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Entry version 64 (10 Feb 2021)
Sequence version 2 (16 Nov 2011)
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Protein

Diacylglycerol kinase

Gene

DGKG

Organism
Meleagris gallopavo (Wild turkey)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycerolipid metabolism

This protein is involved in the pathway glycerolipid metabolism, which is part of Lipid metabolism.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway glycerolipid metabolism and in Lipid metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi182 – 193PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi227 – 238PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseUniRule annotationARBA annotation, Transferase
LigandATP-bindingUniRule annotationARBA annotation, CalciumPROSITE-ProRule annotationARBA annotation, Nucleotide-binding, ZincARBA annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00230

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Diacylglycerol kinaseUniRule annotation (EC:2.7.1.107UniRule annotation)
Short name:
DAG kinaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DGKGImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMeleagris gallopavo (Wild turkey)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9103 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaeMeleagridinaeMeleagris
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001645 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini169 – 204EF-handInterPro annotationAdd BLAST36
Domaini214 – 249EF-handInterPro annotationAdd BLAST36
Domaini264 – 314Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini329 – 378Phorbol-ester/DAG-typeInterPro annotationAdd BLAST50
Domaini416 – 539DAGKcInterPro annotationAdd BLAST124

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.UniRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156768

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003770_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1MWU5

Identification of Orthologs from Complete Genome Data

More...
OMAi
MSEDRWV

TreeFam database of animal gene trees

More...
TreeFami
TF313104

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00029, C1, 2 hits
cd00051, EFh, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.238.110, 2 hits
3.40.50.10330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017438, ATP-NAD_kinase_N
IPR029477, DAG_kinase_typeI_N
IPR037607, DGK
IPR038199, DGK_typeI_N_sf
IPR000756, Diacylglycerol_kin_accessory
IPR001206, Diacylglycerol_kinase_cat_dom
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR016064, NAD/diacylglycerol_kinase_sf
IPR002219, PE/DAG-bd

The PANTHER Classification System

More...
PANTHERi
PTHR11255, PTHR11255, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00130, C1_1, 2 hits
PF14513, DAG_kinase_N, 1 hit
PF00609, DAGK_acc, 1 hit
PF00781, DAGK_cat, 1 hit
PF13499, EF-hand_7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00109, C1, 2 hits
SM00045, DAGKa, 1 hit
SM00046, DAGKc, 1 hit
SM00054, EFh, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111331, SSF111331, 1 hit
SSF47473, SSF47473, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50146, DAGK, 1 hit
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS00479, ZF_DAG_PE_1, 2 hits
PS50081, ZF_DAG_PE_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1MWU5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDGGWITLS PAEFAQLQQY TDYSTKKLKD VLEEFHGDGV LSRYNPEQPI
60 70 80 90 100
DYEGFRLFMK TYLEVEVPEE LCQHLFTSFK RKSCQAAPEA QRQSPSISQL
110 120 130 140 150
EPKSLDAGIS IQTEVACAPV TVLEKRLPFS LRKSHSALKA APQHPPAPLA
160 170 180 190 200
QVVYLKDIVC YLSLLERGRA EDKLEFMFRL YDTDGNGILD SSELDRIINQ
210 220 230 240 250
MVHVAEYLEW DSTELKPILK AMMEEIDYDH DGNVTLEEWI RGGMTTIPLL
260 270 280 290 300
VLLGMETNVK DDGQHAWRLK HFKKPAYCNF CRTMLLGVRK QGLCCSFCKY
310 320 330 340 350
TVHERCVSKD IASCISTYVK SKRNTNVMQH TWIEGNSPVK CDRCHKSIKC
360 370 380 390 400
YQGITGLHCV WCQVTLHNKC ASHVKPECDG GPLRDHILLP SYICPVVLVR
410 420 430 440 450
GHPVPTPLGP CPVPTPXSGG RQGERVLRKF HYLLNPRQVY NLDRGGPAPG
460 470 480 490 500
LSFFRDTPDF RVLACGGDGT VGWILDCIDK ANLLKHPPVA VLPLGTGNDL
510 520 530 540 550
ARCLRWGGGY EGGSLMKVLK DIEHSTEVML DRWQIDVIPS DKEANGDPVP
560 570 580 590 600
YSIINNYFSI GVDASIAHRF HIMREKHPEK FNSRMKNKLW YFEFGTSETF
610 620 630 640 650
AATCKKLHDY VEVECDGTLL DLSNASLEGI AVLNIPSMYG GSNLWGETKK
660 670 680 690 700
QRGYNRLSKK APEKPHAAVV TDAKELKFCA QDLSDHLLEV VGLEGAMEMG
710 720 730 740 750
QIYTGLKSAG KRLAQCSAVT IRTSKLLPMQ VDGEPWMQPS CTVKITHKSQ
760 770
VPMLLGPPQK SSFFFLKRRN RTRD
Length:774
Mass (Da):87,023
Last modified:November 16, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE8D89FF0B962769
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMGAT00000003955; ENSMGAP00000003256; ENSMGAG00000003486

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Genome annotation databases

EnsembliENSMGAT00000003955; ENSMGAP00000003256; ENSMGAG00000003486

Phylogenomic databases

GeneTreeiENSGT00940000156768
HOGENOMiCLU_003770_1_0_1
InParanoidiG1MWU5
OMAiMSEDRWV
TreeFamiTF313104

Enzyme and pathway databases

UniPathwayiUPA00230

Family and domain databases

CDDicd00029, C1, 2 hits
cd00051, EFh, 1 hit
Gene3Di1.10.238.110, 2 hits
3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR017438, ATP-NAD_kinase_N
IPR029477, DAG_kinase_typeI_N
IPR037607, DGK
IPR038199, DGK_typeI_N_sf
IPR000756, Diacylglycerol_kin_accessory
IPR001206, Diacylglycerol_kinase_cat_dom
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR016064, NAD/diacylglycerol_kinase_sf
IPR002219, PE/DAG-bd
PANTHERiPTHR11255, PTHR11255, 1 hit
PfamiView protein in Pfam
PF00130, C1_1, 2 hits
PF14513, DAG_kinase_N, 1 hit
PF00609, DAGK_acc, 1 hit
PF00781, DAGK_cat, 1 hit
PF13499, EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00109, C1, 2 hits
SM00045, DAGKa, 1 hit
SM00046, DAGKc, 1 hit
SM00054, EFh, 2 hits
SUPFAMiSSF111331, SSF111331, 1 hit
SSF47473, SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS50146, DAGK, 1 hit
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS00479, ZF_DAG_PE_1, 2 hits
PS50081, ZF_DAG_PE_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1MWU5_MELGA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1MWU5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: November 16, 2011
Last modified: February 10, 2021
This is version 64 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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