UniProtKB - G1T4R9 (G1T4R9_RABIT)
Protein
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
Gene
PLCG2
Organism
Oryctolagus cuniculus (Rabbit)
Status
Functioni
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.UniRule annotation
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+UniRule annotationEC:3.1.4.11UniRule annotation
Cofactori
Ca2+ARBA annotation
GO - Molecular functioni
- phosphatidylinositol phospholipase C activity Source: UniProtKB
- phosphorylation-dependent protein binding Source: Ensembl
- phosphotyrosine residue binding Source: Ensembl
GO - Biological processi
- activation of store-operated calcium channel activity Source: Ensembl
- B cell receptor signaling pathway Source: Ensembl
- follicular B cell differentiation Source: Ensembl
- inositol trisphosphate biosynthetic process Source: Ensembl
- intracellular signal transduction Source: InterPro
- negative regulation of programmed cell death Source: Ensembl
- phosphatidylinositol biosynthetic process Source: UniProtKB
- phospholipid catabolic process Source: UniProtKB-UniRule
- positive regulation of receptor internalization Source: Ensembl
- positive regulation of type I interferon production Source: Ensembl
- release of sequestered calcium ion into cytosol Source: UniProtKB
- response to lipopolysaccharide Source: Ensembl
- T cell receptor signaling pathway Source: Ensembl
Keywordsi
Molecular function | HydrolaseUniRule annotation, TransducerUniRule annotationARBA annotation |
Biological process | Lipid degradationUniRule annotation, Lipid metabolism |
Ligand | CalciumARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gammaUniRule annotation (EC:3.1.4.11UniRule annotation) |
Gene namesi | Name:PLCG2Imported |
Organismi | Oryctolagus cuniculus (Rabbit)Imported |
Taxonomic identifieri | 9986 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Proteomesi |
|
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Plasma Membrane
- plasma membrane Source: UniProtKB
Keywords - Cellular componenti
MembraneARBA annotationExpressioni
Gene expression databases
Bgeei | ENSOCUG00000013105, Expressed in kidney and 17 other tissues |
Interactioni
GO - Molecular functioni
- phosphorylation-dependent protein binding Source: Ensembl
- phosphotyrosine residue binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9986.ENSOCUP00000011293 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 534 – 637 | SH2InterPro annotationAdd BLAST | 104 | |
Domaini | 648 – 737 | SH2InterPro annotationAdd BLAST | 90 | |
Domaini | 771 – 831 | SH3InterPro annotationAdd BLAST | 61 | |
Domaini | 932 – 1046 | PI-PLC Y-boxInterPro annotationAdd BLAST | 115 | |
Domaini | 1061 – 1154 | C2InterPro annotationAdd BLAST | 94 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1195 – 1215 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotation, SH2 domainPROSITE-ProRule annotationARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG1264, Eukaryota |
GeneTreei | ENSGT00940000157517 |
HOGENOMi | CLU_002738_5_1_1 |
InParanoidi | G1T4R9 |
OMAi | WASTQEK |
OrthoDBi | 368239at2759 |
TreeFami | TF313216 |
Family and domain databases
CDDi | cd09932, SH2_C-SH2_PLC_gamma_like, 1 hit cd10341, SH2_N-SH2_PLC_gamma_like, 1 hit cd11969, SH3_PLCgamma2, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 2 hits 3.30.505.10, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR001192, PI-PLC_fam IPR016279, PLC-gamma IPR028381, PLC-gamma2 IPR035023, PLC-gamma_C-SH2 IPR035024, PLC-gamma_N-SH2 IPR017946, PLC-like_Pdiesterase_TIM-brl IPR035723, PLCgamma2_SH3 IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR10336, PTHR10336, 1 hit PTHR10336:SF25, PTHR10336:SF25, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit PF00017, SH2, 2 hits PF00018, SH3_1, 1 hit |
PIRSFi | PIRSF000952, PLC-gamma, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC PR00401, SH2DOMAIN PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00233, PH, 2 hits SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit SM00252, SH2, 2 hits SM00326, SH3, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF50044, SSF50044, 1 hit SSF51695, SSF51695, 1 hit SSF55550, SSF55550, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit PS50001, SH2, 2 hits PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
G1T4R9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAMPTMVNVE ALPEYEKSQI KRALELGTVM TVFSFRKCTP ERRTVQVIME
60 70 80 90 100
TRQVAWSKTA DKIEGFLDIM DIKEIRPGKN SKDFERAKAV RQKEDCCFTL
110 120 130 140 150
LYGTQFVLST LSLAADSKED AIKWLSGLKI LHQEVMSAST PTIIESWLRK
160 170 180 190 200
QIYSVDQTRR NSISLRELKT ILPLLNFKAS SAKFLKDKFV EIGTQKDELS
210 220 230 240 250
FEQFHLFYKK LMFEHQRSIL DEFKKDSSVF ILGNTDRPDA SAVHLHDFQR
260 270 280 290 300
FLLHEQQELW AQDLNKVRER MTKFIDDTMR ETAEPFLFVD EFLTYLFSRE
310 320 330 340 350
NSIWDEKYDV VDMQDMNNPL SHYWISSSHN TYLTGDQLRS ESSTEAYIRC
360 370 380 390 400
LRLGCRCIEL DCWDGPDGKP IIYHGWTRTT KIKFDDVVQA IKDHAFVTSS
410 420 430 440 450
FPVILSIEEH CSVEQQRHMA RVFKEVLGDL LLTKPTEASA DQLPSPSQLR
460 470 480 490 500
EKIIIKHKKL GPRGDVDVNM EDKKDEHKQQ GELYMWDSID QKWTRHYCAI
510 520 530 540 550
ADAKLSFSDD IEQAVEEEPP QDTPPTELHF GEKWFHKKVE KRMSAEKLLQ
560 570 580 590 600
DYCAETGGKD GTFLVRESET YPDKYTLSFW RSGRVQHCLI RSTVEGGTTK
610 620 630 640 650
YYLTDNLKFT SIYALIQHYR EAHLRCTEFE LQLTDPVPNP NPHESKPWFY
660 670 680 690 700
DALSRGEAED MLMRIPRDGA FLIRRREGSD SYAITFRARG KVKHCRINRD
710 720 730 740 750
GRHFVLGTSA YFESLVELVS YYEKHTLYRK MRLRYPVTPE LLERYSMERD
760 770 780 790 800
INSLYDVSRM YVDPSEINPS MPQRTVKALY DYKAKQSDEL SFCRGALIHN
810 820 830 840 850
VSKEPGGWWK GDYGTRIQQY FPSNYVEDIS TVDVEELEKQ IIEDNPLGTL
860 870 880 890 900
CRGILDLNSY NVVKAPQGKN QKSFVFILEP KKQGDPPVEF ATDRVEELFE
910 920 930 940 950
WFQSIRQINW KMDTKENNMR YWEKNQSIAI ELSDLVVYCK PTSKTKDNLE
960 970 980 990 1000
NPDFREIRSF VETKADSIVR QKPIDLLRYN QKGLTRVYPK GQRVDSSNYD
1010 1020 1030 1040 1050
PFRLWLCGSQ MVALNFQTAD KYMQMNHALF SLNGRTGYVL QPESMRTEKY
1060 1070 1080 1090 1100
DPMPPEAQRR ILMTVTVKVL GARHLPKLGR SIACPFVEVE ICGAECDNNK
1110 1120 1130 1140 1150
FKTTVVNDNG LNPVWASTQE KVTFEIYDPN LAFLRFVVYE EDMFSDPNFL
1160 1170 1180 1190 1200
AHATYPIKGI KSGFRSVPLK NGYSEDIELA SLLVFCEIRP VLESEEELYS
1210 1220 1230 1240 1250
SCRQLRRRQE ELNNQLFLYD THQNLRNANR DALIKEFNVN ENQLQLYQER
1260
CNRRLREKRV SNSKFYS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F9D4G2 | A0A5F9D4G2_RABIT | 1-phosphatidylinositol 4,5-bisphosp... | PLCG2 | 1,232 | Annotation score: | ||
A0A5F9DRZ9 | A0A5F9DRZ9_RABIT | 1-phosphatidylinositol 4,5-bisphosp... | PLCG2 | 1,242 | Annotation score: | ||
A0A5F9CQK5 | A0A5F9CQK5_RABIT | 1-phosphatidylinositol 4,5-bisphosp... | PLCG2 | 1,205 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAGW02055215 Genomic DNA No translation available. AAGW02055216 Genomic DNA No translation available. AAGW02055217 Genomic DNA No translation available. |
RefSeqi | XP_002711703.2, XM_002711657.3 |
Genome annotation databases
Ensembli | ENSOCUT00000013117; ENSOCUP00000011293; ENSOCUG00000013105 |
GeneIDi | 100340139 |
KEGGi | ocu:100340139 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAGW02055215 Genomic DNA No translation available. AAGW02055216 Genomic DNA No translation available. AAGW02055217 Genomic DNA No translation available. |
RefSeqi | XP_002711703.2, XM_002711657.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9986.ENSOCUP00000011293 |
Genome annotation databases
Ensembli | ENSOCUT00000013117; ENSOCUP00000011293; ENSOCUG00000013105 |
GeneIDi | 100340139 |
KEGGi | ocu:100340139 |
Organism-specific databases
CTDi | 5336 |
Phylogenomic databases
eggNOGi | KOG1264, Eukaryota |
GeneTreei | ENSGT00940000157517 |
HOGENOMi | CLU_002738_5_1_1 |
InParanoidi | G1T4R9 |
OMAi | WASTQEK |
OrthoDBi | 368239at2759 |
TreeFami | TF313216 |
Gene expression databases
Bgeei | ENSOCUG00000013105, Expressed in kidney and 17 other tissues |
Family and domain databases
CDDi | cd09932, SH2_C-SH2_PLC_gamma_like, 1 hit cd10341, SH2_N-SH2_PLC_gamma_like, 1 hit cd11969, SH3_PLCgamma2, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 2 hits 3.30.505.10, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR001192, PI-PLC_fam IPR016279, PLC-gamma IPR028381, PLC-gamma2 IPR035023, PLC-gamma_C-SH2 IPR035024, PLC-gamma_N-SH2 IPR017946, PLC-like_Pdiesterase_TIM-brl IPR035723, PLCgamma2_SH3 IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR10336, PTHR10336, 1 hit PTHR10336:SF25, PTHR10336:SF25, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit PF00017, SH2, 2 hits PF00018, SH3_1, 1 hit |
PIRSFi | PIRSF000952, PLC-gamma, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC PR00401, SH2DOMAIN PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00233, PH, 2 hits SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit SM00252, SH2, 2 hits SM00326, SH3, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF50044, SSF50044, 1 hit SSF51695, SSF51695, 1 hit SSF55550, SSF55550, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit PS50001, SH2, 2 hits PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1T4R9_RABIT | |
Accessioni | G1T4R9Primary (citable) accession number: G1T4R9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | November 13, 2013 | |
Last modified: | February 10, 2021 | |
This is version 73 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |