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Entry version 69 (02 Jun 2021)
Sequence version 1 (16 Nov 2011)
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Protein

[F-actin]-monooxygenase MICAL3

Gene

MICAL3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H2O2. Seems to act as Rab effector protein and play a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei97FADBy similarity1
Binding sitei183FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei298FADBy similarity1
Binding sitei398FADBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi764Zinc 1By similarity1
Metal bindingi767Zinc 1By similarity1
Metal bindingi785Zinc 1; via pros nitrogenBy similarity1
Metal bindingi788Zinc 1By similarity1
Metal bindingi791Zinc 2By similarity1
Metal bindingi794Zinc 2By similarity1
Metal bindingi814Zinc 2By similarity1
Metal bindingi817Zinc 2; via pros nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi116 – 118FADBy similarity3
Nucleotide bindingi123 – 125FADBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Monooxygenase, Oxidoreductase
Biological processExocytosis
LigandFAD, Flavoprotein, Metal-binding, NADP, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
[F-actin]-monooxygenase MICAL3 (EC:1.14.13.225By similarity)
Alternative name(s):
Molecule interacting with CasL protein 3
Short name:
MICAL-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MICAL3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000321980 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000009136 Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004163041 – 1960[F-actin]-monooxygenase MICAL3Add BLAST1960

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei649PhosphoserineBy similarity1
Modified residuei685PhosphoserineBy similarity1
Modified residuei687PhosphoserineBy similarity1
Modified residuei887PhosphothreonineBy similarity1
Modified residuei971PhosphoserineBy similarity1
Modified residuei1129PhosphoserineBy similarity1
Modified residuei1139PhosphoserineBy similarity1
Modified residuei1156PhosphoserineBy similarity1
Modified residuei1188PhosphoserineBy similarity1
Modified residuei1250PhosphoserineBy similarity1
Modified residuei1252PhosphothreonineBy similarity1
Modified residuei1254PhosphoserineBy similarity1
Modified residuei1286PhosphoserineBy similarity1
Modified residuei1313PhosphoserineBy similarity1
Modified residuei1317PhosphothreonineBy similarity1
Modified residuei1404PhosphoserineBy similarity1
Modified residuei1425PhosphothreonineBy similarity1
Modified residuei1660PhosphoserineBy similarity1
Modified residuei1663PhosphoserineBy similarity1
Modified residuei1870PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G3MWR8

PRoteomics IDEntifications database

More...
PRIDEi
G3MWR8

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
G3MWR8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000048271, Expressed in myometrium and 96 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAB1B, RAB8A, RAB10, RAB13 and RAB15 (in their GTP-bound forms); binding to RAB1B is of low affinity compared to other Rab proteins; at least in case of RAB8A can bind 2 molecules of RAB8A simultaneously through a high and a low affinity binding site, respectively.

Interacts with ERC1 and RAB8A; may bridge ERC1 with RAB8A.

Interacts with KIF23 and ERC1; enhances the interaction between KIF23 and ERC1.

Interacts with NINL.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000053971

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G3MWR8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini518 – 624Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST107
Domaini762 – 824LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST63
Domaini1799 – 1948bMERBPROSITE-ProRule annotationAdd BLAST150

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 494Monooxygenase domainBy similarityAdd BLAST493
Regioni658 – 704DisorderedSequence analysisAdd BLAST47
Regioni826 – 887DisorderedSequence analysisAdd BLAST62
Regioni906 – 1295DisorderedSequence analysisAdd BLAST390
Regioni1316 – 1550DisorderedSequence analysisAdd BLAST235
Regioni1564 – 1782DisorderedSequence analysisAdd BLAST219

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1779 – 1952Sequence analysisAdd BLAST174

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi662 – 697Basic and acidic residuesSequence analysisAdd BLAST36
Compositional biasi852 – 867Polar residuesSequence analysisAdd BLAST16
Compositional biasi915 – 933Polar residuesSequence analysisAdd BLAST19
Compositional biasi963 – 982Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi983 – 1013Acidic residuesSequence analysisAdd BLAST31
Compositional biasi1037 – 1051Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1095 – 1109Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1149 – 1171Polar residuesSequence analysisAdd BLAST23
Compositional biasi1193 – 1249Pro residuesSequence analysisAdd BLAST57
Compositional biasi1250 – 1284Polar residuesSequence analysisAdd BLAST35
Compositional biasi1395 – 1424Polar residuesSequence analysisAdd BLAST30
Compositional biasi1472 – 1487Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1489 – 1504Acidic residuesSequence analysisAdd BLAST16
Compositional biasi1631 – 1658Polar residuesSequence analysisAdd BLAST28
Compositional biasi1746 – 1782Basic and acidic residuesSequence analysisAdd BLAST37

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The bivalent Mical/EHBP Rab binding (bMERB) domain, mediates binding to predominantly Rab8, Rab10, Rab10, Rab13 and Rab15 (in their GTP-bound forms).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mical family.Curated

Keywords - Domaini

Coiled coil, LIM domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1700, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000329_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3MWR8

Identification of Orthologs from Complete Genome Data

More...
OMAi
ESERIGW

Database of Orthologous Groups

More...
OrthoDBi
430978at2759

TreeFam database of animal gene trees

More...
TreeFami
TF333408

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022735, bMERB_dom
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR002938, FAD-bd
IPR036188, FAD/NAD-bd_sf
IPR029941, MICAL3
IPR001781, Znf_LIM

The PANTHER Classification System

More...
PANTHERi
PTHR24206:SF66, PTHR24206:SF66, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 1 hit
PF12130, DUF3585, 1 hit
PF01494, FAD_binding_3, 1 hit
PF00412, LIM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 1 hit
SM00132, LIM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit
SSF51905, SSF51905, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51848, BMERB, 1 hit
PS50021, CH, 1 hit
PS00478, LIM_DOMAIN_1, 1 hit
PS50023, LIM_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3MWR8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEESKNEATN RAHVLFDRFV QATTCKGTLK AFQELCDHLE LKPKDHRSFY
60 70 80 90 100
HKLKSKLNYW KAKALWAKLD KRGSHKDYKK GKVCTNTKCL IIGAGPCGLR
110 120 130 140 150
TAIDLSLLGA KVVVIEKRDA FSRNNVLHLW PFTIHDLRGL GAKKFYGKFC
160 170 180 190 200
AGAIDHISIR QLQLILLKVA LILGIEIHVN VEFRGLVEPP EDQENERIGW
210 220 230 240 250
RALVHPKTHP VSEYEFEVII GGDGRRNTLE GFRRKEFRGK LAIAITANFI
260 270 280 290 300
NRNTTAEAKV EEISGVAFIF NQKFFQELRE ATGIDLENIV YYKDDTHYFV
310 320 330 340 350
MTAKKQSLLD KGVILHDYAD TELLLSRENV DQEALLSYAR EAADFSTQQQ
360 370 380 390 400
LPSLDFAINH YGQPDVAMFD FTCMYASENA ALVREHNGHQ LLVALVGDSL
410 420 430 440 450
LEPFWPMGTG IARGFLAAMD SAWMVRSWSL GTSPLEVLAE RESIYRLLPQ
460 470 480 490 500
TTPENVSKNF SQYSIDPVTR YPNVNVNFLR PSQVRHLYDT GDTKDVHLEM
510 520 530 540 550
ENLVNSRTTP KLARNESVAR SSKLLGWCQR QTDGYAGVNV TDLTMSWKSG
560 570 580 590 600
LALCAIIHRY RPDLIDFDSL DEQNVEKNNQ LAFDIAEKEL GISPIMTGRE
610 620 630 640 650
MASVGEPDKL SMVMYLTQFY EMFKDSLPSR DASDLNAEER AVLIASTKSP
660 670 680 690 700
ISFLSKLGQT ISRKRSPKDK KEKDLDGAGK RRKTSQSEEE DTPRGHRGAR
710 720 730 740 750
PTLVSTLTDR RMDVALGNQN KVKYMATQLL AKFEENAPPQ SVGVRRQGSI
760 770 780 790 800
KKEFPQNLGG SDTCYFCQKR VYVMERLSAE GKFFHRSCFK CEHCATTLRL
810 820 830 840 850
SAYAYALEDG KFYCKPHYCY RLSGPAQRKR PAGVPLSGKE ARGPLQDSPA
860 870 880 890 900
ADASGRPSTS ASPAERSPGP SVNGLEEPSV AKRLRGTPER IELENYRLSV
910 920 930 940 950
RQAEGLEEVP EETQAEHNLS SVLDTGTEED AASSSSESEM EEEEPPLPTS
960 970 980 990 1000
DLGGVPWKEA VRIHALLRGK SEEELEASRS FGAGEEEEED EEDEEEEEEE
1010 1020 1030 1040 1050
EDEEDEEEDE DESSEVGSPR RLQQLLNPAD PLEIQADVHW THIRESQEER
1060 1070 1080 1090 1100
AALAPKSPLP GVPFDEDDLE RDVDSEPAEI KGEAAENGDA GDTGAELDDD
1110 1120 1130 1140 1150
QHWSDDVPSE ANTELHLPAV GAELELRVSD GEEEPPPASV GHPERGPSRV
1160 1170 1180 1190 1200
SSPTRSPEEP TGLSSPARSP GAQSAHPPLA AVATGVRSPA ESPLPEPSTP
1210 1220 1230 1240 1250
PAEPEAHPPI RSQPEARTPP SPASPQRPSP PTQLPICSQP QPSPEATVPS
1260 1270 1280 1290 1300
PTLSPIRSQP VPARTSTPLA PLPVKNQGVT KDTLGSSLPG DEALKRSDLV
1310 1320 1330 1340 1350
AEFWMKSAEI RRSLGLTPVH RSPGSELAFQ SPPLKACPAE KAPQSEGLRL
1360 1370 1380 1390 1400
LKPPPVPRKL GLPAAEGAQP CPPTPVSPPD REPKGPREEH RDLSSSSGLG
1410 1420 1430 1440 1450
LQGSSSRTRT PGSQSFNTSD STMLTPPSSP PPPPPDEEPA TLHRKPALAG
1460 1470 1480 1490 1500
QLVASAPPPP AVCVRPPREP TQPPQEEARK SFVESVDEIP FADDVEDTYD
1510 1520 1530 1540 1550
DNTCDDRTED SSLQETFFTP PSHWPHPKQP LAPENGRGPE SAVPLQKRGL
1560 1570 1580 1590 1600
PLVSAEAKEL AAERMRAREK SVRSQALRDA MARQLSRMKE MDIAAAAPRT
1610 1620 1630 1640 1650
PRTPAPRRAT AVPPKGPEEP APRHEATSEE LLSPPSDSGG PDGSVTSSEG
1660 1670 1680 1690 1700
SSGKSKKRSS LFSPRRSKKE KKPKGEGRPL ERPSPGTLEE AAAKPRSLWK
1710 1720 1730 1740 1750
SVFSGYRKDK KKSDGRSCPS TPSSGTTVDA GKPRASPVSR AELRTRRQLS
1760 1770 1780 1790 1800
CSEDSDLSSD DVLERTSQKS RKEPRTYTEE ELNAKLTRRV QKAARRQAKQ
1810 1820 1830 1840 1850
EELKRLHRAQ IIQRQLEQVE EKQRQLEERG VAVEKALRGE AGMGKKDDPK
1860 1870 1880 1890 1900
LMQEWFKLVQ EKNAMVRYES ELMIFARELE LEDRQSRLQQ ELRERMAVED
1910 1920 1930 1940 1950
HLKTEEELAE EKRILNEMLE VVEQRDALVA LLEEQRLREK EEDKDLEAAM
1960
LSKGFSLHWS
Length:1,960
Mass (Da):217,545
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i780A13287CAC8CE1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DAAA02014628 Genomic DNA No translation available.
DAAA02014629 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_002687965.2, XM_002687919.5
XP_015319081.1, XM_015463595.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02014628 Genomic DNA No translation available.
DAAA02014629 Genomic DNA No translation available.
RefSeqiXP_002687965.2, XM_002687919.5
XP_015319081.1, XM_015463595.1

3D structure databases

SMRiG3MWR8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000053971

PTM databases

SwissPalmiG3MWR8

Proteomic databases

PaxDbiG3MWR8
PRIDEiG3MWR8

Phylogenomic databases

eggNOGiKOG1700, Eukaryota
HOGENOMiCLU_000329_1_1_1
InParanoidiG3MWR8
OMAiESERIGW
OrthoDBi430978at2759
TreeFamiTF333408

Gene expression databases

BgeeiENSBTAG00000048271, Expressed in myometrium and 96 other tissues

Family and domain databases

CDDicd00014, CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR022735, bMERB_dom
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR002938, FAD-bd
IPR036188, FAD/NAD-bd_sf
IPR029941, MICAL3
IPR001781, Znf_LIM
PANTHERiPTHR24206:SF66, PTHR24206:SF66, 1 hit
PfamiView protein in Pfam
PF00307, CH, 1 hit
PF12130, DUF3585, 1 hit
PF01494, FAD_binding_3, 1 hit
PF00412, LIM, 1 hit
SMARTiView protein in SMART
SM00033, CH, 1 hit
SM00132, LIM, 1 hit
SUPFAMiSSF47576, SSF47576, 1 hit
SSF51905, SSF51905, 1 hit
PROSITEiView protein in PROSITE
PS51848, BMERB, 1 hit
PS50021, CH, 1 hit
PS00478, LIM_DOMAIN_1, 1 hit
PS50023, LIM_DOMAIN_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMICA3_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3MWR8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: November 16, 2011
Last modified: June 2, 2021
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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