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Protein

Actin-related protein 2/3 complex subunit 4

Gene

ARPC4

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 4UniRule annotation
Gene namesi
Name:ARPC4Imported
OrganismiOryctolagus cuniculus (Rabbit)Imported
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation

Expressioni

Gene expression databases

BgeeiENSOCUG00000026353 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000024742

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC4 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1876 Eukaryota
ENOG4111G2F LUCA
GeneTreeiENSGT00390000016233
InParanoidiG1U5Q7
OMAiMLKHKIV
OrthoDBiEOG091G0OI8
TreeFamiTF105621

Family and domain databases

Gene3Di3.30.1460.20, 1 hit
InterProiView protein in InterPro
IPR034666 ARPC2/4
IPR008384 ARPC4
PANTHERiPTHR22629 PTHR22629, 1 hit
PfamiView protein in Pfam
PF05856 ARPC4, 1 hit
PIRSFiPIRSF039100 ARPC4, 1 hit
SUPFAMiSSF69645 SSF69645, 1 hit

Sequencei

Sequence statusi: Complete.

G1U5Q7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVREPGPRPG TPLGSASRLW TATLRPYLSA VRATLQAALC LENFSSQVVE
60 70 80 90 100
RHNKPEVEVR SSKELLLQPV TISRNEKERV LIEGSINSVR VSIAVKQADE
110 120 130 140 150
IEKILCHKFM RFMMMRAENF FILRRKPVEG YDISFLITNF HTEQMYKHKL
160 170 180
VDFVIHFMEE IDKEISEMKL SVNARARIVA EEFLKNF
Length:187
Mass (Da):21,710
Last modified:October 19, 2011 - v1
Checksum:i6BB0C78B2AD12DBB
GO

Genome annotation databases

EnsembliENSOCUT00000022828; ENSOCUP00000024742; ENSOCUG00000026353

Similar proteinsi

Entry informationi

Entry nameiG1U5Q7_RABIT
AccessioniPrimary (citable) accession number: G1U5Q7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: September 12, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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