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Entry version 43 (08 May 2019)
Sequence version 1 (19 Oct 2011)
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Protein
Submitted name:

Glycogen debranching enzyme

Gene

AGL

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Glycogen debranching enzymeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AGLImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryctolagus cuniculus (Rabbit)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9986 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001811 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSOCUG00000009465 Expressed in 3 organ(s), highest expression level in liver

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 117hGDE_NInterPro annotationAdd BLAST86
Domaini122 – 552hDGE_amylaseInterPro annotationAdd BLAST431
Domaini698 – 975hGDE_centralInterPro annotationAdd BLAST278
Domaini1046 – 1528GDE_CInterPro annotationAdd BLAST483

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3625 Eukaryota
COG3408 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012596

Identification of Orthologs from Complete Genome Data

More...
OMAi
FTGSEEM

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11327 AmyAc_Glg_debranch_2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR010401 AGL/Gdb1
IPR032788 AGL_central
IPR029436 AGL_euk_N
IPR032792 AGL_glucanoTrfase
IPR032790 GDE_C
IPR006421 Glycogen_debranch_met
IPR017853 Glycoside_hydrolase_SF

The PANTHER Classification System

More...
PANTHERi
PTHR10569 PTHR10569, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06202 GDE_C, 1 hit
PF14701 hDGE_amylase, 1 hit
PF14702 hGDE_central, 1 hit
PF14699 hGDE_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48208 SSF48208, 1 hit
SSF51445 SSF51445, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01531 glyc_debranch, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1TS42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
KMGHSKQIRI LLLNEMEKLE KTLFRLEQGF ELQFRLGPTL QGKPVTVFTN
60 70 80 90 100
YPFPGETFNR EKFRSLEWEN PTEREDDSDK YCKLNLQQSG SFQYYFLQGN
110 120 130 140 150
EKSGGGYIVV DPILRVGADN HMLHLDCVTL QTFLAKCLGP FDEWESRLRV
160 170 180 190 200
AKESGYNMIH FTPLQTLGLS RSCYSLADQL ELNPDFSRPH KKYTWSDVGQ
210 220 230 240 250
LVEKLKREWN VLCITDVVYN HTAANSKWIQ EHPECAYNLV NSPHLKPAWV
260 270 280 290 300
LDRALWHFSC DVAEGKYKNR GVPALIENDH HLNCIRKVIW EDIFPKLHLW
310 320 330 340 350
EFFQVDVYKA VEKFRGLLTQ ETWRVIKSDP KQHLKIIQDP EYRRFGCTVD
360 370 380 390 400
MNIALATFIP HDNGPAAIEE CCNWFRKRIE ELNSEKHQLM NYHQEQAVNC
410 420 430 440 450
LLGNVFYERL AGHGPKLGPV TRKYPLVTRY FTFPFEEMPV STEETMIHLP
460 470 480 490 500
NKACFFMAHN GWVMGDDPLR NFAEPGSDVY LRRELICWGD SVKLRYGTKP
510 520 530 540 550
EDCPYLWAHM RKYTEIIATY FQGVRLDNCH STPLHVAEYM LDAARKLQPN
560 570 580 590 600
LYVVAELFTG SEDLDNIFVT RLGISSLIRE AMSAYNSHEE GRLVYRYGGE
610 620 630 640 650
PVGSFVQPCL RPLMPAIAHA LFMDITHDNE CPIVHRSVYD ALPSTTIVSM
660 670 680 690 700
ACCASGSTRG YDELVPHQIS VVSEERFYTK WNPEALPSNA GEVNFQSGII
710 720 730 740 750
AARCAINKLH QELGAKGFIQ VYVDQVDEDI VAVTRHSPSI HQSVVAVSRT
760 770 780 790 800
AFRNPKTSFY SKDVPQMCIP GKIEEVVLEA RTIERNISPY RKDENSINGM
810 820 830 840 850
PNITVEIREH IQLNESRIVK QAGVTTKGPN EYIQEIEFEN LSPGSVIIFR
860 870 880 890 900
VSLDPHAQVA VGILRNHLTQ FSAHFKAGSL AVDNSDPILK IPFASIASKL
910 920 930 940 950
TLAEINQILY RCESEEQEDG GGCYDIPNWS SLKYAGLQGL MSVLAEIRPK
960 970 980 990 1000
NDLGHPFCDN LRSGDWMIDY VSGRLISRSG TIAEVGKWLQ AMFFYLKQIP
1010 1020 1030 1040 1050
RYLIPCYFDA ILIGAYTTLL DIAWKQMSSF VQTGSTFVKH LSLGSVQMCG
1060 1070 1080 1090 1100
VGKFPSLPLL SPSLTDVPYR LNEITKEKEQ CCVSLAAGLP HFSSGIFRCW
1110 1120 1130 1140 1150
GRDTFIALRG LLLITGRYLE ARNIILAFAG TLRHGLIPNL LGEGTYARYN
1160 1170 1180 1190 1200
CRDAVWWWLQ CIQDYCKMVP NGLDILKCPV SRMYPTDDSA PLPAGTLDQP
1210 1220 1230 1240 1250
LFDVIQEAMQ RHMQGIQFRE RNAGPQIDRN MKDEGFTVIA GVNEETGFVY
1260 1270 1280 1290 1300
GGNRFNCGTW MDKMGESDRA RNRGIPATPR DGSAVEIVGL CKSTVRWLLE
1310 1320 1330 1340 1350
LSKKNIFPYH EVRVKRHGKV VTVSYEEWNR KIQDNFEKRF HVSEDPSASN
1360 1370 1380 1390 1400
EEHPNLVHKR GIYKDSYGAS SPWCDYQLRP NFTIAMVVAP ELFTAEKAWK
1410 1420 1430 1440 1450
ALEIAEKKLL GPLGMKTLDP DDMVYCGIYD NALDNDNYNL AKGFNYHQGP
1460 1470 1480 1490 1500
EWLWPVGYFL RAKLYFSKLM DRETNARTIF LVKNVLSRHY VHLERSPWKG
1510 1520 1530
LPELTNENGQ YCPFSCETQA WSIATILETL YDL
Length:1,533
Mass (Da):175,120
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i30F8CFF7D7DE2AA9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAGW02001268 Genomic DNA No translation available.
AAGW02001269 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSOCUT00000011894; ENSOCUP00000019854; ENSOCUG00000009465

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGW02001268 Genomic DNA No translation available.
AAGW02001269 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSOCUT00000011894; ENSOCUP00000019854; ENSOCUG00000009465

Phylogenomic databases

eggNOGiKOG3625 Eukaryota
COG3408 LUCA
GeneTreeiENSGT00390000012596
OMAiFTGSEEM

Gene expression databases

BgeeiENSOCUG00000009465 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

CDDicd11327 AmyAc_Glg_debranch_2, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR010401 AGL/Gdb1
IPR032788 AGL_central
IPR029436 AGL_euk_N
IPR032792 AGL_glucanoTrfase
IPR032790 GDE_C
IPR006421 Glycogen_debranch_met
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR10569 PTHR10569, 1 hit
PfamiView protein in Pfam
PF06202 GDE_C, 1 hit
PF14701 hDGE_amylase, 1 hit
PF14702 hGDE_central, 1 hit
PF14699 hGDE_N, 1 hit
SUPFAMiSSF48208 SSF48208, 1 hit
SSF51445 SSF51445, 1 hit
TIGRFAMsiTIGR01531 glyc_debranch, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1TS42_RABIT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1TS42
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: May 8, 2019
This is version 43 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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