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Entry version 60 (25 May 2022)
Sequence version 1 (19 Oct 2011)
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Protein

HECT-type E3 ubiquitin transferase

Gene

UBE3C

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1051Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathwayPROSITE-ProRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HECT-type E3 ubiquitin transferaseARBA annotation (EC:2.3.2.26ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UBE3CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryctolagus cuniculus (Rabbit)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9986 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001811 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSOCUG00000012490, Expressed in skeletal muscle tissue and 19 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9986.ENSOCUP00000010761

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini744 – 1083HECTInterPro annotationAdd BLAST340

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 40DisorderedSequence analysisAdd BLAST40
Regioni355 – 386DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi16 – 40Basic and acidic residuesSequence analysisAdd BLAST25

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0942, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156321

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002173_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1T3G1

Identification of Orthologs from Complete Genome Data

More...
OMAi
TDNKLYP

Database of Orthologous Groups

More...
OrthoDBi
1163565at2759

TreeFam database of animal gene trees

More...
TreeFami
TF106144

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00078, HECTc, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR044611, E3B/C
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR000048, IQ_motif_EF-hand-BS

The PANTHER Classification System

More...
PANTHERi
PTHR45700, PTHR45700, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00632, HECT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00119, HECTc, 1 hit
SM00015, IQ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56204, SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50237, HECT, 1 hit
PS50096, IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

G1T3G1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSFEGDFKT RPKVSLGGAS RKEEKASLLH RTQEERRKRE EERRRLKNAI
60 70 80 90 100
IIQSFIRGYR DRKQQYSIQR SAFDRCANLS QSGGTFPIAN GPNLTLLVRQ
110 120 130 140 150
LLFFYKQNED SKRLIWLYQN LIKHSSLFVK QLDGSERLTC LFQIKRLMSL
160 170 180 190 200
CCRLLQNCND DSLNVALPMR MLEVFSSENT YLPILQDASY VVSVIEQILH
210 220 230 240 250
YMIQNGYYRS LYLLINSKLP SSIEYSDLSR VPIAKTLLEN VLKPLHFTYN
260 270 280 290 300
SCPEGARQQV FSAFTEEFLA APFTDQIFHF VIPALADAQT IFPYEPFLNA
310 320 330 340 350
LLLQERRYSR QSGGAPWLFY FVLTVGESYL GALSEEGLLV YLRVLQTFLS
360 370 380 390 400
QLPVSPASAS CHDSASDSED ESEEADKPKS PEDGRLSVPY ITEECLKKLD
410 420 430 440 450
TKQQTNTLLN LVWRDSASEE VFTRMASICH TLMVQHRMMV PKVRLLYSLA
460 470 480 490 500
FNARFLRHLW FLISSMTTRM ITGSMVPLLQ VISRGSPMSF EDSSRIIPLF
510 520 530 540 550
YLFSSLFSHS LISIHDNEFF GDPIEVVGQR QSSMMPFTLE ELIMLSRCLR
560 570 580 590 600
DACLGIIKLA YPETKPEVRE EYIAAFQSIG VTTSSEMQQC IQMEQKRWIQ
610 620 630 640 650
LFKVITNLVK MLKSRDTRRN FCPPNHWLSE QEDIKADKVT QLYVPASRHV
660 670 680 690 700
WRFRRMGRIG PLQSTLEVGL ESPPLSVSEE RQLAILTELP FVVPFEERVK
710 720 730 740 750
IFQRLIYADK QEVQGDGPFL DGINVTIRRN YIYEDAYDKL SPENEPDLKK
760 770 780 790 800
RIRVHLLNAH GLDEAGIDGG GIFREFLNEL LKSGFNPNQG FFKTTNEGLL
810 820 830 840 850
YPNPAAQMLV GDSFARHYYF LGRMLGKALY ENMLVELPFA GFFLSKLLGT
860 870 880 890 900
SADVDIHHLA SLDPEVYKNL LFLKSYEGDV EELGLNFTVV NNDLGEAQVV
910 920 930 940 950
ELKFGGKDIP VTSANRIAYI HLVADYRLNK QIRPHCLAFR QGLANVVSLE
960 970 980 990 1000
WLRMFDQQEI QVLISGAQVP ISLEDLKSFT NYSGGYSADH PVIKLFWRVV
1010 1020 1030 1040 1050
EGFTDEEKRK LLKFVTSCSR PPLLGFKELY PAFCIHNGGS DLERLPTAST
1060 1070 1080
CMNLLKLPEF YDETLLRSKL LYAIECAAGF ELS
Length:1,083
Mass (Da):124,077
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD6C156ABB84EBEB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F9DFQ7A0A5F9DFQ7_RABIT
HECT-type E3 ubiquitin transferase
UBE3C
1,020Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9DBT1A0A5F9DBT1_RABIT
HECT-type E3 ubiquitin transferase
UBE3C
1,127Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9CX49A0A5F9CX49_RABIT
HECT-type E3 ubiquitin transferase
UBE3C
1,065Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9DFM6A0A5F9DFM6_RABIT
HECT-type E3 ubiquitin transferase
UBE3C
405Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAGW02056774 Genomic DNA No translation available.
AAGW02056775 Genomic DNA No translation available.
AAGW02056776 Genomic DNA No translation available.
AAGW02056777 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_002715065.1, XM_002715019.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSOCUT00000012499; ENSOCUP00000010761; ENSOCUG00000012490

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100352014

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ocu:100352014

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGW02056774 Genomic DNA No translation available.
AAGW02056775 Genomic DNA No translation available.
AAGW02056776 Genomic DNA No translation available.
AAGW02056777 Genomic DNA No translation available.
RefSeqiXP_002715065.1, XM_002715019.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000010761

Genome annotation databases

EnsembliENSOCUT00000012499; ENSOCUP00000010761; ENSOCUG00000012490
GeneIDi100352014
KEGGiocu:100352014

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9690

Phylogenomic databases

eggNOGiKOG0942, Eukaryota
GeneTreeiENSGT00940000156321
HOGENOMiCLU_002173_2_1_1
InParanoidiG1T3G1
OMAiTDNKLYP
OrthoDBi1163565at2759
TreeFamiTF106144

Gene expression databases

BgeeiENSOCUG00000012490, Expressed in skeletal muscle tissue and 19 other tissues

Family and domain databases

CDDicd00078, HECTc, 1 hit
InterProiView protein in InterPro
IPR044611, E3B/C
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR000048, IQ_motif_EF-hand-BS
PANTHERiPTHR45700, PTHR45700, 1 hit
PfamiView protein in Pfam
PF00632, HECT, 1 hit
SMARTiView protein in SMART
SM00119, HECTc, 1 hit
SM00015, IQ, 1 hit
SUPFAMiSSF56204, SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237, HECT, 1 hit
PS50096, IQ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1T3G1_RABIT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1T3G1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: May 25, 2022
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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