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Entry version 54 (29 Sep 2021)
Sequence version 2 (29 Sep 2021)
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Protein
Submitted name:

Rho guanine nucleotide exchange factor 10 like

Gene

ARHGEF10L

Organism
Meleagris gallopavo (Wild turkey)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor 10 likeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGEF10LImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMeleagris gallopavo (Wild turkey)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9103 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaeMeleagridinaeMeleagris
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001645 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 23

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153798

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001213_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1MPX7

Identification of Orthologs from Complete Genome Data

More...
OMAi
CGEDEGK

TreeFam database of animal gene trees

More...
TreeFami
TF331430

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.130.10.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039919, ARHGEF10/ARHGEF17
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011993, PH-like_dom_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR036322, WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12877, PTHR12877, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065, SSF48065, 1 hit
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010, DH_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

G1MPX7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLWEKRRERG GETAQIPASL AAQHSQLRQP QRRLPAAPAG SPQPRHGDPS
60 70 80 90 100
MGLEGVWAAL GPPPPTAAPT AILLGRCGHK GRGDTAFPGK AQGRAQVESV
110 120 130 140 150
HPLCHGFIPA APLPHSSDEE EDEDSATEPS RGAVLQAPPR RHRATSSSTE
160 170 180 190 200
GLVPETQEGL PEQVSNGEAC EDPPDINTQT WKRKSGHQGD RFEFTAAEDD
210 220 230 240 250
VIYDDVPCEN LDANQDGRSL IYEDVQRGEE LGWSSSEFES YSEESGEENK
260 270 280 290 300
PEAEPAKHRA SFQPKMTQLM KAAKSGTKDG LEKTKIAVMR KVTFLHRKEV
310 320 330 340 350
PGDSEEEDTG FLEVTVSDAK HPPPELGPMP TGLSPQQVVR RHILGSIVQS
360 370 380 390 400
ERSYVESLKR ILQDYRNPLM EMEPKVLSAR KCQVVFFRLK EILQCHSMFQ
410 420 430 440 450
IALSSRVAEW DSAEKIGDLF VASFSKSMVL DVYSDYVNNF TTAMSLIKKA
460 470 480 490 500
CLTKPAFLDF LKKRQMASTD RVTLYGLMVK PIQRFPQFIL LLQDMLKNTP
510 520 530 540 550
KGHADRLSLQ LALTELETLA EKLNEQKRVA DQVAEIQQLS KSISDRSSLS
560 570 580 590 600
KLLNSGQRQL LLCETLTETV YGDRGQLIKS KERKVFLLND MLVCANINFK
610 620 630 640 650
PVNPRGQLEI SSLVPLGPKY VVKWSTALPQ VQVVEVGQES GAYDKDNVVI
660 670 680 690 700
HNAGAKKHAP TGPASHNKVY LGPPRLFQEL QDLQKDLAVV EQITLLISTL
710 720 730 740 750
HGTYQNLNMT VAQDWCLALQ RMMKVKEEEI HSANKCRLRL LLPGKPDKSG
760 770 780 790 800
RPISVMVVFI TPNPLSKISW VNCLHLAKIG LREENQPGWL CPDEDKKSKA
810 820 830 840 850
PFWCPILSCH MPAFSSKALD LQLSAAVHNP VQSSLLGFSA VSTSLPQGYL
860 870 880 890 900
WVGGGQEGAG GQVEIFSLNR SVPRTVKSFP VASPVLCMEY IPEAAEGDTE
910 920 930 940 950
GTEEPRAGAE QPPATLHPTV CLGLRDGSIA VYSSVDTGTQ CLLTCKSPGT
960 970 980 990 1000
QPVLCLKHSP EYLFAGLQDG TVAAYPRNNV GLWDLTEQPT RLPVGTSPVR
1010 1020 1030 1040 1050
ALLMLDETLW ASCANQVTVL DASTLCAQQT FEAHPDTEAS VTHMIKAGSG
1060 1070 1080 1090 1100
VWMAFSSGSS IRLFHTETLE HLQEINIATR TTFVLPGQRH VRVTSLLICQ
1110 1120 1130 1140 1150
GLLWVGTDQG IIVLLPVPRL EGIPKITGKG MVSLNGHGGP VDFLAVALST
1160 1170 1180 1190 1200
LAPDVLKGDQ EDEDGEEEKP LELDGPPPRE IRKKGILLQY RLRSTSHLPG
1210 1220 1230 1240 1250
QLLSVRDAPV GTVTPEHTEE DGSIYEMADD PDVWVRSRPC ARDAPRKEIS
1260 1270 1280
SVAIISGGRG YRNFNSEPQR RGGDADSTLL IWQLR
Length:1,285
Mass (Da):141,186
Last modified:September 29, 2021 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i499029EDE265EEB8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A803Y5T9A0A803Y5T9_MELGA
Rho guanine nucleotide exchange fac...
ARHGEF10L
1,249Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A803YAX7A0A803YAX7_MELGA
Rho guanine nucleotide exchange fac...
ARHGEF10L
1,311Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMGAT00000000728; ENSMGAP00000000097; ENSMGAG00000000716

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSMGAT00000000728; ENSMGAP00000000097; ENSMGAG00000000716

Phylogenomic databases

GeneTreeiENSGT00940000153798
HOGENOMiCLU_001213_1_0_1
InParanoidiG1MPX7
OMAiCGEDEGK
TreeFamiTF331430

Family and domain databases

CDDicd00160, RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.130.10.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR039919, ARHGEF10/ARHGEF17
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011993, PH-like_dom_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR036322, WD40_repeat_dom_sf
PANTHERiPTHR12877, PTHR12877, 1 hit
PfamiView protein in Pfam
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00325, RhoGEF, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
SSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50010, DH_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1MPX7_MELGA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1MPX7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: September 29, 2021
Last modified: September 29, 2021
This is version 54 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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