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Entry version 51 (12 Aug 2020)
Sequence version 2 (28 Feb 2018)
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Protein
Submitted name:

Uncharacterized protein

Gene

TNRC6A

Organism
Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRNA-mediated gene silencingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNRC6AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri61853 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHylobatidaeNomascus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001073 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
61853.ENSNLEP00000014436

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1061 – 1187Ago_hookInterPro annotationAdd BLAST127
Domaini1266 – 1465M_domainInterPro annotationAdd BLAST200
Domaini1490 – 1753TNRC6-PABC_bdgInterPro annotationAdd BLAST264

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 137DisorderedSequence analysisAdd BLAST137
Regioni159 – 275DisorderedSequence analysisAdd BLAST117
Regioni421 – 440DisorderedSequence analysisAdd BLAST20
Regioni479 – 502DisorderedSequence analysisAdd BLAST24
Regioni545 – 685DisorderedSequence analysisAdd BLAST141
Regioni704 – 1123DisorderedSequence analysisAdd BLAST420
Regioni1149 – 1180DisorderedSequence analysisAdd BLAST32
Regioni1235 – 1258DisorderedSequence analysisAdd BLAST24
Regioni1409 – 1441DisorderedSequence analysisAdd BLAST33
Regioni1562 – 1620DisorderedSequence analysisAdd BLAST59
Regioni1709 – 1731DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi36 – 94PolarSequence analysisAdd BLAST59
Compositional biasi95 – 109Pro-richSequence analysisAdd BLAST15
Compositional biasi159 – 216PolarSequence analysisAdd BLAST58
Compositional biasi241 – 275PolarSequence analysisAdd BLAST35
Compositional biasi545 – 662PolarSequence analysisAdd BLAST118
Compositional biasi663 – 685PolyampholyteSequence analysisAdd BLAST23
Compositional biasi704 – 723PolarSequence analysisAdd BLAST20
Compositional biasi735 – 768PolarSequence analysisAdd BLAST34
Compositional biasi787 – 804PolarSequence analysisAdd BLAST18
Compositional biasi818 – 936PolarSequence analysisAdd BLAST119
Compositional biasi968 – 990PolyampholyteSequence analysisAdd BLAST23
Compositional biasi997 – 1043PolarSequence analysisAdd BLAST47
Compositional biasi1080 – 1105PolarSequence analysisAdd BLAST26
Compositional biasi1711 – 1725Pro-richSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GW182 family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QPQQ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158180

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001298_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1RMH2

TreeFam database of animal gene trees

More...
TreeFami
TF329702

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019486, Argonaute_hook_dom
IPR026805, GW182_M_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A

The PANTHER Classification System

More...
PANTHERi
PTHR13020:SF28, PTHR13020:SF28, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10427, Ago_hook, 1 hit
PF12938, M_domain, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

G1RMH2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AKIAPLHSSL GNKCETLSKK KKKKPLLKAM CSVPEQIKPS VSQPQPANSN
60 70 80 90 100
NGTSTATSTN NNAKRATANN QQPQQQPQQQ PQQQQQQQQQ PQQQPQQQPP
110 120 130 140 150
QPQPQQQPQQ QPQALPRYPR EVPPRFRHQE HKQLLKRGQH FPVIAANLGS
160 170 180 190 200
AVKVLNSQSE SSALTNQQPQ NNGEVQNSKN QSDINHSTSG SHYENPQRGP
210 220 230 240 250
VSSTSDSSTN CKNAVVSDLS EKEAWPSVPG SDPELASECM DADSASSSES
260 270 280 290 300
EKNITIMASG NTGGEKDGLR NSTGLGSQNK FVVGSSSNNV GHGSSTGPWG
310 320 330 340 350
FSHGAIISTC QVSVDAPESK SESSNNRMNA WGTVSSSSNG GLNPSTLNSN
360 370 380 390 400
SNHGAWPVLE NNGLALKGPV GCGSSGINIQ CSTIGQMPNN QSINSKVSGG
410 420 430 440 450
STHGTWGSLQ ETCESEVSGT QKVSFSGQPQ NITTEMTGPN NTTNFMTSSL
460 470 480 490 500
PNSGSVQNNE LPSSNTGAWR VSTMNHPQMQ APSGMNGTSL SHLSNGESKS
510 520 530 540 550
GGSYGTTWGA YGSNYSGDKC SGPNGQANGD TVNATLMQPG VNGPMGTNFQ
560 570 580 590 600
VNTNKGGGVW ESGAANSQST SWGSGNGANS GGSRRGWGTP AQNTGTNLPS
610 620 630 640 650
VEWNKLPSNQ HSNDSANGNG KTFTNGWKST EEEDQGSATS QTNEQSSVWA
660 670 680 690 700
KTGGTVESDG STESTGRLEE KGTGESQSRD RRKVDQHTLL QSIVNRTDLD
710 720 730 740 750
PRVLSNSGWG QTPIKQNTAW DTETSPRGER KTDNGTEAWG SSATQTFNSG
760 770 780 790 800
ACIDKTSPNS NDTSSVSGWG DPKPALRWGD SKGSNCQGGW EDDSAATGMV
810 820 830 840 850
KSNQWGNCKE EKAAWNDSQK NKQGWGDGQK SSQGWSVSAS DNWGETSRSN
860 870 880 890 900
HWGEANKKSS SGGSDSDRSV SGWNELGKTS SFTWGNNINP NNSSGWDESS
910 920 930 940 950
KPTPSQGWGD PPKSNQSLGW GDSSKPVSSP DWNKQQDIVG SWGIPPATGK
960 970 980 990 1000
PPGTGWLGGP IPAPAKEEEP TGWEEPSPES IRRKMEIDDG TSAWGDPSKY
1010 1020 1030 1040 1050
NYKNVNMWNK NVPNGNSRSD QQAQVHQLLT PASAISNKEA SSGSGWGEPW
1060 1070 1080 1090 1100
GEPSTPATTV DNGTSAWGKP IDSGPSWGEP IAAASSTSTW GSSSVGPQAL
1110 1120 1130 1140 1150
SKSGPKSMQD GWCGDDMPLP GNRPTGWEEE EDVEIGMWNS NSSQELNSSL
1160 1170 1180 1190 1200
NWPPYTKKMS SKGLSGKKRR RERGMMKGGN KQEEAWINPF VKQFSNISFS
1210 1220 1230 1240 1250
RDSPEENVQS NKMDLSGGML QDKRMEIDKH SLNIGDYNRT VGKGPGSRPQ
1260 1270 1280 1290 1300
ISKESSMERN PYFDKDGIVA DESQNMQFMS SQSMKLPPSN SALPNQALGS
1310 1320 1330 1340 1350
IAGLGMQNLN SVRQVSPDYN VAMRCFMFGV GNTAPPAQPL SSSQPNLRAQ
1360 1370 1380 1390 1400
VPPPLLSPQV PVSLLKYAPN NGGLNPLFGP QQVAMLNQLS QLNQLSQISQ
1410 1420 1430 1440 1450
LQRLLAQQQR AQSQRSVPSG NRPQQDQQGR PLSVQQQMMQ QSRQLDPNLL
1460 1470 1480 1490 1500
VKQQTPPSQQ QPLHQPVMKS FLDNVMPHTT PELQKGPSPI NAFSNFPIGL
1510 1520 1530 1540 1550
NSNLNVNMDM NSIKEPQSRL RKWTTVDSIS VNTSLDQNSS KHGAISSGFR
1560 1570 1580 1590 1600
LEESPFVPYD FMNSSTSPAS PPGSIGDGWP RAKSPNGSSS VNWPPEFRPG
1610 1620 1630 1640 1650
EPWKGYPNID PETDPYVTPG SVINNLSINT VREVDHLRDR NSGSSSSLNT
1660 1670 1680 1690 1700
TLPSTSAWSS IRASNYNVPL SSTAQSTSAR NSDSKLTWSP GSVTNTSLAH
1710 1720 1730 1740 1750
ELWKVPLPPK NITAPSRPPP GLTGQKPPLS TWDNSPLRIG GGWGNSDARY
1760 1770 1780 1790 1800
TPGGFLWFIC ETLTSTNSQI DGSTLRTLCM QHGPLITFHL NLPHGNALVR
1810 1820 1830 1840 1850
YSSKEEVVKA QKSLHMCVLG NTTILAEFAS EEEISRFFAQ SQSLTPSPGW
1860 1870 1880 1890 1900
QSLGSSQSRL GSLDCSHSFS SRTDLNHWNG AGLSGTNCGD LHGTSLWGTP
1910 1920 1930 1940
HYSTSLWGPP SSSDPRGISS PSPINAFLSV DHLGGGGESM
Length:1,940
Mass (Da):207,643
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i148C80C75AB8B3BB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3HFT6A0A2I3HFT6_NOMLE
Uncharacterized protein
TNRC6A
1,876Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3HVN3A0A2I3HVN3_NOMLE
Uncharacterized protein
TNRC6A
1,924Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ADFV01197101 Genomic DNA No translation available.
ADFV01197102 Genomic DNA No translation available.
ADFV01197103 Genomic DNA No translation available.
ADFV01197104 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSNLET00000015154; ENSNLEP00000014436; ENSNLEG00000011851

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADFV01197101 Genomic DNA No translation available.
ADFV01197102 Genomic DNA No translation available.
ADFV01197103 Genomic DNA No translation available.
ADFV01197104 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi61853.ENSNLEP00000014436

Genome annotation databases

EnsembliENSNLET00000015154; ENSNLEP00000014436; ENSNLEG00000011851

Phylogenomic databases

eggNOGiENOG502QPQQ, Eukaryota
GeneTreeiENSGT00940000158180
HOGENOMiCLU_001298_3_1_1
InParanoidiG1RMH2
TreeFamiTF329702

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR019486, Argonaute_hook_dom
IPR026805, GW182_M_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A
PANTHERiPTHR13020:SF28, PTHR13020:SF28, 1 hit
PfamiView protein in Pfam
PF10427, Ago_hook, 1 hit
PF12938, M_domain, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1RMH2_NOMLE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1RMH2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: February 28, 2018
Last modified: August 12, 2020
This is version 51 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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