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Entry version 64 (02 Jun 2021)
Sequence version 1 (19 Oct 2011)
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Protein
Submitted name:

CASK interacting protein 2

Gene

CASKIN2

Organism
Myotis lucifugus (Little brown bat)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

ARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CASK interacting protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CASKIN2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMyotis lucifugus (Little brown bat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri59463 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaChiropteraMicrochiropteraVespertilionidaeMyotis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001074 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
59463.ENSMLUP00000013929

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 258ANK_REP_REGIONInterPro annotationAdd BLAST218
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati48 – 80ANKPROSITE-ProRule annotationAdd BLAST33
Repeati81 – 113ANKPROSITE-ProRule annotationAdd BLAST33
Repeati114 – 146ANKPROSITE-ProRule annotationAdd BLAST33
Repeati188 – 220ANKPROSITE-ProRule annotationAdd BLAST33
Repeati220 – 252ANKPROSITE-ProRule annotationAdd BLAST33
Domaini281 – 347SH3InterPro annotationAdd BLAST67
Domaini489 – 552SAMInterPro annotationAdd BLAST64
Domaini558 – 622SAMInterPro annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni355 – 464DisorderedSequence analysisAdd BLAST110
Regioni676 – 1181DisorderedSequence analysisAdd BLAST506

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi399 – 432Polar residuesSequence analysisAdd BLAST34
Compositional biasi698 – 732Polar residuesSequence analysisAdd BLAST35
Compositional biasi763 – 791Pro residuesSequence analysisAdd BLAST29
Compositional biasi830 – 852Polar residuesSequence analysisAdd BLAST23
Compositional biasi863 – 887Pro residuesSequence analysisAdd BLAST25
Compositional biasi985 – 999Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1015 – 1029Polar residuesSequence analysisAdd BLAST15
Compositional biasi1030 – 1068Pro residuesSequence analysisAdd BLAST39
Compositional biasi1138 – 1153Polar residuesSequence analysisAdd BLAST16
Compositional biasi1164 – 1178Basic and acidic residuesSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0507, Eukaryota
KOG4384, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158256

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003619_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1PRZ8

Identification of Orthologs from Complete Genome Data

More...
OMAi
QHLPDEC

Database of Orthologous Groups

More...
OrthoDBi
75723at2759

TreeFam database of animal gene trees

More...
TreeFami
TF320582

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09497, SAM_caskin1_2_repeat1, 1 hit
cd09498, SAM_caskin1_2_repeat2, 1 hit
cd12063, SH3_Caskin2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 2 hits
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR027013, Caskin-1/2
IPR032232, Caskin1-CID
IPR035497, Caskin1/2_SAM_1
IPR035498, Caskin1/2_SAM_2
IPR035499, Caskin2_SH3
IPR032117, Caskin_C
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR24174:SF7, PTHR24174:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 2 hits
PF16632, Caskin-tail, 1 hit
PF16600, Caskin1-CID, 1 hit
PF00536, SAM_1, 2 hits
PF07653, SH3_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 6 hits
SM00454, SAM, 2 hits
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769, SSF47769, 2 hits
SSF48403, SSF48403, 1 hit
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits
PS50105, SAM_DOMAIN, 2 hits
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1PRZ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGREQDLILA VKNGDVTGVQ KLVAKVKAAK TKLLGSTKRL NVNYQDADGF
60 70 80 90 100
SALHHAALGG SLELIALLLE AQATVDIKDS NGMRPLHYAA WQGRLEPVRL
110 120 130 140 150
LLRASAAVNA ASLDGQIPLH LAAQYGHYEV SEMLLQHQSN PCLVNKAKKT
160 170 180 190 200
PLDLACEFGR LKVAQLLLNS HLCVALLEGE AKDPCDPNYT TPLHLAAKNG
210 220 230 240 250
HREVIRQLLR AGIEINRQTK TGTALHEAAL YGKTEVVRLL LEGGVDVNIR
260 270 280 290 300
NTYNQTALDI VNQFTTSQAS REIKQLLREA SGILKVRALK DFWNLHDPTA
310 320 330 340 350
LNVRAGDVIT VLEQHPDGRW KGHIHESQRG TDRVGYFPPG IVEVVSKRVG
360 370 380 390 400
ILAPRLPSAP TPLRPNFSRT PQPPADDSLH PLTYGQLPRV GLSPDSPAGD
410 420 430 440 450
RNSVGSEGSV GSIRSAGSGQ SSEGTNGHGT GLLIENAQPL PSAGEDQGLP
460 470 480 490 500
GLHPPSLAGS LSHRPLANCH SGEQLFTQDV RPEQLLEGKD AQAIYNWLSE
510 520 530 540 550
FQLEGYTAHF LQAGYDVPTI SRMTPEDLTA IGVTKPGHRK KIASEIAQLS
560 570 580 590 600
ITEWLPNYIP ADLLEWLCAL GLPQYHKKLL SSGYDSMGLV ADLTWEELQE
610 620 630 640 650
IGVNKLGHQK KLMLGVKRLA ELRRGLLHGE ATGEGGRRLA RGPELMAIEG
660 670 680 690 700
LENGDGPAAA GPRLLTFQGS ELSPELQAAM AGGGPEPLPL PPARSPSQES
710 720 730 740 750
IGARSRGSGH SQEQPAPQPS SGDPSTPQER NLPEGTERPP KLCSPLPGQG
760 770 780 790 800
PPGYVFMYPQ GSPSSPAPGP PPGAPRAFSY LAGPPAAPPD PPRPKRRSHS
810 820 830 840 850
LSRPGPAEGE AEGEAEGPVG SALGSYATLT RRPGRSTLAR PSPSQTPVRG
860 870 880 890 900
APRSQSFALR ARRKGPPPPP PKRLSSVPGP TPEPPSLDGS LGPKEGAPGP
910 920 930 940 950
RRRTLSEPAG PSEPPGPPAP AGPASDTEEE EDPGPEGTPP SRGSSGEGLP
960 970 980 990 1000
FAEEGNLTIK QRPKPAGPPS RETPVPTGLD FNLTESDTVK RRPKCREREP
1010 1020 1030 1040 1050
LQTALLAFGV ATTMPSPSVP MTSQTPSESP VASPCPPQPD PSSLPTQGAP
1060 1070 1080 1090 1100
APLPPSPPTQ PSKPPCPGPA LENSAGNRQR GEPEPPAPPA ALIKVPGAGT
1110 1120 1130 1140 1150
APKPVSVACT QLAFSGPKLA PRLGPRPVPP PRPESTGAVG SGQAQQRLER
1160 1170 1180 1190 1200
TSSSLAAALR AAEKSIGAEE REGPPSTSTK HILDDISTMF DALADQLDAM

LD
Length:1,202
Mass (Da):126,852
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i53BC38154D55A32A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAPE02047503 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
XP_006103492.1, XM_006103430.2
XP_006103493.1, XM_006103431.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMLUT00000015291; ENSMLUP00000013929; ENSMLUG00000015284

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
102421624

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAPE02047503 Genomic DNA No translation available.
RefSeqiXP_006103492.1, XM_006103430.2
XP_006103493.1, XM_006103431.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi59463.ENSMLUP00000013929

Genome annotation databases

EnsembliENSMLUT00000015291; ENSMLUP00000013929; ENSMLUG00000015284
GeneIDi102421624

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57513

Phylogenomic databases

eggNOGiKOG0507, Eukaryota
KOG4384, Eukaryota
GeneTreeiENSGT00940000158256
HOGENOMiCLU_003619_2_0_1
InParanoidiG1PRZ8
OMAiQHLPDEC
OrthoDBi75723at2759
TreeFamiTF320582

Family and domain databases

CDDicd09497, SAM_caskin1_2_repeat1, 1 hit
cd09498, SAM_caskin1_2_repeat2, 1 hit
cd12063, SH3_Caskin2, 1 hit
Gene3Di1.10.150.50, 2 hits
1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR027013, Caskin-1/2
IPR032232, Caskin1-CID
IPR035497, Caskin1/2_SAM_1
IPR035498, Caskin1/2_SAM_2
IPR035499, Caskin2_SH3
IPR032117, Caskin_C
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR24174:SF7, PTHR24174:SF7, 1 hit
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
PF16632, Caskin-tail, 1 hit
PF16600, Caskin1-CID, 1 hit
PF00536, SAM_1, 2 hits
PF07653, SH3_2, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SM00454, SAM, 2 hits
SM00326, SH3, 1 hit
SUPFAMiSSF47769, SSF47769, 2 hits
SSF48403, SSF48403, 1 hit
SSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits
PS50105, SAM_DOMAIN, 2 hits
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1PRZ8_MYOLU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1PRZ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: June 2, 2021
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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