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Entry version 46 (05 Jun 2019)
Sequence version 1 (19 Oct 2011)
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Protein
Submitted name:

Ataxin 2

Gene

ATXN2

Organism
Myotis lucifugus (Little brown bat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ataxin 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATXN2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMyotis lucifugus (Little brown bat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri59463 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaChiropteraMicrochiropteraVespertilionidaeMyotis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001074 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
59463.ENSMLUP00000014193

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini168 – 236LsmADInterPro annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni218 – 470DisorderedSequence analysisAdd BLAST253
Regioni483 – 672DisorderedSequence analysisAdd BLAST190
Regioni689 – 713DisorderedSequence analysisAdd BLAST25
Regioni898 – 979DisorderedSequence analysisAdd BLAST82

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi218 – 247PolyampholyteSequence analysisAdd BLAST30
Compositional biasi263 – 304PolarSequence analysisAdd BLAST42
Compositional biasi336 – 361Pro-richSequence analysisAdd BLAST26
Compositional biasi426 – 440PolarSequence analysisAdd BLAST15
Compositional biasi449 – 466PolarSequence analysisAdd BLAST18
Compositional biasi512 – 540PolarSequence analysisAdd BLAST29
Compositional biasi543 – 562PolyampholyteSequence analysisAdd BLAST20
Compositional biasi563 – 577PolarSequence analysisAdd BLAST15
Compositional biasi578 – 600PolyampholyteSequence analysisAdd BLAST23
Compositional biasi601 – 629PolarSequence analysisAdd BLAST29
Compositional biasi651 – 668PolyampholyteSequence analysisAdd BLAST18
Compositional biasi911 – 948PolarSequence analysisAdd BLAST38
Compositional biasi964 – 979PolarSequence analysisAdd BLAST16

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2375 Eukaryota
COG5180 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156812

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1PSN5

Identification of Orthologs from Complete Genome Data

More...
OMAi
GAPMMMH

TreeFam database of animal gene trees

More...
TreeFami
TF326591

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033093 ATXN2
IPR010920 LSM_dom_sf
IPR009604 LsmAD_domain
IPR025852 SM_dom_ATX

The PANTHER Classification System

More...
PANTHERi
PTHR12854:SF11 PTHR12854:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06741 LsmAD, 1 hit
PF14438 SM-ATX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01272 LsmAD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50182 SSF50182, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1PSN5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LFRGRNNNKG LPQSTISFDG IYANMRMVHI LTSVVGSKCE VQVKNGGIYE
60 70 80 90 100
GVFKTYSPKC DLVLDAAHEK STESSSGPKR EEIMESILFK CSDFVVVQFK
110 120 130 140 150
DMDSSYARRD AFTDSAISAK VNGEHKEKDL EPWDAGELTA SEELEALEND
160 170 180 190 200
VSNGWDPNDM FRYNEENYGV VSTYDSSLSS YTVPLERDNS EEFLKREARA
210 220 230 240 250
NQLAEEIESS AQYKARVALE NDDRSEEEKY TAVQRNSSER ESHSINTREN
260 270 280 290 300
KYIPPGQRNR EVMSWGSGRQ NSPRMGQPGP GSMASRSTSH TSDFNPNSGS
310 320 330 340 350
DQRVVNGGVP WPSPCPSPSS RPPSRYQSGP NSLPPRAATP TRPPSRPPSR
360 370 380 390 400
PSRPPSHPSA HGSPAPVSTM PKRMSSEGPP RMSPKAQRHP RNHRVSAGRG
410 420 430 440 450
SISSGLEFVS HTPPSEAVAP PTARTSPAGG TWSSVVSGVP RLSPKTHRPR
460 470 480 490 500
SPRQNSIGNT PSGAVLASPQ AGIIPTEAVA MPVPAASPTP ASPASNRAVT
510 520 530 540 550
PSIEAKDSRL QDQRQNSPAG NKENMKPNET SPSFSKVENK GISPVVSEHR
560 570 580 590 600
KQIDDLKKFK NDFRLQPSST SESVDQLLNK NREGEKSRDL IKDKIEPNAK
610 620 630 640 650
DSFIENNSSN CTSGSSKPSS PSISPSVLSH TEHRRGPEVT SQGVQTSSPG
660 670 680 690 700
CKQEKDDKEE KKDAAEQVRK STSGCNNNEL FILIFLQPKP STTPTSPRPQ
710 720 730 740 750
AQPSPSMVGH QQPTPVYTQP VCFAPNMMYP VPVSPGVQPL YPIPMTPMPV
760 770 780 790 800
NQAKTYRAGK VPNMPQQRQD QHHQSTMMHP ASAAGPPIVA TPPAYSTQYV
810 820 830 840 850
AYSPQQFPNQ PLVQHVPHYQ SQHPHVYSPV IQGSARMMAP AAHAQPGLVS
860 870 880 890 900
SSAAQYGAHE QTHAMYACPK LPYNKETSPS FYFAISTGSL AQQYAHPNAT
910 920 930 940 950
LHPHTPHPQP SATPTGQQQS QHGGSHPAPS PVQHHQHQAA QALHLAGPQQ
960 970 980 990 1000
QSAIYHAGLA PTPPSMTPAS NTQSPQNSFP AAQQTVFTIH PSHVQPAYTN
1010 1020 1030 1040 1050
PPHMAHVPQA HVQSGMVPSH PTAHAPMMLM TTQPPGGPQA ALAQSALQPI
1060 1070
PVSTTAHFPY MTHPSVQAHH QQQL
Length:1,074
Mass (Da):116,492
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA228638BA946AA5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAPE02037810 Genomic DNA No translation available.
AAPE02037811 Genomic DNA No translation available.
AAPE02037812 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMLUT00000015583; ENSMLUP00000014193; ENSMLUG00000015559

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAPE02037810 Genomic DNA No translation available.
AAPE02037811 Genomic DNA No translation available.
AAPE02037812 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi59463.ENSMLUP00000014193

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMLUT00000015583; ENSMLUP00000014193; ENSMLUG00000015559

Phylogenomic databases

eggNOGiKOG2375 Eukaryota
COG5180 LUCA
GeneTreeiENSGT00940000156812
InParanoidiG1PSN5
OMAiGAPMMMH
TreeFamiTF326591

Family and domain databases

InterProiView protein in InterPro
IPR033093 ATXN2
IPR010920 LSM_dom_sf
IPR009604 LsmAD_domain
IPR025852 SM_dom_ATX
PANTHERiPTHR12854:SF11 PTHR12854:SF11, 1 hit
PfamiView protein in Pfam
PF06741 LsmAD, 1 hit
PF14438 SM-ATX, 1 hit
SMARTiView protein in SMART
SM01272 LsmAD, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1PSN5_MYOLU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1PSN5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: June 5, 2019
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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