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Protein
Submitted name:

Tet methylcytosine dioxygenase 1

Gene

TET1

Organism
Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri584 – 625CXXC-typePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Tet methylcytosine dioxygenase 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TET1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri61853 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHylobatidaeNomascus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001073 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
61853.ENSNLEP00000014341

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini584 – 625CXXC-typeInterPro annotationAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2063 – 2090Sequence analysisAdd BLAST28

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri584 – 625CXXC-typePROSITE-ProRule annotationAdd BLAST42

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE22 Eukaryota
ENOG410XPWW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158935

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1RM77

KEGG Orthology (KO)

More...
KOi
K13097

Identification of Orthologs from Complete Genome Data

More...
OMAi
NQKAHPL

Database of Orthologous Groups

More...
OrthoDBi
29059at2759

TreeFam database of animal gene trees

More...
TreeFami
TF324004

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024779 2OGFeDO_noxygenase_dom
IPR040175 TET1/2/3
IPR002857 Znf_CXXC

The PANTHER Classification System

More...
PANTHERi
PTHR23358 PTHR23358, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12851 Tet_JBP, 1 hit
PF02008 zf-CXXC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01333 Tet_JBP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51058 ZF_CXXC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

G1RM77-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRSRHARPS RLVRKEDVNK KKKNSQLRKT TKGANKNVAS VKTLSPGKLK
60 70 80 90 100
QLIQERDVKK KTEPKPPMPV RSLLTRAGAA RMNSDRTEVL FQNPESLTCN
110 120 130 140 150
GFTMALRSTS LSRRLSQPPL VIAKSKKVPL SKGLEKQHDC DYKILPDLGV
160 170 180 190 200
KHSENNSVPV QDTQVLPDIE TLIGVQNPSL LKGKSQETTQ SWSQRVEDSK
210 220 230 240 250
INIPTHSGPA AEILLGPLEG TRCGEGLFSE ETLNDTSGSP KMFAQDTVCA
260 270 280 290 300
PFPQRATPKV TSQGNPSIQL EELGSRVESL KLSDSYLDPI KSEHDCYPTS
310 320 330 340 350
SLNKVIPDLN LRNCLALGGS TSPTSVIKFL LAGSKQATLG AKPDHQEAFK
360 370 380 390 400
ATANQQEVSD TTSFLGQAFG AIPHQWELPG ADPVHGEALG ETPDLPEIPG
410 420 430 440 450
AIPVQGEVFG TILDQQETLG MSGSVVPDLP VFLPVPPNPI ATFNAPSKWP
460 470 480 490 500
EPQSTVSYGL AVQGAIQILP LGSGHTPQSS SNSEKNSLPP VMAISNVENE
510 520 530 540 550
KQVHISFLPA NTQEFPLAPE RGLFHASLGV AQLSQAGPSK LDRGNSQVSV
560 570 580 590 600
TSTVHVVNTT VVTMAVPMVS TSSSSYTTLL PTLEKKKRKR CGVCEPCQQK
610 620 630 640 650
TNCGECTYCK NRKNSHQICK KRKCEELKKK PSVVVPLEVI KENKRPQREK
660 670 680 690 700
KPKVLKADFD NKPVNGPKSE SMDYSRCGHG EEQKLELNPH TVENVTKNED
710 720 730 740 750
SMTGIEVEKW TQNKKSQLTD HVKGDFSANV PEAEKSKNSE VDKKRTKSPK
760 770 780 790 800
LFVQTVRNGI KHVHYLPAET NVSFKKFNIE EFGKTLENNS YKFLKDTANH
810 820 830 840 850
NNAMSSVATD MSCDHLKGRS NVLVFQQPGF NCSSIPHSSH SIINRHASIH
860 870 880 890 900
NEGDQPKTPE NMPSKEPKHR SPVQPSLLSL MKDRRLTLEQ VVAIEALTQL
910 920 930 940 950
SEAPSENSSP SKSEKDEESE QRTASLLNSC KAILYTVRKD LQDPNLQGEP
960 970 980 990 1000
PKLNHCPSLE KQSSCNTVVF NGQTTTLSNS HISSATNQAS TKSHEYSKVT
1010 1020 1030 1040 1050
NSLSLFIPKS NSSKIDTNKS IAQGIITLDS CSNDLHQLPP RNNEVDYCNQ
1060 1070 1080 1090 1100
LLDSSKKLDS DDLSCQDATH TQIEEDVATQ LTQLASIIKI NYIKPEDKKV
1110 1120 1130 1140 1150
ESTPTSLVTC NVQQKYNQEK ATIQQKPPSS VHNNHGSSLT KQKNPTQKKT
1160 1170 1180 1190 1200
KSTPSRDRRK KKPTVVSYQE NDRQRWEKLS YMYGTICDIW IASKFQNFGQ
1210 1220 1230 1240 1250
FCPHDFPTVF GKISSSTKIW KPLAQTRSIM QPKTVFPPLT QIKLQRYPES
1260 1270 1280 1290 1300
AEEKVKVEPL DSLSLFHLKT ESNGKAFTDK AYNSQVQLMV NANQKAHPLT
1310 1320 1330 1340 1350
QPSSPPNQCA NVMAGDDQIR FQQVVKEQLM HQRLPALPGI SHETPLPESA
1360 1370 1380 1390 1400
LTLRNVNVVC SGGITVVSTK SEEEVCSSSV GTSQFSTVDS AQKNFNDYAM
1410 1420 1430 1440 1450
NFFTNPTKNL VSITKDSELP TCSCLDRVIQ KDKGPYYTHL GAGPSVAAVR
1460 1470 1480 1490 1500
EIMENRYGQK GNAIRIEIVV YTGKEGKSSH GCPIAKWVLR RSSDEEKVLC
1510 1520 1530 1540 1550
LVRQRTGHHC PTAVMVVLIM VWDGIPLPMA DRLYTELTEN LKSYNGHPTD
1560 1570 1580 1590 1600
RRCTLNENRT CTCQGIDPET CGASFSFGCS WSMYFNGCKF GRSPSPRRFR
1610 1620 1630 1640 1650
IDPSSPLHEK NLEDNLQSLA TRLAPIYKQY APVAYQNQVE YENVARECRL
1660 1670 1680 1690 1700
GSKEGRPFSG VTACLDFCAH PHRDIHNMNN GSTVVCTLTR EDNRSLGVIP
1710 1720 1730 1740 1750
QDEQLHVLPL YKLSDTDEFG SKEGMEAKIK SGAIEVLAPR RKKRTCFTQP
1760 1770 1780 1790 1800
VPRSGKKRAA MMTEVLAHKI RAVEKKPIPR IKRKNNSTTA NNSKASSLPT
1810 1820 1830 1840 1850
LGSKSETVQP EVKSETEPHF ILKSSDNTKT YSLMPSAPHP VKEASPGFSW
1860 1870 1880 1890 1900
SPKTASATPA PLKNDATASC GFSERSSTPH CTMPSGRLSG ANAAAADGPG
1910 1920 1930 1940 1950
ISQLGEVAPL PTLSAPVTEP LVNSEPPTGV TEPLTSHQPN HQPSFLTSPQ
1960 1970 1980 1990 2000
DLASSPMEED EQHSEADEPP SDEPLSDDPL SPAEEKLPHI DEYWSDSEHI
2010 2020 2030 2040 2050
FLDANIGGVA IAPAHGSVLI ECARRELHAT TPVEHPNRNH PTRLSLVFYQ
2060 2070 2080 2090 2100
HKNLNKPQHG FELNKIKFEA KEAKNKKMKA SEQKDQAANE GPEQSSEVNE
2110 2120 2130
LNQIPSHKAL TLTHDNVVTV SPYALTHVAG PYNHWV
Length:2,136
Mass (Da):235,409
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF0121C45556C3D4F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3GE83A0A2I3GE83_NOMLE
Tet methylcytosine dioxygenase 1
TET1
1,293Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3HY89A0A2I3HY89_NOMLE
Tet methylcytosine dioxygenase 1
TET1
694Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ADFV01179483 Genomic DNA No translation available.
ADFV01179484 Genomic DNA No translation available.
ADFV01179485 Genomic DNA No translation available.
ADFV01179486 Genomic DNA No translation available.
ADFV01179487 Genomic DNA No translation available.
ADFV01179488 Genomic DNA No translation available.
ADFV01179489 Genomic DNA No translation available.
ADFV01179490 Genomic DNA No translation available.
ADFV01179491 Genomic DNA No translation available.
ADFV01179492 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_012352478.1, XM_012497024.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSNLET00000015050; ENSNLEP00000014341; ENSNLEG00000011782

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100600438

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
nle:100600438

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADFV01179483 Genomic DNA No translation available.
ADFV01179484 Genomic DNA No translation available.
ADFV01179485 Genomic DNA No translation available.
ADFV01179486 Genomic DNA No translation available.
ADFV01179487 Genomic DNA No translation available.
ADFV01179488 Genomic DNA No translation available.
ADFV01179489 Genomic DNA No translation available.
ADFV01179490 Genomic DNA No translation available.
ADFV01179491 Genomic DNA No translation available.
ADFV01179492 Genomic DNA No translation available.
RefSeqiXP_012352478.1, XM_012497024.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi61853.ENSNLEP00000014341

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSNLET00000015050; ENSNLEP00000014341; ENSNLEG00000011782
GeneIDi100600438
KEGGinle:100600438

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80312

Phylogenomic databases

eggNOGiENOG410IE22 Eukaryota
ENOG410XPWW LUCA
GeneTreeiENSGT00940000158935
InParanoidiG1RM77
KOiK13097
OMAiNQKAHPL
OrthoDBi29059at2759
TreeFamiTF324004

Family and domain databases

InterProiView protein in InterPro
IPR024779 2OGFeDO_noxygenase_dom
IPR040175 TET1/2/3
IPR002857 Znf_CXXC
PANTHERiPTHR23358 PTHR23358, 1 hit
PfamiView protein in Pfam
PF12851 Tet_JBP, 1 hit
PF02008 zf-CXXC, 1 hit
SMARTiView protein in SMART
SM01333 Tet_JBP, 1 hit
PROSITEiView protein in PROSITE
PS51058 ZF_CXXC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1RM77_NOMLE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1RM77
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: January 16, 2019
This is version 38 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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