UniProtKB - G1T6U3 (G1T6U3_RABIT)
Protein
P-type Cu(+) transporter
Gene
ATP7A
Organism
Oryctolagus cuniculus (Rabbit)
Status
Functioni
Catalytic activityi
- EC:7.2.2.8ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 19 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 22 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 181 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 184 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 287 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 290 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 387 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 390 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 498 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 501 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 574 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 577 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATPase-coupled cation transmembrane transporter activity Source: InterPro
- ATP binding Source: UniProtKB-UniRule
- copper-dependent protein binding Source: Ensembl
- cuprous ion binding Source: Ensembl
GO - Biological processi
- cellular copper ion homeostasis Source: Ensembl
- copper ion transport Source: UniProtKB-KW
- positive regulation of oxidoreductase activity Source: Ensembl
Keywordsi
Molecular function | TranslocaseARBA annotation |
Biological process | Copper transportARBA annotation, Ion transport, Transport |
Ligand | ATP-bindingUniRule annotationARBA annotation, Copper, Metal-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ATP7AImported |
Organismi | Oryctolagus cuniculus (Rabbit)Imported |
Taxonomic identifieri | 9986 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Proteomesi |
|
Subcellular locationi
Golgi apparatus
- trans-Golgi network membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane UniRule annotation
Endosome
- late endosome Source: Ensembl
Golgi apparatus
- trans-Golgi network Source: Ensembl
Plasma Membrane
- basolateral plasma membrane Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-UniRule
- perinuclear region of cytoplasm Source: Ensembl
- trans-Golgi network transport vesicle Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 653 – 672 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 708 – 731 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 743 – 765 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 939 – 963 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 983 – 1006 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 1358 – 1380 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 1386 – 1406 | HelicalUniRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSOCUG00000014160, Expressed in zone of skin and 15 other tissues |
Interactioni
GO - Molecular functioni
- copper-dependent protein binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9986.ENSOCUP00000012171 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 75 | HMAInterPro annotationAdd BLAST | 67 | |
Domaini | 171 – 237 | HMAInterPro annotationAdd BLAST | 67 | |
Domaini | 277 – 338 | HMAInterPro annotationAdd BLAST | 62 | |
Domaini | 377 – 443 | HMAInterPro annotationAdd BLAST | 67 | |
Domaini | 488 – 554 | HMAInterPro annotationAdd BLAST | 67 | |
Domaini | 564 – 630 | HMAInterPro annotationAdd BLAST | 67 |
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]UniRule annotation
Keywords - Domaini
RepeatARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG0207, Eukaryota |
GeneTreei | ENSGT00940000159568 |
HOGENOMi | CLU_001771_0_1_1 |
InParanoidi | G1T6U3 |
OMAi | KTGYEAR |
OrthoDBi | 649559at2759 |
TreeFami | TF300460 |
Family and domain databases
CDDi | cd00371, HMA, 6 hits |
Gene3Di | 3.40.1110.10, 1 hit |
InterProi | View protein in InterPro IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR017969, Heavy-metal-associated_CS IPR006122, HMA_Cu_ion-bd IPR006121, HMA_dom IPR036163, HMA_dom_sf IPR027256, P-typ_ATPase_IB IPR001757, P_typ_ATPase |
Pfami | View protein in Pfam PF00403, HMA, 6 hits |
SUPFAMi | SSF55008, SSF55008, 6 hits SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01525, ATPase-IB_hvy, 1 hit TIGR01494, ATPase_P-type, 2 hits TIGR00003, TIGR00003, 6 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit PS01047, HMA_1, 6 hits PS50846, HMA_2, 6 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
G1T6U3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSNMNVHSI TISVEGMTCN SCVRTIEQQI EKVNGVHHIK VSLEEKNATI
60 70 80 90 100
IYDPELQTPK TLQEAINDMG FDAILHNANP LLVSTDTVFL TVTSSLAPPW
110 120 130 140 150
DHIQSILLKT KGVTDIKISP QQRTAVVTII PSIVNANQIV EQVPDLSLDT
160 170 180 190 200
GALDRKSGSE DHSMAQAGEV MMKMKVEGMT CHSCTSTIEG KIGKLQGVQR
210 220 230 240 250
IKVSLDNQEA TIVYQPHLIT AEEIKKQIEA AGFPAFIKKQ PKYLKLGAID
260 270 280 290 300
VERLKNTPVK SPEGSQQRTL SHTSDSTTTF LIDGMHCKSC VSNIESALST
310 320 330 340 350
LQYVSNIVVS LENRSAIVKY NASLVTPETL RKAIEAVSPG QYRVSIASEV
360 370 380 390 400
ESSPNSPSSS SLQKIPLNVV SQPLTQETVI NIDGMTCNSC VQSIEGVISK
410 420 430 440 450
KPGVKSIRVS LANNSGTIEY DPLLTSPETL REAIEDMGFD ATLSDMNEPL
460 470 480 490 500
VVIAQPSSDM PLLTSTNEFY PKMMTPIHDK EEAKTSSKCY IQVTGMTCAS
510 520 530 540 550
CVANIERNLR REEGIYSVLV ALMAGKAEIR YNPTVIQPPM IAEFIRDLGF
560 570 580 590 600
GATVIESASE GDGVLELVVR GMTCASCVHK IESTLTKHRG IFYCSVALAT
610 620 630 640 650
NKAHIKYDPE IIGPRDIIHT IESLGFEASL VKKDRSSSHL DHKREIRQWR
660 670 680 690 700
RSFLVSLFFC IPVMGLMIYM MIMDHHLATL HHHQNISNEE MINIHSSMFL
710 720 730 740 750
ERQIMPGLSI MNLLSFLLCV PVQFFGGWYF YIQAYKALKH KTANMDVLIV
760 770 780 790 800
LATTIAFSYS LVILLVAMYE RAKVNPITFF DTPPMLFVFI ALGRWLEHIA
810 820 830 840 850
KGKTSEALAK LISLQATEAT VVTLGSDNIL LSEEQVDVEL VQRGDIIKVV
860 870 880 890 900
PGGKFPVDGR VIEGHSMVDE SLITGEAMPV AKKPGSTVIA GSINQNGSLL
910 920 930 940 950
IRATHVGADT TLSQIVKLVE EAQTSKAPIQ QFADKLSGYF VPFIVFVSIA
960 970 980 990 1000
TLVVWIIIGF LNFEIVETYF PGYNRSISRT ETIIRFAFQA SITVLCIACP
1010 1020 1030 1040 1050
CSLGLATPTA VMVGTGVGAQ NGILIKGGEP LEMAHKVKVV VFDKTGTITH
1060 1070 1080 1090 1100
GTPVVNQVKV LVESNKISRN KILAIVGTAE SNSEHPLGAA ITKYCKQELD
1110 1120 1130 1140 1150
TETLGTCIDF QVVPGCGISC KVTNIEGLLR KNNWKIEENN IKNASLVQID
1160 1170 1180 1190 1200
ASNEQSSTSS SMIIEVQNSN ALNSQQYKVL IGNREWMIRN GLVIGNDVDA
1210 1220 1230 1240 1250
SMTEHERKGR TAVLVAVDDE LCSLIAIADT VKPEAELAVH ILKSMGLEVV
1260 1270 1280 1290 1300
LMTGDNSKTA RSIASQVGIT KVFAEVLPSH KVAKVKQLQE EGKRVAMVGD
1310 1320 1330 1340 1350
GINDSPALAM ANVGIAIGTG TDVAIEAADV VLIRNDLLDV VASIDLSRKT
1360 1370 1380 1390 1400
VKRIRINFVF ALIYNLVGIP IAAGVFMPVG LVLQPWMGSA AMAASSVSVV
1410 1420 1430 1440 1450
LSSLFLKLYR KPTYENYELH AQSQIGQKSP SEISVHVGID DTSRNSPKLG
1460 1470 1480 1490
LLDRIVNYSR ASINSLLSDK RSLNSVVTSE PDKHSLLVGD FREDDDTTL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F9DDH6 | A0A5F9DDH6_RABIT | P-type Cu(+) transporter | ATP7A | 1,450 | Annotation score: | ||
A0A5F9DEF2 | A0A5F9DEF2_RABIT | P-type Cu(+) transporter | ATP7A | 1,421 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAGW02041655 Genomic DNA No translation available. AAGW02041656 Genomic DNA No translation available. |
RefSeqi | XP_002720177.1, XM_002720131.3 |
Genome annotation databases
Ensembli | ENSOCUT00000014162; ENSOCUP00000012171; ENSOCUG00000014160 |
GeneIDi | 100343248 |
KEGGi | ocu:100343248 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAGW02041655 Genomic DNA No translation available. AAGW02041656 Genomic DNA No translation available. |
RefSeqi | XP_002720177.1, XM_002720131.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9986.ENSOCUP00000012171 |
Genome annotation databases
Ensembli | ENSOCUT00000014162; ENSOCUP00000012171; ENSOCUG00000014160 |
GeneIDi | 100343248 |
KEGGi | ocu:100343248 |
Organism-specific databases
CTDi | 538 |
Phylogenomic databases
eggNOGi | KOG0207, Eukaryota |
GeneTreei | ENSGT00940000159568 |
HOGENOMi | CLU_001771_0_1_1 |
InParanoidi | G1T6U3 |
OMAi | KTGYEAR |
OrthoDBi | 649559at2759 |
TreeFami | TF300460 |
Gene expression databases
Bgeei | ENSOCUG00000014160, Expressed in zone of skin and 15 other tissues |
Family and domain databases
CDDi | cd00371, HMA, 6 hits |
Gene3Di | 3.40.1110.10, 1 hit |
InterProi | View protein in InterPro IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR017969, Heavy-metal-associated_CS IPR006122, HMA_Cu_ion-bd IPR006121, HMA_dom IPR036163, HMA_dom_sf IPR027256, P-typ_ATPase_IB IPR001757, P_typ_ATPase |
Pfami | View protein in Pfam PF00403, HMA, 6 hits |
SUPFAMi | SSF55008, SSF55008, 6 hits SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01525, ATPase-IB_hvy, 1 hit TIGR01494, ATPase_P-type, 2 hits TIGR00003, TIGR00003, 6 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit PS01047, HMA_1, 6 hits PS50846, HMA_2, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1T6U3_RABIT | |
Accessioni | G1T6U3Primary (citable) accession number: G1T6U3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | October 19, 2011 | |
Last modified: | December 2, 2020 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |