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Entry version 44 (02 Dec 2020)
Sequence version 3 (11 Dec 2019)
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Protein
Submitted name:

AF4/FMR2 family member 1

Gene

AFF1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AF4/FMR2 family member 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AFF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryctolagus cuniculus (Rabbit)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9986 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001811 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSOCUG00000002105, Expressed in blood and 16 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9986.ENSOCUP00000001817

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1012 – 1272AF-4_CInterPro annotationAdd BLAST261

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni63 – 91DisorderedSequence analysisAdd BLAST29
Regioni112 – 300DisorderedSequence analysisAdd BLAST189
Regioni313 – 337DisorderedSequence analysisAdd BLAST25
Regioni345 – 364DisorderedSequence analysisAdd BLAST20
Regioni417 – 809DisorderedSequence analysisAdd BLAST393
Regioni822 – 1028DisorderedSequence analysisAdd BLAST207
Regioni1160 – 1181DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi63 – 81PolyampholyteSequence analysisAdd BLAST19
Compositional biasi112 – 127PolarSequence analysisAdd BLAST16
Compositional biasi143 – 159PolarSequence analysisAdd BLAST17
Compositional biasi193 – 211PolarSequence analysisAdd BLAST19
Compositional biasi212 – 229PolyampholyteSequence analysisAdd BLAST18
Compositional biasi257 – 284PolarSequence analysisAdd BLAST28
Compositional biasi421 – 475PolarSequence analysisAdd BLAST55
Compositional biasi507 – 535PolarSequence analysisAdd BLAST29
Compositional biasi631 – 649PolarSequence analysisAdd BLAST19
Compositional biasi760 – 774PolarSequence analysisAdd BLAST15
Compositional biasi830 – 883PolyampholyteSequence analysisAdd BLAST54
Compositional biasi923 – 941PolarSequence analysisAdd BLAST19
Compositional biasi964 – 979PolyampholyteSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AF4 family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QR32, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182974

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006484_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1SGT9

TreeFam database of animal gene trees

More...
TreeFami
TF326216

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
IPR043639, AF4_int

The PANTHER Classification System

More...
PANTHERi
PTHR10528, PTHR10528, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

G1SGT9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAQKQAEAA ATGAGLFERS VVHGEDEQTC HFPLIAAMAF TDRVNSSGGS
60 70 80 90 100
LYNEDRNLLR IREKERRNQE AHQEKEPLPE KIPLFGEPYK TAKGDELSSR
110 120 130 140 150
IQNMLGSYEE VQEFYSSKPQ SQPLDASGNR LERPRYPFFP DKGSSIPSNS
160 170 180 190 200
FQTAVPHQPI HTPASGPLPV GNVNHNPKMA QPRMEPMTSV HARSYGSLDS
210 220 230 240 250
QHLTQDRPGQ EGYSSSHHKK GDRRTDGEHC ALMMASAAGK ELSPLISLPS
260 270 280 290 300
PVPPLSPLHS NQQSLPRTQG SSKVHSSNNS KGYCLAKSPK DPVVKVHEKE
310 320 330 340 350
TPQDSLVAVA SLGIAPPQPP SQTFPPSSLP SKTIAMQQKP TAYVRPMDGQ
360 370 380 390 400
DQAPSESPEL KPLPEDYRQQ TFEKTDLKVP AKVKLTKLKM PSQSAEQTYS
410 420 430 440 450
NEAHCVEEIL KEMTHSWPPP LTAIHTPSTA EPSKFPFPTK ESQHISSATQ
460 470 480 490 500
NQKQYETSSK THPTSQQGTS MLEDDLQLSD SEDSDSEQTP EKPPSSAAPP
510 520 530 540 550
SAPQSLPQPV ASAHSSSAES ESSSDSDSSS DSESESSSSD SEENEPLETP
560 570 580 590 600
APEPEPPTTN KWQLDNWLTK VSQPAALPEG LGRPEPVRRH QEGKGGSDSG
610 620 630 640 650
TTGQEHADPK DPTAKNSSKA PRIPPEGSHS GKRSCQKSPA PQEPLLRQTL
660 670 680 690 700
GTKQPKKPAK VAGQAHSQAG LQVESEPGRA LDSVQQTAKD KPKVKTKGRP
710 720 730 740 750
RSGAGRESKP AVPTPGERKK HKSPPPPAPC KAPAGREPTK EHAEARSPEP
760 770 780 790 800
LALVPLAQSQ GVPPSGSGAR TSGCRQAVVV QEDGRRDKLP VPLRDTKLLS
810 820 830 840 850
PLRDPPLPQS LMVKITLDLL TRIPHPPGKG SRQKKPEDKQ LPAGRKQDSE
860 870 880 890 900
KKSSDPSCKL AKKRKGEAEK DYDNKRIRLE KEVKPQSSSS SSSHRESSKT
910 920 930 940 950
KIPRPSSEPS KKEMPPPPPV SSSSSSSSSS SSSSSSSQKP TKPAHKRSRQ
960 970 980 990 1000
EADSCGSDPH KSASSTKSSH KDSSVVKHRK VPGKGCGGAV EHKGASGDAA
1010 1020 1030 1040 1050
NPFPVPSLPN GNSKPGRPQV KRNRQQADFH MKEAKKLKDK AETMTDKVGK
1060 1070 1080 1090 1100
AFKYLEAVLS FIECGIAMES ESPACKAAYA VYSDTAELLK FIMSLKSFSS
1110 1120 1130 1140 1150
ATTQEKIFAV LCMRCQSILN MAMFRCKKDI AIKYSRTLNE HFCTSSSKVA
1160 1170 1180 1190 1200
QAPSPCIARS TGTPSPLSPM PSPASCLGSQ SSAGSVGSSG MTATVSTPVT
1210 1220 1230 1240 1250
IQNMTSSYVS ITSHILTAFD LWEQAEALAR RNKEFFAQLS TNVGTLALNS
1260 1270
SLVDLVHYTR QGFQRLKQLT RTP
Length:1,273
Mass (Da):137,516
Last modified:December 11, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF33785DA19BFA45C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F9CA73A0A5F9CA73_RABIT
AF4/FMR2 family member 1
AFF1
1,244Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9CHP5A0A5F9CHP5_RABIT
AF4/FMR2 family member 1
AFF1
1,251Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAGW02022735 Genomic DNA No translation available.
AAGW02022736 Genomic DNA No translation available.
AAGW02022737 Genomic DNA No translation available.
AAGW02022738 Genomic DNA No translation available.
AAGW02022739 Genomic DNA No translation available.
AAGW02022740 Genomic DNA No translation available.
AAGW02022741 Genomic DNA No translation available.
AAGW02022742 Genomic DNA No translation available.
AAGW02022743 Genomic DNA No translation available.
AAGW02022744 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSOCUT00000002107; ENSOCUP00000001817; ENSOCUG00000002105

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGW02022735 Genomic DNA No translation available.
AAGW02022736 Genomic DNA No translation available.
AAGW02022737 Genomic DNA No translation available.
AAGW02022738 Genomic DNA No translation available.
AAGW02022739 Genomic DNA No translation available.
AAGW02022740 Genomic DNA No translation available.
AAGW02022741 Genomic DNA No translation available.
AAGW02022742 Genomic DNA No translation available.
AAGW02022743 Genomic DNA No translation available.
AAGW02022744 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000001817

Genome annotation databases

EnsembliENSOCUT00000002107; ENSOCUP00000001817; ENSOCUG00000002105

Phylogenomic databases

eggNOGiENOG502QR32, Eukaryota
GeneTreeiENSGT00950000182974
HOGENOMiCLU_006484_0_0_1
InParanoidiG1SGT9
TreeFamiTF326216

Gene expression databases

BgeeiENSOCUG00000002105, Expressed in blood and 16 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
IPR043639, AF4_int
PANTHERiPTHR10528, PTHR10528, 1 hit
PfamiView protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1SGT9_RABIT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1SGT9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: December 11, 2019
Last modified: December 2, 2020
This is version 44 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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