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Entry version 57 (31 Jul 2019)
Sequence version 1 (19 Oct 2011)
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Protein
Submitted name:

Uncharacterized protein

Gene

PCDH15

Organism
Myotis lucifugus (Little brown bat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCDH15Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMyotis lucifugus (Little brown bat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri59463 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaChiropteraMicrochiropteraVespertilionidaeMyotis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001074 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1323 – 1345HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
59463.ENSMLUP00000012987

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 93CAInterPro annotationAdd BLAST82
Domaini122 – 211CAInterPro annotationAdd BLAST90
Domaini252 – 341CAInterPro annotationAdd BLAST90
Domaini374 – 455CAInterPro annotationAdd BLAST82
Domaini479 – 561CAInterPro annotationAdd BLAST83
Domaini586 – 663CAInterPro annotationAdd BLAST78
Domaini687 – 765CAInterPro annotationAdd BLAST79
Domaini789 – 872CAInterPro annotationAdd BLAST84
Domaini896 – 982CAInterPro annotationAdd BLAST87
Domaini1003 – 1090CAInterPro annotationAdd BLAST88
Domaini1114 – 1198CAInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1368 – 1388DisorderedSequence analysisAdd BLAST21
Regioni1533 – 1613DisorderedSequence analysisAdd BLAST81
Regioni1727 – 1764DisorderedSequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1371 – 1388Pro-richSequence analysisAdd BLAST18
Compositional biasi1545 – 1568PolarSequence analysisAdd BLAST24
Compositional biasi1593 – 1613PolarSequence analysisAdd BLAST21
Compositional biasi1727 – 1759Pro-richSequence analysisAdd BLAST33

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3594 Eukaryota
ENOG410XQHI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156675

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1PPN8

Identification of Orthologs from Complete Genome Data

More...
OMAi
VTYSIYH

TreeFam database of animal gene trees

More...
TreeFami
TF326779

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR041149 EC_dom
IPR030718 Protocadherin-15

The PANTHER Classification System

More...
PANTHERi
PTHR24028:SF11 PTHR24028:SF11, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 8 hits
PF18432 ECD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 11 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1PPN8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GTIIVDNMLI KGTAGGPDPT IELSLKDNVD YWVLLDPIKQ MLFLNSTGRV
60 70 80 90 100
LDRDPPMNIH SIVVQVQCVN KKVGTVIYHE VRIVVRDRND NSPTFKHESY
110 120 130 140 150
YATVNELTPV GTTIFTGFAG DNGATDIDDG PNGQIEYVIQ YNPDDPTSNE
160 170 180 190 200
TFEIPLMLTG NVVLRKRLNY EDKTRYYVII QANDRAQNLN ERRTTTTTLT
210 220 230 240 250
VDVLDGDDLG PMFLPCVLVP NTRDCRPLTY QAAIPELRTP EELNPIIVTP
260 270 280 290 300
PIQAIDQDRN IQPPSDRPGI LYSILVGTPE DYPRFFHMHP RTAELSLLEP
310 320 330 340 350
VNRDFYQKFD LVIKAEQDNG HPLPAFASLH IEILDENNQS PYFTMPSYQG
360 370 380 390 400
YILESAPVGS TISDSVNLTT PLRIVVLDKD IEDTKDPELH LFLNDYTSVF
410 420 430 440 450
TITPTGITRF LTLLQPVDRE EQDTYIFSMT AFDGVQESQP VVVNIRVMDA
460 470 480 490 500
NDNTPTFPEI SYNVYVYTDM SPGDSVIQLT AVDADEGSNG EISYEILIGD
510 520 530 540 550
QGDFIINRET GLITIAPGVE LIVGRTYALT VQAADNAPPA ERRHSICTVY
560 570 580 590 600
IEVLPPNNQS PPRFPQMMYS LEVSEAMRIG AVLLNLQATD REGDPITYAI
610 620 630 640 650
ENGDPQRVFN LSETTGILTL GKALDRESTD RYILIVTAHD GRPDGTSTAT
660 670 680 690 700
VNIVVSDVND NDPVFDPYLP RNLSVVEEEA NAFVGQVRAT DPDAGINGQV
710 720 730 740 750
YYSLGNFNHL FRITSNGSIY TTVKLNREVR DYYELLVVAT DGAVHPRHST
760 770 780 790 800
LTLAIKVLDI DDNSPVFTNS TYTVVVEENL PAGTTFLQVE ATDVDLGANV
810 820 830 840 850
SYRIRSPEVK HLFAMHPFTG ELSLLRSLDY ESFPDQEASI TFLVEAFDIY
860 870 880 890 900
GTMPPGIATV TVIVKDMNDY PPVFSKRIYK GIVAPDAVKG TPITSVYAED
910 920 930 940 950
ADPPGLPASR VRYRVDGVQS PYPASIFDVE EDSGTVITRV NLNEEPTTIF
960 970 980 990 1000
KLVVIAFDDG EPVMSSSAVV KILVLHPGEI PRFTQEEYRP PPVSELAARG
1010 1020 1030 1040 1050
TAVGVISAAA INQSIVYSIV SGNEEGKFGI NNITGVIYVN DLLDYETRTS
1060 1070 1080 1090 1100
YVLRVQADSL EVVLANLRVP SKSNTAKVYI EIQDENDHPP VFQKKFYIGG
1110 1120 1130 1140 1150
VSEDARMFDS VLKVKATDKD TGNYSAIAYR LIIPPIKEGK EGFVVETYTG
1160 1170 1180 1190 1200
LIKTAMLFHN MRRSYFMFQV IATDDYGKGL SGKADVLVSV VNQLDMQVIV
1210 1220 1230 1240 1250
SNVPPTLVEK KIEELTEILD RYVQEQIPGA KVVVESIGAR RHGDAFSLED
1260 1270 1280 1290 1300
YSKCDLTVYA IDPQTNRAID RKELFKFLDG KLLDINKDFQ PHYGEGGRIL
1310 1320 1330 1340 1350
EIRTPEAVTS IKKRGESLGY TEGALLALAF IIILCCIPAV LVVLVSYRQF
1360 1370 1380 1390 1400
KVRQAECTKT ARLQAAAAAM PPPKPAAPAP APVAAPPAPP PPGAHLYEEV
1410 1420 1430 1440 1450
GDSTILYLLY HFQQSRGNKS VSEDQKHQHV AMPFPSNTVE AHEQAYVAGS
1460 1470 1480 1490 1500
LKNSQPTSAR KLTLLSDEDA LNTHSTLYKE NVDQRSTNSD FSLRTDSIGS
1510 1520 1530 1540 1550
ILPRTQAKNE SLRGPRKKIQ RLWNQTFRLP KRPKWELPNR PETIALDQWP
1560 1570 1580 1590 1600
SNRQKAGNES TETYPHTRGS SHPLLVAEDT SVTEKEARRG GSLSMQGTEQ
1610 1620 1630 1640 1650
LKSLPSDSSF SSPWSHSTFS TLPTVSRTVE LRSEPDVIMS PADCSLELLN
1660 1670 1680 1690 1700
APLFRRETPS CMLTIETKRN IFENPPHPPN ISPPPFPPPL PPLPPSLILT
1710 1720 1730 1740 1750
PFALSCPSSP PSSPSPIPPL LPLSVPPSPF STSSPPLSLL PSHPSLPPPP
1760 1770 1780 1790 1800
PPFPSPLPPS TSGLSTKCVS IPAVKRTVNV TPAKEIQSSG GQLSTSTTVC
1810 1820 1830 1840 1850
NADPQREPKG ILKHVKNLAE LEKSVANMYS HIEKNYPPAH IPKLEINYPS
1860 1870 1880
EMTKMEITSG QNQENLHNIV EEFEKQSHTQ STSL
Length:1,884
Mass (Da):208,109
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9EEEFAF0A0A36E3D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAPE02041371 Genomic DNA No translation available.
AAPE02041372 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMLUT00000014278; ENSMLUP00000012987; ENSMLUG00000014263

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAPE02041371 Genomic DNA No translation available.
AAPE02041372 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi59463.ENSMLUP00000012987

Genome annotation databases

EnsembliENSMLUT00000014278; ENSMLUP00000012987; ENSMLUG00000014263

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00940000156675
InParanoidiG1PPN8
OMAiVTYSIYH
TreeFamiTF326779

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR041149 EC_dom
IPR030718 Protocadherin-15
PANTHERiPTHR24028:SF11 PTHR24028:SF11, 3 hits
PfamiView protein in Pfam
PF00028 Cadherin, 8 hits
PF18432 ECD, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 11 hits
SUPFAMiSSF49313 SSF49313, 10 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1PPN8_MYOLU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1PPN8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: July 31, 2019
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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