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Protein
Submitted name:

Erythropoietin receptor

Gene

EPOR

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei162Required for ligand bindingUniRule annotation1
Sitei472Required for STAT5/PTPN11/SOCS3 bindingUniRule annotation1
Sitei502Required for STAT1/STAT3 activationUniRule annotation1
Sitei531Required for CrkL bindingUniRule annotation1

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Erythropoietin receptorImported
Gene namesi
Name:EPORImported
OrganismiOryctolagus cuniculus (Rabbit)Imported
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei297 – 319HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi97 ↔ 107UniRule annotation
Disulfide bondi136 ↔ 152UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSOCUG00000015702

Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei414Interaction with APS and STAT5, and activationUniRule annotation1
Sitei500Interaction with PTPN6UniRule annotation1

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000013491

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini193 – 293Fibronectin type-IIIInterPro annotationAdd BLAST101

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IFGH Eukaryota
ENOG4111PGS LUCA
GeneTreeiENSGT00920000149107
InParanoidiG1TA13
OMAiVGSEHAQ
OrthoDBiEOG091G0AK8
TreeFamiTF336573

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR009167 Erythropoietin_rcpt
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR015152 Growth/epo_recpt_lig-bind
IPR013783 Ig-like_fold
IPR003528 Long_hematopoietin_rcpt_CS
PANTHERiPTHR23037:SF28 PTHR23037:SF28, 1 hit
PfamiView protein in Pfam
PF09067 EpoR_lig-bind, 1 hit
PF00041 fn3, 1 hit
PIRSFiPIRSF001959 EPO_receptor, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS01352 HEMATOPO_REC_L_F1, 1 hit

Sequencei

Sequence statusi: Complete.

G1TA13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWCVLDGGV GWGVTIGLAT CARGFRGRPP CRPHWEPRCG RGRGPACFLS
60 70 80 90 100
AQHRRWEPEE GAVARGPGLC LPDFPHPTHR PPAAALLAAR GPEDLLCFSE
110 120 130 140 150
RLEDLLCFWE EAAVPGVGPR NYSFSYQLEG EPWKSCHLHQ VPTARGAVRF
160 170 180 190 200
WCSLPTADTS SFVPLELRVT AVPSGAQRYN RIIHVNEVVL LDAPEGLLAR
210 220 230 240 250
QADEGGHVVL RWLPPPGAPM TTHIRYEVDV SAGSGAGAAQ RVEILEGRTE
260 270 280 290 300
CVLSNLRRGT RYSFAVRARM AEPSFGGFWS AWSAPASLLT ASDLDPLILT
310 320 330 340 350
LSLILVLILL LLAALGLLAH RRALKQKIWP GIPSPESEFE GLFTTHKGNF
360 370 380 390 400
QLWLHQNEGC LWWSPCTPYP EDPPAPLEVL SERCWGVAQA AEPEAADEGP
410 420 430 440 450
LLEPGSRKHA PDSYLVLDKW LLPRSPPGER LPGPAGGADT AAGDEGSEAS
460 470 480 490 500
SCSSALALKP RPEGASAASF EYTILDPRSQ VLCPRPLPPE LPPTPPHLKY
510 520 530 540 550
LYLVVSDSGI SADYSSGGSQ GAPGSSPDGS YSNPYENSLR PAPEPPPPSY

VACS
Length:554
Mass (Da):59,774
Last modified:November 13, 2013 - v2
Checksum:i8456B35AC3300F48
GO

Genome annotation databases

EnsembliENSOCUT00000015705; ENSOCUP00000013491; ENSOCUG00000015702

Similar proteinsi

Entry informationi

Entry nameiG1TA13_RABIT
AccessioniPrimary (citable) accession number: G1TA13
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: November 13, 2013
Last modified: June 20, 2018
This is version 39 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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