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Entry version 45 (10 Apr 2019)
Sequence version 1 (16 Nov 2011)
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Protein
Submitted name:

Uncharacterized protein

Gene

MYCTH_2299034

Organism
Myceliophthora thermophila (strain ATCC 42464 / BCRC 31852 / DSM 1799) (Sporotrichum thermophile)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:MYCTH_2299034Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMyceliophthora thermophila (strain ATCC 42464 / BCRC 31852 / DSM 1799) (Sporotrichum thermophile)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri573729 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeThermothelomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007322 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
78579.XP_003660571.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini141 – 322Helicase ATP-bindingInterPro annotationAdd BLAST182
Domaini458 – 629Helicase C-terminalInterPro annotationAdd BLAST172
Domaini662 – 752Dicer dsRNA-binding foldInterPro annotationAdd BLAST91
Domaini1059 – 1215RNase IIIInterPro annotationAdd BLAST157
Domaini1268 – 1445RNase IIIInterPro annotationAdd BLAST178
Domaini1476 – 1571DRBMInterPro annotationAdd BLAST96

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. Dicer subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INVH Eukaryota
KOG0701 Eukaryota
COG0571 LUCA
COG1111 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G2Q4D1

KEGG Orthology (KO)

More...
KOi
K11592

Database of Orthologous Groups

More...
OrthoDBi
1337630at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1520.10, 2 hits
3.30.160.380, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF04851 ResIII, 1 hit
PF00636 Ribonuclease_3, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00535 RIBOc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS50137 DS_RBD, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G2Q4D1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVEMREVPS GAPVPDFTLV EDDLIDLDEP LTKSTLEQSA SALTVAEEAL
60 70 80 90 100
TNAEDTDRED GAEADSKKWA INHAPAPRKV SERKRADHAA FDVWIEEHQQ
110 120 130 140 150
DLSKNLLGKF FVDNDETLNS LMRQLENRHI ITSPRDYQLE LFELAKTRNT
160 170 180 190 200
IAVLDTGSGK TLIAALLLRW TIQNELESRS SGLPKRIAFF LVDKVALVFQ
210 220 230 240 250
QHAVLTCNLD YPIEKFCGDM VENVSEDFWR KAFDENMAIV CTADILYQCL
260 270 280 290 300
SHSYVRMDQV NLLVFDEAHH TKKNHPYARI IKDFYTDVKD ENKRPRILGM
310 320 330 340 350
TASPVDAQTD PKVAAAELEG LLHSQIATVA DPTVLHNSSA KPKHEVVAEY
360 370 380 390 400
DKRPPDWETE LNQALKSLVG DLRVFRRPFA FTDTAAAELG PWCADRYWQL
410 420 430 440 450
FFEEGEAVKL ESRAEMEAFS QSTYDQGVGH PVDKVREAHN LVKRHTFARP
460 470 480 490 500
SIGVLSSKVV LLLRILREQF YRANHRRRCI VFVRQRNTVS LLADLLQQPE
510 520 530 540 550
MKIPGLVPGL LVGGGHPDAS YGNAKVTYRD QVRTIYKFKK GELNCIFATS
560 570 580 590 600
VAEEGLDIPD CNAIIRFDLN DTLIQYIQSR GRARQEGSVY IHMVESGNLE
610 620 630 640 650
HRRKLAQNQQ SEDALRKFCE AMPEDRKLTG NNFNMDYFLR KEKGQRQYTV
660 670 680 690 700
PETGAKLNYR QSLVFLAAFV ASLPHPPGVS LTADYLVLPV PGGFQCEVTL
710 720 730 740 750
PDSSPIRNAT GKVHESKAVA KCSAAYEMCL KLIKANYLDQ HLRPTFTKQL
760 770 780 790 800
HAMRNARLAV SAKKKGRYNM RVKPEIWSAV GEPVELYALA LTLSDPTVLG
810 820 830 840 850
RPSSPLLLLT RQPVQEIPSF PLYFGSNRFS AVRCVPVPGS LELDDRQIQG
860 870 880 890 900
LAAFTLAVFK DVFSKEYEAT VAQLPYFIAP TKLEHSSGFT AADGPSCVVD
910 920 930 940 950
WATISFVREN EHIRYTFDEL DDFFRDKYVC DPYDGSRKFF LRRRRHDLRP
960 970 980 990 1000
TDPVPEGVVA PGHRAWRVPG GNRDILNYSL SAWRRSRGSM TLREDQPVVE
1010 1020 1030 1040 1050
AELLPIRRNF LDDNIRDDDL EPKPCFLVLE PLRISPLPVD VVAMVYTFPS
1060 1070 1080 1090 1100
IMHRIDSNLV ALEACKKLGL NIRPDLALEA FTKDSDNTDE NDAEKIHFQG
1110 1120 1130 1140 1150
GMGSNYERLE FLGDCFLKMA TTISIFTLLP DKDESEYHIE RMLLVCNRNL
1160 1170 1180 1190 1200
FNKALEVKLE EYIRSTAFDR RSWYPEGLTL KRGKRRDVDG KHQLADKTIA
1210 1220 1230 1240 1250
DVCEALIGAA YLTAQDRSPS DFDLAVRAVT VMVRDRNHAM SSYGDYYAAY
1260 1270 1280 1290 1300
RPAKWQTVPC SPAQIDMAAR FRERMGYAFR HPRLLRSAFQ HPAYPTFYEG
1310 1320 1330 1340 1350
LPSYQRLEFL GDALLDMACV EFLFRRFPGA DPQWLTEHKM AMVSNQFLAC
1360 1370 1380 1390 1400
LAVYLGFHKS IVHCSSQVQS EVAGFVAEVE GELRAAKEGT EEGEEGEEEE
1410 1420 1430 1440 1450
EEKKERGGEE EAFARDFWVR CARRPPKCLA DVVEAYVGAV FVDSGYDFGE
1460 1470 1480 1490 1500
VRRFFADHVR PFFEDMRPYD AFARKHPVTA LAAVLQSKMR CREWRLLVKE
1510 1520 1530 1540 1550
LPVPAMAPTA DDGGDDGNDD GRRVLDFAAM ASPRLVCAVR VHGRTLAHAV
1560 1570 1580 1590 1600
SGSSRYGKIA AAKQALKVLE GMEPEEFQKA HGCACGVDGT VGGEDREPDH

GSAV
Length:1,604
Mass (Da):181,159
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF5F61CD0F741993
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP003002 Genomic DNA Translation: AEO55326.1

NCBI Reference Sequences

More...
RefSeqi
XP_003660571.1, XM_003660523.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
AEO55326; AEO55326; MYCTH_2299034

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11508215

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mtm:MYCTH_2299034

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003002 Genomic DNA Translation: AEO55326.1
RefSeqiXP_003660571.1, XM_003660523.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi78579.XP_003660571.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAEO55326; AEO55326; MYCTH_2299034
GeneIDi11508215
KEGGimtm:MYCTH_2299034

Phylogenomic databases

eggNOGiENOG410INVH Eukaryota
KOG0701 Eukaryota
COG0571 LUCA
COG1111 LUCA
InParanoidiG2Q4D1
KOiK11592
OrthoDBi1337630at2759

Family and domain databases

CDDicd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits
Gene3Di1.10.1520.10, 2 hits
3.30.160.380, 1 hit
InterProiView protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF04851 ResIII, 1 hit
PF00636 Ribonuclease_3, 2 hits
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00535 RIBOc, 2 hits
SUPFAMiSSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits
PROSITEiView protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS50137 DS_RBD, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG2Q4D1_MYCTT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G2Q4D1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: April 10, 2019
This is version 45 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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