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Protein

L-lactate dehydrogenase

Gene
N/A
Organism
Myotis lucifugus (Little brown bat)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (LOC102441847), L-lactate dehydrogenase (LOC102436121), L-lactate dehydrogenase, L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei107SubstrateUniRule annotation1
Binding sitei139SubstrateUniRule annotation1
Binding sitei173SubstrateUniRule annotation1
Active sitei197Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
OrganismiMyotis lucifugus (Little brown bat)Imported
Taxonomic identifieri59463 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaChiropteraMicrochiropteraVespertilionidaeMyotis
Proteomesi
  • UP000001074 Componenti: Unassembled WGS sequence

Subcellular locationi

Interactioni

Protein-protein interaction databases

STRINGi59463.ENSMLUP00000011075

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 164Ldh_1_NInterPro annotationAdd BLAST142
Domaini168 – 333Ldh_1_CInterPro annotationAdd BLAST166

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1495 Eukaryota
COG0039 LUCA
GeneTreeiENSGT00550000074541
InParanoidiG1PJY1
OMAiRQPGQTR
OrthoDBiEOG091G0HME
TreeFamiTF314963

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

G1PJY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLKEKLIA PVAKEEATTP NNKITVVGVG QVGMACAISI LGKSLADELA
60 70 80 90 100
LVDVLEDKLK GEMMDLQHGS LFLQTPKIVA DKDYSVTANS KIVVVTAGVR
110 120 130 140 150
QQEGESRLNL VQRNVNVFKF IIPQIVKYSP DCIIIVVSNP EFVVDILTYV
160 170 180 190 200
TWKLSGLPKH RVIGSGCNLD SARFRYLMAE KLGIHPSSCH GWILGEHGDS
210 220 230 240 250
SVAVWSGVNV AGVSLQELNP EMGTDKDSEN WKEVHKMVVE SAYEVIKLKG
260 270 280 290 300
YTNWAIGLSV ADLIESMFKN LSRIHPVSTM VKGMYGIENE VFLSLPCILN
310 320 330
ARGLTSVINQ KLKDDEVAQL KKSADTLWNI QKDLKDL
Length:337
Mass (Da):37,062
Last modified:October 19, 2011 - v1
Checksum:iA59723ECF92B1002
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAPE02021857 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMLUT00000012156; ENSMLUP00000011075; ENSMLUG00000012155

Similar proteinsi

Entry informationi

Entry nameiG1PJY1_MYOLU
AccessioniPrimary (citable) accession number: G1PJY1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: May 23, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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