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Entry version 52 (05 Jun 2019)
Sequence version 1 (19 Oct 2011)
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Protein
Submitted name:

Ankyrin 3

Gene

ANK3

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ankyrin 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANK3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryctolagus cuniculus (Rabbit)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9986 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001811 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSOCUG00000003521 Expressed in 3 organ(s), highest expression level in prefrontal cortex

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9986.ENSOCUP00000003069

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 814ANK_REP_REGIONInterPro annotationAdd BLAST775
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati73 – 105ANKPROSITE-ProRule annotationAdd BLAST33
Repeati106 – 138ANKPROSITE-ProRule annotationAdd BLAST33
Repeati139 – 171ANKPROSITE-ProRule annotationAdd BLAST33
Repeati172 – 195ANKPROSITE-ProRule annotationAdd BLAST24
Repeati234 – 266ANKPROSITE-ProRule annotationAdd BLAST33
Repeati267 – 299ANKPROSITE-ProRule annotationAdd BLAST33
Repeati300 – 332ANKPROSITE-ProRule annotationAdd BLAST33
Repeati333 – 365ANKPROSITE-ProRule annotationAdd BLAST33
Repeati366 – 398ANKPROSITE-ProRule annotationAdd BLAST33
Repeati399 – 431ANKPROSITE-ProRule annotationAdd BLAST33
Repeati432 – 464ANKPROSITE-ProRule annotationAdd BLAST33
Repeati465 – 497ANKPROSITE-ProRule annotationAdd BLAST33
Repeati498 – 530ANKPROSITE-ProRule annotationAdd BLAST33
Repeati563 – 595ANKPROSITE-ProRule annotationAdd BLAST33
Repeati596 – 628ANKPROSITE-ProRule annotationAdd BLAST33
Repeati629 – 661ANKPROSITE-ProRule annotationAdd BLAST33
Repeati662 – 694ANKPROSITE-ProRule annotationAdd BLAST33
Repeati695 – 727ANKPROSITE-ProRule annotationAdd BLAST33
Repeati728 – 760ANKPROSITE-ProRule annotationAdd BLAST33
Repeati761 – 793ANKPROSITE-ProRule annotationAdd BLAST33
Domaini983 – 1138ZU5InterPro annotationAdd BLAST156
Domaini1140 – 1287ZU5InterPro annotationAdd BLAST148
Domaini4075 – 4159DeathInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 44DisorderedSequence analysisAdd BLAST44
Regioni1508 – 1539DisorderedSequence analysisAdd BLAST32
Regioni1965 – 2017DisorderedSequence analysisAdd BLAST53
Regioni2067 – 2088DisorderedSequence analysisAdd BLAST22
Regioni2102 – 2261DisorderedSequence analysisAdd BLAST160
Regioni2296 – 2320DisorderedSequence analysisAdd BLAST25
Regioni2373 – 2429DisorderedSequence analysisAdd BLAST57
Regioni2469 – 2496DisorderedSequence analysisAdd BLAST28
Regioni2578 – 2697DisorderedSequence analysisAdd BLAST120
Regioni2714 – 2806DisorderedSequence analysisAdd BLAST93
Regioni2921 – 2987DisorderedSequence analysisAdd BLAST67
Regioni3018 – 3069DisorderedSequence analysisAdd BLAST52
Regioni3113 – 3260DisorderedSequence analysisAdd BLAST148
Regioni3281 – 3309DisorderedSequence analysisAdd BLAST29
Regioni3324 – 3498DisorderedSequence analysisAdd BLAST175
Regioni3523 – 3592DisorderedSequence analysisAdd BLAST70
Regioni3618 – 3648DisorderedSequence analysisAdd BLAST31
Regioni3660 – 3702DisorderedSequence analysisAdd BLAST43
Regioni3796 – 3936DisorderedSequence analysisAdd BLAST141
Regioni4004 – 4076DisorderedSequence analysisAdd BLAST73
Regioni4229 – 4259DisorderedSequence analysisAdd BLAST31
Regioni4309 – 4363DisorderedSequence analysisAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 27PolyampholyteSequence analysisAdd BLAST27
Compositional biasi1965 – 1999PolyampholyteSequence analysisAdd BLAST35
Compositional biasi2108 – 2125PolyampholyteSequence analysisAdd BLAST18
Compositional biasi2126 – 2142PolarSequence analysisAdd BLAST17
Compositional biasi2185 – 2199Pro-richSequence analysisAdd BLAST15
Compositional biasi2215 – 2244PolyampholyteSequence analysisAdd BLAST30
Compositional biasi2306 – 2320PolyampholyteSequence analysisAdd BLAST15
Compositional biasi2399 – 2429PolarSequence analysisAdd BLAST31
Compositional biasi2578 – 2606PolyampholyteSequence analysisAdd BLAST29
Compositional biasi2628 – 2653PolyampholyteSequence analysisAdd BLAST26
Compositional biasi2714 – 2731PolyampholyteSequence analysisAdd BLAST18
Compositional biasi3028 – 3049PolarSequence analysisAdd BLAST22
Compositional biasi3113 – 3169PolarSequence analysisAdd BLAST57
Compositional biasi3360 – 3390PolarSequence analysisAdd BLAST31
Compositional biasi3447 – 3462PolyampholyteSequence analysisAdd BLAST16
Compositional biasi3465 – 3486PolarSequence analysisAdd BLAST22
Compositional biasi3530 – 3554PolyampholyteSequence analysisAdd BLAST25
Compositional biasi3561 – 3584PolarSequence analysisAdd BLAST24
Compositional biasi3674 – 3693PolarSequence analysisAdd BLAST20
Compositional biasi3821 – 3847PolyampholyteSequence analysisAdd BLAST27
Compositional biasi3868 – 3893PolarSequence analysisAdd BLAST26
Compositional biasi3919 – 3934PolyampholyteSequence analysisAdd BLAST16
Compositional biasi4004 – 4019PolyampholyteSequence analysisAdd BLAST16
Compositional biasi4020 – 4042PolarSequence analysisAdd BLAST23
Compositional biasi4043 – 4062PolyampholyteSequence analysisAdd BLAST20
Compositional biasi4324 – 4363PolyampholyteSequence analysisAdd BLAST40

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4177 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154939

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1SJX5

Identification of Orthologs from Complete Genome Data

More...
OMAi
PLKKYTF

TreeFam database of animal gene trees

More...
TreeFami
TF351263

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 7 hits
cd08803 Death_ank3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037971 Ank3_Death
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR040745 Ankyrin_UPA
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR000906 ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 4 hits
PF12796 Ank_2, 8 hits
PF00531 Death, 1 hit
PF17809 UPA_2, 1 hit
PF00791 ZU5, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 22 hits
SM00005 DEATH, 1 hit
SM00218 ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 20 hits
PS50017 DEATH_DOMAIN, 1 hit
PS51145 ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1SJX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHAASQLKK NRDLEINAEE ETEKKRKHRK RSRDRKKKSD ANASYLRAAR
60 70 80 90 100
AGHLEKALDY IKNGVDINIC NQNGLNALHL ASKEGHVEVV SELLQREANV
110 120 130 140 150
DAATKKGNTA LHIASLAGQA EVVKVLVTNG ANVNAQSQNG FTPLYMAAQE
160 170 180 190 200
NHLEVVKFLL DNGASQSLAT EDGFTPLAVA LQQGHDQVVS LLLENDTKGK
210 220 230 240 250
VRLPALHIAA RKDDTKAAAL LLQNDNNADV ESKSGFTPLH IAAHYGNINV
260 270 280 290 300
ATLLLNRAAA VDFTARNDIT PLHVASKRGN ANMVKLLLDR GAKIDAKTRD
310 320 330 340 350
GLTPLHCGAR SGHEQVVEML LDRAAPILSK TKNGLSPLHM ATQGDHLNCV
360 370 380 390 400
QLLLQHNVPV DDVTNDYLTA LHVAAHCGHY KVAKVLLDKK ANPNAKALNG
410 420 430 440 450
FTPLHIACKK NRIKVMELLL KHGASIQAVT ESGLTPIHVA AFMGHVNIVS
460 470 480 490 500
QLMHHGASPN TTNVRGETAL HMAARSGQAE VVRYLVQDGA QVEAKAKDDQ
510 520 530 540 550
TPLHISARLG KADIVQQLLQ QGASPNAATT SGYTPLHLSA RGHEDVAAFL
560 570 580 590 600
LDHGASLSIT TKKGFTPLHV AAKYGKLEVA NLLLQKSASP DAAGKSGLTP
610 620 630 640 650
LHVAAHYDNQ KVALLLLDQG ASPHAAAKNG YTPLHIAAQK NQMDIATTLL
660 670 680 690 700
EYGADANAVT RQGIASVHLA AQEGHVDMVS LLLGRNANVN LSNKSGLTPL
710 720 730 740 750
HLAAQEDRVN VAEVLVNQGA HVDAQTKMGY TPLHVGCHYG NIKIVNFLLQ
760 770 780 790 800
HSAKVNAKTK NGYTPLHQAA QQGHTHIINV LLQNNASPNE LTVNGNTALA
810 820 830 840 850
IARRLGYISV VDTLKVVTEE TITTTTITEK HKMNVPETMN EVLDMSDDEV
860 870 880 890 900
RKANAPEMLS DGEYISDVEE GEDAMTGDTD KYLGPQDLKE LGDDSLPAEG
910 920 930 940 950
YMGFSLGARS ASLRSFSSDR SYTLNRSSYA RDSMMIEELL VPSKEQHLTF
960 970 980 990 1000
TREFDSDSLR HYSWAADTLD NVNLVSSPIH SGFLVSFMVD ARGGSMRGSR
1010 1020 1030 1040 1050
HHGMRIIIPP RKCTAPTRIT CRLVKRHKLA NPPPMVEGEG LASRLVEMGP
1060 1070 1080 1090 1100
AGAQFLGPVI VEIPHFGSMR GKERELIVLR SENGETWKEH QFDSKNEDLT
1110 1120 1130 1140 1150
ELLNGMDEEL DSPEELGKKR ICRIITKDFP QYFAVVSRIK QESNQIGPEG
1160 1170 1180 1190 1200
GILSSTTVPL VQASFPEGAL TKRIRVGLQA QPVPDEIVKK ILGNKATFSP
1210 1220 1230 1240 1250
IVTVEPRRRK FHKPITMTIP VPPPSGEGVS NGYKGDTTPN LRLLCSITGG
1260 1270 1280 1290 1300
TSPAQWEDIT GTTPLTFIKD CVSFTTNVSA RFWLADCHQV LETVGLATQL
1310 1320 1330 1340 1350
YRELICVPYM AKFVVFAKMN DPVESSLRCF CMTDDKVDKT LEQQENFEEV
1360 1370 1380 1390 1400
ARSKDIEVLE GKPIYVDCYG NLAPLTKGGQ QLVFNFYAFK ENRLPFSIKI
1410 1420 1430 1440 1450
RDTSQEPCGR LSFLKEPKTT KGLPQTAVCN LNITLPAHKK ETESDQDDEA
1460 1470 1480 1490 1500
EKADRRQSFA SLALRKRYSY LTEPGMIERS AGATRSLPTT YSYKPFFSTR
1510 1520 1530 1540 1550
PYQSWTTAPN TVPGPAKSGF TSLSSSSSNT PSASPLKSIW SVSTPSPIKS
1560 1570 1580 1590 1600
TLGASTTSSV KSISDVASPI RSFRTISSPI KTVVSQSPYN LQVSSGTLVR
1610 1620 1630 1640 1650
PPTVTEATPL KGLASNSTFS SRTSPVTTGG SLLERSSITM TPPASPKSNL
1660 1670 1680 1690 1700
NMYSSSLPFK SIITSATPLI SSPLKSAVAP AQSAVDVISS AKVTMASALS
1710 1720 1730 1740 1750
SPLKQMPGHA EVALVNGSVS PLKYPSSSTL INGCKATATL QDKISTATNS
1760 1770 1780 1790 1800
VVNAATDTVD KVFATTTAMP FSPLRSYVPA AAPSAFPSLR TPSASALYTS
1810 1820 1830 1840 1850
LGSSLSATTS SVTSSIITVP VYSVVNVLPE PALKKLPDSN SLTKSAAALL
1860 1870 1880 1890 1900
SPIKTLTTET RPQPHFNRTS SPVKSSLFLT PSSLKLSTPS SLSSSQEILK
1910 1920 1930 1940 1950
DVAEMKEDLM RMTAILQTDV PEEKPFPPEL PREGRMEDEE PFKIVEKVKE
1960 1970 1980 1990 2000
DLVKVSEILK KDVCVDDKGS PKSPKSDQGR SPEEDWTEFS SEEIREARQA
2010 2020 2030 2040 2050
AASHAPSLPE RVQVKAKAAS EKDYNLTKVI DYLTNDIGSG SLTNLKYKFE
2060 2070 2080 2090 2100
DAKKDGEERQ KRILKPAMAL QEHKLKMPPA SVRPSTSEKE LCKMADSFFG
2110 2120 2130 2140 2150
TDTILESPDD FSQHDQDKSP LSDSGFETRS EKTPSAPQSA ESTGPKPLFH
2160 2170 2180 2190 2200
EVPIPPVITE TRTEVVHVIR SYEPSAGEAP QSQPEEPGSP KPSPTFTELE
2210 2220 2230 2240 2250
PKPAPSSIKE KVKAFQMKAN GEDEEPSRVL GKGVRVKEET HITTTTRMVY
2260 2270 2280 2290 2300
HSPPGSEGSS ERIEETMSVH DIMKAFQSGR DPSKELAGLF EHKSAVSPDG
2310 2320 2330 2340 2350
HRCAAEASAQ HAEKDSQMKP KLERIIEVHI EKGNQAEPTE VIIRETKKHP
2360 2370 2380 2390 2400
EKEMYVFQKD LPRGDINLKD FLPEKHDAFP CPEEQGQQEE EELTAEESLP
2410 2420 2430 2440 2450
SYLESSRVNT PVSQEEDSRP SSAQLISDDS YKTLKLLSQH SIEYHDDELS
2460 2470 2480 2490 2500
ELRGESYRFA EKMLLSDKLD VSHSDTEESS SELQGSDKRA REKVATAPKK
2510 2520 2530 2540 2550
EILSKIYKDV SENGVGKVSK DEHFDKVTVL HYPGDVGSPK HAMWMRFTED
2560 2570 2580 2590 2600
RLDRGREKLI YEDRVDRTVK EAEEKLTEVS QFFRDKTEKL NDELQSPEKK
2610 2620 2630 2640 2650
PRPRNGKEYS AQSPEKGLLT ELLASNEEWV KARQHGHDGA GFPRAEERRA
2660 2670 2680 2690 2700
PGVSPEKPAL LPPHAGDGKP PEETRGGVAQ SKAPEGPQSG FQLKQSKLSS
2710 2720 2730 2740 2750
IRLKFEQGAH IKSKDVCDED KRPDGQSRIP VKKLQESRLP VHQAFAREKQ
2760 2770 2780 2790 2800
QKGGTDLADQ SGSVQNGALV SKAKDEAAQG GDVVVNDVGS DEATIQRTET
2810 2820 2830 2840 2850
PSKAMPERFS GHQAADLACP VTSDLATAKG PWDKKVFRTW ESSGASYNKS
2860 2870 2880 2890 2900
QKEKLSHVLV HDVRESHLGH PESQSVAQKN EFLSVTEREH RVLTNGSLSE
2910 2920 2930 2940 2950
IKEMTVKSPS KKVLYREYVV TDGDRPGGPP EQPARRGESP AVSHGPVRMA
2960 2970 2980 2990 3000
EERNGLPANG PHAFCEPAAL PKHAPSPKLS QSSLSKETVE TKHFNSIEDA
3010 3020 3030 3040 3050
KVTYSEISKV SKQSYVGLCP PLEEPETSPT KSPDSLEFSP GQESPSSDVF
3060 3070 3080 3090 3100
DHSPMDGLEK LAPLAQTEGG KEIKTLPVYV SFVQVGKQYE KEIQQGSVKK
3110 3120 3130 3140 3150
IISQECKTVQ ETRGTFYTSR QPKQPPSPQG SPEDDTLEQV SFLDSSGKSP
3160 3170 3180 3190 3200
LTPETPSSEE VSYEFTSKTP DSLIAFIPGK PSPIPEVSEE SEEEEQAKST
3210 3220 3230 3240 3250
SLKQPAAEET PVAREMPNEV GRDSSQRPKT NRVAYIEFPP PPPLDAEQLE
3260 3270 3280 3290 3300
SEKQPYRPEK EGELIEVSLQ DEHDKYQLAE PVIRVQPPSP VPPGADVSDS
3310 3320 3330 3340 3350
SDDESIYQPV PVKKYTFKLK EVDDDQKEMT KCKAAAAKAG NQKESESNGS
3360 3370 3380 3390 3400
AKENDFGLPL DSPQNETAQN GNNDQSITEC SIATTAEFSH DTDATEIDSL
3410 3420 3430 3440 3450
DGYDLQDEDD GLTESDSKLP SQTMEIKKDV WNTEGILKPA DRSFSQSKLE
3460 3470 3480 3490 3500
VIEEEGKVGP EEEKPCTQSP SSGKTADKTE QKSGAQFFTL EGRHPDRSVF
3510 3520 3530 3540 3550
PDTYFSYKVD EEFATPFKTV ATKGLDFDPW SNNRGDDEVF DSKSRDDDTK
3560 3570 3580 3590 3600
PFGLAVEDRS PATTPDTTPA RTPTDESTPT SEPNPFPFHE GKMFEMTRSG
3610 3620 3630 3640 3650
AIDMSKRDFV EERLQFFQIG EHTSEGKSGD QGEGDETMVT ATPQPQAGDT
3660 3670 3680 3690 3700
AVETNLERNV EAPPVEPPPS IPTSGEGQED TSGSGSLERA AAAATSTSKV
3710 3720 3730 3740 3750
DPKLRTPIKM GISASTMTMK KEGPAEVPDK LEAVATSCQG LEHEALSMTA
3760 3770 3780 3790 3800
NAASSQMGVR PQERHDFQKD NFNNNNNLDA STMHTDHMTS HVVLPEHSAP
3810 3820 3830 3840 3850
RCATEKAKPV KGSSGKKPGL PHGHCTKDKQ KVLGEQQRTK ESIGIRRQSK
3860 3870 3880 3890 3900
LPIKATAPKD NLPPNHMPNL KASKTKQVSP PGKTTTLPSS SCVDGKSRIP
3910 3920 3930 3940 3950
VKHTHRDNTV SVRKACATQK QEQPEKDKAK QLPSKLPVKV RSTCVTTTTT
3960 3970 3980 3990 4000
TTTTTTTTTT TTSTTTVKVR KSQLKEVCKH SIEYFKGISG ETLKLVDRLS
4010 4020 4030 4040 4050
EEDRKMQSEV SDEEESTSRN TSLSETSRAG KPSVTTKSAR DKNTEAAPLK
4060 4070 4080 4090 4100
SKSEKAGSER RSSRRTGPQS PCERTDIRMA IVADHLGLSW TELARELNFS
4110 4120 4130 4140 4150
VDEINQIRVE NPNSLISQSF MLLKKWVTRD GKNATTDALT SVLTKINRID
4160 4170 4180 4190 4200
IVTLLEGPIF DYGNISGTRS FADENNVFHD PVDGWQNETS GGNVESPAQA
4210 4220 4230 4240 4250
RRIAGGLLDR LDDSPDQCRD SITSYLKGEP GQFEANGSHA EVTPEAKTKS
4260 4270 4280 4290 4300
YFPESQNDIG KQSAKEILKP KIHGSGRVEE PASPLAAYQK SLEETSKLVI
4310 4320 4330 4340 4350
EEPKPCVPVS MKKMSSRTCP AHGKPRLNLH EEEGSSGSEQ KQGEAYKVKA
4360
KKEVRPVEKK SYS
Length:4,363
Mass (Da):476,461
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i559498F6E04C4F4E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AAGW02036712 Genomic DNA No translation available.
AAGW02036713 Genomic DNA No translation available.
AAGW02036714 Genomic DNA No translation available.
AAGW02036715 Genomic DNA No translation available.
AAGW02036716 Genomic DNA No translation available.
AAGW02036717 Genomic DNA No translation available.
AAGW02036718 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSOCUT00000003541; ENSOCUP00000003069; ENSOCUG00000003521

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGW02036712 Genomic DNA No translation available.
AAGW02036713 Genomic DNA No translation available.
AAGW02036714 Genomic DNA No translation available.
AAGW02036715 Genomic DNA No translation available.
AAGW02036716 Genomic DNA No translation available.
AAGW02036717 Genomic DNA No translation available.
AAGW02036718 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

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ModBasei
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000003069

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000003541; ENSOCUP00000003069; ENSOCUG00000003521

Phylogenomic databases

eggNOGiKOG4177 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000154939
InParanoidiG1SJX5
OMAiPLKKYTF
TreeFamiTF351263

Gene expression databases

BgeeiENSOCUG00000003521 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Family and domain databases

CDDicd00204 ANK, 7 hits
cd08803 Death_ank3, 1 hit
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR037971 Ank3_Death
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR040745 Ankyrin_UPA
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR000906 ZU5_dom
PfamiView protein in Pfam
PF00023 Ank, 4 hits
PF12796 Ank_2, 8 hits
PF00531 Death, 1 hit
PF17809 UPA_2, 1 hit
PF00791 ZU5, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 22 hits
SM00005 DEATH, 1 hit
SM00218 ZU5, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 20 hits
PS50017 DEATH_DOMAIN, 1 hit
PS51145 ZU5, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1SJX5_RABIT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1SJX5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: June 5, 2019
This is version 52 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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