKK
610 620 630 640 650
QTASPDGRTS PTNEDLRSSG RTSPSAASTD STDSKTDSMK KPSKKIKEEA
660 670 680 690 700
PSPMKSAKRP REKGASDTEE PERAGVKKSK TQELSRPDSP SECEGEGEGE
710 720 730 740 750
SSDGRSINEE LSSDPKDIDQ DNRSSSPSIP SPRDNESDSD SSAQQQQLLQ
760 770 780 790 800
SQHPAVIQCQ PGTSSASSAP PPPAAAAPSL PPQVSPIVAS TSLPPLPLPQ
810 820 830 840 850
ASPLSLIQSG ASLHPQRLPS PHSPLTQAPP PGLPIPPQSL PSSHHGPMLM
860 870 880 890 900
PPLPHPLQPG PSHMPHPLSM PLQGFPMGQS QVPPLPICGQ SQQRPHTPPS
910 920 930 940 950
QSSAQSGQPP REQPLPPAPM SMPMPHIKPP PTTPIPQMPN PQSHKHPPHA
960 970 980 990 1000
SAPPFPQMPS NLPPPPALKP LSSLSTHHPP SAHPPPLQLM PQGQQLQPPP
1010 1020 1030 1040 1050
AQPPVLTQSQ SLPPSASHQP PPAPPLPPSA AASHSSGPPQ PPFSSHPFST
1060 1070 1080 1090 1100
VLPPTGPPPS SSNSMPGIQP PSSSAPPSSI SMPLPASVAC AGPVLPPVQI
1110 1120 1130 1140 1150
KEEPLDELEE PESPPPPQRS PSPEPTIIST PTHASHASQS ARFYKHLDRG
1160 1170 1180 1190 1200
YNSCARTDYY FTPLASSKLA KKREEALEKA GGECFCLSPF CLPAFNIFCF
1210 1220 1230 1240 1250
TLLNIAFLSS QKASSSSHDS RMCEPQMAGH SHMRSPYDPP TTIAAVPPYI
1260 1270 1280 1290 1300
GPDTPALRTL SEYARPHVMS PTNRNHPFFV SLNPGDPLLA YHMPGLYNAD
1310 1320 1330 1340 1350
PGMRERELRE REMREREIRE RELRERMKPG FEVKPPEMDS LHPSTNPMEH
1360 1370 1380 1390 1400
FARHGAITLP PMAGHHPFAS FHPGLNPLER ERLALAAGPQ LRAEMSYPER
1410 1420 1430 1440 1450
LAAERLHAER MATVANDPIA RLQMFNVTPH HHQHSHIHSH LHLHQQDPLH
1460 1470 1480 1490 1500
QGKGSGGHPL AMDPLGGGPH LARFPYPHGA IPNALLGQNP HEHEMLRHPV
1510 1520 1530 1540 1550
FGTPYPRELQ GGLPPPMSAA HQLQAMHAQS AELQRLAMEQ QWLHGHHHMH
1560 1570
GGPLPGQEDY YSRLKKESDK QL
Length:1,572
Mass (Da):172,898
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1B45E9D6898FE34
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGACT00000009820; ENSGACP00000009800; ENSGACG00000007386

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi69293.ENSGACP00000009800

Genome annotation databases

EnsembliENSGACT00000009820; ENSGACP00000009800; ENSGACG00000007386

Phylogenomic databases

eggNOGiKOG2133 Eukaryota
ENOG410ZIND LUCA
GeneTreeiENSGT00940000153615
InParanoidiG3NWT1
OMAiPCRRLNS
TreeFamiTF328554

Family and domain databases

CDDicd00202 ZnF_GATA, 1 hit
InterProiView protein in InterPro
IPR002951 Atrophin-like
IPR001025 BAH_dom
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR000679 Znf_GATA
PfamiView protein in Pfam
PF03154 Atrophin-1, 2 hits
PF01426 BAH, 1 hit
PF01448 ELM2, 1 hit
PF00320 GATA, 1 hit
SMARTiView protein in SMART
SM00439 BAH, 1 hit
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00401 ZnF_GATA, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51038 BAH, 1 hit
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3NWT1_GASAC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3NWT1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: April 22, 2020
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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