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Protein

AMP deaminase

Gene

AMPD3

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

AMP + H2O = IMP + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
AMP deaminaseUniRule annotation (EC:3.5.4.6UniRule annotation)
Gene namesi
Name:AMPD3Imported
OrganismiOryctolagus cuniculus (Rabbit)Imported
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 1

Expressioni

Gene expression databases

BgeeiENSOCUG00000002805 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000002432

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini361 – 768A_deaminaseInterPro annotationAdd BLAST408

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili100 – 123Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1096 Eukaryota
COG1816 LUCA
GeneTreeiENSGT00390000008190
InParanoidiG1SIC7
KOiK01490
OMAiPSPDVWT
OrthoDBiEOG091G01OU
TreeFamiTF300439

Family and domain databases

CDDicd01319 AMPD, 1 hit
InterProiView protein in InterPro
IPR006650 A/AMP_deam_AS
IPR001365 A/AMP_deaminase_dom
IPR006329 AMPD
IPR029771 AMPD3
IPR032466 Metal_Hydrolase
PANTHERiPTHR11359 PTHR11359, 1 hit
PTHR11359:SF2 PTHR11359:SF2, 1 hit
PfamiView protein in Pfam
PF00962 A_deaminase, 1 hit
PIRSFiPIRSF001251 AMP_deaminase_met, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR01429 AMP_deaminase, 1 hit
PROSITEiView protein in PROSITE
PS00485 A_DEAMINASE, 1 hit

Sequencei

Sequence statusi: Complete.

G1SIC7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSRALPLQP ACRPQPGCLY PDSAQRPAAG GTWPQRASPS AMETPAPGSA
60 70 80 90 100
EMPRQFPKLN ISEVDEQVRL LAEKVFAKVL REEDSKDALS LFTVPEDCPI
110 120 130 140 150
GQKEAKEREL QKELAEQKSL ETAKRKKSFK MIRSQSLSLQ MPTQQDWKGP
160 170 180 190 200
PTASPAMSPA TPVVAGAASQ PAPAPYAMPE YQRVTISGDY CAGITVEDYE
210 220 230 240 250
QAAKSLAKAL MIREKYARLA YHRFPRTTAQ YLGHRRPDVA PPEDGLPDFY
260 270 280 290 300
PPPRPQEDPY CLDDAPPNLG YLVRMQGGIL FVYDNKKMLE RQEPHSLPYP
310 320 330 340 350
DLETYTVDMS HILALITDGP TKTYCHRRLN FLESKFSLHE MLNEMSEFKE
360 370 380 390 400
LKSNPHRDFY NVRKVDTHIH AAACMNQKHL LRFIKHTYQT EPDRTVAEKR
410 420 430 440 450
GRKITLRQVF DSLHMDPYDL TVDSLDVHAG RQTFHRFDKF NSKYNPVGAS
460 470 480 490 500
ELRDLYLKTE NYLGGEYFAR MVKEVARELE ESKYQYSEPR LSIYGRSPEE
510 520 530 540 550
WPNLARWFIQ HKVYSPNMRW IIQVPRIYDI FRSKKLLPNF GKMLENIFLP
560 570 580 590 600
LFKATIDPQD HRELHLFLKY VTGFDSVDDE SKHSDHMFSD KSPSPDIWTS
610 620 630 640 650
EQNPPYSYYL YYMYANIMVL NNLRRERGLS TFLFRPHCGE AGSITHLVAA
660 670 680 690 700
FLTADNISHG LLLKKSPVLQ YLYYLAQIPI AMSPLSNNSL FLEYSKNPLR
710 720 730 740 750
EFLHKGLHVS LSTDDPMQFH YTKEALMEEY AIAAQVWKLS TCDLCEIARN
760 770 780 790 800
SVLQSGLSHQ EKQKFLGQNY YKEGPEGNDI RKTNVAQIRM AFRYETLCNE
810
LSFLSDAMKS EEITALAK
Length:818
Mass (Da):94,099
Last modified:November 13, 2013 - v2
Checksum:i612AF543C3C6C535
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGW02007866 Genomic DNA No translation available.
RefSeqiXP_017200847.1, XM_017345358.1

Genome annotation databases

EnsembliENSOCUT00000002802; ENSOCUP00000002432; ENSOCUG00000002805
GeneIDi100351884
KEGGiocu:100351884

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGW02007866 Genomic DNA No translation available.
RefSeqiXP_017200847.1, XM_017345358.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000002432

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000002802; ENSOCUP00000002432; ENSOCUG00000002805
GeneIDi100351884
KEGGiocu:100351884

Organism-specific databases

CTDi272

Phylogenomic databases

eggNOGiKOG1096 Eukaryota
COG1816 LUCA
GeneTreeiENSGT00390000008190
InParanoidiG1SIC7
KOiK01490
OMAiPSPDVWT
OrthoDBiEOG091G01OU
TreeFamiTF300439

Gene expression databases

BgeeiENSOCUG00000002805 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

CDDicd01319 AMPD, 1 hit
InterProiView protein in InterPro
IPR006650 A/AMP_deam_AS
IPR001365 A/AMP_deaminase_dom
IPR006329 AMPD
IPR029771 AMPD3
IPR032466 Metal_Hydrolase
PANTHERiPTHR11359 PTHR11359, 1 hit
PTHR11359:SF2 PTHR11359:SF2, 1 hit
PfamiView protein in Pfam
PF00962 A_deaminase, 1 hit
PIRSFiPIRSF001251 AMP_deaminase_met, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR01429 AMP_deaminase, 1 hit
PROSITEiView protein in PROSITE
PS00485 A_DEAMINASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG1SIC7_RABIT
AccessioniPrimary (citable) accession number: G1SIC7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: November 13, 2013
Last modified: November 7, 2018
This is version 39 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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