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Protein

RNA polymerase II transcription factor B subunit 2

Gene

SPAPADRAFT_135256

Organism
Spathaspora passalidarum (strain NRRL Y-27907 / 11-Y1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
ORF Names:SPAPADRAFT_135256Imported
OrganismiSpathaspora passalidarum (strain NRRL Y-27907 / 11-Y1)Imported
Taxonomic identifieri619300 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeSpathaspora
Proteomesi
  • UP000000709 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

InParanoidiG3AHH7
KOiK03144
OMAiYLEQYAH
OrthoDBiEOG092C3703

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

G3AHH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSNLFKAT VNEYLEGLPK TVQSKLYEAP ATCLSIYRLL SPMAKFFIMS
60 70 80 90 100
MIFNEKPVAL RDLDKWCMPS ARKLEYEALK QLESLHLIEY DSKASHIRLH
110 120 130 140 150
STFRQNFRDC LTGSQDPTAF GSISTTVDKH QVDVAFLDSF ASSKWETILH
160 170 180 190 200
FMVGTESTAT PSNSVLSLLR LGGLMEGPGR GASNLKITNT GFQFLLQDVN
210 220 230 240 250
AQIWTLLLQY LNLTQELNMD PVDVLNFIFV LGSLELGKSY AVSSLSETQV
260 270 280 290 300
SMLADLKDYG LVYRRTDTSS RFYPTRLATT LTSDSSALKT PAMAVEQALD
310 320 330 340 350
SVEGGTDNEV SQTAPPGNIQ GTVIIETNFK LYAYTNSPLE IAILNLFVHL
360 370 380 390 400
RTRFANMVCG QITRESIRNA LYNGITADQI IRFLETHAHP QMKVLAKEKL
410 420 430 440 450
DKKIEFDTSH NINTAGGAPQ SQALRADGSV AQHKLEILPP NVVDQIKLWQ
460 470 480 490 500
LELDRIQTFD GYLFKDFPNQ QEFDKLSSYA SELGVLIWSD KIKRKFFVTK
510
DGMSQVADFA NRKLKSRGQ
Length:519
Mass (Da):58,156
Last modified:November 16, 2011 - v1
Checksum:i5CD7C49A0635E10E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL996500 Genomic DNA Translation: EGW34141.1
RefSeqiXP_007373725.1, XM_007373663.1

Genome annotation databases

EnsemblFungiiEGW34141; EGW34141; SPAPADRAFT_135256
GeneIDi18869879
KEGGispaa:SPAPADRAFT_135256

Similar proteinsi

Entry informationi

Entry nameiG3AHH7_SPAPN
AccessioniPrimary (citable) accession number: G3AHH7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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