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Protein

Homoserine dehydrogenase

Gene

K7_HOM6

Organism
Saccharomyces cerevisiae (strain Kyokai no. 7 / NBRC 101557) (Baker's yeast)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 3 of the subpathway that synthesizes L-homoserine from L-aspartate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Homoserine dehydrogenase (K7_HOM6)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homoserine from L-aspartate, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Pathwayi: L-threonine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Homoserine dehydrogenase (K7_HOM6)
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93NADPUniRule annotation1
Binding sitei117NADPUniRule annotation1
Binding sitei208SubstrateUniRule annotation1
Active sitei223Proton donorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 17NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesis, Isoleucine biosynthesisUniRule annotation, Methionine biosynthesisUniRule annotation, Threonine biosynthesisUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00050; UER00063
UPA00051; UER00465

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine dehydrogenaseUniRule annotation (EC:1.1.1.3UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:K7_HOM6Imported
ORF Names:SYK7_040681Imported
OrganismiSaccharomyces cerevisiae (strain Kyokai no. 7 / NBRC 101557) (Baker's yeast)Imported
Taxonomic identifieri721032 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000001608 Componenti: Chromosome X

Structurei

3D structure databases

ProteinModelPortaliG2WHE2
SMRiG2WHE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 142NAD_binding_3InterPro annotationAdd BLAST131
Domaini151 – 353Homoserine_dhInterPro annotationAdd BLAST203

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili257 – 277Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the homoserine dehydrogenase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

OrthoDBiEOG092C36D3

Family and domain databases

InterProiView protein in InterPro
IPR005106 Asp/hSer_DH_NAD-bd
IPR001342 HDH_cat
IPR019811 HDH_CS
IPR022697 HDH_short
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00742 Homoserine_dh, 1 hit
PF03447 NAD_binding_3, 1 hit
PIRSFiPIRSF036497 HDH_short, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS01042 HOMOSER_DHGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

G2WHE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKVVNVAV IGAGVVGSAF LDQLLAMKST ITYNLVLLAE AERSLISKDF
60 70 80 90 100
SPLNVGSDWK AALAASTTKT LPLDDLIAHL KTSPKPVILV DNTSSAYIAG
110 120 130 140 150
FYTKFVENGI SIATPNKKAF SSDLATWKAL FSNKPTNGFV YHEATVGAGL
160 170 180 190 200
PIISFLREII QTGDEVEKIE GIFSGTLSYI FNEFSTSQAN DVKFSDVVKV
210 220 230 240 250
AKKLGYTEPD PRDDLNGLDV ARKVTIVGRI SGVEVESPTS FPVQSLIPKP
260 270 280 290 300
LESVKSADEF LEKLSDYDKD LTQLKKEAAT ENKVLRFIGK VDVATKSVSV
310 320 330 340 350
GIEKYDYSHP FASLKGSDNV ISIKTKRYTN PVVIQGAGAG AAVTAAGVLG

DVIKIAQRL
Length:359
Mass (Da):38,502
Last modified:November 16, 2011 - v1
Checksum:i6C106F9EB0BD0CC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DG000046 Genomic DNA Translation: GAA24485.1

Genome annotation databases

EnsemblFungiiGAA24485; GAA24485; SYK7_040681

Similar proteinsi

Entry informationi

Entry nameiG2WHE2_YEASK
AccessioniPrimary (citable) accession number: G2WHE2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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