Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 44 (08 May 2019)
Sequence version 2 (13 Nov 2013)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

Uncharacterized protein

Gene

ABCA8

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi513 – 520ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCA8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryctolagus cuniculus (Rabbit)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9986 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001811 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei30 – 47HelicalSequence analysisAdd BLAST18
Transmembranei224 – 242HelicalSequence analysisAdd BLAST19
Transmembranei263 – 288HelicalSequence analysisAdd BLAST26
Transmembranei294 – 316HelicalSequence analysisAdd BLAST23
Transmembranei328 – 350HelicalSequence analysisAdd BLAST23
Transmembranei356 – 374HelicalSequence analysisAdd BLAST19
Transmembranei395 – 417HelicalSequence analysisAdd BLAST23
Transmembranei857 – 874HelicalSequence analysisAdd BLAST18
Transmembranei1016 – 1033HelicalSequence analysisAdd BLAST18
Transmembranei1068 – 1085HelicalSequence analysisAdd BLAST18
Transmembranei1097 – 1118HelicalSequence analysisAdd BLAST22
Transmembranei1130 – 1149HelicalSequence analysisAdd BLAST20
Transmembranei1156 – 1179HelicalSequence analysisAdd BLAST24
Transmembranei1194 – 1216HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSOCUG00000008011 Expressed in 3 organ(s), highest expression level in liver

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9986.ENSOCUP00000006930

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini477 – 712ABC transporterInterPro annotationAdd BLAST236

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162012

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1SUA7

Identification of Orthologs from Complete Genome Data

More...
OMAi
IERHIPS

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR19229 PTHR19229, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1SUA7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKREISVCQ QTWALLWKNL LNKKRMKRNT FMECFYSLLI LLMLYVFPNS
60 70 80 90 100
HEINDFSSLS TVDLGRIDSF NDSSYVVAYT PFTNTTQRIM SKFSSASFMT
110 120 130 140 150
GREVMALPDE ENITEIISHH YGDVVEVIFT NTHSYNLKFM RGYRMPNMKE
160 170 180 190 200
HQDHLAHCHK TEDMIVCEAT YFWTKGFVAF QAAINAAIIE ITTNHSVMEE
210 220 230 240 250
LMSVTGKYMK IDLFISQGGI LTDFYILTCI ICFSPLTYYA SLGVTRERKK
260 270 280 290 300
MKGFMTMMGL RNLAFWLSWG VLYAGYVFIL ALCLTFIIKS VQFVILPNFM
310 320 330 340 350
VVFLLFLFYG LSLIALTFLM SVLVKKSFLT GLVVFLLTVV WGSLGFTALY
360 370 380 390 400
RQLPASLEWI LSLFSPFAFT LGMTQLLHMD YDLNSNADSM SDSNIIILTI
410 420 430 440 450
FMLFFDSFLY LTLMFYFEKI LPNEYGRRRS PLFFLKCSFS SQQNTADHEV
460 470 480 490 500
LENEIEYDSS NDSFEPISPE FHGKEAIRIR NITKEYIGKP KRIEALKDLV
510 520 530 540 550
FDIYEGQITA ILGHSGAGKS TLINILNGLC VPTKGSITIY NHKLSEMDDL
560 570 580 590 600
ENIYKLIGVC PQCNVQFDFL TVRENLRLFA KIKGIHPHEV DNEVKRVLLE
610 620 630 640 650
LEMKNIQDIL AQNLSGGQKR KLTFGIAILG DPQIFLLDEP TAGLDPLSRH
660 670 680 690 700
RVWSFLKERK TDHVILFSTQ FMDEADILAD RKVFLSKGKL KCAGSSLFLK
710 720 730 740 750
KKWGIGYHLS LQLNETCAPE RITSLIKQHI PEAKLLAESE GKLICTLPLE
760 770 780 790 800
RTNKFPDLYK DLENCPDLGI ESYGVSMTTL NEVFLKLEGK SAFDQSDMNV
810 820 830 840 850
LETDGTRDTG RLAEMEQLVS SLNEMRKTTG GMALWLQQVY AIARVRFLNL
860 870 880 890 900
KHERKCLLIL ILTVGAGILH VLAANARKIL RQDDYCWEIS PHLYFLAPGQ
910 920 930 940 950
EPHGPFTNLL IINKTGKSID DFIRSVAQQN IALEVDAFGT RNGTDDSSYN
960 970 980 990 1000
GAIIVSGDEK NYRFSLACNI KRLNCFPVLV DIVSNGLLGM YTPSAHIQTD
1010 1020 1030 1040 1050
RSTFPEENAQ EQLESVAFLI SWLLLMCSFP PYISMTSNND FKNKAQSQLW
1060 1070 1080 1090 1100
VSGLYPSAYW FGQTLVEVPI YFSLIIFMYI VYYILKLQEG IFKAEDLFIQ
1110 1120 1130 1140 1150
TLYVVGYAIS LTFLTYVISF IFRKGRKNSG IWSFCFFLIT LFSTFFMLIN
1160 1170 1180 1190 1200
GLENALLFYI STLIPSATLI GCTVLHYVYR TYYDIISEGY GMELTFLVFL
1210 1220 1230 1240 1250
APFLHFIIFV FILRCLECKL GKKTMRKDPI FRISPRSSEA HQNPENLEGE
1260 1270 1280 1290 1300
DEDVQMERAR TANALTSPNL EEKPVIIASC LRKEYAYKKK CFSKKKKKIA
1310 1320 1330 1340 1350
TRNISFCVRK GEILGLLGHN GAGKSTSIKM ITGDTKPSAG QVLLKGSSRG
1360 1370 1380 1390 1400
DTLGFLGYCP QEDALWPSLT VRQHLEVFAA VKGLKKAEAN IAISRLADAL
1410
KLQDQLKAPV KTYLRE
Length:1,416
Mass (Da):161,186
Last modified:November 13, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i557CEF5691A7D2EF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAGW02040083 Genomic DNA No translation available.
AAGW02040084 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSOCUT00000008019; ENSOCUP00000006930; ENSOCUG00000008011

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGW02040083 Genomic DNA No translation available.
AAGW02040084 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000006930

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000008019; ENSOCUP00000006930; ENSOCUG00000008011

Phylogenomic databases

GeneTreeiENSGT00940000162012
InParanoidiG1SUA7
OMAiIERHIPS

Gene expression databases

BgeeiENSOCUG00000008011 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR027417 P-loop_NTPase
PANTHERiPTHR19229 PTHR19229, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1SUA7_RABIT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1SUA7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: November 13, 2013
Last modified: May 8, 2019
This is version 44 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again