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Entry version 34 (16 Jan 2019)
Sequence version 1 (16 Nov 2011)
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Protein
Submitted name:

Pleckstrin homology domain containing, family A member 7a

Gene
N/A
Organism
Gasterosteus aculeatus (Three-spined stickleback)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Pleckstrin homology domain containing, family A member 7aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGasterosteus aculeatus (Three-spined stickleback)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri69293 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesCottioideiGasterostealesGasterosteidaeGasterosteus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007635 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

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STRINGi
69293.ENSGACP00000008863

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 41WWInterPro annotationAdd BLAST34
Domaini53 – 86WWInterPro annotationAdd BLAST34
Domaini163 – 283PHInterPro annotationAdd BLAST121

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili714 – 734Sequence analysisAdd BLAST21
Coiled coili1075 – 1098Sequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IG1I Eukaryota
ENOG4111FBI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155817

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3NU45

Identification of Orthologs from Complete Genome Data

More...
OMAi
QEDMSTW

TreeFam database of animal gene trees

More...
TreeFami
TF329090

Family and domain databases

Conserved Domains Database

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CDDi
cd13248 PH_PEPP1_2_3, 1 hit
cd00201 WW, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR040392 PKHA4/5/6/7_PH
IPR001202 WW_dom
IPR036020 WW_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169 PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00456 WW, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51045 SSF51045, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3NU45-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPLGRDAL PEHWSYGVRA DGRVFFINDE ARNTTWLHPR SAEPVNSGHM
60 70 80 90 100
IRSDLPQGWE EGFTNEGASY FINHNQRTTA FRHPVSGQIS AENMDFILQE
110 120 130 140 150
QAQGASMMSK PVGEQLSSTT ISEASTAITS STVDTTSKGS RSSGKVHNFG
160 170 180 190 200
KREQAIKRNP NVPVVVRGWL YKQDSSGMRL WKRKWFVLAD FCLFYYKADS
210 220 230 240 250
REESVLGSIP LPSYVISPVR PEDHISRKYA FKASHTGMRS YIYKRSSVIG
260 270 280 290 300
SQAEHTGMRT YYFSADTQED MSTWLRAMNQ ATLMQNNSNT PRTRTKAEQQ
310 320 330 340 350
AVPQMNHGNH HKTPGPNATR PGVHEVLLEP RHHATGERCS FHKDAAAMEH
360 370 380 390 400
ATSAAVLEMD SHASLSSDHV ASALPQFDHA SASAPVSRAA STLPSGVCTR
410 420 430 440 450
NGLVSTPSPI LEPNGIAAGT YQRGPAATPP SDTPKQGHRR NTLEQVEQWV
460 470 480 490 500
KVQKAEHKGP PSRENTLPRR TPPTQHKFPS IDACQTLPKT PRQSPAPGRL
510 520 530 540 550
GEYKYAQDRL SHFRLAPDPG PNTVWQLYEW QQRHQYRHGS PTAPLYTPAP
560 570 580 590 600
DYPFGPRPPS TVPPSSSAPR SEGPPRCVSV PPSSADLRSR TLSPTRRPHT
610 620 630 640 650
PAGRVTVKPG GNRSAVDVPF ALSPRRAKSQ LLKAATIERR SLPPSGYITH
660 670 680 690 700
TVSAPSLHGK TSDDTYMQLK KDLEYLDLKV AGSQTLKESG KAVKVAESDV
710 720 730 740 750
DVKLSRLCEQ DKILQDLEAR ISSLKEDKDK LEGVLDVSHH QMEQYQEQPA
760 770 780 790 800
HAHKIAYQQR LLQEDLVSIR AQMSRLYSQE MAQAWEEFGR LERSVEQLRT
810 820 830 840 850
ALQAHMNHSA TPQQEKAEMK RELWRIEDVM GGLSASKANY KITIDSVQNP
860 870 880 890 900
ERKLVPSGSD PAVPSLSTEV QPPPRSSAPR ILAHTLPHST VPKWVSVLLP
910 920 930 940 950
HSRDLLPNRN AHSLPDPAVQ AEDDAAPPRP PLPRLCDYEE TPPAVPPLPR
960 970 980 990 1000
EASVIRHTSV RGLKRQSDER KRDRESGQHV ANGDCKADLR SYLSEPELPG
1010 1020 1030 1040 1050
LSQQNAASDE YQYFQSKGPS GCPLRPNQSD SIASYVTLRR GPGSAAPRER
1060 1070 1080 1090 1100
PKSALERLSS PTEAQQPPSG QPRGRMTAEE QLERMKRHQR SLVRERKRNL
1110 1120 1130 1140 1150
SQGERSAVGL SASGVGPRRS SSVFDWQEER LAAEGQSDEG WSQAKERGRI
1160 1170 1180 1190 1200
QSDGWVVATA VPIREVDVEP LDYDLDISRE LSKPQKVPIP ERYVESDPEE
1210 1220 1230 1240 1250
PLSPEEVEER SRRAQRMKNL LAKSSFRSVR PSAPLDFGEL DSALQQQERI
1260 1270
MTASHALAAE ASRKSKLVAG QCTSTT
Length:1,276
Mass (Da):141,652
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1AE2BC439FCEC41
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGACT00000008882; ENSGACP00000008863; ENSGACG00000006687

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi69293.ENSGACP00000008863

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGACT00000008882; ENSGACP00000008863; ENSGACG00000006687

Phylogenomic databases

eggNOGiENOG410IG1I Eukaryota
ENOG4111FBI LUCA
GeneTreeiENSGT00940000155817
InParanoidiG3NU45
OMAiQEDMSTW
TreeFamiTF329090

Family and domain databases

CDDicd13248 PH_PEPP1_2_3, 1 hit
cd00201 WW, 2 hits
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR040392 PKHA4/5/6/7_PH
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00456 WW, 2 hits
SUPFAMiSSF51045 SSF51045, 2 hits
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3NU45_GASAC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3NU45
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: January 16, 2019
This is version 34 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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