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Entry version 64 (07 Apr 2021)
Sequence version 1 (19 Oct 2011)
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Protein

Very low-density lipoprotein receptor

Gene

VLDLR

Organism
Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorARBA annotation
Biological processCholesterol metabolismARBA annotation, EndocytosisARBA annotation, Lipid metabolism, Lipid transportARBA annotation, Steroid metabolism, Sterol metabolism, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Very low-density lipoprotein receptorARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VLDLRImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri61853 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHylobatidaeNomascus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001073 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei770 – 791HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Coated pitARBA annotation, Membrane, VLDLARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500341973525 – 845Very low-density lipoprotein receptorSequence analysisAdd BLAST821

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi33 ↔ 45PROSITE-ProRule annotation
Disulfide bondi40 ↔ 58PROSITE-ProRule annotation
Disulfide bondi52 ↔ 67PROSITE-ProRule annotation
Disulfide bondi72 ↔ 84PROSITE-ProRule annotation
Disulfide bondi79 ↔ 97PROSITE-ProRule annotation
Disulfide bondi134 ↔ 149PROSITE-ProRule annotation
Disulfide bondi154 ↔ 166PROSITE-ProRule annotation
Disulfide bondi161 ↔ 179PROSITE-ProRule annotation
Disulfide bondi173 ↔ 188PROSITE-ProRule annotation
Disulfide bondi193 ↔ 205PROSITE-ProRule annotation
Disulfide bondi200 ↔ 218PROSITE-ProRule annotation
Disulfide bondi239 ↔ 251PROSITE-ProRule annotation
Disulfide bondi246 ↔ 264PROSITE-ProRule annotation
Disulfide bondi258 ↔ 273PROSITE-ProRule annotation
Disulfide bondi278 ↔ 290PROSITE-ProRule annotation
Disulfide bondi285 ↔ 303PROSITE-ProRule annotation
Disulfide bondi297 ↔ 312PROSITE-ProRule annotation
Disulfide bondi326 ↔ 344PROSITE-ProRule annotation
Disulfide bondi400 ↔ 410PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini356 – 395EGF-likeInterPro annotationAdd BLAST40
Domaini396 – 431EGF-likeInterPro annotationAdd BLAST36
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati481 – 524LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati525 – 567LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati568 – 611LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati612 – 656LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati657 – 697LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155460

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008163_2_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
PCLPHEY

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112, LDLa, 8 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 1 hit
4.10.400.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt
IPR032931, VLDLR

The PANTHER Classification System

More...
PANTHERi
PTHR24270:SF16, PTHR24270:SF16, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07645, EGF_CA, 1 hit
PF00057, Ldl_recept_a, 8 hits
PF00058, Ldl_recept_b, 5 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 6 hits
SM00179, EGF_CA, 2 hits
SM00192, LDLa, 8 hits
SM00135, LY, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 1 hit
SSF57424, SSF57424, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 2 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 1 hit
PS01209, LDLRA_1, 4 hits
PS50068, LDLRA_2, 8 hits
PS51120, LDLRB, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

G1RBJ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTSARWALW LLLALCWAPR ESCATGTGRK AKCEPSQFQC TNGRCITLLW
60 70 80 90 100
KCDGDEDCVD GSDEKNCVKK TCAESDFVCN NGQCVPSRWK CDGDPDCEDG
110 120 130 140 150
SDESPEQCHM RTCRINEISC GAHSTQCIPV SWRCDGENDC DSGEDEENCG
160 170 180 190 200
NITCSPNEFT CSSGRCISRN FVCNGQDDCS DGSDELDCAP PTCGAHEFQC
210 220 230 240 250
STSSCIPISW VCDDDADCSD QSDESLEQCG RQPVIHTKCP ASEIQCGSGE
260 270 280 290 300
CIHKKWRCDG DPDCRDGSDE VNCPSRTCRP DQFECEDGSC IHGSRQCNGI
310 320 330 340 350
RDCVDGSDEV NCKNVNQCLG PGKFKCRSGE CIDINKVCNQ EQDCRDWSDE
360 370 380 390 400
PLKECHINEC LVNNGGCSHI CKDLVIGYEC DCAAGFELID RKTCGDIDEC
410 420 430 440 450
QNPGICSQIC INLKGGYKCE CSRGYQMDLA TGVCKAVGKE PSLIFTNRRD
460 470 480 490 500
IRKIGLERKE YIQLVEQLRN TVALDADIAA QKLFWADLSQ KAIFSASIDD
510 520 530 540 550
KVGRHVKMID NVYNPAAIAV DWVYKTIYWT DAASKTISVA TLDGTKRKFL
560 570 580 590 600
FNSDLREPAS IAVDPLSGFV YWSDWGEPAK IEKAGMNGFD RRPLVTVDIQ
610 620 630 640 650
WPNGITLDLI KSRLYWLDSK LHMLSSVDLN GQDRRIVLES LEFLAHPLAL
660 670 680 690 700
TIFEDRVYWI DGENEAVYGA NKFTGSELAT LVNNLNDAQD IIVYHELVQP
710 720 730 740 750
SGKNWCEEDM ENGGCEYLCL PAPQFNDHSP KYTCSCPNGY NLEENGRDCQ
760 770 780 790 800
RINVTTAVSE VSVPPKGTSA AWAILPLLLL VMAAVGGYLM WRNWQHKNMK
810 820 830 840
SMNFDNPVYL KTTEEDLSID IGRHSASVGH TYPAISVVST DDDLA
Length:845
Mass (Da):93,607
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74AB40DD190C97F4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G1RBJ4G1RBJ4_NOMLE
Very low-density lipoprotein recept...
VLDLR
873Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3HYP6A0A2I3HYP6_NOMLE
Very low-density lipoprotein recept...
VLDLR
873Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ADFV01078775 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_003273910.1, XM_003273862.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSNLET00000011112; ENSNLEP00000010596; ENSNLEG00000008596

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100581411

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
nle:100581411

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADFV01078775 Genomic DNA No translation available.
RefSeqiXP_003273910.1, XM_003273862.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSNLET00000011112; ENSNLEP00000010596; ENSNLEG00000008596
GeneIDi100581411
KEGGinle:100581411

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7436

Phylogenomic databases

GeneTreeiENSGT00940000155460
HOGENOMiCLU_008163_2_0_1
OMAiPCLPHEY

Family and domain databases

CDDicd00112, LDLa, 8 hits
Gene3Di2.120.10.30, 1 hit
4.10.400.10, 8 hits
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt
IPR032931, VLDLR
PANTHERiPTHR24270:SF16, PTHR24270:SF16, 2 hits
PfamiView protein in Pfam
PF07645, EGF_CA, 1 hit
PF00057, Ldl_recept_a, 8 hits
PF00058, Ldl_recept_b, 5 hits
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00181, EGF, 6 hits
SM00179, EGF_CA, 2 hits
SM00192, LDLa, 8 hits
SM00135, LY, 5 hits
SUPFAMiSSF57184, SSF57184, 1 hit
SSF57424, SSF57424, 8 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 2 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 1 hit
PS01209, LDLRA_1, 4 hits
PS50068, LDLRA_2, 8 hits
PS51120, LDLRB, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1RBJ9_NOMLE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1RBJ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: April 7, 2021
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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