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UniProtKB - G1T9Y0 (G1T9Y0_RABIT)

Entry version 69 (25 May 2022)
Sequence version 2 (13 Nov 2013)
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Protein
Submitted name:

Netrin 4

Gene

NTN4

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Netrin 4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NTN4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryctolagus cuniculus (Rabbit)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9986 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001811 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

SecretedARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500342302226 – 625Sequence analysisAdd BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi359 ↔ 368PROSITE-ProRule annotation
Disulfide bondi419 ↔ 428PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSOCUG00000015665, Expressed in upper lobe of left lung and 17 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9986.ENSOCUP00000013455

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 258Laminin N-terminalInterPro annotationAdd BLAST232
Domaini329 – 391Laminin EGF-likeInterPro annotationAdd BLAST63
Domaini392 – 445Laminin EGF-likeInterPro annotationAdd BLAST54
Domaini503 – 624NTRInterPro annotationAdd BLAST122

Keywords - Domaini

Laminin EGF-like domainPROSITE-ProRule annotationARBA annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0994, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156615

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_016961_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		G1T9Y0

Identification of Orthologs from Complete Genome Data

More...OMAi		PKAFCGM

Database of Orthologous Groups

More...OrthoDBi		236390at2759

TreeFam database of animal gene trees

More...TreeFami		TF352481

Family and domain databases

Conserved Domains Database

More...CDDi		cd00055, EGF_Lam, 3 hits
cd03578, NTR_netrin-4_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.50.120, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008211, Laminin_N
IPR002049, LE_dom
IPR035811, Netrin-4_NTR
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR008993, TIMP-like_OB-fold

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00053, Laminin_EGF, 3 hits
PF00055, Laminin_N, 1 hit
PF01759, NTR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00643, C345C, 1 hit
SM00180, EGF_Lam, 3 hits
SM00136, LamNT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50242, SSF50242, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01248, EGF_LAM_1, 1 hit
PS50027, EGF_LAM_2, 2 hits
PS51117, LAMININ_NTER, 1 hit
PS50189, NTR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

G1T9Y0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSCAQRLLL LWVAAGLSGV ARVSSRCEKA CNPRMGNLAL GRKLWSDTTC 
        60         70         80         90        100
GQNATELYCF YSENADLTCR PPKCDKCNAA HPHLAHLPSA MADSSFRFPR 
       110        120        130        140        150
TWWQSAEDVH REKIQLDLEA EFYFTHLIMV FKSPRPAAMV LDRSQDFGKT 
       160        170        180        190        200
WKPYKYFATN CSATFGLEDD VVKKGALCTS RYSSPFPCTG GEVIFRALSP 
       210        220        230        240        250
PYDAENPYSA KVQEQLKITN LRVQLLKRQS CPCQRNDLNT KPQHFTHYAI 
       260        270        280        290        300
YDFIVKGSCF CNGHADQCVP VDGFRPVKAP GAFHVVHGKC MCKHNTAGSH 
       310        320        330        340        350
CQQCAPLYND RPWEAADGRT GAPKECRTCK CNGHAEACHF DINVWEASGN 
       360        370        380        390        400
RSGGVCANCQ HNTEGQHCQR CKPGFYRDLR RPFSAPDACK VCSCHPVGSA 
       410        420        430        440        450
VLPFSSVTFC DPSNGDCPCK PGVAGPHCDR CMVGYWGFGD YGCRPCDCAG 
       460        470        480        490        500
SCDPLTGDCI SSNTDVDWYH EMPDFHSTHN KSEPTWEWED EQGFSALRHS 
       510        520        530        540        550
GKCECKEQVL GNPKAFCGMK YSYVLKIKIL SAHDKGSHAE VNVKIKKVLK 
       560        570        580        590        600
STKLKILRGK RTLYPESWTN RGCTCPILNP GLEYLVAGHE DVRTGKLVVN 
       610        620 
MKSFVQHWKP SLGRKVMDIL KRECK
Length:625
Mass (Da):69,717
Last modified:November 13, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6EC3B6430600119B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F9C5F6A0A5F9C5F6_RABIT
Netrin 4
NTN4
602Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9DFL9A0A5F9DFL9_RABIT
Netrin 4
NTN4
697Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAGW02034277 Genomic DNA No translation available.
AAGW02034278 Genomic DNA No translation available.
AAGW02034279 Genomic DNA No translation available.
AAGW02034280 Genomic DNA No translation available.
AAGW02034281 Genomic DNA No translation available.
AAGW02034282 Genomic DNA No translation available.
AAGW02034283 Genomic DNA No translation available.
AAGW02034284 Genomic DNA No translation available.
AAGW02034285 Genomic DNA No translation available.
AAGW02034286 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_002711255.1, XM_002711209.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSOCUT00000015665; ENSOCUP00000013455; ENSOCUG00000015665

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100356958

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ocu:100356958

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGW02034277 Genomic DNA No translation available.
AAGW02034278 Genomic DNA No translation available.
AAGW02034279 Genomic DNA No translation available.
AAGW02034280 Genomic DNA No translation available.
AAGW02034281 Genomic DNA No translation available.
AAGW02034282 Genomic DNA No translation available.
AAGW02034283 Genomic DNA No translation available.
AAGW02034284 Genomic DNA No translation available.
AAGW02034285 Genomic DNA No translation available.
AAGW02034286 Genomic DNA No translation available.
RefSeqiXP_002711255.1, XM_002711209.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000013455

Genome annotation databases

EnsembliENSOCUT00000015665; ENSOCUP00000013455; ENSOCUG00000015665
GeneIDi100356958
KEGGiocu:100356958

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		59277

Phylogenomic databases

eggNOGiKOG0994, Eukaryota
GeneTreeiENSGT00940000156615
HOGENOMiCLU_016961_2_1_1
InParanoidiG1T9Y0
OMAiPKAFCGM
OrthoDBi236390at2759
TreeFamiTF352481

Gene expression databases

BgeeiENSOCUG00000015665, Expressed in upper lobe of left lung and 17 other tissues

Family and domain databases

CDDicd00055, EGF_Lam, 3 hits
cd03578, NTR_netrin-4_like, 1 hit
Gene3Di2.40.50.120, 1 hit
InterProiView protein in InterPro
IPR008211, Laminin_N
IPR002049, LE_dom
IPR035811, Netrin-4_NTR
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR008993, TIMP-like_OB-fold
PfamiView protein in Pfam
PF00053, Laminin_EGF, 3 hits
PF00055, Laminin_N, 1 hit
PF01759, NTR, 1 hit
SMARTiView protein in SMART
SM00643, C345C, 1 hit
SM00180, EGF_Lam, 3 hits
SM00136, LamNT, 1 hit
SUPFAMiSSF50242, SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS01248, EGF_LAM_1, 1 hit
PS50027, EGF_LAM_2, 2 hits
PS51117, LAMININ_NTER, 1 hit
PS50189, NTR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1T9Y0_RABIT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1T9Y0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: November 13, 2013
Last modified: May 25, 2022
This is version 69 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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