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Protein
Submitted name:

Growth hormone releasing hormone receptor

Gene

GHRHR

Organism
Myotis lucifugus (Little brown bat)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Growth hormone releasing hormone receptorImported
Gene namesi
Name:GHRHRImported
OrganismiMyotis lucifugus (Little brown bat)Imported
Taxonomic identifieri59463 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaChiropteraMicrochiropteraVespertilionidaeMyotis
Proteomesi
  • UP000001074 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei131 – 154HelicalSequence analysisAdd BLAST24
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei280 – 303HelicalSequence analysisAdd BLAST24
Transmembranei373 – 390HelicalSequence analysisAdd BLAST18
Transmembranei402 – 421HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500341804323 – 465Sequence analysisAdd BLAST443

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi59463.ENSMLUP00000008946

Structurei

3D structure databases

ProteinModelPortaliG1PEJ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 116G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST77
Domaini129 – 422G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST294

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
InParanoidiG1PEJ8
OMAiFLNQEVR
OrthoDBiEOG091G0NF8
TreeFamiTF315710

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR003288 GPCR_2_GHRH_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR12011:SF209 PTHR12011:SF209, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01352 GHRHRECEPTOR
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

G1PEJ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSRVWGAGT LCLLSPLPAV LGHVHSECDL IAQLREDESA CLQAAKGESN
60 70 80 90 100
ATRGCPVNWD GLLCWPTAGS GEWVTLPCPA FFSLFSSEPG AVQRDCTITG
110 120 130 140 150
WSEPFPPYAV ACPVPLELPT EEESYFSTVK VIYTLGHSVS TVALLVAIAI
160 170 180 190 200
LVALRRLHCP RNYIHTQLFA TFILKAGAVF LKDTALFHGE DTDHCSMSTV
210 220 230 240 250
LCKASVASSH FATMTNFSWL SAEAVYLTCL LSSSPSTRRA FWWLVLAGWG
260 270 280 290 300
LSLLFTGPWV VGNLALEITE CWDLDDSSPY WWIIKGPIVL SVGVNFGLFL
310 320 330 340 350
NIIRILLRKL EPAQGSLHTP SQYWYRARTY WGIPEHTWSM SHDPGLGSSP
360 370 380 390 400
CSLRQTSSVP ASQEIVGRLS KSTLLLIPLF GIHYIIFNFL PDSAGLGIRL
410 420 430 440 450
PLELGLGSFQ GFIVAVLYCF LNQEVRTELS RRWRGHNPEL LPARRTHAKW
460
TVPFRSGTKV VTSVC
Length:465
Mass (Da):51,331
Last modified:October 19, 2011 - v1
Checksum:i178D7EBA3B3C82B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAPE02017967 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMLUT00000009812; ENSMLUP00000008946; ENSMLUG00000009806

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAPE02017967 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliG1PEJ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi59463.ENSMLUP00000008946

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMLUT00000009812; ENSMLUP00000008946; ENSMLUG00000009806

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
InParanoidiG1PEJ8
OMAiFLNQEVR
OrthoDBiEOG091G0NF8
TreeFamiTF315710

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR003288 GPCR_2_GHRH_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR12011:SF209 PTHR12011:SF209, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01352 GHRHRECEPTOR
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG1PEJ8_MYOLU
AccessioniPrimary (citable) accession number: G1PEJ8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: April 25, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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