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Entry version 45 (02 Jun 2021)
Sequence version 1 (16 Nov 2011)
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Protein

Butyryl-CoA:acetate CoA-transferase

Gene

RHOM_13820

Organism
Roseburia hominis (strain DSM 16839 / JCM 17582 / NCIMB 14029 / A2-183)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Coenzyme A-transferase that converts butyryl-CoA to butyrate. Can also use proprionyl-CoA as substrate in vitro.

UniRule annotation1 Publication

Miscellaneous

The fermentation acid butyrate is of special interest, as it has been shown to serve as the preferred energy source for the gut wall and also influences cell differentiation and apoptosis in the colon, and this seems to aid in protection against colon cancer and inflammatory bowel disease. Formation of butyrate via butyryl-CoA CoA-transferase is the only available route for butyrate synthesis in the majority of human gut isolates.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=6.4 mM for acetate1 Publication
  2. KM=0.098 mM for butanoyl-CoA1 Publication
  3. KM=0.099 mM for propanoyl-CoA1 Publication
  1. Vmax=112 µmol/min/mg enzyme with butanoyl-CoA as substrate1 Publication
  2. Vmax=51 µmol/min/mg enzyme with propanoyl-CoA as substrate1 Publication

pH dependencei

Optimum pH is 7-8.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: butanoate metabolism

This protein is involved in the pathway butanoate metabolism, which is part of Lipid metabolism.UniRule annotationCurated
View all proteins of this organism that are known to be involved in the pathway butanoate metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2455-glutamyl coenzyme A thioester intermediateUniRule annotationBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei320Coenzyme A; via carbonyl oxygenUniRule annotationBy similarity1
Binding sitei343Coenzyme A; via amide nitrogenUniRule annotationBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processFatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
RHOM585394:G1H02-2743-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.8.3.8, 10484

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00863

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Butyryl-CoA:acetate CoA-transferase1 PublicationUniRule annotation (EC:2.8.3.-UniRule annotation)
Short name:
Butyryl-CoA CoA-transferaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:RHOM_13820
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRoseburia hominis (strain DSM 16839 / JCM 17582 / NCIMB 14029 / A2-183)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri585394 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaEubacterialesLachnospiraceaeRoseburia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008178 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004473431 – 446Butyryl-CoA:acetate CoA-transferaseAdd BLAST446

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
585394.RHOM_13820

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G2SYC0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni220 – 224Coenzyme A bindingUniRule annotationBy similarity5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the acetyl-CoA hydrolase/transferase family. Butyryl-CoA CoA-transferase subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0427, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_030703_1_0_9

Identification of Orthologs from Complete Genome Data

More...
OMAi
VAMFQVA

Database of Orthologous Groups

More...
OrthoDBi
319106at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1080.20, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_03227, But_acet_CoA_trans, 1 hit
MF_03228, But_CoA_trans, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026888, AcetylCoA_hyd_C
IPR038460, AcetylCoA_hyd_C_sf
IPR003702, ActCoA_hydro
IPR023990, Butryl-CoA_acetate_CoA_Tfrase
IPR037171, NagB/RpiA_transferase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13336, AcetylCoA_hyd_C, 1 hit
PF02550, AcetylCoA_hydro, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100950, SSF100950, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03948, butyr_acet_CoA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G2SYC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDFREEYKQK LVSADEAVKL IKSGDWVDYG WCTNTVDALD QALAKRTDEL
60 70 80 90 100
TDVKLRGGIL MKPLAVFARE DAGEHFCWNS WHMSGIERKM INRGVAYYCP
110 120 130 140 150
IRYSELPRYY RELDCPDDVA MFQVAPMDAH GYFNFGPSAS HLGAMCERAK
160 170 180 190 200
HIIVEVNENM PRCLGGTECG IHISDVTYIV EGSNPPIGEL GAGGPATDVD
210 220 230 240 250
KAVAKLIVDE IPNGACLQLG IGGMPNAVGS LIAESDLKDL GVHTEMYVDA
260 270 280 290 300
FVDIAKAGKI NGSKKNIDRY RQTYAFGAGT KKMYDYLDDN PELMSAPVDY
310 320 330 340 350
TNDIRSISAL DNFISINNAV DIDLYGQVNA ESAGIKQISG AGGQLDFVLG
360 370 380 390 400
AYLSKGGKSF ICLSSTFKTK DGQVQSRIRP TLANGSIVTD ARPNTHYVVT
410 420 430 440
EYGKVNLKGL STWQRAEALI SIAHPDFRDD LIKEAEQMHI WRRSNR
Length:446
Mass (Da):49,163
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA3AF7CF45C20BCA0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY796317 Genomic DNA Translation: AAX19660.1
CP003040 Genomic DNA Translation: AEN97870.1

NCBI Reference Sequences

More...
RefSeqi
WP_014080837.1, NC_015977.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AEN97870; AEN97870; RHOM_13820

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rho:RHOM_13820

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY796317 Genomic DNA Translation: AAX19660.1
CP003040 Genomic DNA Translation: AEN97870.1
RefSeqiWP_014080837.1, NC_015977.1

3D structure databases

SMRiG2SYC0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi585394.RHOM_13820

Genome annotation databases

EnsemblBacteriaiAEN97870; AEN97870; RHOM_13820
KEGGirho:RHOM_13820

Phylogenomic databases

eggNOGiCOG0427, Bacteria
HOGENOMiCLU_030703_1_0_9
OMAiVAMFQVA
OrthoDBi319106at2

Enzyme and pathway databases

UniPathwayiUPA00863
BioCyciRHOM585394:G1H02-2743-MONOMER
BRENDAi2.8.3.8, 10484

Family and domain databases

Gene3Di3.40.1080.20, 1 hit
HAMAPiMF_03227, But_acet_CoA_trans, 1 hit
MF_03228, But_CoA_trans, 1 hit
InterProiView protein in InterPro
IPR026888, AcetylCoA_hyd_C
IPR038460, AcetylCoA_hyd_C_sf
IPR003702, ActCoA_hydro
IPR023990, Butryl-CoA_acetate_CoA_Tfrase
IPR037171, NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF13336, AcetylCoA_hyd_C, 1 hit
PF02550, AcetylCoA_hydro, 1 hit
SUPFAMiSSF100950, SSF100950, 2 hits
TIGRFAMsiTIGR03948, butyr_acet_CoA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCACT_ROSHA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G2SYC0
Secondary accession number(s): Q2TME9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 5, 2019
Last sequence update: November 16, 2011
Last modified: June 2, 2021
This is version 45 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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