Nuclear receptor DAX-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA hairpin binding Source: Ensembl
• protein domain specific binding Source: Ensembl
• protein homodimerization activity Source: Ensembl
• RNA binding Source: Ensembl
• steroid hormone receptor binding Source: Ensembl
• transcription corepressor activity Source: Ensembl

GO - Biological processⁱ

• adrenal gland development Source: Ensembl
• Leydig cell differentiation Source: Ensembl
• male sex determination Source: Ensembl
• negative regulation of DNA-binding transcription factor activity Source: Ensembl
• negative regulation of intracellular steroid hormone receptor signaling pathway Source: Ensembl
• negative regulation of steroid biosynthetic process Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: Ensembl
• protein localization Source: Ensembl
• response to immobilization stress Source: Ensembl
• Sertoli cell differentiation Source: Ensembl
• spermatogenesis Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• protein domain specific binding Source: Ensembl
• protein homodimerization activity Source: Ensembl
• steroid hormone receptor binding Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MAGGGHPLQG SILYNLLMSA KQKHAAAPVE PKVRLGVQCW GCACGAQSIG 
        60         70         80         90        100
DEEGLPGGQT SSLLYRCCLC GENHPRQGSI LYSMLTSAKQ SGSGTQASRA 
       110        120        130        140        150
RFGAPCWGCA CGSPEPLVSR EGTPARRAAS LLYRCCFCGE EHPKQGSILY 
       160        170        180        190        200
SLLTSAKQTH VSPEASEARR GGEWWQLSYC TESMDDPEGL QSAQAMAFLY 
       210        220        230        240        250
RSYVCGEEQP QQSSLACGTP GSSDQLPRAP EEQPRALWWD ASSGVQRPLT 
       260        270        280        290        300
LKNPQVVCEA ASAGLLKTLR FVKYLPCFQI LPLDQQLVLV RSCWAPLLML 
       310        320        330        340        350
ELAQDHLHIE MMEISEPSVL QKTLTTRQQE TQGAEPADPL AKEQPQMVST 
       360        370        380        390        400
AEAGHLPSAA PPQAIKSCWS LNIDTKEYAY LKGAVLFNPD LPGLQCVKYI 
       410        420        430        440        450
QGLQWRTQQI LTEHIRVMQR EYQIRSAELN SALFLLRFIN TDVVTELFFR 
       460        470
PIIGAVSMDD MMLEMLCAKL                                  

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ