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Entry version 46 (07 Oct 2020)
Sequence version 1 (16 Nov 2011)
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Protein
Submitted name:

Vitronectin

Gene

I79_001034

Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi502 – 548HomeoboxPROSITE-ProRule annotationAdd BLAST47

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
VitronectinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:I79_001034Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10029 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeCricetulus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001075 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation, SecretedARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500344386620 – 876Sequence analysisAdd BLAST857

Keywords - PTMi

Disulfide bondARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10029.XP_007620159.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 63SMBInterPro annotationAdd BLAST44
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati159 – 203HemopexinPROSITE-ProRule annotationAdd BLAST45
Repeati204 – 251HemopexinPROSITE-ProRule annotationAdd BLAST48
Repeati252 – 306HemopexinPROSITE-ProRule annotationAdd BLAST55
Repeati428 – 478HemopexinPROSITE-ProRule annotationAdd BLAST51
Domaini500 – 547HomeoboxInterPro annotationAdd BLAST48
Domaini743 – 868ApaGInterPro annotationAdd BLAST126

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni85 – 135DisorderedSequence analysisAdd BLAST51
Regioni361 – 400DisorderedSequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi85 – 126PolarSequence analysisAdd BLAST42
Compositional biasi367 – 390BasicSequence analysisAdd BLAST24

Keywords - Domaini

HomeoboxPROSITE-ProRule annotation, RepeatARBA annotation, SignalSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1565, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3GTP7

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086, homeodomain, 1 hit
cd00094, HX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.110.10.10, 2 hits
2.60.40.1470, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007474, ApaG_domain
IPR036767, ApaG_sf
IPR011722, Hemimethylated_DNA-bd_dom
IPR036623, Hemimethylated_DNA-bd_sf
IPR000585, Hemopexin-like_dom
IPR036375, Hemopexin-like_dom_sf
IPR018487, Hemopexin-like_repeat
IPR018486, Hemopexin_CS
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
IPR036024, Somatomedin_B-like_dom_sf
IPR020436, Somatomedin_B_chordata
IPR001212, Somatomedin_B_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04379, DUF525, 1 hit
PF00045, Hemopexin, 4 hits
PF00046, Homeodomain, 1 hit
PF01033, Somatomedin_B, 1 hit
PF08755, YccV-like, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00022, SOMATOMEDINB

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389, HOX, 1 hit
SM00120, HX, 4 hits
SM00201, SO, 1 hit
SM00992, YccV-like, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF110069, SSF110069, 1 hit
SSF141255, SSF141255, 1 hit
SSF46689, SSF46689, 1 hit
SSF50923, SSF50923, 1 hit
SSF90188, SSF90188, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51087, APAG, 1 hit
PS00024, HEMOPEXIN, 2 hits
PS51642, HEMOPEXIN_2, 4 hits
PS50071, HOMEOBOX_2, 1 hit
PS00524, SMB_1, 1 hit
PS50958, SMB_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3GTP7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPLRPFLML TLLAWVSLAD QESCKGRCNQ GFVANKKCQC DELCSYYQSC
60 70 80 90 100
CADYVAQCKP QVTRGDVFTM PEDEYWSYDY TEETKNGTST HVQPENTSLH
110 120 130 140 150
PDLQPQTSEP TSFLKPEEQA PTLEASTSGP EVGYLEVTSR PDTTAQGTSD
160 170 180 190 200
FPEEELCSGK PFDAFTDLKN GSLFAFRGQY CYELDETAVR PGYPKLIRDV
210 220 230 240 250
WGIEGPIDAA FTRINCQGKT YLFKGSLYWR FEDGVLDPGY PRNISEGFSG
260 270 280 290 300
IPDNVDAALA LPAHRYSGRE RVYFFKGKQY WEYEFQQQPS QEDCEGSSLS
310 320 330 340 350
AVFEHFALLQ RDSWEDIFEL LFWGRSTGGV REPQFISRDW HGVPGKVDAA
360 370 380 390 400
MAGRIYISGS TSHSFQAKKQ KSRRRSRKRY RSRRGRGRSR SPSSSHSLNS
410 420 430 440 450
RRSSRSVWFS LFSSEERGLG DYNYDYDMDW LPPATCEPIQ SVYFFSGDKY
460 470 480 490 500
YRVNLKTRRV DSVNPPYPRS IAQYWLGCPA PENSMASPVE ASPGCASGLG
510 520 530 540 550
PHRRKRTTFS VGQLLELERV FAARPYPDIS TREHLAQVTH LPEAKIQECA
560 570 580 590 600
GAKMYLFIFP IRNRAEGKVL ETVGVFEVPK QNGKYETGQL FLHSVFGYRG
610 620 630 640 650
VVLFPWQARL YDRDVASSAP EKAENPAGHG SKEVKGKTHT YYQVLIDARD
660 670 680 690 700
CPHISQRSQT EAVTFLANHD DSRALYAIPG LDYVSHEDIL PYTSTDQVPI
710 720 730 740 750
QHELFERFLL YDQTKAPPFV ARETLRAWQE KNHPWLELSD VHRETTENIR
760 770 780 790 800
VTVIPFYMGM REAQNSHVYW WRYCIRLENL DSDVVQLRER HWRIFSLSGT
810 820 830 840 850
LETVRGRGVV GREPVLSKEQ PAFQYSSHVS LQASSGHMWG TFRFERPDGS
860 870
HFDVRIPPFS LESNKDEKTP PSGLHW
Length:876
Mass (Da):100,146
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03953298EA9ED9B2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JH000022 Genomic DNA Translation: EGV94342.1

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JH000022 Genomic DNA Translation: EGV94342.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10029.XP_007620159.1

Phylogenomic databases

eggNOGiKOG1565, Eukaryota
InParanoidiG3GTP7

Family and domain databases

CDDicd00086, homeodomain, 1 hit
cd00094, HX, 1 hit
Gene3Di2.110.10.10, 2 hits
2.60.40.1470, 1 hit
InterProiView protein in InterPro
IPR007474, ApaG_domain
IPR036767, ApaG_sf
IPR011722, Hemimethylated_DNA-bd_dom
IPR036623, Hemimethylated_DNA-bd_sf
IPR000585, Hemopexin-like_dom
IPR036375, Hemopexin-like_dom_sf
IPR018487, Hemopexin-like_repeat
IPR018486, Hemopexin_CS
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
IPR036024, Somatomedin_B-like_dom_sf
IPR020436, Somatomedin_B_chordata
IPR001212, Somatomedin_B_dom
PfamiView protein in Pfam
PF04379, DUF525, 1 hit
PF00045, Hemopexin, 4 hits
PF00046, Homeodomain, 1 hit
PF01033, Somatomedin_B, 1 hit
PF08755, YccV-like, 1 hit
PRINTSiPR00022, SOMATOMEDINB
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SM00120, HX, 4 hits
SM00201, SO, 1 hit
SM00992, YccV-like, 1 hit
SUPFAMiSSF110069, SSF110069, 1 hit
SSF141255, SSF141255, 1 hit
SSF46689, SSF46689, 1 hit
SSF50923, SSF50923, 1 hit
SSF90188, SSF90188, 1 hit
PROSITEiView protein in PROSITE
PS51087, APAG, 1 hit
PS00024, HEMOPEXIN, 2 hits
PS51642, HEMOPEXIN_2, 4 hits
PS50071, HOMEOBOX_2, 1 hit
PS00524, SMB_1, 1 hit
PS50958, SMB_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3GTP7_CRIGR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3GTP7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: October 7, 2020
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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