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Entry version 70 (25 May 2022)
Sequence version 2 (28 Feb 2018)
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Protein
Submitted name:

Uncharacterized protein

Gene

MACF1

Organism
Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation
LigandMetal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MACF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri61853 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHylobatidaeNomascus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001073 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projectionARBA annotation, Cytoplasm, CytoskeletonPROSITE-ProRule annotation, MembraneARBA annotation, MicrotubuleARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
61853.ENSNLEP00000014476

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini66 – 169Calponin-homology (CH)InterPro annotationAdd BLAST104
Domaini182 – 286Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini851 – 908SH3InterPro annotationAdd BLAST58
Domaini5050 – 5085EF-handInterPro annotationAdd BLAST36
Domaini5086 – 5121EF-handInterPro annotationAdd BLAST36
Domaini5126 – 5198GARInterPro annotationAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni5214 – 5397DisorderedSequence analysisAdd BLAST184

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili233 – 253Sequence analysisAdd BLAST21
Coiled coili465 – 485Sequence analysisAdd BLAST21
Coiled coili490 – 517Sequence analysisAdd BLAST28
Coiled coili1029 – 1049Sequence analysisAdd BLAST21
Coiled coili1386 – 1416Sequence analysisAdd BLAST31
Coiled coili1480 – 1500Sequence analysisAdd BLAST21
Coiled coili1505 – 1532Sequence analysisAdd BLAST28
Coiled coili1568 – 1588Sequence analysisAdd BLAST21
Coiled coili1612 – 1646Sequence analysisAdd BLAST35
Coiled coili1776 – 1806Sequence analysisAdd BLAST31
Coiled coili2170 – 2197Sequence analysisAdd BLAST28
Coiled coili2210 – 2237Sequence analysisAdd BLAST28
Coiled coili2275 – 2295Sequence analysisAdd BLAST21
Coiled coili2380 – 2400Sequence analysisAdd BLAST21
Coiled coili2540 – 2560Sequence analysisAdd BLAST21
Coiled coili2599 – 2619Sequence analysisAdd BLAST21
Coiled coili2640 – 2674Sequence analysisAdd BLAST35
Coiled coili2791 – 2811Sequence analysisAdd BLAST21
Coiled coili2912 – 2953Sequence analysisAdd BLAST42
Coiled coili3090 – 3110Sequence analysisAdd BLAST21
Coiled coili3116 – 3136Sequence analysisAdd BLAST21
Coiled coili3880 – 3900Sequence analysisAdd BLAST21
Coiled coili4113 – 4140Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5233 – 5312Polar residuesSequence analysisAdd BLAST80
Compositional biasi5344 – 5397Polar residuesSequence analysisAdd BLAST54

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0516, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155824

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000015_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1RML2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits
cd00051, EFh, 1 hit
cd00176, SPEC, 16 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
3.30.920.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR23169, PTHR23169, 8 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 18 hits
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 32 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

G1RML2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
FFFFETESCS VSQAGVQWHN FGSLQPPPPR LKQFSCLSLL SSWDYRHVPL
60 70 80 90 100
TCPCLLCVSF TDERDRVQKK TFTKWVNKHL MKVRKHINDL YEDLRDGHNL
110 120 130 140 150
ISLLEVLSGI KLPREKGRMR FHRLQNVQIA LDFLKQRQVK LVNIRNDDIT
160 170 180 190 200
DGNPKLTLGL IWTIILHFQI SDIYISGESG DMSAKEKLLL WTQKVTAGYT
210 220 230 240 250
GIKCTNFSSC WSDGKMFNAL IHRYRPDLVD MERVQIQSNR ENLEQAFEVA
260 270 280 290 300
ERLGVTRLLD AEDVDVPSPD EKSVITYVSS IYDAFPKVPE GGEGISATEV
310 320 330 340 350
DSRWQEYQSR VDSLIPWIKQ HTILMSDKTF PQNPVELKAL YNQYIHFKET
360 370 380 390 400
EILAKEREKG RIEELYKLLE VWIEFGRIKL PQGYHPNDVE EEWGKLIIEM
410 420 430 440 450
LEREKSLRPA VERLELLLQI ANKIQNGALN CEEKLTLAKN TLQADAAHLE
460 470 480 490 500
SGQPVQCESD VIMYIQECEG LIRQLQVDLQ ILRDENYYQL EELAFRVMRL
510 520 530 540 550
QDELVTLRLE CTNLYRKGHF TSLELVPPST LTTTHLKAEP LTKATHSSST
560 570 580 590 600
SWFRKPMTRA ELVAISSSED EGNLRFVYEL LSWVEEMQMK LERAEWGNDL
610 620 630 640 650
PSVELQLEMQ QHIHTSVEEL GSSVKEARLY EGKMSQNFHT SYAETLGKLE
660 670 680 690 700
TQYCKLKETS SFRMRHLQSL HKFVSRATAE LIWLNEKEEE ELAYDWSDNN
710 720 730 740 750
SNISAKRNYF SELTMELEEK QDVFRSLQDT AELLSLENHP AKQTVEAYSA
760 770 780 790 800
AVQSQLQWMK QLCLCVEQHV KENTAYFQLE SFLRNLQDSI KRKYSCDHNT
810 820 830 840 850
SLSRLEDLLQ DSMVGDEKEQ LIQSKSSVAS LVGRSKTIVQ LKPRSPDHVL
860 870 880 890 900
KSTISVKAIC DYRQIEITIC KNDECVLEDN SQRTKWKVIS PTGNEAMVPS
910 920 930 940 950
VCFLIPPPNK DAIEMASRVE QSYQKVMALW HQLHVNTKSL ISWNYLRKDL
960 970 980 990 1000
DLVQTWNLEK LRSSAPGECH QIMKNLQGHY EDFLQDSRDS VLFSVADRLR
1010 1020 1030 1040 1050
LEKEVEACKA HFQHLMKSME NEDKEETVAK MYISELKNIR LRLEEYEQRV
1060 1070 1080 1090 1100
VKRIQSLASS RTDKDARQDN ALRIAEQEHT QEDLQKLRSD LDAVSMKCDS
1110 1120 1130 1140 1150
FLHQSPSSSS VPTLRSELNL LVEKMDHVYG LSTVYLNKLK TVDVIVRSIQ
1160 1170 1180 1190 1200
DAELLVKGYE IKLSQEEAVL ADLSALEAHR STLRHWLSDV KDKNSVFSVL
1210 1220 1230 1240 1250
DEEIAKAKAV AEQMSRLTPE RNLDLERYQE KGSQLQERWH RVIAQLEIRQ
1260 1270 1280 1290 1300
SELESIQEVL GDYRACHGTL IKWIEETTAQ QEMMKPGQAE DSRVLSEQLS
1310 1320 1330 1340 1350
QQTALFAEIE RNQTKLDQCQ KFSQQYSTIV KDYELQLMTY KAFVESQQKS
1360 1370 1380 1390 1400
PGKRRRMLSS SDAITQEFMD LRTRYTALVT LTTQHVKYIS DALRRLEEEE
1410 1420 1430 1440 1450
KVVEEEKQEH VEKVKELLGW VSTLARNTQG KATSSETKES TDIEKAILEQ
1460 1470 1480 1490 1500
QVLSEELTTK KEQVSEAIKT SQIFLAKHGH KLSEKEKKQI SEQLNALNKA
1510 1520 1530 1540 1550
YHDLCDGSAN QLQQLQSQLA HQTEQKTLQK QQNTCHQQLE DLCSWVGQAE
1560 1570 1580 1590 1600
RALAGHQGRT TQQDLSALQK NQSDLKDLQD DIQNHATSFA TVVKDIEGFM
1610 1620 1630 1640 1650
EENQTKLSPR ELTALREKLH QAKEQYEALQ EQTRVAQKEL EEAVTSALQQ
1660 1670 1680 1690 1700
ETEKSKAAKE LAENKKKIDA LLNWVTSVGS SGGQLLTSLP GMEQLSGASL
1710 1720 1730 1740 1750
KKGALDTTDG YMGVNQAPEK LDKQCEMMKA RHQELLSQQQ NFILATQSAQ
1760 1770 1780 1790 1800
AFLDQHGHNL TPEEQQMLRE KLGELKEQYS TSLAQSEAEL KQVQTLQDEL
1810 1820 1830 1840 1850
QKFMQDHREF ESWLKRSEKE LENMHKGGSS PEALPSLLKR QGSFSEDVIS
1860 1870 1880 1890 1900
HKGDLRFVTI SGQKVLDMEN SFKEGKEPSE IGNLIKDKLK DATERYTALH
1910 1920 1930 1940 1950
SKCTRLGSHL NMLLGQYHQF QNSADSLQAW MQTCEANVEK LLSDTVASDP
1960 1970 1980 1990 2000
GVLQEQLATT KQLQEELAEH QVPVEKLQKV ARDIMEIEGE PAPDHKHVQE
2010 2020 2030 2040 2050
TTDSILSHFQ SLSCSLAERS SLLQKAIAQS QSVQESLESL LQSIGEVEQN
2060 2070 2080 2090 2100
LEGKQVSSLS SGVIQEALAT NMKLKQDVAR QKSSLEATRE MVTRFMETAD
2110 2120 2130 2140 2150
STTAAVLQGK LAEVSQRFEQ LCLQQQEKES SLKKLLPQAE MFEHLSGKLQ
2160 2170 2180 2190 2200
QFMENKSRML ASGNQPDQDI THFFQQIQEL NLEMEDQQEN LGTLEHLVTE
2210 2220 2230 2240 2250
LSSCGFALDL SQHQDRVQNL RKDFTELQKI VKEREKDASS CQEQLDEFRK
2260 2270 2280 2290 2300
LVRTFQKWLK ETEGSIPPTE TSMSAKELEK QIEHLKSLLD DWASKGTLME
2310 2320 2330 2340 2350
EINYKGTSLE NLIMEITAPD SQGKTGSILP SVGSSVGSVN GYHTCKDLTE
2360 2370 2380 2390 2400
IQCDMSDVNL KYEKLGGVLH ERQESLQAIL NRMEEVHKEA NSVLQWLESK
2410 2420 2430 2440 2450
EEVLKSMDAM SSPTKTETVK AQAESNKAFL AELEQNSPKI QKVKEALAGL
2460 2470 2480 2490 2500
LVTYPNSQEA ENWKKIQEEL NSRWERATEV TVARQRQLEE SASHLACFQA
2510 2520 2530 2540 2550
AESQLRPWLM EKELMMGVLG PLSIDPNMLN AQKQQVQFML KEFEARRQQH
2560 2570 2580 2590 2600
EQLNEAAQGI LTGPGDVSLS TSQVQKELQS INQKWVELTD KLNSRSSQID
2610 2620 2630 2640 2650
QAIVKSTQYQ ELLQDLSEKV RAVGQRLSGQ SAISTQPEAV KQQLEETSEI
2660 2670 2680 2690 2700
RSDLEQLDHE VKEAQTLCDE LSVLIGEQYL KDELKKRLET VALPLQGLED
2710 2720 2730 2740 2750
LAADRMNRLQ AALASTQQFQ QMFDELRTWL DDKQSQQAKN CPISAKLERL
2760 2770 2780 2790 2800
QSQLQENEEF QKSLNQHSGS YEVIVAEGES LLLSVPPGEE KRTLQNQLVE
2810 2820 2830 2840 2850
LKNHWEELSR KTADRQSRLK DCMQKAQKYQ WHVEDLVPWI EDCKAKMSEL
2860 2870 2880 2890 2900
RVTLDPVQLE SSLLRSKAML SEVEKRRSLL EILNSAADIL INSSEADEDG
2910 2920 2930 2940 2950
IRDEKAGINQ NMDAITEELQ AKTGSLEEMT QRLKEFQESF KNIEKKVEGA
2960 2970 2980 2990 3000
KHQLEIFDAL GSQACSNKNL EKLRAQQEVL QALEPQVDYL RNFTQGLVED
3010 3020 3030 3040 3050
APDGSDASQL LHQAEVAQQE FLEVKQRVNS GCVMMENKLE GIGQFHCRVR
3060 3070 3080 3090 3100
EMFSQLADLD DELDGMGAIG RDTDSLQSQI EDVRLFLNKI QVLKLDIEAS
3110 3120 3130 3140 3150
EAECRHMLEE EGTLDLLGLK RELEALNKQC GKLTERGKAR QEQLELTLGR
3160 3170 3180 3190 3200
VEDFYRKLKG LNDATTAAEE AEALQWVVGT EVEIINQQLA DFKMFQKEQV
3210 3220 3230 3240 3250
DPLQMKLQQV NGLGQGLIQS AGKDCDVQGL EHDMEEINTR WNTLNKKVAQ
3260 3270 3280 3290 3300
RIAQLQEALL HCGKFQDALE PLLSWLADTE ELIANQKPPS AEYKVVKAQI
3310 3320 3330 3340 3350
QEQKLLQRLL DDRKATVDML QAEGGRIAQS AELADREKIT GQLQSLESRW
3360 3370 3380 3390 3400
TELLSKAAAR QKQLEDILIL AKQFHETAEP ISDFLSVTEK KLANSEPVGT
3410 3420 3430 3440 3450
QTAKIQQQII RHKALEEDIE NHATDVHQAV KIGQSLSSLT SPAEQGVLSE
3460 3470 3480 3490 3500
KIDSLQARYS EIQDRCCRKA TLLDQALSNA RLFGEDEVEV LNWLAEVEDK
3510 3520 3530 3540 3550
LGSVFVKDFK QDVLHRQHAD HLALNEEIVN RKKNVDQAIK NGQALLKQTT
3560 3570 3580 3590 3600
GEEVLLIQEK LDGIKTRYAD ITVTSSKALR TLEQARQLAT KFQSTYEELT
3610 3620 3630 3640 3650
GWLREVEEEL AASGGQSPTG EQIPQFQQRQ KELKKEVMEH RLVLDTVNEV
3660 3670 3680 3690 3700
SRALLELVPW RAREGLDKLV SDANEQYKLV SDTIGQRVDE IDAAIQRSQQ
3710 3720 3730 3740 3750
YEQAADAELA WVAETKRKLM ALGPIRLEQD QTTAQLQVQK AFSIDIIRHK
3760 3770 3780 3790 3800
DSMDELFSHR SEIFGTCGEE QKTVLQEKTE SLIQQYEAIS LLNSERYARL
3810 3820 3830 3840 3850
ERAQVLVNQF WETYEELSPW IEETRALIAQ LPPPAIDHEQ LRQQQEEMRQ
3860 3870 3880 3890 3900
LRESIAEHKP HIDKLLKIGP QLKELNPEEG EMVEEKYQKA ENMYAQIKEE
3910 3920 3930 3940 3950
VRQRALALDE AVSQSTQFHD KIEPMLETLE NLSSRLRMPP LIPAEVDKIR
3960 3970 3980 3990 4000
ECISDNKSAT VELEKLQPSF EALKHRGEEL IGRSQGADKD LAAKEIQDKL
4010 4020 4030 4040 4050
DQMVFFWEDI KARAEEREIK FLDVLELAEK FWYDMAALLT TIKDTQDIVH
4060 4070 4080 4090 4100
DLESPGIDPS IIKQQVEAAE TIKEETDGLH EELEFIRILG ADLIFACGET
4110 4120 4130 4140 4150
EKPEVRKSID EMNNAWENLN KTWKERLEKL EDAMQAAVQY QDTLQAMFDW
4160 4170 4180 4190 4200
LDNTVIKLCT MPPVGTDLNT VKDQLNEMKE FKVEVYQQQI EMEKLNHQGE
4210 4220 4230 4240 4250
LMLKKATDET DRDIIREPLT ELKHLWENLG EKIAHRQHKL EEVLLALGQF
4260 4270 4280 4290 4300
QHALEELMSW LTHTEELLDA QRPISGDPKV IEVELAKHHV LKNDVLAHQA
4310 4320 4330 4340 4350
TVETVNKAGN ELLESSAGDD ASSLRSRLET MNQCWESVLQ KTEEREQQLQ
4360 4370 4380 4390 4400
STLQQAQGFH SEIEDFLLEL TRMESQLSAS KPTGGLPETA REQLDTHMEL
4410 4420 4430 4440 4450
YSQLKAKEET YNQLLDKGRL MLLSRDDSGS GSKTEQSVAL LEQKWHVVSS
4460 4470 4480 4490 4500
KMEERKSKLE EALNLATEFQ NSLQEFINWL TLAEQSLNIA SPPSLILNTV
4510 4520 4530 4540 4550
LSQIEEHKVF ANEVNAHRDQ IIELDQTGNQ LKFLSQKQDV VLIKNLLVSV
4560 4570 4580 4590 4600
QSRWEKVVQR SIERGRSLDD ARKRAKQFHE AWKKLIDWLE DAESHLDSEL
4610 4620 4630 4640 4650
EISNDPDKIK LQLSKHKEFQ KTLGGKQPVY DTTIRTGRAL KEKTLLPEDT
4660 4670 4680 4690 4700
QKLDNFLGEV RDKWDTVCGK SVERQHKLEE ALLFSGQFMD ALQALVDWLY
4710 4720 4730 4740 4750
KVEPQLAEDQ PVHGDLDLVM NLMDAHKVFQ KELGKRTGTV QVLKRSGREL
4760 4770 4780 4790 4800
IENSRDDTTW VKGQLQELST RWDTVCKLSV SKQSRLEQAL KQAEVFRDTV
4810 4820 4830 4840 4850
HMLLEWLSEA EQTLRFRGAL PDDTEALQSL IDTHKEFMKK VEEKRVDVNS
4860 4870 4880 4890 4900
AVAMGEVILA VCHPDCITTI KHWITIIRAR FEEVTQEFKT SLGNMVKPVS
4910 4920 4930 4940 4950
TKIRKISWAW WHKSTTLIQR DQEPIPQNID RVKALIAEHQ VLTLFILFSK
4960 4970 4980 4990 5000
ASRHVLPTHC SPQVTTVLPP SFFRKSLSQP APPPMPILSQ SEAKNPRINQ
5010 5020 5030 5040 5050
LSARWQQVWL LALERQRKLN DALDRLEELK EFANFDFDVW RKKYMRWMNH
5060 5070 5080 5090 5100
KKSRVMDFFR RIDKDQDGKI TRQEFIDGIL ASKFPTTKLE MTAVADIFDR
5110 5120 5130 5140 5150
DGDGYIDYYE FVAALHPNKD AYRPTTDADK IEDEVTRQVA QCKCAKRFQV
5160 5170 5180 5190 5200
EQIGENKYRF GDSQQLRLVR ILRSTVMVRV GGGWMALDEF LVKNDPCRAR
5210 5220 5230 5240 5250
GRTNIELREK FILPEGASQG MTPFRSRGRR SKPSSRAASP TRSSSSASQS
5260 5270 5280 5290 5300
NHSCTSMPSS PATPASGTKV IPSSGSKLKR PTPTFHSSRT SLAGDTSNSS
5310 5320 5330 5340 5350
SPASTGAKTN RADPKKSASR PGSRAGSRAG SRASSRRGSD ASDFDLLETQ
5360 5370 5380 5390
SACSDTSESS AAGGQGNSRR GLNKPSKIPT MSKKTTTASP RTPGPKR
Length:5,397
Mass (Da):616,295
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6CD792D5DC350B06
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3HD65A0A2I3HD65_NOMLE
Uncharacterized protein
MACF1
7,284Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3GJ43A0A2I3GJ43_NOMLE
Uncharacterized protein
MACF1
7,278Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3HBV1A0A2I3HBV1_NOMLE
Uncharacterized protein
MACF1
7,315Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3HNL3A0A2I3HNL3_NOMLE
Uncharacterized protein
MACF1
7,114Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3H5X9A0A2I3H5X9_NOMLE
Calponin-homology (CH) domain-conta...
MACF1
1,054Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
ADFV01076415 Genomic DNA No translation available.
ADFV01076416 Genomic DNA No translation available.
ADFV01076417 Genomic DNA No translation available.
ADFV01076418 Genomic DNA No translation available.
ADFV01076419 Genomic DNA No translation available.
ADFV01076420 Genomic DNA No translation available.
ADFV01076421 Genomic DNA No translation available.
ADFV01076422 Genomic DNA No translation available.
ADFV01076423 Genomic DNA No translation available.
ADFV01076424 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSNLET00000015195; ENSNLEP00000014476; ENSNLEG00000011857

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADFV01076415 Genomic DNA No translation available.
ADFV01076416 Genomic DNA No translation available.
ADFV01076417 Genomic DNA No translation available.
ADFV01076418 Genomic DNA No translation available.
ADFV01076419 Genomic DNA No translation available.
ADFV01076420 Genomic DNA No translation available.
ADFV01076421 Genomic DNA No translation available.
ADFV01076422 Genomic DNA No translation available.
ADFV01076423 Genomic DNA No translation available.
ADFV01076424 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi61853.ENSNLEP00000014476

Genome annotation databases

EnsembliENSNLET00000015195; ENSNLEP00000014476; ENSNLEG00000011857

Phylogenomic databases

eggNOGiKOG0516, Eukaryota
GeneTreeiENSGT00940000155824
HOGENOMiCLU_000015_1_0_1
InParanoidiG1RML2

Family and domain databases

CDDicd00014, CH, 2 hits
cd00051, EFh, 1 hit
cd00176, SPEC, 16 hits
Gene3Di1.10.418.10, 2 hits
3.30.920.20, 1 hit
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR23169, PTHR23169, 8 hits
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 18 hits
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 32 hits
SUPFAMiSSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1RML2_NOMLE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1RML2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: February 28, 2018
Last modified: May 25, 2022
This is version 70 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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