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Protein

Homeobox protein

Gene

PITX2

Organism
Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi93 – 152HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinUniRule annotationSAAS annotation, DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox proteinUniRule annotation
Gene namesi
Name:PITX2Imported
OrganismiNomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)Imported
Taxonomic identifieri61853 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHylobatidaeNomascus
Proteomesi
  • UP000001073 Componenti: Chromosome 18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi61853.ENSNLEP00000019990

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini91 – 151HomeoboxInterPro annotationAdd BLAST61
Domaini287 – 300OARInterPro annotationAdd BLAST14

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi287 – 300OARPROSITE-ProRule annotationAdd BLAST14

Sequence similaritiesi

Belongs to the paired homeobox family. Bicoid subfamily.UniRule annotation

Keywords - Domaini

HomeoboxPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0486 Eukaryota
ENOG410ZZ6J LUCA
GeneTreeiENSGT00930000150861
InParanoidiG1S3A2
KOiK04686
OMAiSACPYAP
OrthoDBiEOG091G0H7U
TreeFamiTF351940

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR016233 Homeobox_Pitx/unc30
IPR003654 OAR_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03826 OAR, 1 hit
PIRSFiPIRSF000563 Homeobox_protein_Pitx/Unc30, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS50803 OAR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

G1S3A2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNCMKGPLHL EHRAAGTKLS AISSSSSCHH PQPLAMASVL APGQPRSLDS
60 70 80 90 100
SKHRLEVHTI SDTSSPEAAE KDKSQQGKNE DVGAEDPSKK KRQRRQRTHF
110 120 130 140 150
TSQQLQELEA TFQRNRYPDM STREEIAVWT NLTEARVRVW FKNRRAKWRK
160 170 180 190 200
RERNQQAELC KNGFGPQFNG LMQPYDDMYP GYSYNNWAAK GLTSASLSTK
210 220 230 240 250
SFPFFNSMNV NPLSSQSMFS PPNSISSMSM SSSMVPSAVT GVPGSSLNSL
260 270 280 290 300
NNLNNLSSPS LNSAVPTPAC PYAPPTPPYV YRDTCNSSLA SLRLKAKQHS
310 320
SFGYASVQNP ASNLSACQYA VDRPV
Length:325
Mass (Da):35,897
Last modified:October 19, 2011 - v1
Checksum:i642194D1A842BB25
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3HKM7A0A2I3HKM7_NOMLE
Homeobox protein
PITX2
271Annotation score:
A0A2I3HYM5A0A2I3HYM5_NOMLE
Homeobox protein
PITX2
420Annotation score:
A0A2I3HRW6A0A2I3HRW6_NOMLE
Homeobox protein
PITX2
296Annotation score:
A0A2I3FQC1A0A2I3FQC1_NOMLE
Uncharacterized protein
PITX2
264Annotation score:
A0A2I3HWY5A0A2I3HWY5_NOMLE
Uncharacterized protein
PITX2
173Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADFV01049744 Genomic DNA No translation available.
ADFV01049745 Genomic DNA No translation available.
ADFV01049746 Genomic DNA No translation available.
RefSeqiXP_003269394.1, XM_003269346.2

Genome annotation databases

EnsembliENSNLET00000020991; ENSNLEP00000019990; ENSNLEG00000016466
GeneIDi100587298
KEGGinle:100587298

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADFV01049744 Genomic DNA No translation available.
ADFV01049745 Genomic DNA No translation available.
ADFV01049746 Genomic DNA No translation available.
RefSeqiXP_003269394.1, XM_003269346.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi61853.ENSNLEP00000019990

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSNLET00000020991; ENSNLEP00000019990; ENSNLEG00000016466
GeneIDi100587298
KEGGinle:100587298

Organism-specific databases

CTDi5308

Phylogenomic databases

eggNOGiKOG0486 Eukaryota
ENOG410ZZ6J LUCA
GeneTreeiENSGT00930000150861
InParanoidiG1S3A2
KOiK04686
OMAiSACPYAP
OrthoDBiEOG091G0H7U
TreeFamiTF351940

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR016233 Homeobox_Pitx/unc30
IPR003654 OAR_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03826 OAR, 1 hit
PIRSFiPIRSF000563 Homeobox_protein_Pitx/Unc30, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS50803 OAR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG1S3A2_NOMLE
AccessioniPrimary (citable) accession number: G1S3A2
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: November 7, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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