C-X3-C motif chemokine ligand 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chemoattractant activity Source: Ensembl
• chemokine activity Source: Ensembl
• CX3C chemokine receptor binding Source: Ensembl
• CXCR1 chemokine receptor binding Source: Ensembl
• integrin binding Source: Ensembl

GO - Biological processⁱ

• angiogenesis involved in wound healing Source: Ensembl
• cell adhesion Source: Ensembl
• chemokine-mediated signaling pathway Source: Ensembl
• immune response Source: InterPro
• integrin activation Source: Ensembl
• leukocyte adhesive activation Source: InterPro
• leukocyte migration involved in inflammatory response Source: Ensembl
• lymphocyte chemotaxis Source: Ensembl
• microglial cell proliferation Source: Ensembl
• negative regulation of cell migration Source: Ensembl
• negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
• negative regulation of hippocampal neuron apoptotic process Source: Ensembl
• negative regulation of tumor necrosis factor production Source: Ensembl
• neutrophil chemotaxis Source: Ensembl
• positive regulation of actin filament bundle assembly Source: Ensembl
• positive regulation of calcium-independent cell-cell adhesion Source: Ensembl
• positive regulation of cell population proliferation Source: Ensembl
• positive regulation of I-kappaB phosphorylation Source: Ensembl
• positive regulation of inflammatory response Source: Ensembl
• positive regulation of MAPK cascade Source: Ensembl
• positive regulation of microglial cell migration Source: Ensembl
• positive regulation of NF-kappaB transcription factor activity Source: Ensembl
• positive regulation of protein kinase B signaling Source: Ensembl
• positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
• positive regulation of transforming growth factor beta1 production Source: Ensembl
• regulation of lipopolysaccharide-mediated signaling pathway Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• chemoattractant activity Source: Ensembl
• chemokine activity Source: Ensembl
• CX3C chemokine receptor binding Source: Ensembl
• CXCR1 chemokine receptor binding Source: Ensembl
• integrin binding Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MAPIAPQWLL RLAAFCPLMV PLAGQHLGVA KCSIICNNMT PKIPVALLIS 
        60         70         80         90        100
YQWNQESCGK PAIVLETKRH KRFCADPQAP WVQEAMKHLD RQAVARTPNS 
       110        120        130        140        150
GTFEKQIGAV KPGASTVKPG TTAAPGGMPE PAVSEPRPTG DSRSPEPTPA 
       160        170        180        190        200
PQEAQTTLGT SPALPAGVPS SSGSGSLVTQ KPQDGRPPVG PTGPEFVNTA 
       210        220        230        240        250
PVSTAGSWQT SAHQHGATES PSAETPSTEH PSTQALTTSY PASEENLGSE 
       260        270        280        290        300
SQSPGAPALS PRPGDPQSTW ETVPVVAHTG AFQDGGAGST AYASVVPGSS 
       310        320        330        340        350
EGTPSREPAA SGSWTPKAEE PVHATVDPQR LGVLITPVPD SQAATRRQAV 
       360        370        380        390        400
GLLAFLGLLF CLGVAMFAYQ SLQGCPRKMA GEMVEGLRYV PRSCGANSYV 

LVPV                                                   

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ