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Entry version 47 (02 Jun 2021)
Sequence version 1 (19 Oct 2011)
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Protein
Submitted name:

AF4/FMR2 family member 1

Gene

AFF1

Organism
Myotis lucifugus (Little brown bat)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AF4/FMR2 family member 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AFF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMyotis lucifugus (Little brown bat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri59463 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaChiropteraMicrochiropteraVespertilionidaeMyotis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001074 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
59463.ENSMLUP00000000270

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini955 – 1211AF-4_CInterPro annotationAdd BLAST257

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni15 – 47DisorderedSequence analysisAdd BLAST33
Regioni74 – 321DisorderedSequence analysisAdd BLAST248
Regioni372 – 966DisorderedSequence analysisAdd BLAST595
Regioni1093 – 1127DisorderedSequence analysisAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili969 – 989Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi107 – 135Polar residuesSequence analysisAdd BLAST29
Compositional biasi164 – 187Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi210 – 240Polar residuesSequence analysisAdd BLAST31
Compositional biasi244 – 260Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi270 – 284Pro residuesSequence analysisAdd BLAST15
Compositional biasi377 – 431Polar residuesSequence analysisAdd BLAST55
Compositional biasi464 – 491Polar residuesSequence analysisAdd BLAST28
Compositional biasi548 – 569Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi588 – 612Polar residuesSequence analysisAdd BLAST25
Compositional biasi640 – 680Basic and acidic residuesSequence analysisAdd BLAST41
Compositional biasi787 – 844Basic and acidic residuesSequence analysisAdd BLAST58
Compositional biasi869 – 885Polar residuesSequence analysisAdd BLAST17
Compositional biasi914 – 929Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi930 – 952Polar residuesSequence analysisAdd BLAST23
Compositional biasi1112 – 1127Polar residuesSequence analysisAdd BLAST16

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QR32, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182974

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006484_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1NSZ5

Identification of Orthologs from Complete Genome Data

More...
OMAi
YMAMFRY

TreeFam database of animal gene trees

More...
TreeFami
TF326216

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD

The PANTHER Classification System

More...
PANTHERi
PTHR10528, PTHR10528, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18876, AF-4_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1NSZ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
NSLYNEDRNL LRIREKERRN QEAHQEKEAF SEKIPLFGEP YKTEKGDELS
60 70 80 90 100
SRIQNMLGNY EEVKELLSTK SLAHHLDASE SRPGKPRYPL FPEKGSGVPP
110 120 130 140 150
HSFHTRVHHQ PGSTPASGPL PVGNMSHNQK VTQPRMEPMP SLHVKSYGAP
160 170 180 190 200
DSQHLAQDRL GQEGYSSSHR KNGDRRAEGD HCASTADSAP ERELSPLLSS
210 220 230 240 250
LPSPLPPLSP LHSNQQTLPR SHGSSKVHSS NNNNNNKGYC HAKSPKDLAV
260 270 280 290 300
KIRDKETPKD SLVAVSSLGV APPQPPPQSF PPPSLPSKSV AMQQKPTAYV
310 320 330 340 350
RPMDGQDQAP SESPELKPLP EDYRQQTFEK TDLKVPAKAK LTKLKMPSQS
360 370 380 390 400
VEQTYSNEVH CVEEILKEMT HSWPPPLTAI HTPSTAEPSK FPFPTKDSQH
410 420 430 440 450
ISSATQNQKQ YDTSSKTRPH SQQGTSMLED DLQLSDSEDS ESEQAPEKPP
460 470 480 490 500
ATSAPPSAPQ SLPEAAASAH SSGAESESTS DSDSSSDSES ESSSSDSEEN
510 520 530 540 550
EPQDTPAPEP EPPTTNKWQL DNWLTKVSQP AAPPEALGSA APPLRHPDGK
560 570 580 590 600
GKGGDGTTSH EHSESKDPPP PKSSGRAPRI PPEGSHTGKR SCQKSPAQQE
610 620 630 640 650
PPQRQTVGTK QPKKPVKASA PADSRASLQV ESEPGLPHSS KDQPSKDKPK
660 670 680 690 700
VKTKGRPRAG DREPKPAVPT PSEKKKHRGG PPAPTKARSG PEPTKDNVED
710 720 730 740 750
RSPEHLALVP LTHGQGPKHD SNSGGRTSGC RRAVVVQEDP GKDKLQVPLR
760 770 780 790 800
DTKLLSPLRD TPPLQSLVVK ITLDLLSWVP QPPGKGSRQK KPEDKQPPAG
810 820 830 840 850
KKLDSEKRSS DNSSKLAKKR KGEAERDHDS KKVRLEKEVK SQSSSSSHKE
860 870 880 890 900
ASKTKTPRPS EPSKKEMLPP TLVSSSSSSS QKPAKPTQKR PRREAHPCSQ
910 920 930 940 950
DPPKSASSTK GNHKDSPAPK RRKAEGKGSG SSTEQKGSSG DTANSFPVPS
960 970 980 990 1000
LPNGNSKPGK PPSKLDKQAD LHMKEAKKLK QKAELMTDKV GKAFKYLEAV
1010 1020 1030 1040 1050
LSFIECGIAM ESESPVSKSA SKSAFAVYSE TEDLVKVIMS LKSFSDPTAP
1060 1070 1080 1090 1100
TQEKIFAVLC MRCQSILNMA MFRCKKERAI KYSRALNDHF QSPSKVTQAP
1110 1120 1130 1140 1150
SPCIARSTGA PSPLSPMPSA SSVGSQASAG SVGGSGIPAN IQNMTSSYIT
1160 1170 1180 1190 1200
ITSHIFAAVD LWEQAEVLTR KNKEFFAQLS TSVCTLALNS SLADLVHYTR
1210
QGFQWLKQGS RAP
Length:1,213
Mass (Da):131,385
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB3090AE134FA1FB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAPE02007717 Genomic DNA No translation available.
AAPE02007718 Genomic DNA No translation available.
AAPE02007719 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMLUT00000000296; ENSMLUP00000000270; ENSMLUG00000000293

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAPE02007717 Genomic DNA No translation available.
AAPE02007718 Genomic DNA No translation available.
AAPE02007719 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi59463.ENSMLUP00000000270

Genome annotation databases

EnsembliENSMLUT00000000296; ENSMLUP00000000270; ENSMLUG00000000293

Phylogenomic databases

eggNOGiENOG502QR32, Eukaryota
GeneTreeiENSGT00950000182974
HOGENOMiCLU_006484_0_0_1
InParanoidiG1NSZ5
OMAiYMAMFRY
TreeFamiTF326216

Family and domain databases

InterProiView protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
PANTHERiPTHR10528, PTHR10528, 1 hit
PfamiView protein in Pfam
PF18876, AF-4_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1NSZ5_MYOLU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1NSZ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: June 2, 2021
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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