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Protein

1,4-dihydroxy-2-naphthoyl-CoA synthase

Gene

menB

Organism
Bacillus coagulans 36D1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

4-(2-carboxyphenyl)-4-oxobutanoyl-CoA = 1,4-dihydroxy-2-naphthoyl-CoA + H2O.UniRule annotation

Cofactori

hydrogencarbonateUniRule annotation

Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (menD)
  3. Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (menH)
  4. o-succinylbenzoate synthase (menC)
  5. 2-succinylbenzoate--CoA ligase (menE)
  6. 1,4-dihydroxy-2-naphthoyl-CoA synthase (menB)
  7. no protein annotated in this organism
This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.

Pathwayi: menaquinone biosynthesis

This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33SubstrateUniRule annotation1
Binding sitei84SubstrateUniRule annotation1
Sitei84Important for catalysisUniRule annotation1
Binding sitei142SubstrateUniRule annotation1
Binding sitei148SubstrateUniRule annotation1
Binding sitei245Substrate; shared with neighboring subunitUniRule annotation1
Sitei245Important for catalysisUniRule annotation1
Binding sitei260Substrate; shared with neighboring subunitUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
Biological processMenaquinone biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciBCOA345219:G1GP7-2530-MONOMER
UniPathwayi
UPA00079

UPA01057;UER00167

Names & Taxonomyi

Protein namesi
Recommended name:
1,4-dihydroxy-2-naphthoyl-CoA synthaseUniRule annotation (EC:4.1.3.36UniRule annotation)
Short name:
DHNA-CoA synthaseUniRule annotation
Gene namesi
Name:menBUniRule annotation
ORF Names:Bcoa_2400Imported
OrganismiBacillus coagulans 36D1Imported
Taxonomic identifieri345219 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000009283 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi345219.Bcoa_2400

Structurei

3D structure databases

ProteinModelPortaliG2TN69
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni72 – 76Substrate bindingUniRule annotation5
Regioni116 – 120Substrate bindingUniRule annotation5
Regioni141 – 143Hydrogencarbonate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IPT Bacteria
COG0447 LUCA
KOiK01661
OrthoDBiPOG091H05HP

Family and domain databases

Gene3Di1.10.12.10, 1 hit
HAMAPiMF_01934 MenB, 1 hit
InterProiView protein in InterPro
IPR029045 ClpP/crotonase-like_dom_sf
IPR010198 DHNA-CoA_synthase_MenB
IPR018376 Enoyl-CoA_hyd/isom_CS
IPR001753 Enoyl-CoA_hydra/iso
IPR014748 Enoyl-CoA_hydra_C
PANTHERiPTHR43113 PTHR43113, 1 hit
PfamiView protein in Pfam
PF00378 ECH_1, 1 hit
SUPFAMiSSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR01929 menB, 1 hit
PROSITEiView protein in PROSITE
PS00166 ENOYL_COA_HYDRATASE, 1 hit

Sequencei

Sequence statusi: Complete.

G2TN69-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVEWKTEHE YEDILYESYN GIAKITINRP HVRNAFRPET VTEMYDAFSR
60 70 80 90 100
ARDDANIGVI ILTGMGEKAF CSGGDQKVRG NGGYVGSDNI PRLNVLDLQH
110 120 130 140 150
LIRVIPKPVI AMVAGYAIGG GNVLQVVCDL TIAADNAIFG QTGPKVGSFD
160 170 180 190 200
GGYGAGYLAR IVGHKKAREI WYLCRQYNAQ EALEMGLVNA VVPYEKLEEE
210 220 230 240 250
TIKWAEEILE KSPMAIRFLK AAFNADTDGL AGLQQFAGDA TLLYYTTDEA
260 270
KEGRDAFKEK RKPDFGQFPR FP
Length:272
Mass (Da):30,125
Last modified:November 16, 2011 - v1
Checksum:i24F1C2AD8059522A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003056 Genomic DNA Translation: AEP01578.1
RefSeqiWP_014097638.1, NC_016023.1

Genome annotation databases

EnsemblBacteriaiAEP01578; AEP01578; Bcoa_2400
KEGGibag:Bcoa_2400

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003056 Genomic DNA Translation: AEP01578.1
RefSeqiWP_014097638.1, NC_016023.1

3D structure databases

ProteinModelPortaliG2TN69
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi345219.Bcoa_2400

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEP01578; AEP01578; Bcoa_2400
KEGGibag:Bcoa_2400

Phylogenomic databases

eggNOGiENOG4108IPT Bacteria
COG0447 LUCA
KOiK01661
OrthoDBiPOG091H05HP

Enzyme and pathway databases

UniPathwayi
UPA00079

UPA01057;UER00167

BioCyciBCOA345219:G1GP7-2530-MONOMER

Family and domain databases

Gene3Di1.10.12.10, 1 hit
HAMAPiMF_01934 MenB, 1 hit
InterProiView protein in InterPro
IPR029045 ClpP/crotonase-like_dom_sf
IPR010198 DHNA-CoA_synthase_MenB
IPR018376 Enoyl-CoA_hyd/isom_CS
IPR001753 Enoyl-CoA_hydra/iso
IPR014748 Enoyl-CoA_hydra_C
PANTHERiPTHR43113 PTHR43113, 1 hit
PfamiView protein in Pfam
PF00378 ECH_1, 1 hit
SUPFAMiSSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR01929 menB, 1 hit
PROSITEiView protein in PROSITE
PS00166 ENOYL_COA_HYDRATASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG2TN69_BACCO
AccessioniPrimary (citable) accession number: G2TN69
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: June 20, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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