UniProtKB - G1TBU5 (G1TBU5_RABIT)
Protein
Submitted name:
TIAM Rac1 associated GEF 1
Gene
TIAM1
Organism
Oryctolagus cuniculus (Rabbit)
Status
Functioni
GO - Molecular functioni
- kinase binding Source: Ensembl
- Rac guanyl-nucleotide exchange factor activity Source: Ensembl
GO - Biological processi
- activation of GTPase activity Source: Ensembl
- cell-matrix adhesion Source: Ensembl
- cell migration Source: Ensembl
- cellular protein-containing complex assembly Source: Ensembl
- positive regulation of cell migration Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of protein binding Source: Ensembl
- Rac protein signal transduction Source: Ensembl
- regulation of epithelial to mesenchymal transition Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: TIAM Rac1 associated GEF 1Imported |
Gene namesi | Name:TIAM1Imported |
Organismi | Oryctolagus cuniculus (Rabbit)Imported |
Taxonomic identifieri | 9986 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Proteomesi |
|
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: Ensembl
Other locations
- cell-cell contact zone Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSOCUG00000016524, Expressed in autopod skin and 14 other tissues |
Interactioni
GO - Molecular functioni
- kinase binding Source: Ensembl
- Rac guanyl-nucleotide exchange factor activity Source: Ensembl
Protein-protein interaction databases
STRINGi | 9986.ENSOCUP00000014211 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 439 – 547 | PHInterPro annotationAdd BLAST | 109 | |
Domaini | 765 – 832 | RBDInterPro annotationAdd BLAST | 68 | |
Domaini | 845 – 908 | PDZInterPro annotationAdd BLAST | 64 | |
Domaini | 1040 – 1234 | DHInterPro annotationAdd BLAST | 195 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 70 | DisorderedSequence analysisAdd BLAST | 70 | |
Regioni | 297 – 379 | DisorderedSequence analysisAdd BLAST | 83 | |
Regioni | 393 – 422 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 961 – 997 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 1011 – 1032 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 1456 – 1483 | DisorderedSequence analysisAdd BLAST | 28 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 553 – 580 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 24 – 45 | BasicSequence analysisAdd BLAST | 22 | |
Compositional biasi | 48 – 70 | PolarSequence analysisAdd BLAST | 23 | |
Compositional biasi | 297 – 328 | PolarSequence analysisAdd BLAST | 32 | |
Compositional biasi | 340 – 379 | PolarSequence analysisAdd BLAST | 40 | |
Compositional biasi | 961 – 977 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1458 – 1478 | PolarSequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG3519, Eukaryota |
GeneTreei | ENSGT00940000156294 |
HOGENOMi | CLU_000494_3_0_1 |
InParanoidi | G1TBU5 |
OMAi | LRLKFLM |
OrthoDBi | 34437at2759 |
TreeFami | TF319686 |
Family and domain databases
CDDi | cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 2 hits 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR035899, DBL_dom_sf IPR000219, DH-domain IPR001331, GDS_CDC24_CS IPR001478, PDZ IPR036034, PDZ_sf IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR003116, RBD_dom IPR033360, Tiam1 IPR043537, Tiam1/Tiam2/Sif IPR040655, TIAM1_CC-Ex |
PANTHERi | PTHR46001, PTHR46001, 1 hit PTHR46001:SF1, PTHR46001:SF1, 1 hit |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit PF00169, PH, 2 hits PF02196, RBD, 1 hit PF00621, RhoGEF, 1 hit PF18385, Tiam_CC_Ex, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit SM00233, PH, 2 hits SM00455, RBD, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS00741, DH_1, 1 hit PS50010, DH_2, 1 hit PS50106, PDZ, 1 hit PS50003, PH_DOMAIN, 1 hit PS50898, RBD, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
G1TBU5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGNAESQTVA HEFYGEKHAS LGRKHTSRSL RLSHKTRRTR HASSGKVIHR
60 70 80 90 100
NSEVSTRSSS TPSIPQSLAE NGLEPFSQEG TLEDFGSPIW VDRVDMGLRP
110 120 130 140 150
VSYTDSSVTP SVDSSIVLTA ASVQSMPDSE ESRLYGDDAT YLAEGGRRQH
160 170 180 190 200
LFTSNGPAFM ETASFKKKRS KSADIWREDS LEFSLSDLSQ EHLTSNEEIL
210 220 230 240 250
GSAEEKECEE ARGMETQASP RQLSTCQRAN SLGDLYAQKN SGVTANGGPR
260 270 280 290 300
SKFAGYCRNL VSDIPDLANH KMPPAAADET PPYSNYNTLP CRKSHCLSEG
310 320 330 340 350
ATNPQISHSN SMQGRRAKTT QDVNTGEGSE FADSGIEGAT TDTDLLSRRS
360 370 380 390 400
NATNSSYSPP TGRAFVGSDS GSSSTGDAAR QGVYENFRRE LEMSTANSES
410 420 430 440 450
LEEAGSAHSD EQSSGTLSSP GQSDILLTAA QGTVRKAGAL AVKNFLVHKK
460 470 480 490 500
NKKVESATRR KWKHYWVSLK GCTLFFYESD GRSGIDHNSI PKHAVWVENS
510 520 530 540 550
IVQAVPEHPK KDFVFCLSNS LGDAFLFQTT SQTELENWIT AIHSACAAAV
560 570 580 590 600
ARHHHKEDTL RLLKSEIKKL EQKIDMDEKM KKMGEMQLSS VTDSKKKKTI
610 620 630 640 650
LDQIFVWEQN LEQFQMDLFR FRCYLASLQG GELPNPKRLL AFASRPTKVA
660 670 680 690 700
MGRLGIFSVS SFHALVAART GETGVRRRTQ AMSRSASKRR SRFSSLWGLD
710 720 730 740 750
TTSKKKQGRP SINQVFGEGT DAVKKSLEGI FDDTVPDGKR EKEVVLPSVH
760 770 780 790 800
QHNPDCDIWV HEYFSPSWFC LPNNQPALTV VRPGDTARDT LELICKTHQL
810 820 830 840 850
DHSAHYLRLK FLIENKVQLY VPQPEEDIYE LLYKEIEICP KVTQNIQIEK
860 870 880 890 900
SDTTADNYGF SLSSVEEDGV RRLYVNSVKE TGLASKKGLK AGDEILEINN
910 920 930 940 950
RAAGTLNSSM LKGFLSQPSL GLLVRTYPEL EGGAELLESP PHRVDGLADL
960 970 980 990 1000
SESPLAFLTS NPGHRFCSEQ GSSGETAPEE TEGPDAESSD EIDHSGKSTE
1010 1020 1030 1040 1050
QVAAFCRSLH EMNPSDSSPS PQDCSGPQMA TMRQLSDADK LRKVICELLE
1060 1070 1080 1090 1100
TERTYVKDLN CLMERYLKPL QKETFLTQDE LDVLFGNLTE MVEFQVEFLK
1110 1120 1130 1140 1150
TLEDGVRLVP DLEKLEKVDQ FKKVLFSLGG SFLYYADRFK LYSAFCASHT
1160 1170 1180 1190 1200
KVPKVLVKAK TDTAFKAFLD AQNPRQQHSS TLESYLIKPI QRILKYPLLL
1210 1220 1230 1240 1250
KELFALTDAE SEEHYHLDVA IKTMNKVASH INEMQKIHEE FGAVFDQLIA
1260 1270 1280 1290 1300
EQTGEKKEVA DLSMGDLLLH TTVIWLNPPA SLGKWKKEPE LAAFVFKTAV
1310 1320 1330 1340 1350
VLVYKDGSKQ KKKLVGSHRL SIYEEWDPFR FRHMIPTEAL QVRALASADA
1360 1370 1380 1390 1400
EANAVCEIVH VKSESEGRPE RVFHLCCSSP ESRKDFLKAV HSILRDKHRR
1410 1420 1430 1440 1450
QLLKTESLPS SQQYVPFGGK RLCALKGARP AMSRAVSAPS KSLGRRRRRL
1460 1470 1480 1490 1500
ARNRFTIDSD AVSASSPEKE SQQPPGGSGD TDRWVEEQFD LAQYEEQDDI
1510 1520 1530 1540 1550
KETDILSDDD EFCESVKGAS VDGDLQERLQ AASISQRERG RRTLDSHASR
1560 1570 1580 1590
MAQLKKQAAL SGGSGGLESA SDEVIWVRRE DFAPSRKLNT EI
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F9CD16 | A0A5F9CD16_RABIT | TIAM Rac1 associated GEF 1 | TIAM1 | 1,532 | Annotation score: | ||
A0A5F9D6Q4 | A0A5F9D6Q4_RABIT | TIAM Rac1 associated GEF 1 | TIAM1 | 1,530 | Annotation score: | ||
A0A5F9CQL2 | A0A5F9CQL2_RABIT | TIAM Rac1 associated GEF 1 | TIAM1 | 625 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAGW02017659 Genomic DNA No translation available. AAGW02017660 Genomic DNA No translation available. |
RefSeqi | XP_002716851.1, XM_002716805.3 XP_017202697.1, XM_017347208.1 XP_017202698.1, XM_017347209.1 XP_017202699.1, XM_017347210.1 XP_017202700.1, XM_017347211.1 XP_017202701.1, XM_017347212.1 XP_017202702.1, XM_017347213.1 XP_017202703.1, XM_017347214.1 |
Genome annotation databases
Ensembli | ENSOCUT00000016533; ENSOCUP00000014211; ENSOCUG00000016524 |
GeneIDi | 100338333 |
KEGGi | ocu:100338333 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAGW02017659 Genomic DNA No translation available. AAGW02017660 Genomic DNA No translation available. |
RefSeqi | XP_002716851.1, XM_002716805.3 XP_017202697.1, XM_017347208.1 XP_017202698.1, XM_017347209.1 XP_017202699.1, XM_017347210.1 XP_017202700.1, XM_017347211.1 XP_017202701.1, XM_017347212.1 XP_017202702.1, XM_017347213.1 XP_017202703.1, XM_017347214.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9986.ENSOCUP00000014211 |
Genome annotation databases
Ensembli | ENSOCUT00000016533; ENSOCUP00000014211; ENSOCUG00000016524 |
GeneIDi | 100338333 |
KEGGi | ocu:100338333 |
Organism-specific databases
CTDi | 7074 |
Phylogenomic databases
eggNOGi | KOG3519, Eukaryota |
GeneTreei | ENSGT00940000156294 |
HOGENOMi | CLU_000494_3_0_1 |
InParanoidi | G1TBU5 |
OMAi | LRLKFLM |
OrthoDBi | 34437at2759 |
TreeFami | TF319686 |
Gene expression databases
Bgeei | ENSOCUG00000016524, Expressed in autopod skin and 14 other tissues |
Family and domain databases
CDDi | cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 2 hits 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR035899, DBL_dom_sf IPR000219, DH-domain IPR001331, GDS_CDC24_CS IPR001478, PDZ IPR036034, PDZ_sf IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR003116, RBD_dom IPR033360, Tiam1 IPR043537, Tiam1/Tiam2/Sif IPR040655, TIAM1_CC-Ex |
PANTHERi | PTHR46001, PTHR46001, 1 hit PTHR46001:SF1, PTHR46001:SF1, 1 hit |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit PF00169, PH, 2 hits PF02196, RBD, 1 hit PF00621, RhoGEF, 1 hit PF18385, Tiam_CC_Ex, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit SM00233, PH, 2 hits SM00455, RBD, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS00741, DH_1, 1 hit PS50010, DH_2, 1 hit PS50106, PDZ, 1 hit PS50003, PH_DOMAIN, 1 hit PS50898, RBD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1TBU5_RABIT | |
Accessioni | G1TBU5Primary (citable) accession number: G1TBU5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | October 19, 2011 | |
Last modified: | December 2, 2020 | |
This is version 70 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |