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Protein

Dihydrofolate reductase

Gene

folA

Organism
Buchnera aphidicola str. Ak (Acyrthosiphon kondoi)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.UniRule annotation

Catalytic activityi

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.UniRule annotation

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Dihydrofolate reductase (folA)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processOne-carbon metabolismUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

BioCyciBAPH1005090:G1H03-142-MONOMER
UniPathwayi
UPA00077;UER00158

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrofolate reductaseUniRule annotation (EC:1.5.1.3UniRule annotation)
Gene namesi
Name:folAImported
ORF Names:BAKON_142Imported
OrganismiBuchnera aphidicola str. Ak (Acyrthosiphon kondoi)Imported
Taxonomic identifieri1005090 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000001269 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi1005090.BAKON_142

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 160DHFRInterPro annotationAdd BLAST159

Sequence similaritiesi

Belongs to the dihydrofolate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108YYV Bacteria
COG0262 LUCA
KOiK00287
OrthoDBiPOG091H01KY

Family and domain databases

CDDicd00209 DHFR, 1 hit
Gene3Di3.40.430.10, 1 hit
InterProiView protein in InterPro
IPR012259 DHFR
IPR024072 DHFR-like_dom_sf
IPR017925 DHFR_CS
IPR001796 DHFR_dom
PANTHERiPTHR22778:SF16 PTHR22778:SF16, 1 hit
PfamiView protein in Pfam
PF00186 DHFR_1, 1 hit
PIRSFiPIRSF000194 DHFR, 1 hit
SUPFAMiSSF53597 SSF53597, 1 hit
PROSITEiView protein in PROSITE
PS00075 DHFR_1, 1 hit
PS51330 DHFR_2, 1 hit

Sequencei

Sequence statusi: Complete.

G2LML5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNVSLIAAMS KNLVIGYNNK IPWYLPEDLK WFKQKTINKS VIMGRLTWES
60 70 80 90 100
IKRPLPTRKN IVISSNEIKK KGIIWADSIS NALISAKYNK EIMVIGGSKI
110 120 130 140 150
YKKMLFYANK LYLTHIDINI IGDAYFPKYT LYPSWKVLFR KKIFKDKKNP
160
YNYSFEILSR
Length:160
Mass (Da):18,822
Last modified:November 16, 2011 - v1
Checksum:i6EF46D2E8BAD51A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002645 Genomic DNA Translation: AEO08503.1
RefSeqiWP_014499303.1, NC_017256.1

Genome annotation databases

EnsemblBacteriaiAEO08503; AEO08503; BAKON_142
KEGGibak:BAKON_142
PATRICifig|1005090.4.peg.136

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002645 Genomic DNA Translation: AEO08503.1
RefSeqiWP_014499303.1, NC_017256.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1005090.BAKON_142

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEO08503; AEO08503; BAKON_142
KEGGibak:BAKON_142
PATRICifig|1005090.4.peg.136

Phylogenomic databases

eggNOGiENOG4108YYV Bacteria
COG0262 LUCA
KOiK00287
OrthoDBiPOG091H01KY

Enzyme and pathway databases

UniPathwayi
UPA00077;UER00158

BioCyciBAPH1005090:G1H03-142-MONOMER

Family and domain databases

CDDicd00209 DHFR, 1 hit
Gene3Di3.40.430.10, 1 hit
InterProiView protein in InterPro
IPR012259 DHFR
IPR024072 DHFR-like_dom_sf
IPR017925 DHFR_CS
IPR001796 DHFR_dom
PANTHERiPTHR22778:SF16 PTHR22778:SF16, 1 hit
PfamiView protein in Pfam
PF00186 DHFR_1, 1 hit
PIRSFiPIRSF000194 DHFR, 1 hit
SUPFAMiSSF53597 SSF53597, 1 hit
PROSITEiView protein in PROSITE
PS00075 DHFR_1, 1 hit
PS51330 DHFR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG2LML5_9GAMM
AccessioniPrimary (citable) accession number: G2LML5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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