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Entry version 38 (10 Apr 2019)
Sequence version 1 (16 Nov 2011)
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Protein
Submitted name:

RNase3 domain protein

Gene

CCM_09257

Organism
Cordyceps militaris (strain CM01) (Caterpillar fungus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
RNase3 domain proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CCM_09257Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCordyceps militaris (strain CM01) (Caterpillar fungus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri983644 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesCordycipitaceaeCordyceps
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001610 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
73501.XP_006674454.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini70 – 250Helicase ATP-bindingInterPro annotationAdd BLAST181
Domaini393 – 549Helicase C-terminalInterPro annotationAdd BLAST157
Domaini580 – 670Dicer dsRNA-binding foldInterPro annotationAdd BLAST91
Domaini975 – 1121RNase IIIInterPro annotationAdd BLAST147
Domaini1172 – 1330RNase IIIInterPro annotationAdd BLAST159

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. Dicer subfamily.PROSITE-ProRule annotation

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3JTW7

KEGG Orthology (KO)

More...
KOi
K11592

Database of Orthologous Groups

More...
OrthoDBi
1337630at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1520.10, 2 hits
3.30.160.380, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270 DEAD, 1 hit
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF00636 Ribonuclease_3, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00535 RIBOc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3JTW7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MISLGTGSNC PPLKAKFKDN TVFTAWLADH ARLDDDGADL SATAPSEGIS
60 70 80 90 100
ETAAEISALM ITPREYQNEL FERAKKKNTI VVLDTGSGKT LIAIMLLRHV
110 120 130 140 150
LEQELEDRSN GCHRKTAFFI VDKVALCVQQ YQVVKSNLPF PITKCYGDLQ
160 170 180 190 200
PIEQVQSHWD ELFDKNMIVV CTAQMLLDCL SHGFINMKQI NLLIFDEVHH
210 220 230 240 250
AKKEHPYAAI MKRYYPRNDD AKPRILGLTA SPIDTGTLDM DASVQQLESL
260 270 280 290 300
LCSEIATVSD EVLEAGWVKR EQQEKVCFYQ PPQPIQNAYT ELTAMVADYA
310 320 330 340 350
RHIPQLSSAV HCAAKMGSVL GPWCAHRFWQ LLMTDNTMRT MTLQSARSNR
360 370 380 390 400
VYFSYDRYDA VSAAFESLGP LVNHHQLTTL PTDEGATSSK LTVLRETLCV
410 420 430 440 450
AFEKNRATKC LVFVDEQYVA LVLADYFQQP GTAPSGMVAD FMIGLSRASA
460 470 480 490 500
FSNVSQRQQI MKLNNFKFGD TNCLFATSVA EEGLDIPACD LVIRFDMCVS
510 520 530 540 550
AIQYIQSRGR ARKASSVFIT MMEQDNNQHM SRFQNVNIDA LSLRRFCQSL
560 570 580 590 600
PADRKIEKYE RPPERELFVA ETSTLSNQNS MVVLARFVST LGQGTEKSPA
610 620 630 640 650
PEYVVSGVGT NFTCWVILPD SAPFKSTSGS MERSKIKARC AAAYEACTRL
660 670 680 690 700
IDLGSINKNL QPTFRKKLPK MRNARLALRD KKQKQYDMVI KPKVWTSLPA
710 720 730 740 750
EIPTQLFQTF IQVHPDSAGI TTMTLLTREK LPDIEPIRLF VTIDLTMSAT
760 770 780 790 800
LVPGGVVEVS AEQVQQLAAF TLCLFGQVFS KQFDARAEEI PFYLAPASVS
810 820 830 840 850
LHGPEKCAVD WRRVEHTVLS KKRDPEVKPQ DMMRQQFVVD PHDGSRKFFI
860 870 880 890 900
YEIVPTLRAT DPAPAGIPDH KNPGYQLSDK SIMQYSCSTK QPHRQKIVFD
910 920 930 940 950
TEQPVYRALL LSLRRNFLRS DDVEAAKEDQ PCYLTLQCLK ISPIPADVAR
960 970 980 990 1000
AALLLPSILY FVDCTLVVGE ALQMLGLNIP LPLLLQAFTK NGVDADDEED
1010 1020 1030 1040 1050
VKADEEHGGQ RNYERLEFLG DTFLKMGTTI AMYTHKTNAT EFEHHVDRML
1060 1070 1080 1090 1100
MLCNKNLLKT ALDLGLHTYI RSESFNRRTW YPSLRLVHGK PTKASAIQNL
1110 1120 1130 1140 1150
GDKTIADVCE AIIGAAYMSG VPDGNMDEAV KAVTKMVADP NHTMQCFADY
1160 1170 1180 1190 1200
YAGFSVPAWH ASSGSASVRA AVDRVAGLIG YRFRSPLLLR SAFTHPSYKA
1210 1220 1230 1240 1250
EEIPDYQTLE FLGDALLDMA IVDHLFRAHP DAGPQWLTEH KMGVCSNQFL
1260 1270 1280 1290 1300
GYLCVSLGLQ REVLAADAAV PGQIRSFEER LAYLKDAAET AAAQQGRPVS
1310 1320 1330 1340 1350
KGYWTLATRP PKVLADVVEA LIGAMFVDAR YDYAVVQRFF EAFVRPHIDD
1360 1370 1380 1390 1400
MDGYDALGAG HVVTQAAHAL QGYGCRRWRF CMAEVPCESR TGLLAITASD
1410 1420 1430 1440 1450
YVCALVIHSK VHWHAKAAST IDAKSKVAAM ALGHLHRVSP DAYRAEMGCD

CDGWA
Length:1,455
Mass (Da):162,263
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA8353A18C288E15
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JH126406 Genomic DNA Translation: EGX88121.1

NCBI Reference Sequences

More...
RefSeqi
XP_006674454.1, XM_006674391.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EGX88121; EGX88121; CCM_09257

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
18171260

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cmt:CCM_09257

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JH126406 Genomic DNA Translation: EGX88121.1
RefSeqiXP_006674454.1, XM_006674391.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi73501.XP_006674454.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEGX88121; EGX88121; CCM_09257
GeneIDi18171260
KEGGicmt:CCM_09257

Phylogenomic databases

InParanoidiG3JTW7
KOiK11592
OrthoDBi1337630at2759

Family and domain databases

CDDicd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits
Gene3Di1.10.1520.10, 2 hits
3.30.160.380, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF00636 Ribonuclease_3, 2 hits
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00535 RIBOc, 2 hits
SUPFAMiSSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits
PROSITEiView protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3JTW7_CORMM
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3JTW7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: April 10, 2019
This is version 38 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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