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UniProtKB - G3CCC1 (CABS_TOBAC)
Protein
Cis-abienol synthase, chloroplastic
Gene
ABS
Organism
Nicotiana tabacum (Common tobacco)
Status
Functioni
Involved in the biosynthesis of cis-abienol, a labdane diterpene that can be used as synthesis precursor of ambergris substitution fragance products.
1 PublicationMiscellaneous
The expression of both CPS2 and ABS is necessary and sufficient to catalyze the biosynthesis of cis-abienol from geranylgeranyl diphosphate in a heterologous system.1 Publication
Catalytic activityi
- EC:4.2.3.1401 Publication
Cofactori
Mg2+Curated
: terpenoid biosynthesis Pathwayi
This protein is involved in the pathway terpenoid biosynthesis, which is part of Secondary metabolite biosynthesis.1 PublicationView all proteins of this organism that are known to be involved in the pathway terpenoid biosynthesis and in Secondary metabolite biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 539 | Magnesium 1By similarity | 1 | |
Metal bindingi | 539 | Magnesium 2By similarity | 1 | |
Metal bindingi | 543 | Magnesium 1By similarity | 1 | |
Metal bindingi | 543 | Magnesium 2By similarity | 1 | |
Metal bindingi | 684 | Magnesium 3By similarity | 1 | |
Metal bindingi | 692 | Magnesium 3By similarity | 1 |
GO - Molecular functioni
- carbon-oxygen lyase activity, acting on phosphates Source: UniProtKB
- magnesium ion binding Source: GO_Central
- terpene synthase activity Source: UniProtKB
GO - Biological processi
- cis-abienol biosynthetic process Source: UniProtKB
- copal-8-ol diphosphate(3-) catabolic process Source: UniProtKB
- diterpenoid biosynthetic process Source: GO_Central
- gibberellin biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Lyase |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00213 |
Names & Taxonomyi
Protein namesi | Recommended name: Cis-abienol synthase, chloroplastic1 Publication (EC:4.2.3.1401 Publication)Short name: NtABS1 Publication |
Gene namesi | Name:ABS1 Publication |
Organismi | Nicotiana tabacum (Common tobacco) |
Taxonomic identifieri | 4097 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › asterids › lamiids › Solanales › Solanaceae › Nicotianoideae › Nicotianeae › Nicotiana |
Proteomesi |
|
Subcellular locationi
Chloroplast
- chloroplast By similarity
Chloroplast
- chloroplast Source: GO_Central
Keywords - Cellular componenti
Chloroplast, PlastidPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 37 | ChloroplastSequence analysisAdd BLAST | 37 | |
ChainiPRO_5000793117 | 38 – 792 | Cis-abienol synthase, chloroplasticAdd BLAST | 755 |
Expressioni
Tissue specificityi
Expressed specifically in trichomes.1 Publication
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 539 – 543 | DDXXD motif | 5 |
Domaini
The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg2+.By similarity
Sequence similaritiesi
Belongs to the terpene synthase family.Curated
Keywords - Domaini
Transit peptideFamily and domain databases
Gene3Di | 1.10.600.10, 1 hit 1.50.10.130, 1 hit |
InterProi | View protein in InterPro IPR008949, Isoprenoid_synthase_dom_sf IPR001906, Terpene_synth_N IPR036965, Terpene_synth_N_sf IPR005630, Terpene_synthase_metal-bd IPR008930, Terpenoid_cyclase/PrenylTrfase |
Pfami | View protein in Pfam PF01397, Terpene_synth, 1 hit PF03936, Terpene_synth_C, 1 hit |
SUPFAMi | SSF48239, SSF48239, 2 hits SSF48576, SSF48576, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
G3CCC1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVLGLRSKII PLPDHKLGNI KLGSVTNAIC HRPCRVRCSH STASSMEEAK
60 70 80 90 100
ERIRETFGKI ELSPSSYDTA WVAMVPSRYS MNQPCFPQCL DWILENQRED
110 120 130 140 150
GSWGLNPSHP LLVKDSLSST LASLLALRKW RIGDNQVQRG LGFIETHGWA
160 170 180 190 200
VDNKDQISPL GFEIIFPCMI NYAEKLNLDL PLDPNLVNMM LCERELTIER
210 220 230 240 250
ALKNEFEGNM ANVEYFAEGL GELCHWKEMM LRQRHNGSLF DSPATTAAAL
260 270 280 290 300
IYHQYDEKCF GYLNSILKLH DNWVPTICPT KIHSNLFLVD ALQNLGVDRY
310 320 330 340 350
FKTEVKRVLD EIYRLWLEKN EEIFSDVAHC AMAFRLLRMN NYEVSSEELE
360 370 380 390 400
GFVDQEHFFT TSSGKLMNHV AILELHRASQ VAIHERKDHI LDKISTWTRN
410 420 430 440 450
FMEQKLLDKH IPDRSKKEME FAMRKFYGTF DRVETRRYIE SYKMDSFKIL
460 470 480 490 500
KAAYRSSGIN NIDLLKFSEH DFNLCQTRHK EELQQMKRWF TDCKLEQVGL
510 520 530 540 550
SQQYLYTSYF IIAAILFEPE YADARLAYAK YAIIITAVDD FFDCFICKEE
560 570 580 590 600
LQNIIELVER WEGYSTVGFR SERVRIFFLA LYKMVEEIAA KAETKQGRCV
610 620 630 640 650
KDHLINLWID MLKCMLVELD LWKIKSTTPS IEEYLSVACV TIGVPCFVLT
660 670 680 690 700
SLYLLGPKLS KDVIESSEVS ALCNCTAAVA RLINDIHSYK REQAESSTNM
710 720 730 740 750
VSILITQSQG TISEEEAIRQ IKEMMESKRR ELLGMVLQNK ESQLPQVCKD
760 770 780 790
LFWTTINAAY SIHTHGDGYR FPEEFKNHIN DVIYKPLNQY SP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HE588140 mRNA Translation: CCD33019.1 KF000066 mRNA Translation: AGN95433.1 |
RefSeqi | NP_001312911.1, NM_001325982.1 |
Genome annotation databases
GeneIDi | 107816701 |
KEGGi | ag:CCD33019 nta:107816701 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HE588140 mRNA Translation: CCD33019.1 KF000066 mRNA Translation: AGN95433.1 |
RefSeqi | NP_001312911.1, NM_001325982.1 |
3D structure databases
SMRi | G3CCC1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4097.G3CCC1 |
Genome annotation databases
GeneIDi | 107816701 |
KEGGi | ag:CCD33019 nta:107816701 |
Enzyme and pathway databases
UniPathwayi | UPA00213 |
Family and domain databases
Gene3Di | 1.10.600.10, 1 hit 1.50.10.130, 1 hit |
InterProi | View protein in InterPro IPR008949, Isoprenoid_synthase_dom_sf IPR001906, Terpene_synth_N IPR036965, Terpene_synth_N_sf IPR005630, Terpene_synthase_metal-bd IPR008930, Terpenoid_cyclase/PrenylTrfase |
Pfami | View protein in Pfam PF01397, Terpene_synth, 1 hit PF03936, Terpene_synth_C, 1 hit |
SUPFAMi | SSF48239, SSF48239, 2 hits SSF48576, SSF48576, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CABS_TOBAC | |
Accessioni | G3CCC1Primary (citable) accession number: G3CCC1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 18, 2013 |
Last sequence update: | November 16, 2011 | |
Last modified: | February 23, 2022 | |
This is version 40 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families