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Entry version 59 (12 Aug 2020)
Sequence version 3 (11 Dec 2019)
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Protein
Submitted name:

PKHD1 ciliary IPT domain containing fibrocystin/polyductin

Gene

PKHD1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
PKHD1 ciliary IPT domain containing fibrocystin/polyductinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PKHD1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryctolagus cuniculus (Rabbit)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9986 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001811 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3774 – 3797HelicalSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_502383420425 – 3985Sequence analysisAdd BLAST3961

Keywords - PTMi

GlycoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSOCUG00000004246, Expressed in kidney and 8 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9986.ENSOCUP00000003684

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini323 – 483PA14InterPro annotationAdd BLAST161
Domaini1929 – 2050G8InterPro annotationAdd BLAST122
Domaini2661 – 2787G8InterPro annotationAdd BLAST127

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni3806 – 3829DisorderedSequence analysisAdd BLAST24
Regioni3942 – 3967DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3942 – 3965PolarSequence analysisAdd BLAST24

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QR85, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160697

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000057_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1SLE8

TreeFam database of animal gene trees

More...
TreeFami
TF329582

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.160.20.10, 1 hit
2.60.40.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039448, Beta_helix
IPR019316, G8_domain
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR037524, PA14/GLEYA
IPR006626, PbH1
IPR012334, Pectin_lyas_fold
IPR011050, Pectin_lyase_fold/virulence
IPR028839, PKHD1

The PANTHER Classification System

More...
PANTHERi
PTHR46769:SF1, PTHR46769:SF1, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13229, Beta_helix, 1 hit
PF10162, G8, 2 hits
PF01833, TIG, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01225, G8, 2 hits
SM00429, IPT, 5 hits
SM00710, PbH1, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51126, SSF51126, 2 hits
SSF81296, SSF81296, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51484, G8, 2 hits
PS51820, PA14, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G1SLE8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGWLISLMS IEVLLLAVPH LTLRIEPKEG SLAGGTWITV IFDGLETSVL
60 70 80 90 100
YPTNGSQLKI RLVNMVVPAL PSVPCDVFPV FLQLPVVKCQ TRSLLSETHE
110 120 130 140 150
GLYSLEVHSE GQVLDNPSPV SKDSCTFKFS KAQTPIVYHV NPSSGVPGNL
160 170 180 190 200
IHVHGWIFTG KLETFDFDTE YIDSPLVLES QRDRWVTPCS LVNRQTGSCY
210 220 230 240 250
PIQEDHGLGT LQCRVEGDYI GSQNVSFSVF NKGKSMVHKN AWLISAKQDL
260 270 280 290 300
FLYQTHSEIL SVFPETGSIG GRTDVTITGD FFDNSAQVTI AGIPCDVRHV
310 320 330 340 350
SSRKIECTTR PPGKGARLTP PQAGNRGLLF EVADAAEGLE LTETTPGYRW
360 370 380 390 400
QIVPNASSPI RFWSKEGQPF RARLSGFFVA PETNNYTFWI QADSQASLHF
410 420 430 440 450
SWSEEPRTQV KVASIRAGTA DWFDSWEQNG DEGAWQQKTP KLKLLSGVQY
460 470 480 490 500
YLEAEHVGIS PSKGMRIGVQ IHNTWLNPDV VNTYLREKHQ IRARAQRLPE
510 520 530 540 550
IQMLNVSGRG TFFLTWDNVS SQPIPANATA HQIQTTLEEL LAVKCKLEPH
560 570 580 590 600
SANILLRLGF EQGLEGYSSD GDPTTGTEPF CGRFSLRQPQ HLVLTPPAPQ
610 620 630 640 650
KSFRLDQYTH LCIAYKGHTS NILKMTVFFT LGLQNIVKNT TCDWSLPGIN
660 670 680 690 700
PNSWQFTCEN LWETCVHQFG DLQAHLANPP VLILQINLLP LAPEKGLLYV
710 720 730 740 750
DEVIIADTNL TVSQEDSGIA RPGGHLVESV SVTGSPPVYN ISLLAGCATE
760 770 780 790 800
LPLITACSVP TNGTEEGAEL VQGTTQRLQR TSPPLGGHFR IHLPNAVIPD
810 820 830 840 850
VPVHISANYL QKLLQNNADN FTSRYLNVSD FTVKEDLNSC YEHIWTLSWS
860 870 880 890 900
TQIGDLPNFI RVSDEDLTGL DPVATTRVVY DGGVFLGPIF GDMLATANQH
910 920 930 940 950
PQVVVLVNDI PAHCPGNCSF QYLQESTPCM HSVWYSLDGD INLLVYISGT
960 970 980 990 1000
GFSGDSKSLQ VTVNETSCKV VFSNQTNVVC QTDLLPVGVH QISMLVRPCG
1010 1020 1030 1040 1050
LAVSASGEGL FLNVEPRLDA VEPSRAAEIG GIWATIRGSS LEGVSMVLFG
1060 1070 1080 1090 1100
SQSCAINVSA SNSRRIECKV PSRGNDGHTV NVTVISGDYY AVLHSGFTFV
1110 1120 1130 1140 1150
PSLNPVILSL SRNQSSIAGG EALFIRMTQL VNYTDLDMQV HIQDALAEIH
1160 1170 1180 1190 1200
AQTAQGLEVV LPALPTGLYG VSVSINGVNI CSQGVDLHIQ YITDVYSIQP
1210 1220 1230 1240 1250
CCGSLMGGTI LSILGTGFSR DPASVWVLVG NRSCDVVNVT EVSVWCETSP
1260 1270 1280 1290 1300
APVRPDANAL SVPAPVEVWA GSTSFTRGPS PQLVGKGFTF IYEAASTPVV
1310 1320 1330 1340 1350
TTMWGEITND SLMLYVQGNN LSDAVILLGS LTCELETHSP GSRMNLSGCS
1360 1370 1380 1390 1400
FPLLSLEAGI YPLQVRQKQV GLADMSAVPQ QFVVTPQITT ISPTQGSACG
1410 1420 1430 1440 1450
GTVLTVRGVA FHSRKRSVQV DLSGPFTCAI LSLGDHAIVC QVTLIGDPLP
1460 1470 1480 1490 1500
GASFSLNVTV LVNGLRSACQ GNCTVFMWEE TTPTVDTLAT NTSGSLTTVV
1510 1520 1530 1540 1550
MRGQRLGTAA DELLVFVDDQ LPCNVTFFNA SRVACQIGDL TPGRHYLSVF
1560 1570 1580 1590 1600
HARSGYTCFG NISRYFHVMP QVIHYYPKNF SIYGGGLLAI EGTALRGQNT
1610 1620 1630 1640 1650
TFVYVGQQAC RMVTINAELI CCTVPAGNGS ATLELEVDGL LYHVGAVGYS
1660 1670 1680 1690 1700
TAFTPELLSL SQTDDMVTFA VGRISGALNV DIFIGTSPCV GVSGNHTILQ
1710 1720 1730 1740 1750
CTAPLLPAGQ YQVTGYDHTR GWASSVLVFT STVRISAVTE NFGCLDGRLV
1760 1770 1780 1790 1800
HVFGAGFSPG NISAAVCGAP CQVLANATVS AFSCLVLPLD VSLAFLCDLK
1810 1820 1830 1840 1850
PEEDSCEAAS LTYVRCDLTV AVGMERAPES WPYLYICAES FQSRLVPDHW
1860 1870 1880 1890 1900
TESAFPTWSG LFISPKVERD EVLIYNSSCN ITMETEAKME CETPNQPITA
1910 1920 1930 1940 1950
KITEIRKSWG QNTQGNFSFQ FCRRWSRAHS WYPERVPQDG DNVTVESGQV
1960 1970 1980 1990 2000
LLLDTNTSIL NLLHVKGGKL VFMDLGPIEL RAHAILVSDG GELLIGSEAE
2010 2020 2030 2040 2050
PFQSRAQIKL YGSSYSSTFF PYGVKFLAVR NGTLSLHGLL PEVLVTHLRA
2060 2070 2080 2090 2100
AAQAQDTVLA LEDAVDWHPG DEVVIISRAG VEGAKPMEEI VVVETVHNTD
2110 2120 2130 2140 2150
LHLRSPLRYS HSFPENWEAG GYHVLKATVA LLSRNIIIQG NLTTERKRLL
2160 2170 2180 2190 2200
ASCQEINASE GNLQNCLYSK SEKILGSRDL GAKVIIQSFK EEPSCVQLKG
2210 2220 2230 2240 2250
VQFRDMGQTF RRHLSSLTVV GAVKDSYIQG CTVWRSFSRG LSLDSTWGLK
2260 2270 2280 2290 2300
VDNNVFYNIL GHALLVGTYI NIRPISWEAI PGRKYDWSEK GNMIRNNVII
2310 2320 2330 2340 2350
RLSGAEGLSS SEMMTPSGIY VCSPTNVIEG NRVCAAGYGY FFHLVTKRTS
2360 2370 2380 2390 2400
QAPLLSFSQN VAHSCTRCGL FVYPEFQPPW DNGSGPTLFQ NFTVWGSAGG
2410 2420 2430 2440 2450
VQIFRSSNLH LKNLQVYECR DFGIDILESD ANTSVTDSLL VGHFTHKGSL
2460 2470 2480 2490 2500
CMSSGIKTPK RWELMISNTT FANFDRISCV AIRTCSGCSQ GQADAPDVSY
2510 2520 2530 2540 2550
NLTLTDSRNK STTVNYVVDT LSNLHGWMAL LLDQETYSLR FENPWIHSSL
2560 2570 2580 2590 2600
QYSATFDNFA HGNYLLLVHT DVPPYPDILI RCGSQVGRSL LSLPSPGQDQ
2610 2620 2630 2640 2650
SCDWFFSSQL RQLTYLVSGK GQIQVILQVR EGMPPTIAAS TSVPESALRW
2660 2670 2680 2690 2700
SNPETWQDIE EGWGGHNHSV PGPGDDVLIL PNRTVLVDTD LPALKGLYVL
2710 2720 2730 2740 2750
GTLEFPVDRS NVLSVACMVI AGGELKVGTL ENPLQKEQKL TILLRASEGV
2760 2770 2780 2790 2800
FCDRFNGIQI DPGIIGVYGK VQLHSAYTKK SWTHLGADIA SGNERIIIED
2810 2820 2830 2840 2850
AVDWKPHDKI VLSSTSYEPH EAEVLTVKEV KGYHVGIHER LKHRHIGSVH
2860 2870 2880 2890 2900
VIEDGRHISL AAEVGLLTRN IQIRPDTSCR GRLLVGSFRK SDREEFSGVL
2910 2920 2930 2940 2950
QLLNVEIQNF GTPLYSSIEF NNVSSGSWIM SSTVHQSCGG GIHAAASHGI
2960 2970 2980 2990 3000
ILKDNIVFGA AGHGIDLEGQ AYSLTNNLVI LVTQSALSTV WVAGIKVNQA
3010 3020 3030 3040 3050
KEIDLHGNVV AGSERLGFHI RGHRCSSPEV LWSDNVAHSN LHGLHLYKEI
3060 3070 3080 3090 3100
GLDNCTSISG FLAFKNFDYG AMLHVENSME IENITLVDNA IGLFVVVYVS
3110 3120 3130 3140 3150
FVPQSSRQDV QIVLRDSDIV ATSSSFDCIQ DRVKPQTANM TFRDRAPSNP
3160 3170 3180 3190 3200
RGGRVGILWP AFTSQPNQWP QEPWHKVRNG YSISGIMKLQ DVTFSSFGKS
3210 3220 3230 3240 3250
CYSDDLDICI LPNVQNTGIM HPITAERTRM LNMKDKNKFY FPPLHLRKDL
3260 3270 3280 3290 3300
ERVICMESGC ENPRKYLFKD LDGNTLNLPA PVSVFPKIEA EWTGSFFNTG
3310 3320 3330 3340 3350
TFREKKKCTY QPLMQGFICK QTDQVVLILD NADVTWAIQK LYPVVSVTNG
3360 3370 3380 3390 3400
FVDTFSHINA NPPCSTFRSV STFYSILPTG KITKVCFMDQ TPEVLQFFLL
3410 3420 3430 3440 3450
GNKSTSKLLL AVFYYELQSP HVFLRETFIP PTLGKSASSL LEESIGTNYF
3460 3470 3480 3490 3500
NIMDNFLYVV LQGEEPIEIR SGVSLHLAFT VTFSVVENGW EIVILERLTD
3510 3520 3530 3540 3550
FLHLHQNQIR IVHTMPGNEG TLKAIADSRA KRKRNCPTVA CASYYSRVGQ
3560 3570 3580 3590 3600
RKPLMMEMSS SHKVSPPPTM ETVSTVIVIE IGDLPSVKNT GLISSLSSNK
3610 3620 3630 3640 3650
LQNLAHQLII AQQTGVLKNV LNITTGALLV TQPKGIIGSG NTSSFKTGNL
3660 3670 3680 3690 3700
IYIQPCALSV LVQPSDGEVG KELPVQPQLV FLDEQNRRVE SLGPPSEPWT
3710 3720 3730 3740 3750
VLVSLEGTSD SVLKGYTLAE TQDGYVSFSN LAVLISGSNW HFIFTVTSPP
3760 3770 3780 3790 3800
GVNFTARSRQ FAVLPVTEKE SSTIILSASL CSVASWLALI CLVCCWFKKK
3810 3820 3830 3840 3850
KNRKTKPEEI SESQANDPKN HIQVSSKRQG SHVDTVKEDI VMGEDMLGKL
3860 3870 3880 3890 3900
NQLAHQSLNG VSRRKVGRPT AGQETTAVPV PSVTGITSHR HSCSPSSPAQ
3910 3920 3930 3940 3950
QVYMQESGNW KEAQEQLLRY QLARQNQLLL LCPDLKEGRQ QLQGQSQLGK
3960 3970 3980
EGGSLGPSQE TKTACDASVA VHLHSAHPDP MPEQL
Length:3,985
Mass (Da):436,322
Last modified:December 11, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB259A8D3FC2B6CB5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F9CGX9A0A5F9CGX9_RABIT
PKHD1 ciliary IPT domain containing...
PKHD1
3,311Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAGW02018249 Genomic DNA No translation available.
AAGW02018250 Genomic DNA No translation available.
AAGW02018251 Genomic DNA No translation available.
AAGW02018252 Genomic DNA No translation available.
AAGW02018253 Genomic DNA No translation available.
AAGW02018254 Genomic DNA No translation available.
AAGW02018255 Genomic DNA No translation available.
AAGW02018256 Genomic DNA No translation available.
AAGW02018257 Genomic DNA No translation available.
AAGW02018258 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSOCUT00000004260; ENSOCUP00000003684; ENSOCUG00000004246

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGW02018249 Genomic DNA No translation available.
AAGW02018250 Genomic DNA No translation available.
AAGW02018251 Genomic DNA No translation available.
AAGW02018252 Genomic DNA No translation available.
AAGW02018253 Genomic DNA No translation available.
AAGW02018254 Genomic DNA No translation available.
AAGW02018255 Genomic DNA No translation available.
AAGW02018256 Genomic DNA No translation available.
AAGW02018257 Genomic DNA No translation available.
AAGW02018258 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000003684

Genome annotation databases

EnsembliENSOCUT00000004260; ENSOCUP00000003684; ENSOCUG00000004246

Phylogenomic databases

eggNOGiENOG502QR85, Eukaryota
GeneTreeiENSGT00940000160697
HOGENOMiCLU_000057_1_0_1
InParanoidiG1SLE8
TreeFamiTF329582

Gene expression databases

BgeeiENSOCUG00000004246, Expressed in kidney and 8 other tissues

Family and domain databases

Gene3Di2.160.20.10, 1 hit
2.60.40.10, 6 hits
InterProiView protein in InterPro
IPR039448, Beta_helix
IPR019316, G8_domain
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR037524, PA14/GLEYA
IPR006626, PbH1
IPR012334, Pectin_lyas_fold
IPR011050, Pectin_lyase_fold/virulence
IPR028839, PKHD1
PANTHERiPTHR46769:SF1, PTHR46769:SF1, 2 hits
PfamiView protein in Pfam
PF13229, Beta_helix, 1 hit
PF10162, G8, 2 hits
PF01833, TIG, 8 hits
SMARTiView protein in SMART
SM01225, G8, 2 hits
SM00429, IPT, 5 hits
SM00710, PbH1, 9 hits
SUPFAMiSSF51126, SSF51126, 2 hits
SSF81296, SSF81296, 6 hits
PROSITEiView protein in PROSITE
PS51484, G8, 2 hits
PS51820, PA14, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1SLE8_RABIT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1SLE8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: December 11, 2019
Last modified: August 12, 2020
This is version 59 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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