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UniProtKB - G1RML2 (G1RML2_NOMLE)

Entry version 70 (25 May 2022)
Sequence version 2 (28 Feb 2018)
Previous versions | rss
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Protein
Submitted name:

Uncharacterized protein

Gene

MACF1

Organism
Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation
LigandMetal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MACF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri61853 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hylobatidae › Nomascus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001073 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projectionARBA annotation, Cytoplasm, CytoskeletonPROSITE-ProRule annotation, MembraneARBA annotation, MicrotubuleARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		61853.ENSNLEP00000014476

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini66 – 169Calponin-homology (CH)InterPro annotationAdd BLAST104
Domaini182 – 286Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini851 – 908SH3InterPro annotationAdd BLAST58
Domaini5050 – 5085EF-handInterPro annotationAdd BLAST36
Domaini5086 – 5121EF-handInterPro annotationAdd BLAST36
Domaini5126 – 5198GARInterPro annotationAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni5214 – 5397DisorderedSequence analysisAdd BLAST184

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili233 – 253Sequence analysisAdd BLAST21
Coiled coili465 – 485Sequence analysisAdd BLAST21
Coiled coili490 – 517Sequence analysisAdd BLAST28
Coiled coili1029 – 1049Sequence analysisAdd BLAST21
Coiled coili1386 – 1416Sequence analysisAdd BLAST31
Coiled coili1480 – 1500Sequence analysisAdd BLAST21
Coiled coili1505 – 1532Sequence analysisAdd BLAST28
Coiled coili1568 – 1588Sequence analysisAdd BLAST21
Coiled coili1612 – 1646Sequence analysisAdd BLAST35
Coiled coili1776 – 1806Sequence analysisAdd BLAST31
Coiled coili2170 – 2197Sequence analysisAdd BLAST28
Coiled coili2210 – 2237Sequence analysisAdd BLAST28
Coiled coili2275 – 2295Sequence analysisAdd BLAST21
Coiled coili2380 – 2400Sequence analysisAdd BLAST21
Coiled coili2540 – 2560Sequence analysisAdd BLAST21
Coiled coili2599 – 2619Sequence analysisAdd BLAST21
Coiled coili2640 – 2674Sequence analysisAdd BLAST35
Coiled coili2791 – 2811Sequence analysisAdd BLAST21
Coiled coili2912 – 2953Sequence analysisAdd BLAST42
Coiled coili3090 – 3110Sequence analysisAdd BLAST21
Coiled coili3116 – 3136Sequence analysisAdd BLAST21
Coiled coili3880 – 3900Sequence analysisAdd BLAST21
Coiled coili4113 – 4140Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5233 – 5312Polar residuesSequence analysisAdd BLAST80
Compositional biasi5344 – 5397Polar residuesSequence analysisAdd BLAST54

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0516, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155824

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000015_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		G1RML2

Family and domain databases

Conserved Domains Database

More...CDDi		cd00014, CH, 2 hits
cd00051, EFh, 1 hit
cd00176, SPEC, 16 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 2 hits
3.30.920.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...PANTHERi		PTHR23169, PTHR23169, 8 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 18 hits
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 32 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

G1RML2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
FFFFETESCS VSQAGVQWHN FGSLQPPPPR LKQFSCLSLL SSWDYRHVPL 
        60         70         80         90        100
TCPCLLCVSF TDERDRVQKK TFTKWVNKHL MKVRKHINDL YEDLRDGHNL 
       110        120        130        140        150
ISLLEVLSGI KLPREKGRMR FHRLQNVQIA LDFLKQRQVK LVNIRNDDIT 
       160        170        180        190        200
DGNPKLTLGL IWTIILHFQI SDIYISGESG DMSAKEKLLL WTQKVTAGYT 
       210        220        230        240        250
GIKCTNFSSC WSDGKMFNAL IHRYRPDLVD MERVQIQSNR ENLEQAFEVA 
       260        270        280        290        300
ERLGVTRLLD AEDVDVPSPD EKSVITYVSS IYDAFPKVPE GGEGISATEV 
       310        320        330        340        350
DSRWQEYQSR VDSLIPWIKQ HTILMSDKTF PQNPVELKAL YNQYIHFKET 
       360        370        380        390        400
EILAKEREKG RIEELYKLLE VWIEFGRIKL PQGYHPNDVE EEWGKLIIEM 
       410        420        430        440        450
LEREKSLRPA VERLELLLQI ANKIQNGALN CEEKLTLAKN TLQADAAHLE 
       460        470        480        490        500
SGQPVQCESD VIMYIQECEG LIRQLQVDLQ ILRDENYYQL EELAFRVMRL 
       510        520        530        540        550
QDELVTLRLE CTNLYRKGHF TSLELVPPST LTTTHLKAEP LTKATHSSST 
       560        570        580        590        600
SWFRKPMTRA ELVAISSSED EGNLRFVYEL LSWVEEMQMK LERAEWGNDL 
       610        620        630        640        650
PSVELQLEMQ QHIHTSVEEL GSSVKEARLY EGKMSQNFHT SYAETLGKLE 
       660        670        680        690        700
TQYCKLKETS SFRMRHLQSL HKFVSRATAE LIWLNEKEEE ELAYDWSDNN 
       710        720        730        740        750
SNISAKRNYF SELTMELEEK QDVFRSLQDT AELLSLENHP AKQTVEAYSA 
       760        770        780        790        800
AVQSQLQWMK QLCLCVEQHV KENTAYFQLE SFLRNLQDSI KRKYSCDHNT 
       810        820        830        840        850
SLSRLEDLLQ DSMVGDEKEQ LIQSKSSVAS LVGRSKTIVQ LKPRSPDHVL 
       860        870        880        890        900
KSTISVKAIC DYRQIEITIC KNDECVLEDN SQRTKWKVIS PTGNEAMVPS 
       910        920        930        940        950
VCFLIPPPNK DAIEMASRVE QSYQKVMALW HQLHVNTKSL ISWNYLRKDL 
       960        970        980        990       1000
DLVQTWNLEK LRSSAPGECH QIMKNLQGHY EDFLQDSRDS VLFSVADRLR 
      1010       1020       1030       1040       1050
LEKEVEACKA HFQHLMKSME NEDKEETVAK MYISELKNIR LRLEEYEQRV 
      1060       1070       1080       1090       1100
VKRIQSLASS RTDKDARQDN ALRIAEQEHT QEDLQKLRSD LDAVSMKCDS 
      1110       1120       1130       1140       1150
FLHQSPSSSS VPTLRSELNL LVEKMDHVYG LSTVYLNKLK TVDVIVRSIQ 
      1160       1170       1180       1190       1200
DAELLVKGYE IKLSQEEAVL ADLSALEAHR STLRHWLSDV KDKNSVFSVL 
      1210       1220       1230       1240       1250
DEEIAKAKAV AEQMSRLTPE RNLDLERYQE KGSQLQERWH RVIAQLEIRQ 
      1260       1270       1280       1290       1300
SELESIQEVL GDYRACHGTL IKWIEETTAQ QEMMKPGQAE DSRVLSEQLS 
      1310       1320       1330       1340       1350
QQTALFAEIE RNQTKLDQCQ KFSQQYSTIV KDYELQLMTY KAFVESQQKS 
      1360       1370       1380       1390       1400
PGKRRRMLSS SDAITQEFMD LRTRYTALVT LTTQHVKYIS DALRRLEEEE 
      1410       1420       1430       1440       1450
KVVEEEKQEH VEKVKELLGW VSTLARNTQG KATSSETKES TDIEKAILEQ 
      1460       1470       1480       1490       1500
QVLSEELTTK KEQVSEAIKT SQIFLAKHGH KLSEKEKKQI SEQLNALNKA 
      1510       1520       1530       1540       1550
YHDLCDGSAN QLQQLQSQLA HQTEQKTLQK QQNTCHQQLE DLCSWVGQAE 
      1560       1570       1580       1590       1600
RALAGHQGRT TQQDLSALQK NQSDLKDLQD DIQNHATSFA TVVKDIEGFM 
      1610       1620       1630       1640       1650
EENQTKLSPR ELTALREKLH QAKEQYEALQ EQTRVAQKEL EEAVTSALQQ 
      1660       1670       1680       1690       1700
ETEKSKAAKE LAENKKKIDA LLNWVTSVGS SGGQLLTSLP GMEQLSGASL 
      1710       1720       1730       1740       1750
KKGALDTTDG YMGVNQAPEK LDKQCEMMKA RHQELLSQQQ NFILATQSAQ 
      1760       1770       1780       1790       1800
AFLDQHGHNL TPEEQQMLRE KLGELKEQYS TSLAQSEAEL KQVQTLQDEL 
      1810       1820       1830       1840       1850
QKFMQDHREF ESWLKRSEKE LENMHKGGSS PEALPSLLKR QGSFSEDVIS 
      1860       1870       1880       1890       1900
HKGDLRFVTI SGQKVLDMEN SFKEGKEPSE IGNLIKDKLK DATERYTALH 
      1910       1920       1930       1940       1950
SKCTRLGSHL NMLLGQYHQF QNSADSLQAW MQTCEANVEK LLSDTVASDP 
      1960       1970       1980       1990       2000
GVLQEQLATT KQLQEELAEH QVPVEKLQKV ARDIMEIEGE PAPDHKHVQE 
      2010       2020       2030       2040       2050
TTDSILSHFQ SLSCSLAERS SLLQKAIAQS QSVQESLESL LQSIGEVEQN 
      2060       2070       2080       2090       2100
LEGKQVSSLS SGVIQEALAT NMKLKQDVAR QKSSLEATRE MVTRFMETAD 
      2110       2120       2130       2140       2150
STTAAVLQGK LAEVSQRFEQ LCLQQQEKES SLKKLLPQAE MFEHLSGKLQ 
      2160       2170       2180       2190       2200
QFMENKSRML ASGNQPDQDI THFFQQIQEL NLEMEDQQEN LGTLEHLVTE 
      2210       2220       2230       2240       2250
LSSCGFALDL SQHQDRVQNL RKDFTELQKI VKEREKDASS CQEQLDEFRK 
      2260       2270       2280       2290       2300
LVRTFQKWLK ETEGSIPPTE TSMSAKELEK QIEHLKSLLD DWASKGTLME 
      2310       2320       2330       2340       2350
EINYKGTSLE NLIMEITAPD SQGKTGSILP SVGSSVGSVN GYHTCKDLTE 
      2360       2370       2380       2390       2400
IQCDMSDVNL KYEKLGGVLH ERQESLQAIL NRMEEVHKEA NSVLQWLESK 
      2410       2420       2430       2440       2450
EEVLKSMDAM SSPTKTETVK AQAESNKAFL AELEQNSPKI QKVKEALAGL 
      2460       2470       2480       2490       2500
LVTYPNSQEA ENWKKIQEEL NSRWERATEV TVARQRQLEE SASHLACFQA 
      2510       2520       2530       2540       2550
AESQLRPWLM EKELMMGVLG PLSIDPNMLN AQKQQVQFML KEFEARRQQH 
      2560       2570       2580       2590       2600
EQLNEAAQGI LTGPGDVSLS TSQVQKELQS INQKWVELTD KLNSRSSQID 
      2610       2620       2630       2640       2650
QAIVKSTQYQ ELLQDLSEKV RAVGQRLSGQ SAISTQPEAV KQQLEETSEI 
      2660       2670       2680       2690       2700
RSDLEQLDHE VKEAQTLCDE LSVLIGEQYL KDELKKRLET VALPLQGLED 
      2710       2720       2730       2740       2750
LAADRMNRLQ AALASTQQFQ QMFDELRTWL DDKQSQQAKN CPISAKLERL 
      2760       2770       2780       2790       2800
QSQLQENEEF QKSLNQHSGS YEVIVAEGES LLLSVPPGEE KRTLQNQLVE 
      2810       2820       2830       2840       2850
LKNHWEELSR KTADRQSRLK DCMQKAQKYQ WHVEDLVPWI EDCKAKMSEL 
      2860       2870       2880       2890       2900
RVTLDPVQLE SSLLRSKAML SEVEKRRSLL EILNSAADIL INSSEADEDG 
      2910       2920       2930       2940       2950
IRDEKAGINQ NMDAITEELQ AKTGSLEEMT QRLKEFQESF KNIEKKVEGA 
      2960       2970       2980       2990       3000
KHQLEIFDAL GSQACSNKNL EKLRAQQEVL QALEPQVDYL RNFTQGLVED 
      3010       3020       3030       3040       3050
APDGSDASQL LHQAEVAQQE FLEVKQRVNS GCVMMENKLE GIGQFHCRVR 
      3060       3070       3080       3090       3100
EMFSQLADLD DELDGMGAIG RDTDSLQSQI EDVRLFLNKI QVLKLDIEAS 
      3110       3120       3130       3140       3150
EAECRHMLEE EGTLDLLGLK RELEALNKQC GKLTERGKAR QEQLELTLGR 
      3160       3170       3180       3190       3200
VEDFYRKLKG LNDATTAAEE AEALQWVVGT EVEIINQQLA DFKMFQKEQV 
      3210       3220       3230       3240       3250
DPLQMKLQQV NGLGQGLIQS AGKDCDVQGL EHDMEEINTR WNTLNKKVAQ 
      3260       3270       3280       3290       3300
RIAQLQEALL HCGKFQDALE PLLSWLADTE ELIANQKPPS AEYKVVKAQI 
      3310       3320       3330       3340       3350
QEQKLLQRLL DDRKATVDML QAEGGRIAQS AELADREKIT GQLQSLESRW 
      3360       3370       3380       3390       3400
TELLSKAAAR QKQLEDILIL AKQFHETAEP ISDFLSVTEK KLANSEPVGT 
      3410       3420       3430       3440       3450
QTAKIQQQII RHKALEEDIE NHATDVHQAV KIGQSLSSLT SPAEQGVLSE 
      3460       3470       3480       3490       3500
KIDSLQARYS EIQDRCCRKA TLLDQALSNA RLFGEDEVEV LNWLAEVEDK 
      3510       3520       3530       3540       3550
LGSVFVKDFK QDVLHRQHAD HLALNEEIVN RKKNVDQAIK NGQALLKQTT 
      3560       3570       3580       3590       3600
GEEVLLIQEK LDGIKTRYAD ITVTSSKALR TLEQARQLAT KFQSTYEELT 
      3610       3620       3630       3640       3650
GWLREVEEEL AASGGQSPTG EQIPQFQQRQ KELKKEVMEH RLVLDTVNEV 
      3660       3670       3680       3690       3700
SRALLELVPW RAREGLDKLV SDANEQYKLV SDTIGQRVDE IDAAIQRSQQ 
      3710       3720       3730       3740       3750
YEQAADAELA WVAETKRKLM ALGPIRLEQD QTTAQLQVQK AFSIDIIRHK 
      3760       3770       3780       3790       3800
DSMDELFSHR SEIFGTCGEE QKTVLQEKTE SLIQQYEAIS LLNSERYARL 
      3810       3820       3830       3840       3850
ERAQVLVNQF WETYEELSPW IEETRALIAQ LPPPAIDHEQ LRQQQEEMRQ 
      3860       3870       3880       3890       3900
LRESIAEHKP HIDKLLKIGP QLKELNPEEG EMVEEKYQKA ENMYAQIKEE 
      3910       3920       3930       3940       3950
VRQRALALDE AVSQSTQFHD KIEPMLETLE NLSSRLRMPP LIPAEVDKIR 
      3960       3970       3980       3990       4000
ECISDNKSAT VELEKLQPSF EALKHRGEEL IGRSQGADKD LAAKEIQDKL 
      4010       4020       4030       4040       4050
DQMVFFWEDI KARAEEREIK FLDVLELAEK FWYDMAALLT TIKDTQDIVH 
      4060       4070       4080       4090       4100
DLESPGIDPS IIKQQVEAAE TIKEETDGLH EELEFIRILG ADLIFACGET 
      4110       4120       4130       4140       4150
EKPEVRKSID EMNNAWENLN KTWKERLEKL EDAMQAAVQY QDTLQAMFDW 
      4160       4170       4180       4190       4200
LDNTVIKLCT MPPVGTDLNT VKDQLNEMKE FKVEVYQQQI EMEKLNHQGE 
      4210       4220       4230       4240       4250
LMLKKATDET DRDIIREPLT ELKHLWENLG EKIAHRQHKL EEVLLALGQF 
      4260       4270       4280       4290       4300
QHALEELMSW LTHTEELLDA QRPISGDPKV IEVELAKHHV LKNDVLAHQA 
      4310       4320       4330       4340       4350
TVETVNKAGN ELLESSAGDD ASSLRSRLET MNQCWESVLQ KTEEREQQLQ 
      4360       4370       4380       4390       4400
STLQQAQGFH SEIEDFLLEL TRMESQLSAS KPTGGLPETA REQLDTHMEL 
      4410       4420       4430       4440       4450
YSQLKAKEET YNQLLDKGRL MLLSRDDSGS GSKTEQSVAL LEQKWHVVSS 
      4460       4470       4480       4490       4500
KMEERKSKLE EALNLATEFQ NSLQEFINWL TLAEQSLNIA SPPSLILNTV 
      4510       4520       4530       4540       4550
LSQIEEHKVF ANEVNAHRDQ IIELDQTGNQ LKFLSQKQDV VLIKNLLVSV 
      4560       4570       4580       4590       4600
QSRWEKVVQR SIERGRSLDD ARKRAKQFHE AWKKLIDWLE DAESHLDSEL 
      4610       4620       4630       4640       4650
EISNDPDKIK LQLSKHKEFQ KTLGGKQPVY DTTIRTGRAL KEKTLLPEDT 
      4660       4670       4680       4690       4700
QKLDNFLGEV RDKWDTVCGK SVERQHKLEE ALLFSGQFMD ALQALVDWLY 
      4710       4720       4730       4740       4750
KVEPQLAEDQ PVHGDLDLVM NLMDAHKVFQ KELGKRTGTV QVLKRSGREL 
      4760       4770       4780       4790       4800
IENSRDDTTW VKGQLQELST RWDTVCKLSV SKQSRLEQAL KQAEVFRDTV 
      4810       4820       4830       4840       4850
HMLLEWLSEA EQTLRFRGAL PDDTEALQSL IDTHKEFMKK VEEKRVDVNS 
      4860       4870       4880       4890       4900
AVAMGEVILA VCHPDCITTI KHWITIIRAR FEEVTQEFKT SLGNMVKPVS 
      4910       4920       4930       4940       4950
TKIRKISWAW WHKSTTLIQR DQEPIPQNID RVKALIAEHQ VLTLFILFSK 
      4960       4970       4980       4990       5000
ASRHVLPTHC SPQVTTVLPP SFFRKSLSQP APPPMPILSQ SEAKNPRINQ 
      5010       5020       5030       5040       5050
LSARWQQVWL LALERQRKLN DALDRLEELK EFANFDFDVW RKKYMRWMNH 
      5060       5070       5080       5090       5100
KKSRVMDFFR RIDKDQDGKI TRQEFIDGIL ASKFPTTKLE MTAVADIFDR 
      5110       5120       5130       5140       5150
DGDGYIDYYE FVAALHPNKD AYRPTTDADK IEDEVTRQVA QCKCAKRFQV 
      5160       5170       5180       5190       5200
EQIGENKYRF GDSQQLRLVR ILRSTVMVRV GGGWMALDEF LVKNDPCRAR 
      5210       5220       5230       5240       5250
GRTNIELREK FILPEGASQG MTPFRSRGRR SKPSSRAASP TRSSSSASQS 
      5260       5270       5280       5290       5300
NHSCTSMPSS PATPASGTKV IPSSGSKLKR PTPTFHSSRT SLAGDTSNSS 
      5310       5320       5330       5340       5350
SPASTGAKTN RADPKKSASR PGSRAGSRAG SRASSRRGSD ASDFDLLETQ 
      5360       5370       5380       5390 
SACSDTSESS AAGGQGNSRR GLNKPSKIPT MSKKTTTASP RTPGPKR
Length:5,397
Mass (Da):616,295
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6CD792D5DC350B06
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3HD65A0A2I3HD65_NOMLE
Uncharacterized protein
MACF1
7,284Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3GJ43A0A2I3GJ43_NOMLE
Uncharacterized protein
MACF1
7,278Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3HBV1A0A2I3HBV1_NOMLE
Uncharacterized protein
MACF1
7,315Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3HNL3A0A2I3HNL3_NOMLE
Uncharacterized protein
MACF1
7,114Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3H5X9A0A2I3H5X9_NOMLE
Calponin-homology (CH) domain-conta...
MACF1
1,054Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
ADFV01076415 Genomic DNA No translation available.
ADFV01076416 Genomic DNA No translation available.
ADFV01076417 Genomic DNA No translation available.
ADFV01076418 Genomic DNA No translation available.
ADFV01076419 Genomic DNA No translation available.
ADFV01076420 Genomic DNA No translation available.
ADFV01076421 Genomic DNA No translation available.
ADFV01076422 Genomic DNA No translation available.
ADFV01076423 Genomic DNA No translation available.
ADFV01076424 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSNLET00000015195; ENSNLEP00000014476; ENSNLEG00000011857

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADFV01076415 Genomic DNA No translation available.
ADFV01076416 Genomic DNA No translation available.
ADFV01076417 Genomic DNA No translation available.
ADFV01076418 Genomic DNA No translation available.
ADFV01076419 Genomic DNA No translation available.
ADFV01076420 Genomic DNA No translation available.
ADFV01076421 Genomic DNA No translation available.
ADFV01076422 Genomic DNA No translation available.
ADFV01076423 Genomic DNA No translation available.
ADFV01076424 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi61853.ENSNLEP00000014476

Genome annotation databases

EnsembliENSNLET00000015195; ENSNLEP00000014476; ENSNLEG00000011857

Phylogenomic databases

eggNOGiKOG0516, Eukaryota
GeneTreeiENSGT00940000155824
HOGENOMiCLU_000015_1_0_1
InParanoidiG1RML2

Family and domain databases

CDDicd00014, CH, 2 hits
cd00051, EFh, 1 hit
cd00176, SPEC, 16 hits
Gene3Di1.10.418.10, 2 hits
3.30.920.20, 1 hit
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR23169, PTHR23169, 8 hits
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 18 hits
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 32 hits
SUPFAMiSSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1RML2_NOMLE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1RML2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: February 28, 2018
Last modified: May 25, 2022
This is version 70 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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