RNA helicase

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• ATP

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  + H₂O

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  = ADP

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  + H⁺

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  + phosphate

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  ARBA annotation

  <p>Information which has been generated by the UniProtKB automatic annotation system, without manual validation.</p> <p><a href="/manual/evidences#ECO:0000256">More...</a></p> Automatic assertion according to rulesⁱ

  • ARBA:ARBA00001556
  EC:3.6.4.13
  • Search proteins in UniProtKB for this EC number.
  • See the description of this EC number in ENZYME.
  • Search reactions for this EC number in Rhea.
  ARBA annotation

  Automatic assertion according to rulesⁱ

  • ARBA:ARBA00001556
  Source: Rhea

  • Search for this reaction in UniProtKB.
  • See the description of this reaction in Rhea.

  . Show »« Hide
  ATP

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  

  +

  H₂O

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  

  =

  ADP

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  

  +

  H⁺

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  

  +

  phosphate

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  zoom

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: UniProtKB-KW
• ATP hydrolysis activity Source: Ensembl
• CTPase activity Source: Ensembl
• DNA binding Source: Ensembl
• DNA helicase activity Source: Ensembl
• eukaryotic initiation factor 4E binding Source: Ensembl
• gamma-tubulin binding Source: Ensembl
• GTPase activity Source: Ensembl
• mRNA 5'-UTR binding Source: Ensembl
• poly(A) binding Source: Ensembl
• protein serine/threonine kinase activator activity Source: Ensembl
• ribosomal small subunit binding Source: Ensembl
• RNA helicase activity Source: UniProtKB-EC
• RNA stem-loop binding Source: Ensembl
• RNA strand annealing activity Source: Ensembl

GO - Biological processⁱ

• cellular response to arsenic-containing substance Source: Ensembl
• cellular response to osmotic stress Source: Ensembl
• cellular response to virus Source: Ensembl
• chromosome segregation Source: Ensembl
• extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
• innate immune response Source: Ensembl
• intrinsic apoptotic signaling pathway Source: Ensembl
• lipid homeostasis Source: Ensembl
• mature ribosome assembly Source: Ensembl
• negative regulation of cell growth Source: Ensembl
• negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
• negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
• negative regulation of intrinsic apoptotic signaling pathway Source: Ensembl
• negative regulation of NIK/NF-kappaB signaling Source: Ensembl
• negative regulation of protein-containing complex assembly Source: Ensembl
• negative regulation of translation Source: Ensembl
• positive regulation of apoptotic process Source: Ensembl
• positive regulation of canonical Wnt signaling pathway Source: Ensembl
• positive regulation of cell growth Source: Ensembl
• positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
• positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
• positive regulation of interferon-alpha production Source: Ensembl
• positive regulation of interferon-beta production Source: Ensembl
• positive regulation of NIK/NF-kappaB signaling Source: Ensembl
• positive regulation of protein acetylation Source: Ensembl
• positive regulation of protein autophosphorylation Source: Ensembl
• positive regulation of protein K63-linked ubiquitination Source: Ensembl
• positive regulation of toll-like receptor 7 signaling pathway Source: Ensembl
• positive regulation of toll-like receptor 8 signaling pathway Source: Ensembl
• positive regulation of transcription by RNA polymerase II Source: Ensembl
• positive regulation of translational initiation Source: Ensembl
• positive regulation of translation in response to endoplasmic reticulum stress Source: Ensembl
• positive regulation of viral genome replication Source: Ensembl
• protein localization to cytoplasmic stress granule Source: Ensembl
• RNA secondary structure unwinding Source: Ensembl
• stress granule assembly Source: Ensembl
• translational initiation Source: Ensembl
• Wnt signaling pathway Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• eukaryotic initiation factor 4E binding Source: Ensembl
• gamma-tubulin binding Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
QRKTPSSRYS SGMSHVAVEN ALGLDQQFAG LDLNSSDNQS GGSTASKGRY 
        60         70         80         90        100
IPPHLRNREA TKGFYDKDSS GWSSSKDKDA YSNFGARGDS RGKSSFFSDR 
       110        120        130        140        150
GSGSRGRFDD RGRGDYDGIG GRGDRSGFGK FERGGNSRWC DKSDEDDWSK 
       160        170        180        190        200
PLPPSERLEQ ELFSGGNTGI NFEKYDDIPV EATGNNCPPH IESFSDVEMG 
       210        220        230        240        250
EIIMGNIELT RYTRPTPVQK HAIPIIKEKR DLMACAQTGS GKTAAFLLPI 
       260        270        280        290        300
LSQIYTDGPG EALRAMKENG RYGRRKQYPI SLVLAPTREL AVQIYEEARK 
       310        320        330        340        350
FSYRSRVRPC VVYGGADIGQ QIRDLERGCH LLVATPGRLV DMMERGKIGL 
       360        370        380        390        400
DFCKYLVLDE ADRMLDMGFE PQIRRIVEQD TMPPKGVRHT MMFSATFPKE 
       410        420        430        440        450
IQMLARDFLD EYIFLAVGRV GSTSENITQK VVWVEDADKR SFLLDLLNAT 
       460        470        480        490        500
GKDSLTLVFV ETKKGADSLE DFLYHEGYAC TSIHGDRSQR DREEALHQFR 
       510        520        530        540        550
SGKSPILVAT AVAARGLDIS NVKHVINFDL PSDIEEYVHR IGRTGRVGNL 
       560        570        580        590        600
GLATSFFNER NINITKDLLD LLVEAKQEVP SWLESMAYEH HYKGSSRGRS 
       610        620        630        640        650
KSSRFSGGFG ARDYRQSSGA SSSSFSSSRA SSSRSGGGGH GGSRGFGGGG 
       660        670 
YGGFYNSDGY GGNYNSQGVD WWGN                             

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ