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Entry version 43 (02 Jun 2021)
Sequence version 2 (11 Dec 2019)
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Protein
Submitted name:

Dispatched RND transporter family member 2

Gene

DISP2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Dispatched RND transporter family member 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DISP2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryctolagus cuniculus (Rabbit)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9986 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001811 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei478 – 496HelicalSequence analysisAdd BLAST19
Transmembranei503 – 522HelicalSequence analysisAdd BLAST20
Transmembranei534 – 557HelicalSequence analysisAdd BLAST24
Transmembranei578 – 595HelicalSequence analysisAdd BLAST18
Transmembranei607 – 626HelicalSequence analysisAdd BLAST20
Transmembranei689 – 709HelicalSequence analysisAdd BLAST21
Transmembranei952 – 971HelicalSequence analysisAdd BLAST20
Transmembranei978 – 999HelicalSequence analysisAdd BLAST22
Transmembranei1005 – 1028HelicalSequence analysisAdd BLAST24
Transmembranei1049 – 1070HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSOCUG00000025843, Expressed in frontal cortex and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9986.ENSOCUP00000017183

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini494 – 632SSDInterPro annotationAdd BLAST139

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni50 – 79DisorderedSequence analysisAdd BLAST30
Regioni222 – 241DisorderedSequence analysisAdd BLAST20
Regioni1123 – 1142DisorderedSequence analysisAdd BLAST20
Regioni1206 – 1312DisorderedSequence analysisAdd BLAST107
Regioni1325 – 1375DisorderedSequence analysisAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi58 – 79Polar residuesSequence analysisAdd BLAST22
Compositional biasi222 – 238Polar residuesSequence analysisAdd BLAST17
Compositional biasi1206 – 1231Polar residuesSequence analysisAdd BLAST26
Compositional biasi1260 – 1283Polar residuesSequence analysisAdd BLAST24
Compositional biasi1326 – 1340Polar residuesSequence analysisAdd BLAST15

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3664, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159551

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004076_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1TJQ4

Identification of Orthologs from Complete Genome Data

More...
OMAi
LMGFEPR

TreeFam database of animal gene trees

More...
TreeFami
TF324144

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000731, SSD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12349, Sterol-sensing, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50156, SSD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1TJQ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
WLGQPHPLSG CLGPTPSSAD SSFQLMRPCE AAGDGVSSWT KAVAPEASPE
60 70 80 90 100
RSCSLHSCPL EDPSSSSGRP QTNSILPPVG PSSPLAPAHF IYPQAPQDYQ
110 120 130 140 150
GGSSLLGPGD QTALCSHGSS LSPSPAPSQL DGAWKPPLQH HVLPPAAASY
160 170 180 190 200
SQLIAEWPVA MLLLCLGVIL LCTMAGLLGS RPPDFSEPLL GFEPRDTDIG
210 220 230 240 250
RKLVVWRTLQ VLTGPRKLLS LSPDLEQNSS SSHGTRSPAP GVVAQANVVR
260 270 280 290 300
SRRMVEPPEE KQEESFFCGP PEKSYAKLVF MSTSSGSLWN VHAIHSMCRM
310 320 330 340 350
EQDQIRSHTR FGALCQRTAA NECCPSWSLG NYVAVLSNRS SCLDTTHADT
360 370 380 390 400
ARILLLLRAC ALYYHRGALV PSCLGPAHDK SPHCAQVPTK CTQSSAIYQL
410 420 430 440 450
LHFLLDRDFL SPQTADYQVP SLKYSLLFLP TQKGASMMDI YLDGLVTPWA
460 470 480 490 500
ISDNYTSITG MDLGLKQALL RHYLAQDTVY PVLSLAAIFF GIALYLRSLF
510 520 530 540 550
VTLMVLLGVL GSLLVAFFLY HVAFRMAYFP FVNLAAVILL SGVCANHTLI
560 570 580 590 600
FFDLWRLSKN QLPSGGLAQR VARTMHHFGY LLLVSGLTTS AAFYASYLSH
610 620 630 640 650
LPAVRCFALY MGTAVLAHLA LTLAWLPASA VIHERYVARG CAPQGPWGRS
660 670 680 690 700
APGRLVLALH RRLRGLRKAA AMGSRLLFQR LLPCGVIKFR YIWICWFAAL
710 720 730 740 750
AAGGAYIGGV SPRLQLPILP PRGGQVFRPS HPFERFDAEY RQQFLFEQPA
760 770 780 790 800
QGKGGRMPVV LVWGVLPVDT GDPLDPRSNS SLLSDPAFSA SGPEAQRWLL
810 820 830 840 850
ALCHSARNQS FFGPQPEGGP TLCFMEALQR WMEGPGCARL GPDLCCGQSG
860 870 880 890 900
FPWAPQLFLH CLKMMALEQG PNGTRDLGPR FDAQGSLAAL VLQFQTNFEY
910 920 930 940 950
SPDYSQIHHF YTEVSHWLAT ELRAAPPGLR GGWFTSRLDL FSLQHSLSTE
960 970 980 990 1000
PAVVLGLALA LAFATMLLGT FRSVCSPWLL KGGTVLLTVG LLVLLEWQLN
1010 1020 1030 1040 1050
TAEALFLSAS VGLSVDFTVN YCISYHLCPH PDRLSRVAFS LRQTSRATAA
1060 1070 1080 1090 1100
GTAALFAAGV LMLPATVLLY RKLGIILMMV KCVSCGFASF FFQSLCCFFG
1110 1120 1130 1140 1150
PEKNCGQILW PCAHLPWDIG TGDPAGEKSG HPRPGSVGGG SGSCSDHYDF
1160 1170 1180 1190 1200
DTSTATSKLS HRPSVLSEDL QLHDGSCCSR LPPAPASPRE LLLDHQAVFS
1210 1220 1230 1240 1250
QCPALQTSSP YKQAGPSPKT QARQEPQGQK DEPLQASPEA PPHSPKTKAE
1260 1270 1280 1290 1300
ELPDGLCSSA STLEGLSVSD ETCLSTSEPS ARVPDSMGAS PEDLDDTGQP
1310 1320 1330 1340 1350
VPERGQLNGK RDTLWLALRE TVYDPSLPAS HQSSSSWKGR GGLGDDSPVM
1360 1370
LPNSQPDLPD VWLRRPSSHT SGYSS
Length:1,375
Mass (Da):148,772
Last modified:December 11, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i68B428EF49E18B77
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAGW02024507 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSOCUT00000021569; ENSOCUP00000017183; ENSOCUG00000025843

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGW02024507 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000017183

Genome annotation databases

EnsembliENSOCUT00000021569; ENSOCUP00000017183; ENSOCUG00000025843

Phylogenomic databases

eggNOGiKOG3664, Eukaryota
GeneTreeiENSGT00940000159551
HOGENOMiCLU_004076_1_1_1
InParanoidiG1TJQ4
OMAiLMGFEPR
TreeFamiTF324144

Gene expression databases

BgeeiENSOCUG00000025843, Expressed in frontal cortex and 5 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR000731, SSD
PfamiView protein in Pfam
PF12349, Sterol-sensing, 1 hit
PROSITEiView protein in PROSITE
PS50156, SSD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1TJQ4_RABIT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1TJQ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: December 11, 2019
Last modified: June 2, 2021
This is version 43 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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