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Entry version 53 (02 Jun 2021)
Sequence version 2 (16 Nov 2011)
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Protein
Submitted name:

ARFGEF family member 3

Gene

ARFGEF3

Organism
Meleagris gallopavo (Wild turkey)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factorARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ARFGEF family member 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARFGEF3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMeleagris gallopavo (Wild turkey)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9103 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaeMeleagridinaeMeleagris
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001645 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini539 – 751SEC7InterPro annotationAdd BLAST213

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni464 – 514DisorderedSequence analysisAdd BLAST51
Regioni570 – 602DisorderedSequence analysisAdd BLAST33
Regioni992 – 1026DisorderedSequence analysisAdd BLAST35
Regioni1797 – 1827DisorderedSequence analysisAdd BLAST31
Regioni1892 – 1954DisorderedSequence analysisAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili115 – 142Sequence analysisAdd BLAST28
Coiled coili408 – 428Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi464 – 492Polar residuesSequence analysisAdd BLAST29
Compositional biasi496 – 513Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1892 – 1907Polar residuesSequence analysisAdd BLAST16

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000064150

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000867_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1NJZ7

Identification of Orthologs from Complete Genome Data

More...
OMAi
TCCWDSM

TreeFam database of animal gene trees

More...
TreeFami
TF300714

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR032629, DCB_dom
IPR015403, Sec7_C
IPR000904, Sec7_dom
IPR035999, Sec7_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16213, DCB, 1 hit
PF09324, DUF1981, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00222, Sec7, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF48425, SSF48425, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1NJZ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
REKCLLPLQL ALESKSMKLA QQALAGMQKL LSDERFVSVE TDSDEKQLLN
60 70 80 90 100
QMLNAVKVTP SLNEDLQVEV MKVLLCITYT STFELNGSSV LKIAEVCIET
110 120 130 140 150
YVSSCHQRSI NTAVRATLSQ MLSDLTLQLR QKQENMTIEN NEALQKFKSQ
160 170 180 190 200
GGTSAESLCD DVVSVLTVLC EKLQAVINDN RQLQLLYLEC ILSMLNSSSP
210 220 230 240 250
SMHQHKGFTD LIWKQLCPAL VVILGNPIHD KTITSAHSSI CLEADSPSSG
260 270 280 290 300
VSDHGRGSGC SSTAPALSGP VARTIYYIAA ELVRLVGTVE SMKPVLQSLY
310 320 330 340 350
HRILLYPPPQ HRVEAIKIMK EILGSPRRLC DLAGPCSSES ESRKRSISKR
360 370 380 390 400
KSHLDLLKLI MDGMTEACIK GGIEACYASV SCVFALLGAL DELSHGRGLS
410 420 430 440 450
EEQVHLLLRR LEELKDGTET SRDSMEINDA DFRWQRRILS SENPAWESGN
460 470 480 490 500
EKSPDISISV TTDTGQTTLE GDMGQTTPED NLESQKNSLP SPAGHESKEI
510 520 530 540 550
HYREPESETI DQPDVVQRSH NIVYPDITNF LSVDCKTRSY GSRYSESNFS
560 570 580 590 600
VDDQDLSRTE FDSCDQYSMA AEKDSGRSDV SDIGSDNCSL ADEEQTPRDC
610 620 630 640 650
PGTRSLRTAA LSLKLLKNQE ADQHSAQLFI QSLEALLPRL IALPSIEEVD
660 670 680 690 700
AALQNFSSAF CSGMMHSPGF EGNPNFSFQT LMNADSLYMV SHYTLLLNLK
710 720 730 740 750
LANSDYYRKK PPQAPVLLKE FMKQVQSSGV LMIFSQAWVE ELYHQVLERN
760 770 780 790 800
MLGEAGYWGS PEEHSLPLIT MLTDIDGLGS STVGGQLMAS ASAQSPLSQN
810 820 830 840 850
QKTDDSVVAG VAFARYLLIG CWKNLIDTLS TPLTGRMAGS SKGLAFILGA
860 870 880 890 900
EGAKEQNQKE KDSICLSLDG LRRAARLSCA LGVAANCASA LAQMAAASCV
910 920 930 940 950
QEEKEEKEIQ EPSDAIAQVK QKVEQKLEQM GKVQGVCLHT AHVLCMDAVL
960 970 980 990 1000
NVGLEMGSHN QDCWPHVFRV CEYISTLEHT HFSDGTSQPC LTITQSQQAP
1010 1020 1030 1040 1050
GGPHSDTELG EASQEQTPEQ ETTLSSNPVI QPVSIQELVK ESSKGRAFDF
1060 1070 1080 1090 1100
RGGSLLCGTS AAKAVLTLST QADRLFEDAA DKLNLMALAG FLYQLKKASQ
1110 1120 1130 1140 1150
AQLFHSVTDT VDYSLAMPGE VKSTQDRRSA LHLFRLGDAM LRIVRSKSRP
1160 1170 1180 1190 1200
LLHLMRCWSL VAPHLVEAAC HKERHVSRKA VSFIHDILTE VLTDWNEPSH
1210 1220 1230 1240 1250
FHFNESLFRP FERIMQLELC DEDVQDQVVT SIGELVEMCS TQIQSGWRPL
1260 1270 1280 1290 1300
FSALETVHSG NKSEVKEYLV GEYSMGKRQA PVFDVFEAFL NTDSIQVFAN
1310 1320 1330 1340 1350
AATSYIMCLM KFVKGLGEVD CKEMGDCVPG SGSASTDLCL PALDYLRRCS
1360 1370 1380 1390 1400
QLLAKIYKMP LKPIFLSGRL INMPRRVQEQ SASSEDGIEC ILSDFDDDTG
1410 1420 1430 1440 1450
LINVWIILLE ELTTAISNCP RQHQPPTLDL LFELLRDVAK TPGPGFGIYA
1460 1470 1480 1490 1500
VVHLLLPTMS LWLHRSHGDH SYWDVASANF KHAIGLSCEL VVEHIQNFIH
1510 1520 1530 1540 1550
SDIGYENMIN TMLKDLFKLL VACVAEPTEI ISRVGCSCIR KKKKFNCFVC
1560 1570 1580 1590 1600
FRIYSFAHCC VCHSCKICTI HIHKELVGCK YLKEVTQSFK VKYYCIKKVE
1610 1620 1630 1640 1650
IESRSPSYCS CFWNGRFSEP EPLMIFLQQK TTFPQGAPVL VLCILFLSLP
1660 1670 1680 1690 1700
ILGSPSIPFR TIVVSLLSHQ VLLQNLYDIL LEEFVKGPSN LEEKMTIQVP
1710 1720 1730 1740 1750
ENKLAGFLRY ISMQNLAVIF DLLLDSYRTA REFDTRPGLK CLLKKVSGIS
1760 1770 1780 1790 1800
GAANLYRQSA MSFNIYFHAL ICAILTNQEN ITAEQVKKIL FEDDERSTDS
1810 1820 1830 1840 1850
SQQCSSEDED IFEETAQVSP PRGKEKRQWR ARIPSLSVQP VSNADWGWLI
1860 1870 1880 1890 1900
KRLHKLCMEL CNNYIQMHLD LENNTEEPPV FKGDPFFILP SFHSETSTPS
1910 1920 1930 1940 1950
TGGQSGKDTP SEDDRSQIRD QLGDSLTPRS GEMLLLPPLS SPKPEKKEQN
1960 1970 1980 1990 2000
RKKEWWESAG NKIYTIATDK TISKFMTEYK KRKQQQQAMT SFTKEVKVDK
2010 2020 2030 2040 2050
KGELLGSRGQ DSPILQRPQH LIDQGQMRHS FSAGPEILRQ EKRPRSGSTV
2060 2070 2080 2090 2100
SSLNISVRDA EAQIQAWTNM VLTVLNQIQA LPDQTFTALQ PAVFPCISQL
2110 2120
TCHVTDIRVR QAVREWLGRV GRVYDIII
Length:2,128
Mass (Da):237,149
Last modified:November 16, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC7B2DBBFD42B88E
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMGAT00000014621; ENSMGAP00000013706; ENSMGAG00000012982

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSMGAT00000014621; ENSMGAP00000013706; ENSMGAG00000012982

Phylogenomic databases

GeneTreeiENSGT00530000064150
HOGENOMiCLU_000867_1_0_1
InParanoidiG1NJZ7
OMAiTCCWDSM
TreeFamiTF300714

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR032629, DCB_dom
IPR015403, Sec7_C
IPR000904, Sec7_dom
IPR035999, Sec7_dom_sf
PfamiView protein in Pfam
PF16213, DCB, 1 hit
PF09324, DUF1981, 1 hit
SMARTiView protein in SMART
SM00222, Sec7, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF48425, SSF48425, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1NJZ7_MELGA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1NJZ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: November 16, 2011
Last modified: June 2, 2021
This is version 53 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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